Download - Centre for NanoHealth Future Healthcare
Centre for NanoHealthSwansea University www.nanohealth.swansea.ac.uk
Centre for NanoHealthFuture Healthcare
Dr Steve Conlan
Director - Centre for NanoHealthInstitute of Life Science
School of Medicine
www.nanohealth.swansea.ac.uk
Centre for NanoHealthSwansea University
Overview
• Nanotechnology
• NanoHealth
• Impact of NanoHealth
• Centre for NanoHealth
• Challenges and Opportunities
• R&D
www.nanohealth.swansea.ac.uk
Centre for NanoHealthSwansea University
Please turn off your Nanotechnology based devices.
www.nanohealth.swansea.ac.uk
Centre for NanoHealthSwansea University
The nano-scale
www.nanohealth.swansea.ac.uk
Centre for NanoHealthSwansea University
What is NanoHealth?
www.nanohealth.swansea.ac.uk
Centre for NanoHealthSwansea University
Ability to manipulate and control the properties and interaction of material where at least 1-D is nm.
• Structural• Mechanical• Electronic• Optical• Chemical• Biological• Computational• Modelling
Nanotechnology…
Multidisciplinary
…For Healthcare
Centre for NanoHealthSwansea University www.nanohealth.swansea.ac.uk
The impact of NanoHealth
www.nanohealth.swansea.ac.uk
Centre for NanoHealthSwansea University
NanoHealth…… has the potential to impact on the prevention, early and reliable diagnosis and treatment of diseases.
European Technology Platform on NanoMedicine Vision Paper (2005)
NanoHealth embraces five main sub-disciplines
that in many ways are overlapping
• Analytical Tools
• Imaging Tools
• Materials and Devices
• Novel Therapeutics and Drug Delivery Systems: ‘Nanomedicines’
• Clinical, Regulatory and Toxicological Issues
ESF forward look on Nanomedicine (2005)
www.nanohealth.swansea.ac.uk
Centre for NanoHealthSwansea University
• Diagnosing and treating diseases• Enhancing early intervention• Non-hospital environments• Personalised Medicine
Impact on Healthcare
www.nanohealth.swansea.ac.uk
Centre for NanoHealthSwansea University
Economic Impact
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Centre for NanoHealthSwansea University
Economic Impact
www.nanohealth.swansea.ac.uk
Centre for NanoHealthSwansea University
Global Networks/Global Investment EU, US, South America and Asia
Alliance for Nanohealth
ETP for Nanomedicine
Centre for NanoHealthSwansea University www.nanohealth.swansea.ac.uk
Centre for NanoHealth
www.nanohealth.swansea.ac.uk
Centre for NanoHealthSwansea University
Partnership for SuccessInstitute of Life Science
£52m collaborative venture between IBM, Swansea University, WAG, opening its doors in 2007
Home in the Medical School, 25 specialist teams (27 Professors and 220 Research active staff)
Multidisciplinary Nanotechnology Centre
More than £5M funding in 2002 from HEFCW, Royal Society/ Wolfson Foundation, SRIF and Swansea University
Home in Engineering, major research centre (20 academic staff, 20 RAs and 40 PhD students)
Outstanding RAE 2008 results (THES)
MNC 5th out of 52 in UK in General Engineering, 80% of activity rated 4* and 3*
ILS 7th out of 70 in UK in Allied and Professional Health, 55% of activity 4* and 3*
www.nanohealth.swansea.ac.uk
Centre for NanoHealthSwansea University
Partnership for Success
• Successfully managed Objective 1 project• On time - On budget• Outputs met– sustainability/job creation/strong links with business/IP• Blue C IBM partnership• Interdisciplinary research base
• University NHS Trust• Patient base of 600,000+• Partnership with ILS and MNC • Joint MNC and ILS laboratories in Morriston Hospital• Commitment to CNH
• Successfully managed HEFCW project• Model interdisciplinary centre• Self-sustaining (£2M per year)• Strong links with business/IP• Pan-Wales focus for nanotech
www.nanohealth.swansea.ac.uk
Centre for NanoHealthSwansea University
Centre for NanoHealth
• £22M EU Convergence funded project, started January 2009
• 12 new staff (8 academic, 4 project management and delivery).
• £13M investment in state of the art open access nano- and bio-facilities.
• Industry to come and work with us, access to facilities, expertise and incubation space.
Unique interdisciplinary R&D environment Based on the application of Nanotechnology Leading innovations in Healthcare.
Driving the Knowledge Economy
www.nanohealth.swansea.ac.uk
Centre for NanoHealthSwansea University
Centre for NanoHealth
www.nanohealth.swansea.ac.uk
Centre for NanoHealthSwansea University
Project Funding
• £22 Million, 5 year Knowledge Economy project• Supported by:• WEFO [£10.5 Million]• DHSS [£1.5 Million]• Swansea University [£7.6 Million] • Industry [£2.5 Million]
www.nanohealth.swansea.ac.uk
Centre for NanoHealthSwansea University
CNH Targets & Deliverables
• Establishing a European R&D Centre of Excellence• Assisting 400 Enterprises (>80% Welsh SMEs)• Assisting 100 Individuals• Creating 450 Jobs• Achieving sustainability by 2014
Through Welsh, UK, Industrial and EU funding
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Centre for NanoHealthSwansea University
Building opens Q3 2011Facilities available nowCNH
Bio-suite• NanoToxicology• Cell Imaging• Tissue Engineering• Molecular biology• Microbiology
Nano-suite• Class 100/1000 ‘dirty’ clean room• Bio-clean room• Nanostructure growth• SEM & AFM/SNOM• NMR & Rheology• Printing and Coating
Direct access to: Clinical Trials Unit & Patient imaging (MRI&CT)
Centre for NanoHealthSwansea University www.nanohealth.swansea.ac.uk
Projects challenges & opportunities
www.nanohealth.swansea.ac.uk
Centre for NanoHealthSwansea University
Challenges & Opportunities
• Company recruitment
• Business development
• IP
• State Aid
• Managing stakeholder expectations
• Sustainability
www.nanohealth.swansea.ac.uk
Centre for NanoHealthSwansea University
Company recruitment & Business development
• Project must offer real opportunities to businesses across Wales
• Take the project to the companies
• Launch Events/BioWales/KTNs etc
• Initial assistance is only the first step in the relationship
• Ensure multiple entries for engagement
• Pool of relevant expertise is essential
• Awareness of funding opportunities is essential
• Beware of ERDF overload – internal/institutional management vital
www.nanohealth.swansea.ac.uk
Centre for NanoHealthSwansea University
• Access Clinical/Biomedical/Engineering teams
• Fully integrated work flow
• Access at any stage
• Translational applications
• Great opportunities in a new area of healthcare
CNH
www.nanohealth.swansea.ac.uk
Centre for NanoHealthSwansea University
IP / IPR
• IP policy of University has to be flexible
• Case by case consideration – one model DOES NOT fit all
• Primary consideration to companies – SHOW STOPPER
• Has to be managed differently to IP generated in house
• Early negotiation
• Companies understand and appreciate position of University
• State Aid compliance
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Centre for NanoHealthSwansea University
State Aid
• Necessarily a major consideration under European law
• Documentation from WEFO offers clarity in their expectations
• Seek legal advice on wording used in business plans
• De minimus scheme easy to implement
www.nanohealth.swansea.ac.uk
Centre for NanoHealthSwansea University
Sustainability – R&D pipeline
• Start early
• Awareness of all opportunities
• Development pipeline
www.nanohealth.swansea.ac.uk
Centre for NanoHealthSwansea University
Delivery = Team work!!
• Medicine
• Engineering
• Finance
• Research and Innovation
• Procurement
• VC’s office
• ABMUHB
• External project managers / build team
• WEFO
Early/Continued/Agreed/Managed engagement
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Centre for NanoHealthSwansea University
CNH operational structure
Centre for NanoHealthSwansea University www.nanohealth.swansea.ac.uk
NanoHealth R&D
www.nanohealth.swansea.ac.uk
Centre for NanoHealthSwansea University
www.nanohealth.swansea.ac.uk
Centre for NanoHealthSwansea University
Ultra-sensitive biosensor for the detection of bio-markers using bio-compatible ZnO nanowires.
Diagnostics – Biosensors
ZnO nanowires (AFM)
Novel Materials
Antibody
Antigen
Nanowire
Electrode
www.nanohealth.swansea.ac.uk
Centre for NanoHealthSwansea University
• Surface topography.• Material properties.• Spatial resolution 5 - 20 nm.
Cellular Analysis for Clinical Diagnostics
www.nanohealth.swansea.ac.uk
Centre for NanoHealthSwansea University
Volume additive printing for the integration of biosensors with flexible polymer electronics, photonics and displays.
Biosensors / Biomarker Detection
www.nanohealth.swansea.ac.uk
Centre for NanoHealthSwansea University
Centre for NanoHealth
www.nanohealth.swansea.ac.uk
Centre for NanoHealthSwansea University
Centre for NanoHealth