Download - Effect of local tissue factor
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EFFECT OF EFFECT OF LOCAL TISSUE LOCAL TISSUE
FACTORSFACTORSHORMONES TO CAUSE HORMONES TO CAUSE
SMOOTH MUSCLE SMOOTH MUSCLE CONTRACTION WITHOUT CONTRACTION WITHOUT
ACTION POTENTIALACTION POTENTIAL
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SMOOTH MUSCLE CONTRACTION SMOOTH MUSCLE CONTRACTION IN RESPONSE TO LOCAL TISSUE IN RESPONSE TO LOCAL TISSUE
CHEMICAL FACTORSCHEMICAL FACTORS Initiation of smooth muscle Initiation of smooth muscle
contraction by stimulatory factorscontraction by stimulatory factors Without action potentialWithout action potential Non-nervous stimulatory factorsNon-nervous stimulatory factors
1.Local tissue factors1.Local tissue factors 2.Various hormones2.Various hormones
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SMOOTH MUSCLE CONTRACTION SMOOTH MUSCLE CONTRACTION IN RESPONSE TO LOCAL TISSUE IN RESPONSE TO LOCAL TISSUE
CHEMICAL FACTORSCHEMICAL FACTORS Smallest vessels have absence of nervous Smallest vessels have absence of nervous
supplysupply Responding rapidly to changes in local Responding rapidly to changes in local
chemical condition in the surrounding chemical condition in the surrounding interstitial fluidinterstitial fluid
In normal resting state contraction of blood In normal resting state contraction of blood vessels occurvessels occur
Extra blood is needed by tissueExtra blood is needed by tissue Relaxation of vessel by multiple factorsRelaxation of vessel by multiple factors Allowing for increased flow Allowing for increased flow
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CONTROL SYSTEMSCONTROL SYSTEMS Local feedback control systemLocal feedback control system Control blood flow to local tissue areaControl blood flow to local tissue area Lack of oxygen in the local tissueLack of oxygen in the local tissue It causes smooth muscle relaxation and It causes smooth muscle relaxation and
vasodilationvasodilation Excess carbon dioxide causes Excess carbon dioxide causes
vasodilationvasodilation Increased hydrogen ion concentration Increased hydrogen ion concentration
causes vasodilationcauses vasodilation
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CONTROL FACTORS CONTROL FACTORS CAUSING VASODILATIONCAUSING VASODILATION
AdenosineAdenosine Lactic acidLactic acid Increased potassium ionsIncreased potassium ions Low calcium ion concentrationLow calcium ion concentration High body temperatureHigh body temperature
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EFFECT OF HORMONES ON EFFECT OF HORMONES ON SMOOTH MUSCLE CONTRACTIONSMOOTH MUSCLE CONTRACTION EpinephrineEpinephrine Nor-epinephrineNor-epinephrine AcetylcholineAcetylcholine AngiotensinAngiotensin EndothelinEndothelin VasopressinVasopressin OxytocinOxytocin
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EFFECT OF HORMONES ON EFFECT OF HORMONES ON SMOOTH MUSCLE CONTRACTIONSMOOTH MUSCLE CONTRACTION SerotoninSerotonin HistamineHistamine Hormone-gated excitatory receptorHormone-gated excitatory receptor Hormone-gated excitatory receptorHormone-gated excitatory receptor
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MECHANISM OF SMOOTH MUSCLE MECHANISM OF SMOOTH MUSCLE EXCITATION OR INHIBITION BY EXCITATION OR INHIBITION BY HORMONES OR LOCAL TISSUE HORMONES OR LOCAL TISSUE
FACTORSFACTORS MECHANISM OF SMOOTH MUSCLE MECHANISM OF SMOOTH MUSCLE
EXCITATION EXCITATION Nerve stimulationNerve stimulation Hormone receptor in membraneHormone receptor in membrane Open sodium and calcium channelsOpen sodium and calcium channels DepolariztionDepolariztion Enhancement of action potential Enhancement of action potential
alreadty occuringalreadty occuring
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MECHANISM OF SMOOTH MECHANISM OF SMOOTH MUSCLE EXCITATIONMUSCLE EXCITATION
In other casesIn other cases No action potentialNo action potential Depolarization occursDepolarization occurs Allows Ca influxAllows Ca influx Promotes contractionPromotes contraction
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MECHANISM OF SMOOTH MECHANISM OF SMOOTH MUSCLE INHIBITIONMUSCLE INHIBITION
Hormone or tissue factors closes sodium Hormone or tissue factors closes sodium and calcium channelsand calcium channels
Entry is non-permissibleEntry is non-permissible Normally closed potassium channels are Normally closed potassium channels are
openedopened Allowing positive ions to diffuse out of the Allowing positive ions to diffuse out of the
cellcell Increase of negativityIncrease of negativity HyperpolarizationHyperpolarization Cessation of contractionCessation of contraction
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MECHANISM OF SMOOTH MECHANISM OF SMOOTH MUSCLE EXCITATION BY MUSCLE EXCITATION BY
HORMONESHORMONES No change in membrane potentialNo change in membrane potential Hormone activate a membrane receptorHormone activate a membrane receptor No ion channel openingNo ion channel opening Cause an internal change in muscle cellCause an internal change in muscle cell Release of calcium ions from Release of calcium ions from
intracellular sarcoplasmic reticulumintracellular sarcoplasmic reticulum ContractionContraction
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MECHANISM OF SMOOTH MUSCLE MECHANISM OF SMOOTH MUSCLE INHIBITION BY RECEPTOR INHIBITION BY RECEPTOR
MECHANISMSMECHANISMS Activation of enzyme adenylate cyclase Activation of enzyme adenylate cyclase
or guanylate cyclaseor guanylate cyclase Present in cell membranePresent in cell membrane Portions of receptor protrude in cellPortions of receptor protrude in cell Receptors are coupled with the enzymesReceptors are coupled with the enzymes Formation of cyclic adenosine Formation of cyclic adenosine
monophosphatemonophosphate Second messengerSecond messenger
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SECOND MESSENGERSECOND MESSENGER They are molecules that relay signals from They are molecules that relay signals from
receptor on the cell surface to target receptor on the cell surface to target molecules inside the cellmolecules inside the cell
cAMP system, phosphoinositol, arachidonic cAMP system, phosphoinositol, arachidonic systemsystem
The binding of ligands (first messenger) to The binding of ligands (first messenger) to many cell surface receptors leads to a short many cell surface receptors leads to a short lived increase or decrease in concentration of lived increase or decrease in concentration of certain low molecular weight intracellular certain low molecular weight intracellular signalling molecules termed second messengersignalling molecules termed second messenger
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EFFECTS OF SECONFD EFFECTS OF SECONFD MESSENGERMESSENGER
To change the degree of To change the degree of phosphorylation of enzymes phosphorylation of enzymes inhibiting contractioninhibiting contraction
Acivation of sarco pumpAcivation of sarco pump Acivation of cell membrane pumpAcivation of cell membrane pump Reduction of calcium ion Reduction of calcium ion
concentration in cellconcentration in cell Cessation of contractionCessation of contraction
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EFFECTS OF EFFECTS OF SUBSTANCESSUBSTANCES
Same substance cause contraction Same substance cause contraction and relaxation in different locationsand relaxation in different locations
Nor-epinephrine inhibits contraction Nor-epinephrine inhibits contraction in intestinein intestine
Stimulates contraction in blood Stimulates contraction in blood vesselsvessels
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SMOOTH MUSCLE SMOOTH MUSCLE CONTRACTIONCONTRACTION
SOURCE OF CALCIUM IONSSOURCE OF CALCIUM IONS Sarcoplasmic reticulum is slightly Sarcoplasmic reticulum is slightly
developeddeveloped Entry of calcium ions from extracellular Entry of calcium ions from extracellular
fluidfluid Concentration of calcium ions in Concentration of calcium ions in
extracellular fluid is greaterextracellular fluid is greater 10-3 molar inside smooth muscle10-3 molar inside smooth muscle Calcium pores openingCalcium pores opening Rapid diffusionRapid diffusion
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SMOOTH MUSCLE SMOOTH MUSCLE CONTRACTIONCONTRACTION
200-300ms200-300ms Latent periodLatent period 50times great as compared to 50times great as compared to
skeletal musclesskeletal muscles
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ROLE OF SMOOTH ROLE OF SMOOTH MUSCLE SARCOPLASMIC MUSCLE SARCOPLASMIC
RETICULUMRETICULUM Slightly developed sarcoplasmic reticulumSlightly developed sarcoplasmic reticulum CaveolaeCaveolae Small invaginations of cell membraneSmall invaginations of cell membrane Present to near to tubulesPresent to near to tubules Rudimentary analog of transverse tubule Rudimentary analog of transverse tubule
systemsystem Action potential reaches at caveloaeAction potential reaches at caveloae Transmission through sarco-tubulesTransmission through sarco-tubules Release of calcium ionsRelease of calcium ions
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EFFECT OF SMOOTH MUSCLE CONTRACTION EFFECT OF SMOOTH MUSCLE CONTRACTION CAUSED BY CHANGING OF EXTRACELLULAR CAUSED BY CHANGING OF EXTRACELLULAR
CALCIUM ION CONCENTRATIONCALCIUM ION CONCENTRATION
Changing in extracellular calcium Changing in extracellular calcium ion concentration in skeletal musclesion concentration in skeletal muscles
Opposite effect for smooth musclesOpposite effect for smooth muscles Calcium ion concentration falls from Calcium ion concentration falls from
1/3 to 1/101/3 to 1/10 Contraction is inhibitedContraction is inhibited
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CALCIUM PUMPCALCIUM PUMP Calcium ions must be removed from Calcium ions must be removed from
intracellular enviromentintracellular enviroment Pumps calcium back to extracellular Pumps calcium back to extracellular
fluid or sacroplasmic reticulumfluid or sacroplasmic reticulum Slow actingSlow acting Comparison to skeletal musclesComparison to skeletal muscles Prolonged contractionProlonged contraction