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ELETTROFISIOLOGIA OSPEDALE MAURIZIANO -TORINO-
Madden JL. Resection of the left auricular appendix lAMA 1948;140:769 -72.
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Inability to achieve high rates of LAA successful occlusion The highest success rate was 93% Means success rate 55–66% successful occlusion in a variety of methods including stapling, ligation and amputation.
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B. UNSWORTH JACC 2011
IMPROPER POSITIONINGPERI DEVICE LEAKS
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jce
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jce
IMPROPER POSITIONING
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DEVICE RELATED THROMBUSThe majority of thrombi at 6 month follow up
• All patients should be assessed for thrombus at 45 day, 6 month and 12 month follow up TEE visits.
• The following medication regimen is recommended.
• Discontinue ASA/Plavix and restart coumadin for at least 12weeks. Repeat TEE after 12 weeks
• If thrombus is resolved on the follow-up TEE,patient may resume ASA 325mg until the next scheduled follow-up visit.
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•Non-Rheumatic AF found thrombus present in 12.6% of patients.
•90% of the thrombus was found in the LAA
Orhan Onalan and Eugene Crystal, Stroke 2007;38;624-630ELETTROFISIOLOGIA OSPEDALE MAURIZIANO -TORINO-
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COMBINED END POINT
Stroke, cardiovascular/unexplained death, systemic cardioembolization
Watchman group (RR:0,68)
32%
800 pts non valvular AF CHADS2 > 1
Randomization 2:1 warfarin/ watchman
Procedure warfarin 45 days clopidogrel +ASA 6 months ASA
PROTECT AF
COMPLICATIONS
Overall: 12,3%
Pericardial tamponade : 5%
Stroke : 1 %
Removal : 4 pts ( sepsis/embolisation)
Surgical intervention: 2,2%
Holmes DR Lancet 2009;374:534-42ELETTROFISIOLOGIA OSPEDALE MAURIZIANO -TORINO-
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RELY STUDYTIME TO FIRST STROKE OR SSE
Warfarin
Years
RRR35%
Cum
ulat
ive
haza
rd r
ates
0
0.01
0.02
0.03
0.05
0.04
0.0
0.5 1.0 1.5 2.0 2.5
RR 0.90(95% CI: 0.74–1.10)P<0.001 (NI)P=0.30 (Sup)
RR 0.65(95% CI: 0.52–0.81)P<0.001 (NI)P<0.001 (Sup)
RR = relative risk; RRR = relative risk reduction; SSE = systemic embolism.Dabigatran etexilate is not approved for clinical use in stroke prevention in atrial fibrillation outside the US and Canada.Connolly SJ, et al. N Engl J Med 2010;363:1875-1876.
Dabigatran 150 mg BID Dabigatran 110 mg BID
3.0
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Apixaban WarfarinEvent Rate 1.27 1.60
HR (95% CI): 0.79 (0.66, 0.95)
P-value Non-Inferiority <0.001
P-value Superioriy = 0.01
Apixaban Warfarin
Event Rate 2.13 3.09
HR (95% CI): 0.69 (0.60, 0.80)
P-value <0.001
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3% SR no OAT
23% AF , OAT
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ELETTROFISIOLOGIA OSPEDALE MAURIZIANO -TORINO-
CONCLUSION