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GENETIC MAPPING
CAROLINA CARDONA TOBÓNMedicine Student
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INTRODUCTION
Genetic mapping locates a gene on a chromosome
Allows you to find hereditary diseases related to an alteration.
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New technique maps elusive chemical markers on proteins. Salk Institute for Biological Studies (2015, July 2).
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New technique maps elusive chemical
markers on proteins
Phosphates bond to aminoacids in the final stages of creating a protein.
It is hard to visualize phosphates on histidine aminoacid.
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New technique maps elusive chemical markers on proteins
Researchers used phosphonate, which binds more tightly to the histidine aminoacid.
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New technique maps elusive chemical markers on proteins
They developed antibodies that recognized phosphohistidine in proteins and added them to mammalian cells.
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New technique maps elusive chemical markers on proteins
STUDENT´S OBSERVATION
I think this investigation is important because they found a way of visualizing a bond hard to see because of the histidine aminoacid instability, now they can analyze more aminoacids and study its process related with diseases.
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The Regenerators. Stanford University.(2015, September 1).
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THE REGENERATORS
In mammals hair cells of the utricle can regenerate after damage.
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THE REGENERATORS
They developed a genetic marker based in a gene Lgr5, its expression increased in supporting cells after chemical damage.
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THE REGENERATORS
Lgr5 expressing cells proliferated in vivo after chemical damage and supporting cells became hair cells.
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THE REGENERATORSSTUDENT´S OBSERVATION
I think it is an amazing discovery, because its application can be really useful for people with hearing loss, it can actually be a solution for deaf people.
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MEDICAL UTILITY
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MEDICAL UTILITY
These investigations are medically useful because they both analize the illness process based on genome and also based on an alteration of the normal function of cells they evaluated.
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MEDICAL UTILITY
Genome mapping is important for medical utility because once you are aware of the location of the gene in the genome you can use some technique to improve investigation, and to treat some diseases.
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MEDICAL UTILITY
Genome mapping allows researchers to find te cure for a disease, an specific diagnosis and the right treatment improving cuality of life.
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BIBLIOGRAPHY Salk Institute for Biological Studies. (2015, July 2). “New
technique maps elusive chemical markers on proteins”. Retrieved from www.sciencedaily.com/releases/2015/07/150702131801-htm.
Stanford University, Amanda B. Keener. (2015, September 1). “The regenerators, a molecular signature makes it posible to trace the details of hair cell replacement in the mammalian inner ear”. Retrieved from www.thescientist.com/?articles.view/articleNo/43825/title/The-Regenerators/.
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