Contrl siRNA + -PIK3R3 siRNA - +

actin

PIK3R3

2.9% 2.58%

Control siRNA PIK3R3 siRNA

Anne

xin-

V

PI

C

ctrl siRNA PIK3R3 siRNABrdu incorporation (%) 46.2 ± 2.0 37.0 ± 3.8 *

Brdu

-FIT

C

7-ADD

Control siRNA PIK3R3 siRNA

day 1 day 2 day 3 day 40

0.5

1

1.5

2

2.5

3

HGC27

control siRNA

PIK3R3 siRNA

OD

(A59

5)

A B

D

Supplemental Figure 2