Download - Combi Chem: letzter Block
Library Synthesis 6-1
Combi Chem: letzter Block•http://pubs.acs.org/isubscribe/journals/cen/81/i19/html/8119sci2.html
•THE SMALL-MOLECULE APPROACH TO BIOLOGY http://pubs.acs.org/isubscribe/journals/cen/81/i09/html/8109genomics.html
•Steven V. Ley's group at the University of Cambridge carried out the first total synthesis of the bioactive alkaloid(+)-plicamine (Image 4) [Angew. Chem. Int. Ed., 41, 2194 (2002); C&EN, June 17, page 26]. All transformations used in the synthesis were done with supported reagents and scavengers, avoiding the need for any chromatographic, crystallization, or distillation steps.
Library Synthesis 6-2
Dynamic CombinatorialChemistry
•http://pubs.acs.org/isubscribe/journals/cen/80/i50/html/8050chemhighlights2.html
•Update Combi Chem
•http://pubs.acs.org/isubscribe/journals/cen/80/i45/html/8045combinatorial.html
Library Synthesis 6-3
Library Synthesis
•Multicomponent one-pot reactions
•Multigeneration reactions
•Liquid-liquid phase extraction (LPE)
•Liquid-solid phase extractions (SPE) using polymeric scavengers
•Solution reactions using polymer-bound reagents or catalysts
SPOS Examples 6-11
Ugi 4CC (3)
Zu einer Lösung von 0.42 mmol Aldehyd in 0.5 ml Me0H wirdeine Lösung von 0.42 mmol Säure, 0.42 mmol Isonitril und 0.42 mmol Amin (methanolische Lösung) in 1.5 ml Me0Hzugetropft. 65 Stdn. bei Raumtemp. rühren