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Cellular Cellular RespirationRespiration
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Cellular RespirationCellular Respiration A catabolic, exergonic, oxygen (Ocatabolic, exergonic, oxygen (O22))
requiring process that uses energyenergy extracted from macromolecules (glucose)macromolecules (glucose) to produce energy (ATP)energy (ATP) and water (Hwater (H22O).O).
C6H12O6 + 6O2 6CO2 + 6H2O + energyglucoseglucose ATP
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Question:Question: In what kinds organisms does In what kinds organisms does
cellular respiration take place?cellular respiration take place?
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Plants and AnimalsPlants and Animals Plants - AutotrophsPlants - Autotrophs: self-producers. Animals - Heterotrophs: consumers.
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MitochondriaMitochondria OrganelleOrganelle where cellular respirationcellular respiration takes
place.
Innermembrane
Outermembrane
Innermembrane space
Matrix Cristae
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Redox ReactionRedox Reaction Transfer of one or more electrons
from one reactant to another.
Two types:Two types:1.1. OxidationOxidation2.2. ReductionReduction
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Oxidation ReactionOxidation Reaction The lossloss of electrons from a
substance. Or the gaingain of oxygenoxygen.
C6H12O6 + 6O2 6CO2 + 6H2O + energy
glucose ATP
OxidationOxidation
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Reduction ReactionReduction Reaction The gaingain of electrons to a
substance. Or the lossloss of oxygenoxygen.
glucose ATP
C6H12O6 + 6O2 6CO2 + 6H2O + energy
ReductionReduction
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Breakdown of Cellular Breakdown of Cellular RespirationRespiration
Four main parts (reactions).Four main parts (reactions).
1. Glycolysis (splitting of sugar)1. Glycolysis (splitting of sugar)a. cytosol, just outside of mitochondria.
2. Grooming Phase2. Grooming Phasea. migration from cytosol to matrix.
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Breakdown of Cellular Breakdown of Cellular RespirationRespiration3. Krebs Cycle (Citric Acid Cycle)3. Krebs Cycle (Citric Acid Cycle)
a. mitochondrial matrix
4. Electron Transport Chain (ETC) and4. Electron Transport Chain (ETC) and Oxidative PhosphorylationOxidative Phosphorylation
a. Also called Chemiosmosisb. inner mitochondrial membrane.
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1. Glycolysis1. Glycolysis Occurs in the cytosol just outside of
mitochondria. Two phases (10 steps):Two phases (10 steps):
A. Energy investment phaseA. Energy investment phasea. Preparatory phase (first 5 steps).B. Energy yielding phaseB. Energy yielding phasea. Energy payoff phase (second 5 steps).
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1. Glycolysis1. GlycolysisA. Energy Investment Phase:A. Energy Investment Phase:
Glucose (6C)
Glyceraldehyde phosphate (2 - 3C) (G3P or GAP)
2 ATP - used0 ATP - produced0 NADH - produced
2ATP
2ADP + P
C-C-C-C-C-C
C-C-C C-C-C
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1. Glycolysis1. GlycolysisB. Energy Yielding PhaseB. Energy Yielding Phase
Glyceraldehyde phosphate (2 - 3C) (G3P or GAP)
Pyruvate (2 - 3C) (PYR)
0 ATP - used4 ATP - produced2 NADH - produced
4ATP
4ADP + PC-C-C C-C-C
C-C-C C-C-C
GAP GAP
(PYR) (PYR)
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1. Glycolysis1. Glycolysis Total Net YieldTotal Net Yield
2 - 3C-Pyruvate (PYR)2 - ATP (Substrate-level Phosphorylation)2 - NADH
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Substrate-Level Phosphorylation
ATP is formed when an enzyme transfers a phosphate groupphosphate group from a substrate to ADP.
Enzyme
Substrate
O-
C=OC-O-CH2
P P P Adenosine
ADP(PEP)Example:PEP to PYR
P PPATP
O-
C=OC=OCH2
Product(Pyruvate)
Adenosine
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Fermentation Fermentation Occurs in cytosol when “NO Oxygen”“NO Oxygen” is
present (called anaerobic).(called anaerobic). Remember: glycolysisglycolysis is part of
fermentationfermentation. Two Types:Two Types:
1.1. Alcohol FermentationAlcohol Fermentation2. Lactic Acid Fermentation2. Lactic Acid Fermentation
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Alcohol FermentationAlcohol Fermentation Plants and FungiPlants and Fungi beer and beer and
winewine
glucose
Glycolysis
CCCCCC
CCC
2 Pyruvic acid
2ATP2ATP2ADP+ 2
2NADH
P
2 NAD+
CC
2 Ethanol2 Ethanol2CO2CO22
releasedreleased
2NADH 2 NAD+
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Alcohol FermentationAlcohol Fermentation End Products: Alcohol fermentationEnd Products: Alcohol fermentation
2 - ATP (substrate-level phosphorylation)2 - CO2
2 - Ethanol’s
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Lactic Acid FermentationLactic Acid Fermentation Animals (pain in muscle after a Animals (pain in muscle after a
workout).workout).
2 Lactic2 Lactic acidacid
2NADH 2 NAD+
CCC
Glucose
GlycolysisCCC
2 Pyruvic acid
2ATP2ATP2ADP+ 2
2NADH
P
2 NAD+
CCCCCC
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Lactic Acid FermentationLactic Acid Fermentation End Products: Lactic acid End Products: Lactic acid
fermentationfermentation
2 - ATP (substrate-level phosphorylation)2 - Lactic Acids
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2. Grooming Phase2. Grooming Phase Occurs when Oxygen is present (aerobic).Oxygen is present (aerobic). 2 Pyruvate (3C) molecules are transported
through the mitochondria membrane to the matrix and is converted to 2 Acetyl CoA (2C) molecules.
CytosolCCC
2 Pyruvate
2 CO2 CO22
2 Acetyl CoA2 Acetyl CoAC-CC-C
2NADH2NADH2 NAD+
Matrix
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2. Grooming Phase2. Grooming Phase End Products: End Products: grooming phasegrooming phase
2 - NADH2 - NADH2 - CO2 - CO22
2- Acetyl CoA (2C)2- Acetyl CoA (2C)
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3. Krebs Cycle (Citric Acid 3. Krebs Cycle (Citric Acid Cycle)Cycle) Location:Location: mitochondrial matrix. Acetyl CoA (2C) bonds to Oxalacetic
acid (4C - OAA) to make Citrate (6C). It takes 2 turns of the krebs cycle to
oxidize 1 glucose molecule.
MitochondrialMatrix
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3. Krebs Cycle (Citric Acid 3. Krebs Cycle (Citric Acid Cycle)Cycle)
KrebsCycle
1 Acetyl CoA (2C)
3 NAD+
3 NADH3 NADHFAD
FADHFADH22
ATPATP ADP + P
(one turn)(one turn)
OAA (4C) Citrate (6C)
2 CO2
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3. Krebs Cycle (Citric Acid 3. Krebs Cycle (Citric Acid Cycle)Cycle)
KrebsCycle
2 Acetyl CoA (2C)
6 NAD+
6 NADH6 NADH2 FAD
2 FADH2 FADH22
2 ATP2 ATP 2 ADP + P
(two turns)(two turns)
OAA (4C)Citrate (6C)
4 CO2
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3. Krebs Cycle (Citric Acid 3. Krebs Cycle (Citric Acid Cycle)Cycle) Total net yield (2 turns2 turns of krebs
cycle)
1. 2 - ATP (substrate-level phosphorylation)2. 6 - NADH3. 2 - FADH2
4. 4 - CO2
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4. Electron Transport Chain (ETC) 4. Electron Transport Chain (ETC) andand Oxidative Phosphorylation Oxidative Phosphorylation ((ChemiosmosisChemiosmosis))
Location:Location: inner mitochondrial membrane.
Uses ETC (cytochrome proteins)ETC (cytochrome proteins) and ATP Synthase (enzyme) to make ATP.
ETC pumps H+ (protons) across innermembrane (lowers pH in innermembrane space).Inner
MitochondrialMembranecopyright cmassengale
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4. Electron Transport Chain (ETC) 4. Electron Transport Chain (ETC) andand Oxidative Phosphorylation Oxidative Phosphorylation ((ChemiosmosisChemiosmosis))
The H+ then move via diffusiondiffusion (Proton Motive Force) through ATP Synthase to make ATP.
All NADH and FADH2 converted to ATP during this stage of cellular respirationcellular respiration.
Each NADH converts to 3 ATP. Each FADH2 converts to 2 ATP (enters the
ETC at a lower level than NADH).
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4. Electron Transport Chain (ETC) 4. Electron Transport Chain (ETC) andand Oxidative Phosphorylation Oxidative Phosphorylation ((ChemiosmosisChemiosmosis))
Innermembrane
Outermembrane
Innermembrane space
MatrixCristae
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4. 4. ETC and Oxidative Phosphorylation ETC and Oxidative Phosphorylation ((Chemiosmosis for Chemiosmosis for NADHNADH))
NADH+ H+
ATPSynthase
1H+ 2H+ 3H+
higher Hhigher H++
concentrationconcentration
H+
ADP + ATP
lower Hlower H++
concentrationconcentration
H+
(Proton Pumping)
P
E T C
NAD+2H+ + 1/2O2 H2O
Intermembrane SpaceIntermembrane Space
MatrixMatrix
InnerMitochondrialMembrane
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4. 4. ETC ETC and and Oxidative Phosphorylation Oxidative Phosphorylation (Chemiosmosis for (Chemiosmosis for FADH2)
FADH2
+ H+
ATPSynthase
1H+ 2H+
higher Hhigher H++
concentrationconcentration
H+
ADP + ATP
lower Hlower H++
concentrationconcentration
H+
(Proton Pumping)
P
E T C
FAD+ 2H+ +
1/2O2H2O
Intermembrane SpaceIntermembrane Space
MatrixMatrix
InnerMitochondrialMembrane
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TOTAL ATP YIELDTOTAL ATP YIELD1. 04 ATP - substrate-level
phosphorylation2. 34 ATP - ETC & oxidative
phosphorylation 38 ATP - TOTAL YIELD
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Eukaryotes(Have Membranes)
Total ATP Yield02 ATP - glycolysis (substrate-level phosphorylation)
04 ATP - converted from 2 NADH - glycolysis06 ATP - converted from 2 NADH - grooming
phase02 ATP - Krebs cycle (substrate-level phosphorylation)
18 ATP - converted from 6 NADH - Krebs cycle04 ATP - converted from 2 FADH2 - Krebs cycle36 ATP - TOTAL
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Maximum ATP Yield for Cellular Respiration (Eukaryotes)
36 ATP (maximum per glucose)
Glucose
Glycolysis
2ATP 4ATP 6ATP 18ATP 4ATP 2ATP
2 ATP(substrate-levelphosphorylation)
2NADH
2NADH6NADH
KrebsCycle
2FADH2
2 ATP(substrate-levelphosphorylation)
2 Pyruvate2 Acetyl CoA
ETC and Oxidative Phosphorylation
CytosolMitochondria
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ProkaryotesProkaryotes(Lack Membranes)(Lack Membranes)
Total ATP Yield02 ATP - glycolysis (substrate-level phosphorylation)
06 ATP - converted from 2 NADH - glycolysis06 ATP - converted from 2 NADH - grooming
phase02 ATP - Krebs cycle (substrate-level phosphorylation)
18 ATP - converted from 6 NADH - Krebs cycle04 ATP - converted from 2 FADH2 - Krebs cycle38 ATP - TOTAL
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Question:Question: In addition to glucose, what other In addition to glucose, what other
various food molecules are use in various food molecules are use in Cellular Respiration?Cellular Respiration?
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Catabolism of VariousCatabolism of VariousFood MoleculesFood Molecules Other organic molecules used for
fuel.
1. Carbohydrates: polysaccharides
2. Fats: glycerol’s and fatty acids3. Proteins: amino acids
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