EVOLUTIONARY GENOMICS OF ORGANISMAL DIVERSITY
Steve Moss
My PhD
• Introduction
• Summer work
• First year
• Second year
• Third year
• In a Nutshell
Introduction
• Deliberately broad title
• Comparative Genomics
• Genome evolution
• Organismal adaptation
• Bioinformatics and Computational Biology
• Cross-discipline
“Evolutionary Genomics of Organismal Diversity”
Summer work
• Previous PhD work
• Teleost fish
• Genome architecture
• Introns and exons
• EnsEMBL
• Comparative genomics
Summer Work
Corroboration
• Retrieve original data
• Developed novel scripts
• EnsEMBL release 46
• EnsEMBL release 58
• Unable to reproduce
The PhD
First Year• Phylogenetic comparative
method?• Genome size• Intron number and size• Transposable elements
• Orthologous loci?• Do orthologous introns
evolve in a clock-like manner?
• Gene families?• Significance of gene family
size changes?• Social insect data
The PhD
First Year
• Data
• Computational evolutionary comparative genomics
• Develop software toolkit
• Implement basic pipeline
• Genomic components
• Include orthology
• Expand across taxa
The PhD
Second Year
• Patterns of heterozygosity
• Expansion of transposable element families
• Polyploidy• Decay of alleles• Regain of diploidy
• Nematode genomics• Blaxter Lab• Meiosis• Sequence pair• 3 nematode genomes
The PhD
Third Year
• Follow up interesting ideas and discoveries
• Analyze any new genomes
• GOLD
• Make updates to toolkit
In a nutshell…
• Answer important biological questions
• Evolution of genome architecture
• Evolutionary Comparative Genomics
• Bioinformatics and Computational Biology
• Development of software and tools
Thank you!
Any questions?
Steve MossEmail: [email protected]
Web: http://stevemoss.ath.cx/Twitter: @gawbul