2003 Quinoline derivatives

Quinoline derivativesR 0410 Design and Synthesis of Novel Pyrrolidine-Containing Bradykinin Antagonists.

— Novel pyrrolidine containing bradykinin antagonists (X) are synthesized (no yields given). Contrary to the expectations by reason of conformational analysis, binding data indicate that the (S)-enantiomer is a little more potent than the (R)-enantiomer. — (LEE*, J.; REYNOLDS, C.; JETTER, M. C.; YOUNGMAN, M. A.; HLASTA, D. J.; DAX, S. L.; STONE, D. J.; ZHANG, S.-P.; CODD, E. E.; Bioorg. Med. Chem. Lett. 13 (2003) 11, 1879-1882; Drug Discovery, Johnson & Johnson Pharm. Res. Dev., Spring House, PA 19477, USA; Eng.) — M. Schroeter

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