Transcript
![Page 1: Chapter 15 – The Chromosomal Basis of Inheritance](https://reader036.vdocuments.net/reader036/viewer/2022081519/568134d7550346895d9c0640/html5/thumbnails/1.jpg)
Chapter 15 – The Chromosomal Basis of Inheritance
![Page 2: Chapter 15 – The Chromosomal Basis of Inheritance](https://reader036.vdocuments.net/reader036/viewer/2022081519/568134d7550346895d9c0640/html5/thumbnails/2.jpg)
Sex Determination
![Page 3: Chapter 15 – The Chromosomal Basis of Inheritance](https://reader036.vdocuments.net/reader036/viewer/2022081519/568134d7550346895d9c0640/html5/thumbnails/3.jpg)
Sex-linked genes
![Page 4: Chapter 15 – The Chromosomal Basis of Inheritance](https://reader036.vdocuments.net/reader036/viewer/2022081519/568134d7550346895d9c0640/html5/thumbnails/4.jpg)
Sex linked inheritance
• Must show sex chromosomes
• Hemizygous
![Page 5: Chapter 15 – The Chromosomal Basis of Inheritance](https://reader036.vdocuments.net/reader036/viewer/2022081519/568134d7550346895d9c0640/html5/thumbnails/5.jpg)
X inactivation
• Barr body
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Linked genes
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Nondisjunction
• Aneuploidy
– Monosomy
– Trisomy
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Down syndrome
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Trisomies in sex chromosomes
• Klinefelter syndrome 47, XXY
• Jacob syndrome 47, XYY
• TriploX 47, XXX
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Monosomy in sex chromosome
• Turner syndrome 45, XO
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Chromosome structural abnormalities • Deletion
• Duplication
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Chromosome structural abnormalities cont
• Inversion
• Translocation