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Hanson Buyer’s Guide March 2011
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SaleS & Support
Corporate HeadquartersHanson Research Corporation9810 Variel AvenueChatsworth, CA 91311 USA
pHone 800.821.8165 or 818.882.7266Press 1 for Technical SupportPress 4 for Customer Support (Place & Track Orders)Press 5 for Sales Department (Request Quote or Literature)Press 6 for Service Department
Fax orders to 818.882.9470
online hansonresearch.comSales Support [email protected] Support [email protected] Support hansonresearch.com/tsrService Support (US) [email protected] Support (International) Contact your local Hanson representative
WarrantyHanson products are warranted for one full year including parts and labor (except for glass and consumables). International dealer warranties may vary. A variety of HRCare service and preventive maintenance contracts are available to maintain peak operation of your Hanson equipment. Consult your Hanson representative for details.
Hanson Research is a certified ISO 9001:2008 corporation.
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Table of Contents | 99-300-001 Rev. 3-11 | hansonresearch.com
Table of ContentsSales & Support .................................................................Front Inside CoverVision® Dissolution Testers ............................................................................ 1
Hanson Vision® Technology .......................................................................2Vision® Classic 6™ & Elite 8™ Dissolution Testers ........................................2Vision®-Enabled AutoPlus™ ......................................................................3Vision Dissolution Test Supplies & Accessories ..........................................5
SR8-Plus™ Dissolution Testers .................................................................... 11SR8-Plus™—Standard .............................................................................11SR8-Plus™—High Stand ..........................................................................12SR8-Plus™ Dissolution Test Supplies & Accessories .................................13
Media-Mate Plus™ Automatic Prep System ................................................ 26Dissolution Media Concentrates ................................................................. 27Dissolution Validation & Calibration Accessories ......................................... 29
Q-Pak™ IQ/OQ/PQ Validation Guideline....................................................29
AutoPlus Autosampling Systems ................................................................ 31AutoPlus™ DissoScan™ & Maximizer™ Autosamplers ................................32AutoPlus System Components ................................................................33
UV-Vis System ........................................................................................... 34UV Detection & Data Analysis with Agilent................................................34
Legacy DDS™ (Dissolution Data System) .................................................... 35Bill™ DDS™ (Dissolution Data System) ......................................................... 37Diffusion Cell Test Systems ......................................................................... 40
“Start-up” 6-Cell Manual Test System ......................................................40MicroettePlus™ Automated Test System ...................................................41MicroettePlus Multi-Group ......................................................................42Vertical Diffusion Cells (required with system) ...........................................43
Physical Test Equipment ............................................................................. 47Flodex™ Powder Flowability Test Apparatus .............................................47QC-21™ Disintegration Test System .........................................................47
HRCare™ .................................................................................................... 48Service & Validation Plans ........................................................................48ASTM Program ........................................................................................49
Terms, Conditions, and Warranty ................................................................ 50Packaging Information ................................................................................ 51Trademarks ................................................................................................ 52Notices ....................................................................................................... 52About Hanson ....................................................................Back Inside Cover
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hansonresearch.com | 99-300-001 Rev. 3-11 | Vision Dissolution Testers�
Vision Dissolution Testers
Special Order
Special Order
ViSion® DiSSolution teSterS
Vision Standard Features & Accessory Options
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� Vision Dissolution Testers | 99-300-001 Rev. 3-11 | hansonresearch.com
Vision Dissolution Testers
Hanson Vision® TechnologyVision technology presents a brand new, holistic dissolution test platform for the pharmaceutical industry. These units are designed for the 24/7 rigors of the modern research, formulations, and quality control labs. The term “Vision” was coined by Steve Shaw, our Chief Engineer. Steve’s long-standing dream of a rugged, yet extremely compact 6-vessel tester has been brilliantly realized in our new Classic 6. Our new Elite 8 is a complete redesign of our popular SR8-Plus, providing a new standard for automation-ready performance dissolution testers. Both units include all new design features for critical operation and user-friendly setup, saving analysts time, hassle, and job fatigue.
Vision® Classic 6™ & Elite 8™ Dissolution TestersHanson has traditionally offered one dissolution tester with each product platform. With Vision, we now offer two distinct choices. The Classic 6 is a rugged 6-vessel workhorse, ideal for manual test routines, space-limited labs, and budget-minded programs. The Elite 8 is an 8-vessel performance machine, built for automation and extended applications. Both units include PC and web-ready communications and can be serviced by autosamplers with fixed vessel-mount cannulas. The Elite 8 offers an automatic magazine option for inserting and withdrawing sample probes
and digital temperature probes into the dissolution media.
Vision Classic 6 and Elite 8 dissolution testers are built for easy laboratory setup, including factory-mounted spindle shafts (6 & 8, for USP spin-paddles & spin-baskets), and a rugged molded waterbath with Vision heater circulator system. Order USP vessels, vessel covers, USP spin-paddles and spin-baskets, and other accessory options separately—“a la carte.” Vision equipment is 115/230 V 50/60 Hz compatible. U.S. Patents.
Vision Dissolution Testersp/n Description
74-201-001 Vision Classic 6 Dissolution Tester6-VesselFixed HeadLow-cost & Compact
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74-101-001 Vision Elite 8 Dissolution Tester8-VesselEasi-LiftAutomation-ready
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74-101-070 Elite 8 Auto-MagThe auto-magazine requires sample probes and/or DTPs (digital temperature probes) and can be factory installed or field retrofitted. Probes ordered separately (see pg. 7). (Not compatible with small volume.)
See Vision Dissolution Test Supplies & Accessories for “a la carte” choice of USP vessels, vessel covers, USP paddles & baskets, and other Vision accessory options. Vision accessories are exclusive for the Classic 6 and Elite 8 testers.
Elite 8 & Classic 6 Dissolution Testers
Auto-Mag (Elite 8 only)74-101-070
Sample Auto-Probe(includes tubing harness)
Digital Temperature Probe
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hansonresearch.com | 99-300-001 Rev. 3-11 | Vision Dissolution Testers�
Vision Dissolution Testers
Vision®-Enabled AutoPlus™
Vision-Enabled AutoPlus System Diagrams(pictured with an Elite 8 dissolution tester)
Validation PrinterValidation Printer
Validation Printer
Validation Printer
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� Vision Dissolution Testers | 99-300-001 Rev. 3-11 | hansonresearch.com
Vision Dissolution Testers
Vision®-Enabled AutoPlus™ The popular Hanson AutoPlus dissolution autosampling system is easily adapted to work with the Vision Classic 6 and Elite 8 dissolution testers. Version 4.0 firmware provides communication for speed, temperature, and time, as well as Auto-Mag operation on the Elite 8. Both DissoScan and Maximizer options are available, including the MultiFill collector with test tube and vial racks. Choose 6- or 8-vessel sampling capability. Connect the Vision-enabled Maximizer with 1 or 2 Classic 6 testers or with 1 or 2 Elite 8 testers, both including media replace/rinse. See page 31 for details on AutoPlus features and ordering information.
Version 4.0 firmware modifies the AutoPlus to program and work directly with the Vision Classic 6 and Elite 8 testers. All protocol test parameters are entered on the AutoPlus, providing “single-point” programming. (The Classic 6 and Elite 8 do not have stand-alone protocols.) Programming features include:
25 protocols (edit, manage, and save)
Single-point programming on the AutoPlus
Autosampling from 1 or 2 Vision testers with media replace (Maximizer)
Sample collection in MultiFill (UV test tubes or HPLC vials)
Advanced protocol scripting
21 CFR Part 11 security tools
System validation protocols and diagnostics
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Vision-Enabled AutoPlus Firmwarep/n Description
60-200-923 AutoPlus Firmware ver. 4.0 (factory installed)
60-200-725 AutoPlus Firmware ver. 4.0 Upgrade Kit for Vision (field installed)
Q-Pak IQ/OQ/PQ Validation Guidelinep/n Description
60-200-851 Q-Pak IQ/OQ/PQ for Vision-Enabled AutoPlus
Vision sample probes (either “fixed” vessel-mount probes or “auto-probes” for use in the Auto-Mag) are required for interface with the new Classic 6 and Elite 8 dissolution testers. See AutoPlus Autosampling Systems for complete details on AutoPlus features and functionality.
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hansonresearch.com | 99-300-001 Rev. 3-11 | Vision Dissolution Test Supplies & Accessories�
Vision Dissolution Test Supplies & Accessories
Vision Dissolution Test Supplies & Accessories
Paddles, Baskets, Printers, and Holders74-105-201 Spin-Paddle, USP, PVDF
74-105-202 Spin-Paddle, USP, 316 SS
74-105-251 Spin-Basket Shaft, USP, 316 SS
74-105-252 Precision Basket, USP, 40 Mesh, 316 SS
74-104-060 Validation Printer for Classic 6 & Elite 8,115 V (uses non-thermal paper rolls; 1 printer per bath required)
74-104-061 Validation Printer for Classic 6 & Elite 8, 230 V (uses non-thermal paper rolls; 1 printer per bath required)
95-590-059 Shaft Holder, 16 Position, Captured (stores and protects baskets and all Vision shafts)
95-590-062 Basket Holder, 12 Capacity, Stackable
Spin-Paddle & Spin-Basket Assembly and Shaft
Drive Head Spindle Shaft(included w/ Classic 6 and Elite 8)
Spin-Basket Assembly
Spin-Paddle
-OR-
Basket Holder, 12 Capacity95-590-062
95-590-059 Vision Shaft Holder
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� Vision Dissolution Test Supplies & Accessories | 99-300-001 Rev. 3-11 | hansonresearch.com
Vision Dissolution Test Supplies & Accessories
VesselsHanson Precision USP vessels have been an industry standard for many years. These precision vessels, manufactured of quality borosilicate glass, meet or exceed USP vessel dimensions and are an excellent choice for dissolution testing, including ASTM requirements. Vision “Easi-Lock” precision vessels include rugged CPVC tops for easy lock-in position in the vessel plate, and no more accidental chipping of glass vessel lids.
Easi-Lock vessels come with individual serial numbers and a USP Certificate of Conformity (COC), and are available for Hanson Vision Classic 6 and Elite 8 dissolution testers. (See HRCare—ASTM Program for more COC information.)p/n Description
74-104-101 Easi-Lock Vessel, USP, Precision, 1 L, Glass
74-104-102 Easi-Lock Vessel, USP, Precision, 1 L, Glass, Amber (Special Order—min order 6)
Vessel Coversp/n Description
74-104-151 Easi-Lock Vessel Cover (for 1 or 2 L)
74-104-152 ADD (Auto-Dosage Delivery) Vessel Cover for Vision (manual or automated w/ Elite 8 Auto-Mag)
72-800-430 Vessel Hole Cover
Easi-Lock Vessel
ADD Cover for Vision(closed view)74-104-152
Easi-Lock Cover74-104-151
ADD Cover for Vision(opened view)74-104-152
Loading ChamberTrigger
Universal Vessel Carrier, 6 Position95-590-069
Universal Vessel Carrier, 8 Position95-590-070
Vessel CarriersMade of all non-corrosive rigid ABS plastic construction with sturdy non-skid rubber legs, these vessel carriers transport filled vessels to and from media prep stations and dissolution baths. Holds all brands of 1 liter and 2 liter dissolution vessels. Space-saving stackable design when empty. p/n Description
95-590-069 Universal Vessel Carrier, 6 Position
95-590-070 Universal Vessel Carrier, 8 Position
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hansonresearch.com | 99-300-001 Rev. 3-11 | Vision Dissolution Test Supplies & Accessories�
Vision Dissolution Test Supplies & Accessories
Cartridge Filters (for Fixed Vessel-Mount Probes; 100% Porous Polyethylene)p/n Description
74-104-301 Cartridge Filters, 10 micron (100/pk)
74-104-302 Cartridge Filters, 10 micron (1,000/pk)
74-104-303 Cartridge Filters, 35 micron (100/pk)
74-104-304 Cartridge Filters, 35 micron (1,000/pk)
74-104-307 Cartridge Filters, 70 micron (100/pk)
74-104-308 Cartridge Filters, 70 micron (1,000/pk)
Sample Filters (for Auto-Probes; 100% Porous Polyethylene)p/n Description
27-101-074 Sample Filters, 10 micron, 1/8 in. (100/pk)
27-101-091 Sample Filters, 10 micron, 1/8 in. (1,000/pk)
27-101-085 Sample Filters, 35 micron, 1/8 in. (100/pk)
27-101-095 Sample Filters, 35 micron, 1/8 in. (1,000/pk)
27-101-082 Sample Filters, 70 micron, 1/8 in (100/pk)
27-101-092 Sample Filters, 70 micron, 1/8 in (1,000/pk)
Probes & Cannulasp/n Description
74-104-201 Manual Sampling Cannula, Adjustable, 1/8 in., PEEK (for all Vision manual sampling)
74-104-202 Fixed Vessel-Mount Sample Probe, 500 mL, 1/16 in., 316 SS
74-104-203 Fixed Vessel-Mount Sample Probe, 900 mL, 1/16 in., 316 SS
74-104-204 Fixed Vessel-Mount Sample Probe, Adjustable, 1/16 in., 316 SS (App. 5 and other volumes, except small volume)
74-104-211 Fixed Vessel-Mount Sample Probe, Adjustable, 1/16 in., 316 SS (small volume only)
74-104-205 * Return Port Fitting (return to vessel)
65-233-246 * Return Harness, 6 ft., 6-Sample, 1/16 in.
65-233-248 * Return Harness, 6 ft., 8-Sample, 1/16 in.
74-104-206 Auto-Probes, 6 Sample, 1/8 in., PEEK (w/ tubing harness for Auto-Mag)
74-104-208 Auto-Probes, 8 Sample, 1/8 in., PEEK (w/ tubing harness for Auto-Mag)
74-104-209 Digital Temperature Probes for Auto-Mag (set/6) (includes circuit board)
74-104-210 Digital Temperature Probe for Auto-Mag (1)
* Return Harness is required when sample is to be returned to vessel (single-bath application only).
Manual Sampling Cannula74-104-201
Fixed Vessel-Mount Sample Probe(adjustable shown)
Return Port Fitting
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Vision Dissolution Test Supplies & Accessories
Sinkers (for all Hanson dissolution systems)p/n Description
65-190-012 Sinkers (6/pk) (wt 1.3 g; 9.5 mm x 25 mm capacity)
65-190-013 Sinkers (12/pk) (wt 1.3 g; 9.5 mm x 25 mm capacity)
65-700-316 Stainless Wire to Sink Capsules, 316 SS (50 ft roll)
95-590-021 Sinker, Spiral Coated (0.90 in. x 0.37 in. capacity)
95-590-022 Sinker, Spiral Uncoated, 316 SS (0.90 in. x 0.37 in. capacity)
95-590-023 Sinker, Spiral Coated (1.02 in. x 0.38 in. capacity)
95-590-024 Sinker, Spiral Uncoated (1.02 x 0.38 in. capacity)
95-590-025 Sinker, 3 Prong
95-590-026 Sinker, Japanese Pharmacopoeia Cage
Sprial coated sinkers are coated with 100% inert epoxy.
Hanson Transdermal Sandwich (USP Apparatus 5 “Paddle Over Disk”)The Transdermal Sandwich is a convenient disk assembly recommended by the FDA for testing patch dosage forms in a standard dissolution test station for USP Apparatus 5 “Paddle Over Disk.” The Transdermal Sandwich consists of a glass watchglass (on which the patch is placed, delivery side up), a 17-mesh PVDF screen (to hold the patch), and PVDF clips to hold the disk assembly together. For use with standard USP 1 liter vessel and paddle. Accommodates patches up to 90 mm diameter. Used on all Hanson dissolution testers.p/n Description
65-190-092 Transdermal Sandwich for Patch
65-190-093 Transdermal Sandwich for Patch (set/6)
Transdermal Sandwich
Sinker65-190-012/013
Sprial Coated Sinker95-590-021
Spiral Uncoated Sinker95-590-024
3 Prong Sinker95-590-025
Japanese Pharmacopoeia Cage Sinker95-590-026
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hansonresearch.com | 99-300-001 Rev. 3-11 | Vision Dissolution Test Supplies & Accessories�
Vision Dissolution Test Supplies & Accessories
Return Port Fitting (optional)
Vessel Cover
Easi-Lock Adapter Ring
Flat-Bottom VesselMini Spin-Paddle
Ointment Cell
Small Volume Dissolution AccessoriesUsed for low concentration drug formulations and other special applications when small volume dissolution media is required. Provides everything you need to convert from the standard USP 1 liter vessel and paddle to small volume testing. The 150 mL round-bottom vessel is patterned after the standard USP 1 liter vessel. The 150 mL flat-bottom vessel is used with the Hanson Ointment Cell. The mini spin-paddle is patterned after the standard USP Apparatus 2 paddle. Consult Hanson for special mini-basket and other special requirements.
The Hanson Ointment Cell is designed for use with the flat-bottom vessel to eliminate dead volume. The cell uses standard 25 mm filter disks, and its 3 mm deep dosage area provides for testing of infinite dose topical applications. Ointment Cells with convenient assembly tool and grip tool are available as a set; extra cells may be ordered separately.
For Hanson Vision testers, order accessories as required “ala carte”.
1. Choose your Vessel
p/n Description
74-105-151 Vessel, Round Bottom, 150 mL, Glass
74-105-161 Vessel, Round Bottom, 150 mL, Glass, Amber (Special Order—min order 6)
74-105-152 Vessel, Flat Bottom, 150 mL, Glass
74-105-162 Vessel, Flat Bottom, 150 mL, Glass, Amber (Special Order—min order 6)
2. Choose your Paddle
p/n Description
74-105-203 Mini Spin-Paddle, PVDF Coated
74-105-204 Mini Spin-Paddle, 316 SS
3. Choose your Probe
p/n Description
74-104-211 Fixed Vessel-Mount Sample Probe, Adjustable, 1/16 in., 316 SS (small volume only)
74-104-201 Manual Sampling Cannula, Adjustable, 1/8 in., PEEK (for all Vision manual sampling)
4. Add one each per position
p/n Description
74-104-153 Vessel Cover (for small volume vessels)
74-104-155 Easi-Lock Adapter Ring (for small volume vessels)
74-104-205 Return Port Fitting (optional)
5. Ointment Cells for Flat-Bottom Vessels (order one for each position)
p/n Description
65-190-043 Ointment Cell, 15 mm (cell only)
65-190-051 Ointment Cell, 15 mm (1 cell w/ tools)
65-190-052 Ointment Cell, 15 mm (set/6 w/ tools)
Small Volume accessories for SR8-Plus and Vision are not interchangeable except for Ointment Cells.
Membrane Area
Dosage Area
Ointment Cell(cross section)
Small Volume—Flat Bottom
Vessel Cover
Easi-Lock Adapter RingRound-Bottom Vessel
Mini Spin-Paddle
Fixed Vessel-Mount Sample Probe
Small Volume—Round Bottom
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Vision Dissolution Test Supplies & Accessories
Q-Pak IQ/OQ/PQ Validation Guidelinep/n Description
74-108-005 Q-Pak IQ/OQ/PQ for Vision Dissolution Testers—USP
74-108-006 Q-Pak IQ/OQ for Vision Dissolution Testers—ASTM
Certificates & Service7-920 * Recalibration Service (for Validation Tool Kit p/n 74-107-004)
7-909 * Individual Certificate of Conformity for USP Accessory (Special Order)
7-910 * Document Replacement Service for Certificate of Conformity (Special Order)
7-911 * Document Replacement Service for Blank IQ/OQ ProtocolsAvailable to U.S. customers only with proof of related HRCare service purchase
7-912 * Document Replacement Service for Blank PQ Protocols Available to U.S. customers only with proof of related HRCare service purchase
* No discounts apply to p/n 7-XXX. Please supply serial numbers at time of order if applicable.
Accessories & Toolsp/n Description
74-107-002 Digital Level Kit (self-calibrating)(required for Vision dissolution baths and all ASTM bath validation)
74-107-003 O-Ring Tool Kit (service only tool)
74-107-004 Validation Tool Kit (for Vision baths and ASTM validation on SR8-Plus)
74-107-005 Height Set & Check Kit (set tool for go/no go depth gauge)
91-600-037 Super Siphon (bath drain hose)
91-902-020 Electro-Mechanical Tool Kit
Digital Height Gauge
Sweep Gauge
Height Check Tool
Height Set Tool
Bubble Level
Wobble Gauge
Wobble Bracket (non-Vision)
Wobble Bracket (Vision)
Indicator Bracket
Wobble Shaft
Sweep Shaft
Case (2)
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Validation Tool Kit74-107-004
Q-Pak IQ/OQ/PQ for Vision—USP74-108-005
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hansonresearch.com | 99-300-001 Rev. 3-11 | SR8-Plus Dissolution Testers��
SR8-Plus Dissolution Testers
Sr8-pluS™ DiSSolution teSterSSR8-Plus™—StandardHanson model SR8-Plus (“Sustained Release”) dissolution testers provide state-of-the-art performance, meeting/exceeding all USP/FDA requirements and other international specifications for dissolution testing. Each SR8-Plus dissolution tester includes:
Intuitive, interactive “virtual instrument” programming
Easy-Icon control pad, status lights, and graphical display
“Pop-up” menus and convenient help screens
Program memory for 25 complete dissolution test protocols
Password control for 21 CFR Part 11 compliant firmware
Programmable chime and alarm times
Rear-mounted easy-access CPU with expansion slots
RS232 computer interface
Optional printer for hardcopy test validation
Programs for calibration and diagnostics
Precision SR “Sustained Release” drive system mounted on Easi-Lift
Choice of 6 or 8 operational drive spindles
Hidden counterweight system
SR high performance, maintenance-free motor
Easy speed selection
Programmable infinity test
Molded PETG waterbath
Easy temperature set with programmable morning wakeup
Temperature probe for individual vessel validation
Bath low-water fail-safe
Thick, rugged powder-coated vessel plate
Self-centering USP 1 liter vessel with rotary covers (6 or 8)
Please choose paddles, baskets, and printer separately to create a complete test system. Height adjustment spacers are included only if paddles and/or baskets are ordered with system. Specify voltage when ordering. U.S. Patents. CE Approved.
SR8-Plus Dissolution Tester p/n Description
SR8-Plus-6S 6-Spindle, 6-Vessel Dissolution Tester
SR8-Plus-8S 8-Spindle, 8-Vessel Dissolution Tester
Paddles, Baskets, Printer (needed to create a complete test system)p/n Description
72-800-456 Paddle, USP, w/ 15 in. Shaft, PVDF
65-240-000 Basket Assembly, USP, w/ 15 in. Shaft
73-100-116 Validation Printer for SR8-Plus, 115/230 V
Additional paddles, baskets, and accessories are listed on the following pages.
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SR8-Plus Dissolution Tester
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SR8-Plus Dissolution Testers
SR8-Plus™—High StandThe SR8-Plus “High Stand” dissolution tester is designed for maximum flexibility in the dissolution lab, allowing for easy expansion of traditional 1 liter dissolution testing and accommodating large volume 2 liter testing. The SR8-Plus “High Stand” is available as a factory assembly or as a convenient field upgrade kit. Specify voltage when ordering.
“Small Volume” dissolution kits are also available. Please consult Hanson for any other special volume requirements.
SR8-Plus “High Stand” Factory Assembledp/n Description
SR8-Plus-6S-HS 6-Spindle, 6-Vessel Dissolution Tester, 2 L (w/ extended bath and frame)
SR8-Plus-8S-HS 8-Spindle, 8-Vessel Dissolution Tester, 2 L (w/ extended bath and frame)
SR8-Plus “High Stand” Field Upgrade Kit (includes extended bath w/ heater assembly and 4 frame extensions)p/n Description
73-111-011 SR8-Plus High Stand Field Upgrade Kit, 115 V
73-111-012 SR8-Plus High Stand Field Upgrade Kit, 230 V
Large 2 liter vessels, extra-long paddles and/or baskets, and 2 liter probes must be ordered separately. A 1 liter E-Probe may be converted to a 2 liter E-Probe with addition of 9 in. Lead Screw p/n 91-220-037.
SR8-Plus “High Stand” dissolution tester shown here represents the versatility of the 2 liter system to accommodate 1 liter, 2 liter, and small volume vessels.
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hansonresearch.com | 99-300-001 Rev. 3-11 | SR8-Plus Dissolution Test Supplies & Accessories��
SR8-Plus Dissolution Test Supplies & Accessories
SR8-Plus™ Dissolution Test Supplies & AccessoriesPaddlesp/n Description
72-800-456 Paddle, USP, w/ 15 in. Shaft, PVDF
72-800-461 Paddle, USP, w/ 18 in. Shaft, PVDF, “Long”
72-800-457 Paddle, USP, w/ 21 in. Shaft, 2 L, PVDF, “Extra Long”
65-700-036 Paddle, USP, w/ 15 in. Shaft, 316 SS
65-700-037 Paddle, USP, w/ 21 in. Shaft, 2 L, 316 SS, “Extra Long”
72-800-460 Mini-Paddle, PVDF Coated (for 150 mL vessel)
All paddles in this section are serialized.
15 in. 18 in. 21 in. 15 in. 21 in. Mini-Paddle
PVDF (Polyvinylidene Fluoride) 316 Stainless Steel PVDF Coated
Shaft HoldersMade of non-corrosive plastic, these shaft holders efficiently organize the dissolution lab, hold all lengths of paddle and basket shafts, and safely transport paddle and basket shafts without dropping.p/n Description
95-590-060 Shaft Holder, 16 Position, Captured (Vision model also available)
95-590-061 Shaft Holder, 12 Position, Captured
Shaft Holder, 16 Position95-590-060
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SR8-Plus Dissolution Test Supplies & Accessories
Baskets & Shaftsp/n Description
65-240-000 Basket Assembly, USP, w/ 15 in. Shaft
65-240-400 Basket Assembly, USP, w/ 21 in. Shaft, 2 L
74-105-252 Basket, USP, Precision, 40 Mesh
65-220-010 Basket, 10 Mesh, 316 SS (Special Order—min order 6)
65-220-020 Basket, 20 Mesh, 316 SS (Special Order—min order 6)
65-700-048 Suppository Basket
65-237-000 Basket Shaft, USP, 15 in.
65-260-000 Basket Shaft, USP, 21 in., 2 L
65-590-011 USP Apparatus 6 Rotating Cylinder (max patch area = 2 in. x 5.5 in.)
65-590-012 Extension for Apparatus 6 Rotating Cylinder (max patch area w/ extension = 5.5 in. x 5.69 in.)
95-590-150 Stationary Basket, 8 Mesh, 316 SS (Stationary Basket Vessel Cover p/n 95-590-151 sold separately)Complies with USP Monograph for Felodipine Extended-Release TabletsHelps with problems associated with floating, sticking, and swelling dosage formsFor convenient installation and removal of the basket and cover assembly, extra-long paddle shafts recommendedManual sampling only
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95-590-151 Stationary Basket Vessel Cover
All baskets and shafts in this section are serialized. Apparatus 6 Rotating Cylinder and extensions are serialized alike when ordered together. Extensions ordered separately may still be serialized to the cylinder upon request if original cylinders are returned for proper matching.
Basket HolderMade of non-corrosive plastic, this basket holder safely stores and transports baskets, leaving your dissolution lab more organized. p/n Description
95-590-062 Basket Holder, 12 Capacity, Stackable
15 in. 21 in. Basket Suppository 15 in. 21 in. Apparatus 6 & Extension Stationary Basket
Basket Assemblies only basket Shafts
Basket Holder, 12 Capacity95-590-062
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hansonresearch.com | 99-300-001 Rev. 3-11 | SR8-Plus Dissolution Test Supplies & Accessories��
SR8-Plus Dissolution Test Supplies & Accessories
VesselsHanson Precision USP vessels have been an industry standard for many years. These precision vessels, manufactured of quality borosilicate glass, meet or exceed USP vessel dimensions and are an excellent choice for dissolution testing. For labs requiring even tighter manufacturing tolerance and precision in vessel dimensions (such as that required by ASTM E2503-07), new Super Precision vessels are available. Hanson Super Precision vessels are manufactured with a unique proprietary method providing a “super” precision inside diameter and spherical radius.
Both Precision and Super Precision vessels come with individual serial numbers and a USP Certificate of Conformity (COC), and are available for Hanson SR8-Plus dissolution testers. (See HRCare—ASTM Program for more COC information.)p/n Description
72-600-510 Vessel, USP, Precision, 1 L, Glass
91-030-003 Vessel, USP, 1 L, Plastic (not serialized)
72-600-556 Vessel, USP, Precision, 1 L, Glass, Amber (Special Order—min order 6)
72-600-509 Vessel, USP, Precision, 2 L, Glass
72-600-580 Vessel, USP, Precision, 2 L, Glass, Amber (Special Order—min order 6)
73-101-520 Vessel, USP, Super Precision, 1 L, Glass (requires Vessel Centering Ring p/n 73-101-515)
73-101-521 Vessel, USP, Super Precision, 1 L, Glass, Amber (requires Vessel Centering Ring p/n 73-101-515 ;Special Order—min order 6)
72-600-573 Vessel, Round Bottom, 150 mL, Glass
72-600-583 Vessel, Round Bottom, 150 mL, Glass, Amber (Special Order—min order 6)
72-600-572 Vessel, Flat Bottom, 150 mL, Glass
95-590-047 Vessel, Peak, 1 L (includes Vessel Centering Ring p/n 73-101-515; Special Order)
73-101-515 Vessel Centering Ring (required for Super Precision and Peak Vessels)
73-100-550 Vessel Centering Ring (1 & 2 L Vessels)
All vessels have volumetric graduation marks and serial numbers except Plastic Vessel p/n 91-030-003.
Round Bottom Round Bottom, Amber
Flat Bottom Clear Amber Clear Amber
150 mL Vessels 1 L Vessels 2 L Vessels
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SR8-Plus Dissolution Test Supplies & Accessories
Vessel CarriersMade of all non-corrosive rigid ABS plastic construction with sturdy non-skid rubber legs, these vessel carriers transport filled vessels to and from media prep stations and dissolution baths. Holds all brands of 1 liter and 2 liter dissolution vessels. Space-saving stackable design when empty. p/n Description
95-590-069 Universal Vessel Carrier, 6 Position
95-590-070 Universal Vessel Carrier, 8 Position
SR8-Plus Vessel Coversp/n Description
73-100-430 ADD (Auto-Dosage Delivery) Vessel Cover for SR8-Plus (manual only)
65-233-170 Low-Evaporation Vessel Cover, Rotary
95-590-046 Low-Evaporation Vessel Cover, Hinged, Clear Acrylic
72-600-587 Slide-Open Vessel Cover (w/ 2 hole plugs)
72-800-430 Vessel Hole Cover
Low-Evaporation Vessel Cover, Hinged
95-590-046
Low-Evaporation Vessel Cover, Rotary65-233-170
ADD Cover for SR8-Plus73-100-430
Slide-Open Vessel Cover72-600-587
Universal Vessel Carrier, 6 Position95-590-069
Universal Vessel Carrier, 8 Position95-590-070
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hansonresearch.com | 99-300-001 Rev. 3-11 | SR8-Plus Dissolution Test Supplies & Accessories��
SR8-Plus Dissolution Test Supplies & Accessories
E-Probe Actuator Kits Hanson E-Probes provide electrically actuated sampling probes for Hanson SR8-Plus dissolution testers. E-Probes are mounted directly onto the SR8-Plus drive head (field retrofits available). E-Probe kits provide up/down electronic actuators for each vessel. Head Mount Probes are required for E-Probes and are ordered separately.p/n Description
73-105-106 E-Probe Actuator Kit, 1 L, 6 Sample
73-105-108 E-Probe Actuator Kit, 1 L, 8 Sample
73-105-116 E-Probe Actuator Kit, 2 L, 6 Sample
73-105-118 E-Probe Actuator Kit, 2 L, 8 Sample
Multi-Position E-Probe Option (for programmable height adjustments)The standard 1 liter E-Probe with 1 liter Sample Probe provides the ability to sample from 1000 mL to 500 mL with manual height adjustment. Retrofit your 1 liter E-Probe with a longer 9 in. Lead Screw and 2 liter Sample Probes, and this 1000 mL to 500 mL change is easily programmed on the SR8-Plus.p/n Description
91-220-037 Lead Screw, 9 in. (for E-Probes, Multi-Position Probe; requires 1 for each position)
Digital Temperature ProbesHanson Digital Temperature Probes (DTPs) are rugged and robust digital devices, intelligent in design, and virtually impervious to analog noise. Our exclusive “digital-sensor” technology ensures precision temperature resolution, reporting, and validation and provides extensive data on multiple vessel temperatures, including maximum/minimum/average statistical data. Each Hanson Digital Temperature Probe carries an individual and unique electronic signature, serial number, and calibration log ideal for USP/FDA/21 CFR Part 11 compliancy. Easy retrofit on all Hanson SR8-Plus dissolution testers, DTPs are normally attached to a sampling probe.p/n Description
73-108-100 Digital Temperature Probes (set/6) (factory installed)
73-108-105 Digital Temperature Probes (set/6) (field upgrade kit)
73-108-405 Digital Temperature Probe (1)
Digital Temperature Probes require SR8-Plus firmware ver. 3.10 or higher.
E-Probe Actuator Kit
Digital Temperature Probe (DTP)
Digital Temperature Probe Board
Digital Temperature Probe
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�� SR8-Plus Dissolution Test Supplies & Accessories | 99-300-001 Rev. 3-11 | hansonresearch.com
SR8-Plus Dissolution Test Supplies & Accessories
Head Mount Probes (for E-Probe Actuator Kits)p/n Description
60-151-106 Sample Probe Kit, 1 L, 6 Sample, 1/8 in.
60-151-108 Sample Probe Kit, 1 L, 8 Sample, 1/8 in.
60-151-116 Sample Probe Kit, 2 L, 6 Sample, 1/8 in.
60-151-118 Sample Probe Kit, 2 L, 8 Sample, 1/8 in.
65-233-235 * Sample & Return Probe Kit, 1 L, 6 Sample, 1/16 in.
65-233-236 * Sample & Return Probe Kit, 1 L, 8 Sample, 1/16 in.
65-233-237 * Sample & Return Probe Kit, 2 L, 6 Sample, 1/16 in.
65-233-238 * Sample & Return Probe Kit, 2 L, 8 Sample, 1/16 in.
65-233-246 * Return Harness, 6 ft, 6 Sample, 1/16 in.
65-233-248 * Return Harness, 6 ft, 8 Sample, 1/16 in.
73-105-705 Head Kit (set/8) (use with head mount probes without E-Probe Actuators)
* Return Harness is required when sample is to be returned to vessel (single-bath application only). Internal volume of 1 liter, 1/8 in. probe is approx. 1.4 mL; Internal volume of 1 liter, 1/16 in. probe is approx. 0.2 mL.
Sample & Return ProbesUses 1/16 in. filtersReturn Harness purchased separatelyUse with AutoPlus & E-ProbesSuitable for single bath system or to reduce rinse volume requirements
••••
Sample Probe KitUses 1/8 in. filtersUse with AutoPlus & E-Probes
••
Head KitUsed to mount head mount probes without E-Probe Actuators
•Return HarnessUse with sample & return probes or Fixed Vessel Sample Probe Kit
•
If not using E-Probes, order Vessel-Mount Probes, Easi-Probes, or a Head Mount Probe Kit with a Head Kit. Head Mount Easi-Probe Kits are used for manual sampling from the SR8-Plus. Vessel-Mount Probe Kits include vessel covers with stainless sample probes and return probes, tubing connectors, and a wash station. Order 1 set for each bath. Use of standard tip filters or 5 micron in-line filters are required for sample filtration into the AutoPlus.
Fixed Vessel-Mount Probes (includes covers)p/n Description
60-200-206 Fixed Vessel Sample Probe Kit, 1 L, 6 Sample, 1/16 in.
60-200-208 Fixed Vessel Sample Probe Kit, 1 L, 8 Sample, 1/16 in.
60-200-216 Fixed Vessel Sample Probe Kit, 1 L, 6 Sample, 1/8 in.
60-200-218 Fixed Vessel Sample Probe Kit, 1 L, 8 Sample, 1/8 in.
Easi-Probe Manual Sampling Probes (Head Mount for SR8-Plus only)p/n Description
72-300-304 Easi-Probe Kit, 1 L, 6 Sample, 1/8 in. (manual sampling)
72-300-305 Easi-Probe Kit, 1 L, 8 Sample, 1/8 in. (manual sampling)
72-300-324 Easi-Probe Kit, 2 L, 6 Sample, 1/8 in. (manual sampling)
72-300-326 Easi-Probe Kit, 2 L, 8 Sample, 1/8 in. (manual sampling)
Fixed Vessel-Mount Sample Probe KitUses 1/8 in. or 1/16 in. filtersUsed with AutoPlusMay be used with Return HarnessMay be used with In-Line Filters
••••
Easi-Probe KitUses 1/8 in. or In-Line FiltersFor manual sampling
••(top)
(bottom)
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hansonresearch.com | 99-300-001 Rev. 3-11 | SR8-Plus Dissolution Test Supplies & Accessories��
SR8-Plus Dissolution Test Supplies & Accessories
SR8-Plus Manual Cannula Kitp/n Description
72-300-232 Manual Sampling Cannula Kit (set/8) (includes probes and syringes for Slide-Open Vessel Covers)
316 Stainless Steel Cannulas (with inert Tefzel female luer)1/8 in. o.d. Low hold-up volume. Accomodates in-line filters and/or probe filters.p/n Description
95-590-001 Manual Sampling Cannula, 500 mL, 7.75 in., 316 SS
95-590-002 Manual Sampling Cannula, 900 mL, 4.75 in., 316 SS
95-590-003 Manual Sampling Cannula, Head Mount, 15 in., 316 SS
PEEK Cannulas (with inert Tefzel female luer) 1/8 in. o.d. PEEK and Tefzel are biocompatible, chemically inert, and non-corrosive. Accomodates in-line filters and/or sample filters. p/n Description
95-590-005 Manual Sampling Cannula, 900 mL, 4.75 in., PEEK
95-590-006 Manual Sampling Cannula, Head Mount, 15 in., PEEK
95-590-007 Stopper for 15 in. Cannula
Sampling Cannulas
Fixed Vessel-Mount Sample Probe KitUses 1/8 in. or 1/16 in. filtersUsed with AutoPlusMay be used with Return HarnessMay be used with In-Line Filters
••••
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�0 SR8-Plus Dissolution Test Supplies & Accessories | 99-300-001 Rev. 3-11 | hansonresearch.com
SR8-Plus Dissolution Test Supplies & Accessories
Sample Filters (100% Porous Polyethylene)This material is 100% inert in all applications and meets all current FDA and USP guidelines. p/n Description
27-101-087 Sample Filters, 1 micron, 1/8 in. (100/pk) (not available 1/16 in.)
27-101-097 Sample Filters, 1 micron, 1/8 in. (1,000/pk) (not available 1/16 in.)
27-101-088 Sample Filters, 4 micron, 1/8 in. (100/pk) (not available 1/16 in.)
27-101-098 Sample Filters, 4 micron, 1/8 in. (1,000/pk) (not available 1/16 in.)
27-101-074 Sample Filters, 10 micron, 1/8 in. (100/pk)
27-101-091 Sample Filters, 10 micron, 1/8 in. (1,000/pk)
27-101-083 Sample Filters, 10 micron, 1/16 in. (100/pk)
27-101-093 Sample Filters, 10 micron, 1/16 in. (1,000/pk)
27-101-085 Sample Filters, 35 micron 1/8 in. (100/pk)
27-101-095 Sample Filters, 35 micron 1/8 in. (1,000/pk)
27-101-086 Sample Filters, 35 micron 1/16 in. (100/pk)
27-101-096 Sample Filters, 35 micron 1/16 in. (1,000/pk)
27-101-089 Sample Filters. 45 micron 1/8 in. (100/pk)
27-101-090 Sample Filters. 45 micron 1/16 in. (100/pk)
27-101-082 Sample Filters, 70 micron, 1/8 in. (100/pk)
27-101-092 Sample Filters, 70 micron, 1/8 in. (1,000/pk)
27-101-084 Sample Filters, 70 micron, 1/16 in. (100/pk)
27-101-094 Sample Filters, 70 micron, 1/16 in. (1,000/pk)
Sample Filters (High Purity Porous Polyvinylidene Fluoride)This new material offers lower protein-binding characterisitics to a larger variety of active drug substances. They are 100% inert in all applications and meet all current FDA and USP guidelines. p/n Description
27-101-101 Sample Filters, 10 micron, 1/8 in., PVDF (100/pk)
27-101-102 Sample Filters, 10 micron, 1/8 in., PVDF (1,000/pk)
In-Line Filtersp/n Description
91-450-062 In-Line Filters, 5 micron (75/pk)
72-300-262 In-Line Filter Fitting Kit (8/pk)
Sample Filter1, 4, 10, 35, and 70 micronIn packs of 100 or 1,000
••
In-Line Filter91-450-062
In-Line Filter Fitting Kit72-300-262
In-Line Filter (optional)
91-450-062
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hansonresearch.com | 99-300-001 Rev. 3-11 | SR8-Plus Dissolution Test Supplies & Accessories��
SR8-Plus Dissolution Test Supplies & Accessories
SR8-Plus™ Small Volume Kits & Hanson Ointment CellHanson Small Volume accessories are used for low concentration drug formulations and other special applications when small volume dissolution media is required. The 150 mL round-bottom vessel is patterned after the standard USP 1 liter vessel; the flat-bottom vessel is used with the Hanson Ointment Cell. The mini-paddle is patterned after the USP Apparatus 2 paddle. Small Volume Kits for the SR8-Plus include mini-paddle, 150 mL vessel with special vessel cover (choice of round or flat-bottom vessel), and adapter for use on the SR8-Plus vessel plate. Extras may be ordered separately. Small Volume Probe Retrofit Kits (replaces the Sample Probe Kit) are ordered separately (1 per position).
The Hanson Ointment Cell is designed for use with the flat-bottom vessel to eliminate dead volume. The cell uses standard 25 mm filter disks, and its 3 mm deep dosage area provides for testing of infinite dose topical applications. Ointment Cells and convenient assembly tool and grip tool are available in kits; extras may be ordered separately.
p/n Description
72-800-719 Small Volume Dissolution Kit, Round Bottom, 150 mL (1)
72-800-720 Small Volume Dissolution Kit, Round Bottom, 150 mL (set/6)
72-800-721 Small Volume Dissolution Kit, Flat Bottom, 150 mL (1)
72-800-722 Small Volume Dissolution Kit, Flat Bottom, 150 mL (set/6)
72-800-714 Vessel Adapter Kit (1 per vessel)
65-190-043 Ointment Cell, 15 mm (cell only)
65-190-051 Ointment Cell, 15 mm (one cell w/ tools)
65-190-052 Ointment Cell, 15 mm (set/6 w/ tools)
72-300-259 Small Volume Probe Retrofit Kit (replaces probe in Sample Probe Kit; order 1 for each vessel)
Small Volume accessories for SR8-Plus and Vision are not interchangeable except for Ointment Cells.
Ointment Cell(cross section)
Round-Bottom Vessel
Mini-Paddle
Vessel Cover
Small Volume—Round BottomMembrane Area
Dosage Area
Flat-Bottom Vessel
Vessel Cover
Small Volume—Flat Bottom
Mini-Paddle
Ointment Cell
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�� SR8-Plus Dissolution Test Supplies & Accessories | 99-300-001 Rev. 3-11 | hansonresearch.com
SR8-Plus Dissolution Test Supplies & Accessories
Sinkers (for all Hanson dissolution systems)p/n Description
65-190-012 Sinkers (6/pk) (wt 1.3 g; 9.5 mm x 25 mm capacity)
65-190-013 Sinkers (12/pk) (wt 1.3 g; 9.5 mm x 25 mm capacity)
65-700-316 Stainless Wire to Sink Capsules, 316 SS (50 ft roll)
95-590-021 Sinker, Spiral Coated (0.90 in. x 0.37 in. capacity)
95-590-022 Sinker, Spiral Uncoated, 316 SS (0.90 in. x 0.37 in. capacity)
95-590-023 Sinker, Spiral Coated (1.02 in. x 0.38 in. capacity)
95-590-024 Sinker, Spiral Uncoated (1.02 x 0.38 in. capacity)
95-590-025 Sinker, 3 Prong
95-590-026 Sinker, Japanese Pharmacopoeia Cage
Sprial Coated Sinkers are coated with 100% inert epoxy.
Sinker65-190-012/013
Sprial Coated Sinker95-590-021
Spiral Uncoated Sinker95-590-024
3 Prong Sinker95-590-025
Japanese Pharmacopoeia Cage Sinker95-590-026
Hanson Transdermal Sandwich (USP Apparatus 5 “Paddle Over Disk”)The Transdermal Sandwich is a convenient disk assembly recommended by the FDA for testing patch dosage forms in a standard dissolution test station for USP Apparatus 5 “Paddle Over Disk.” The Transdermal Sandwich consists of a glass watchglass (on which the patch is placed, delivery side up), a 17-mesh PVDF screen (to hold the patch), and PVDF clips to hold the disk assembly together. For use with standard USP 1 liter vessel and paddle. Accommodates patches up to 90 mm diameter. Used on all Hanson dissolution testers.p/n Description
65-190-092 Transdermal Sandwich for Patch
65-190-093 Transdermal Sandwich for Patch (set/6)
Transdermal Sandwich
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hansonresearch.com | 99-300-001 Rev. 3-11 | SR8-Plus Dissolution Test Supplies & Accessories��
SR8-Plus Dissolution Test Supplies & Accessories
Accessoriesp/n Description
64-705-722 Air Stone, Soft-Flo, for SR8-Plus (10/pk)
65-233-706 Auto Pill Droppers, 6 Sample (requires E-Probes)
65-233-708 Auto Pill Droppers, 8 Sample (requires E-Probes)
72-800-501 Basket Height Adjustment Spacer, Serialized
72-800-502 Paddle Height Adjustment Spacer, Serialized
91-902-020 Electro-Mechanical Tool Kit
64-700-128 Analog Temperature Probe for SR6-ValiData and SR8-Plus
73-100-714 SR8-Plus 2-Year Spare Parts Kit, 115 V
73-100-715 SR8-Plus 2-Year Spare Parts Kit, 230 V
73-100-700 SR8-Plus Drive Spindle Retrofit Kit (single position)
73-100-722 SR8-Plus Firmware Upgrade Kit ver. 3.10
64-710-410 Circulating Water Pump—Reverse Plug (since 1997)
64-710-411 Circulating Water Pump—Non-reverse Plug (1995–1996)
Basket & Paddle Spacers72-800-501/502
Air Stone64-705-722
Auto Pill Dropper65-233-706/708
Electro-Mechanical Tool Kit91-902-020
Circulating Water Pump
Volumetric Flasksp/n Description
95-590-041 Volumetric Flask, 500 mL, Class A/20 °C
95-590-042 Volumetric Flask, 900 mL, Class A/20 °C
95-590-043 Volumetric Flask, 1000 mL, Class A/20 °C
95-590-044 Volumetric Flask, 500 mL, Class A/37 °C
95-590-045 Volumetric Flask, 900 mL, Class A/37 °C
Volumetric Flask
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�� SR8-Plus Dissolution Test Supplies & Accessories | 99-300-001 Rev. 3-11 | hansonresearch.com
SR8-Plus Dissolution Test Supplies & Accessories
Intrinsic Dissolution ApparatusThe Intrinsic Dissolution Apparatus is a frequently used tool in determining functionality and characterization of bulk drug substances and excipients by assessing the dissolution rate of pure substances under the condition of a constant surface area. This basic configuration was developed in 1963 and is currently used in numerous validated methods worldwide. See USP General Chapter Intrinsic Dissolution for more information.
The Intrinsic Dissolution Apparatus is based on the conventional “Wood Apparatus Design” also known as the “Rotating Disk System.” This configuration was chosen for development because of its current widespread usage and long successful history.
The corrosion-resistant, hardened steel used for punch and surface plate does not require oiling between uses—an improvement over competitor products currently available.
p/n Description
95-590-201 Intrinsic Dissolution Apparatus Kit (requires Collar p/n 91-406-012, 1/ea)Includes:
Shaft and HolderSurface Plate (screws included)Punch and HandleDie
••••
95-590-202 Shaft and Holder, 316 SS, Electropolished
95-590-203 Punch and Handle, 8 mm
95-590-204 Die, 8 mm, 316 SS, Electropolished
95-590-205 Surface Plate (w/ 3 metal and 3 plastic screws)
91-406-012 Collar, 3/8 in., 316 SS (w/ set screw; 1 Collar required for each Shaft and Holder when used on an SR8-Plus)
Instrinsic Dissolution Apparatus Kit95-590-201
Shaft and Holder
Die
Punchand Handle
Surface Plate
Screws included w/ Surface Plate
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hansonresearch.com | 99-300-001 Rev. 3-11 | SR8-Plus Dissolution Test Supplies & Accessories��
SR8-Plus Dissolution Test Supplies & Accessories
Certified Calibrated Tachometer
Digital Thermometer
Alignment Kit
Vibration Meter Kit
Certified Calibrated Digital Thermometer
Certified Vibration Meter KitTypically measures displacement, but may also be used to measure
acceleration and velocity
Tachometer
Certified Alignment KitIncludes Alignment Gauge, Shaft
Wobble Meter, Level, Depth Gauge, and Height Ball Gauge
Q-Pak IQ/OQ/PQ Validation Guidelinep/n Description
73-100-805 Q-Pak IQ/OQ/PQ for SR8-Plus—USP
73-100-876 Q-Pak IQ/OQ for SR8-Plus—ASTM
Certificates & Servicep/n Description
7-920 * Recalibration Service (for items below)
7-909 * Individual Certificate of Conformity for USP Accessory (Special Order)
7-910 * Document Replacement Service for Certificate of Conformity (Special Order)
7-911 * Document Replacement Service for Blank IQ/OQ ProtocolsAvailable to U.S. customers only with proof of related HRCare service purchase
7-912 * Document Replacement Service for Blank PQ Protocols Available to U.S. customers only with proof of related HRCare service purchase
* No discounts apply to p/n 7-XXX. Please supply serial numbers at time of order if applicable.
ToolsThese calibration tools are used by HRCare Specialists when performing service and validation on Hanson SR8-Plus dissolution testers and are recommended for in-house validation programs.p/n Description
65-233-101 Certified Alignment Kit
65-233-203 Certified Vibration Meter Kit
65-233-301 Certified Calibrated Tachometer
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�� Media-Mate Plus Automatic Prep System | 99-300-001 Rev. 3-11 | hansonresearch.com
Media-Mate Plus Automatic Prep System
MeDia-Mate pluS™ autoMatic prep SySteMDesigned for ease of use in the modern dissolution lab, the Media-Mate Plus provides automatic media pre-heat, filtration, deaeration, and volumetric dispensing into 6 or 7 vessels of your dissolution tester. At only 5 minutes per bath, this system saves hours in the busy dissolution lab. Completely portable, the Media-Mate Plus system includes a built-in control unit, filtration-deaeration-measure-dispense unit, and easily adjusts for precise volume changes (250–1000 mL) in 50 mL increments. Media deaeration below the recommended 95% saturation level, interchangeable pre-heat tank with temperature control, dispense bar for dissolution testers, air pump system, and supply kit are also standard. Tanks easily accommodate from 10 liters to 40 liters media volume, and the dispense bar interfaces with most commercial baths by simple quick disconnects, usable with either 3+3, 4+2, and 4+3 vessel layouts. A special dispense bar is available for the Sotax AT7 tester. U.S. Patents. CE Approved.
Specify voltage when ordering.
Media-Mate Plusp/n Description
25-710-101 Media-Mate Plus, 10–40 L, 115 V25-710-102 Media-Mate Plus, 10–40 L, 230 V
Media-Mate Plus Accessoriesp/n Description
91-902-045 Calibration Gauge Set (required for fine volume adjustment)
25-710-415 Single Vessel Filler
25-710-705 Calibration KitIncludes:
8-Position Universal Vessel Carrier8 Plastic Vessels, 1 LCalibration Gauge Set
•••
25-710-803 Q-Pak IQ/OQ/PQ for Media-Mate Plus
25-710-115 Tank, Heater, and Control, 115 V
25-710-116 Tank, Heater, and Control, 230 V
25-710-723 Filter Sediment Cartridge, Polypropylene, 5 micron (5/pk)
11-000-004 Media Filler Hose Extension with Filter (draws media from other source)
25-710-113 Dispense Bar for Sotax AT7
25-710-125 Temperature Control Only, 115 V
25-710-126 Temperature Control Only, 230 V
25-710-402 Tank Assembly Only, 40 L
25-710-130 Heater Assembly Only, 115 V
25-710-131 Heater Assembly Only, 230 V
25-710-701 Media-Mate Plus 2-Year Spare Parts Kit, 115/230 V
Media-Mate Plus(includes Tank, Heater, and Control)
Tank, Heater, and Control
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hansonresearch.com | 99-300-001 Rev. 3-11 | Media Concentrates��
Media Concentrates
DiSSolution MeDia concentrateSPre-mixed concentrates reduce the amount of time and cost to prepare dissolution media by up to 75%, so laboratory analysts/chemists can focus on performing more valued-added activities.
All media concentrates are available in convenient sizes, which can be used to produce 6 liters, 10 liters, or 25 liters of dissolution media. This makes it the ideal solution for pharmaceutical research, formulation, and quality control laboratories.
Dissolution media concentrates are available in different bottle sizes (250 mL, 500 mL, and 1L), supplying the right solution for individual dissolution testing needs. The small bottle sizes also reduce storage space requirements and freight charges. Available in full cases only.
Hanson is the exclusive distributor of Dissolution Accessories Media Concentrates in North America.
Acidsp/n* Description
DMC020-06-12 0.01 N HCl (230.8 mL concentrate volume/250 mL bottle; 12/case)
DMC020-10-12 0.01 N HCl (250 mL concentrate volume/250 mL bottle; 12/case)
DMC020-25-06 0.01 N HCl (961.5 mL concentrate volume/1 L bottle; 6/case)
DMC021-06-12 0.1 N HCl (230.8 mL concentrate volume/250 mL bottle; 12/case)
DMC021-10-12 0.1 N HCl (250 mL concentrate volume/250 mL bottle; 12/case)
DMC021-25-06 0.1 N HCl (961.5 mL concentrate volume/1 L bottle; 6/case)
*Key:
DMCXXX-06-12 = produces 6L of media, 12 bottles/case
DMCXXX-10-12 = produces 10 L of media, 12 bottles/case
DMCXXX-25-06 = produces 25 L of media, 6 bottles/case
Dissolution Accessories Media Concentrates
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�� Media Concentrates | 99-300-001 Rev. 3-11 | hansonresearch.com
Media Concentrates
Buffersp/n* Description
DMC022-06-12 Acetate Buffer, pH 4.5 (230.8 mL concentrate volume/250 mL bottle; 12/case)
DMC022-10-12 Acetate Buffer, pH 4.5 (250 mL concentrate volume/250 mL bottle; 12/case)
DMC022-25-06 Acetate Buffer, pH 4.5 (961.5 mL concentrate volume/1 L bottle; 6/case)
DMC023-06-12 Potassium Phosphate, pH 5.8 (230.8 mL concentrate volume/250 mL bottle; 12/case)
DMC023-10-12 Potassium Phosphate, pH 5.8 (250 mL concentrate volume/250 mL bottle; 12/case)
DMC023-25-06 Potassium Phosphate, pH 5.8 (961.5 mL concentrate volume/1 L bottle; 6/case)
DMC024-06-12 Potassium Phosphate, pH 6.0 (230.8 mL concentrate volume/250 mL bottle; 12/case)
DMC024-10-12 Potassium Phosphate, pH 6.0 (250 mL concentrate volume/250 mL bottle; 12/case)
DMC024-25-06 Potassium Phosphate, pH 6.0 (961.5 mL concentrate volume/1 L bottle; 6/case)
DMC025-06-12 Potassium Phosphate, pH 6.8 (230.8 mL concentrate volume/250 mL bottle; 12/case)
DMC025-10-12 Potassium Phosphate, pH 6.8 (250 mL concentrate volume/250 mL bottle; 12/case)
DMC025-25-06 Potassium Phosphate, pH 6.8 (961.5 mL concentrate volume/1 L bottle; 6/case)
DMC026-06-12 Potassium Phosphate, pH 7.2 (230.8 mL concentrate volume/250 mL bottle; 12/case)
DMC026-10-12 Potassium Phosphate, pH 7.2 (250 mL concentrate volume/250 mL bottle; 12/case)
DMC026-25-06 Potassium Phosphate, pH 7.2 (961.5 mL concentrate volume/1 L bottle; 6/case)
DMC027-06-12 Potassium Phosphate, pH 7.4 (230.8 mL concentrate volume/250 mL bottle; 12/case)
DMC027-10-12 Potassium Phosphate, pH 7.4 (250 mL concentrate volume/250 mL bottle; 12/case)
DMC027-25-06 Potassium Phosphate, pH 7.4 (961.5 mL concentrate volume/1 L bottle; 6/case)
DMC028-06-12 Potassium Phosphate, pH 7.5 (230.8 mL concentrate volume/250 mL bottle; 12/ case)
DMC028-10-12 Potassium Phosphate, pH 7.5 (250 mL concentrate volume/250 mL bottle; 12/case)
DMC028-25-06 Potassium Phosphate, pH 7.5 (961.5 mL concentrate volume/1 L bottle; 6/case)
DMC029-06-12 Sodium Lauryl Sulfate 0.50% (400 mL concentrate volume/500 mL bottle; 12/case)
DMC029-10-12 Sodium Lauryl Sulfate 0.50% (500 mL concentrate volume/500 mL bottle; 12/case)
Gastric and Intestinal Fluidsp/n* Description
DMC030-06-12 Simulated Gastric Fluid, without enzyme (230.8 mL concentrate volume/250 mL bottle; 12/case)
DMC030-10-12 Simulated Gastric Fluid, without enzyme (250 mL concentrate volume/250 mL bottle; 12/case)
DMC030-25-06 Simulated Gastric Fluid, without enzyme (961.5 mL concentrate volume/1 L bottle; 6/case)
DMC031-06-12 Simulated Intestinal Fluid, without enzyme (230.8 mL concentrate volume/250 mL bottle; 12/case)
DMC031-10-12 Simulated Intestinal Fluid, without enzyme (250 mL concentrate volume/250 mL bottle; 12/case)
DMC031-25-06 Simulated Intestinal Fluid, without enzyme (961.5 mL concentrate volume/1 L bottle; 6/case)
Dissolution Accessories Media Concentrates
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hansonresearch.com | 99-300-001 Rev. 3-11 | Dissolution Validation & Calibration Accessories��
Dissolution Validation & Calibration Accessories
DiSSolution ValiDation & calibration acceSSorieSQ-Pak™ IQ/OQ/PQ Validation GuidelineThe Hanson Q-Pak addresses manufacturers’ and USP/FDA recommendations for dissolution instrument IQ, OQ, and PQ (Installation, Operation, and Performance Qualifications). This unique guideline directs the user through instrument qualification, providing a log book matrix as well as prompting for and documentation of key elements of functional validation. Combined with our easy-to-use calibration tools, the Q-Pak can ensure optimum dissolution performance and maximum regulatory compliance. Q-Paks are ideal guidelines to help develop document system qualification for audit trail.
HRCare provides for U.S. Service and Validation Contracts. See HRCare—Service & Validation Plans for information.
Q-Pak IQ/OQ/PQ Validation Guidelinesp/n Description
74-108-005 Q-Pak IQ/OQ/PQ for Vision Dissolution Testers—USP
74-108-006 Q-Pak IQ/OQ for Vision Dissolution Testers—ASTM
73-100-805 Q-Pak IQ/OQ/PQ for SR8-Plus—USP
73-100-876 Q-Pak IQ/OQ for SR8-Plus—ASTM
60-200-805 Q-Pak IQ/OQ/PQ for AutoPlus
60-200-851 Q-Pak IQ/OQ/PQ for Vision-Enabled AutoPlus
25-710-803 Q-Pak IQ/OQ/PQ for Media-Mate Plus
58-001-805 Q-Pak IQ/OQ/PQ for MicroettePlus
58-001-815 Q-Pak IQ/OQ/PQ for Manual Diffusion Cell System Printersp/n Description
74-104-060 Validation Printer for Vision, 115 V
74-104-061 Validation Printer for Vision, 230 V
73-100-116 Validation Printer for SR8-Plus, 115/230 V
60-200-101 Validation Printer for Autosampler, 115 V (AutoPlus or MicroettePlus)
60-200-102 Validation Printer for Autosampler, 230 V (AutoPlus or MicroettePlus)
47-200-703 Printer Paper Rolls (5/pk)
47-200-704 Printer Ribbon (2/pk) Reference & Calibration Accessoriesp/n Description
91-030-000 Handbook of Dissolution Testing, 3rd Edition (By Royal Hanson & Vivian Gray)
91-951-007 USP Calibrator Tabs, Prednisone (30 tabs) (disintegrating)
91-951-017 USP Standard, Prednisone
65-233-000 Shaft Straightening Kit with Dial Indicator
64-700-128 Analog Temperature Probe for SR6-ValiData and SR8-Plus
10-101-601 Air Flow Meter (not certified, for reference only)
91-902-020 Electro-Mechanical Tool Kit
Q-Pak IQ/OQ/PQ for Vision—USP74-108-005
Handbook of Dissolution Testing, 3rd ed.91-030-000
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�0 Dissolution Validation & Calibration Accessories | 99-300-001 Rev. 3-11 | hansonresearch.com
Dissolution Validation & Calibration Accessories
SR8-Plus Calibration ToolsUsed by HRCare Specialists when performing service and validation on Hanson SR8-Plus dissolution testers and are recommended for in-house validation programs. For more information on these tools, please see SR8-Plus—Tools.p/n Description
65-233-101 Certified Alignment Kit
65-233-203 Certified Vibration Meter Kit
65-233-301 Certified Calibrated Tachometer
65-233-402 Certified Calibrated Digital Thermometer
Vision Calibration ToolsUsed by HRCare Specialists when performing service and validation on Hanson Vision dissolution testers and are recommended for in-house validation programs. For more information on these tools, please see Vision—Accessories & Tools.p/n Description
74-107-002 Digital Level Kit (required for Vision dissolution baths and all ASTM bath validation)
74-107-003 O-Ring Tool Kit (service only tool)
74-107-004 Validation Tool Kit (for Vision baths and ASTM validation on SR8-Plus)
74-107-005 Height Set & Check Kit (set tool for go/no go depth gauge)
Certificates & Servicep/n Description
7-920 * Recalibration Service
7-909 * Individual Certificate of Conformity for USP Accessory (Special Order)
7-910 * Document Replacement Service for Certificate of Conformity (Special Order)
7-911 * Document Replacement Service for Blank IQ/OQ ProtocolsAvailable to U.S. customers only with proof of related HRCare service purchase
7-912 * Document Replacement Service for Blank PQ Protocols Available to U.S. customers only with proof of related HRCare service purchase
* No discounts apply to p/n 7-XXX. Please supply serial numbers at time of order if applicable.
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hansonresearch.com | 99-300-001 Rev. 3-11 | AutoPlus��
AutoPlus Autosampling Systems
AutoPlus System Diagrams
autopluS autoSaMpling SySteMS
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�� AutoPlus | 99-300-001 Rev. 3-11 | hansonresearch.com
AutoPlus Autosampling Systems
hansonresearch.com | 99-300-001 Rev. 3-11 | AutoPlus��
AutoPlus Autosampling Systems
AutoPlus™ DissoScan™ & Maximizer™ AutosamplersThe Hanson AutoPlus DissoScan and Maximizer autosampling systems are designed for maximum performance in dissolution testing. Complete on-line UV dissolution systems are available with the Agilent 8453 ChemStation. The AutoPlus includes precision syringe pump sampling with “virtual instrument” programming and graphical interface, all-in-one ergonomic, small-footprint package. The AutoPlus is an intelligent sampler with Easi-Icon programming, dissolution protocol templates, status screens with performance menus, user-prompts and help screens that are ideal for training and quick setup. The ability to change and save up to 25 protocols, easy-to-use routines, password control for 21 CFR Part 11, built-in validation, calibration, and diagnostics, plus unique advanced features are standard on all units.
Two models are available: the DissoScan and the Maximizer. Both models come in either 6-sample or 8-sample configurations (8-sample units provide standard and blank; 6-sample units cannot be upgraded to 8-sample). Both systems handle surfactants and problem media, provide easy setup for sample collection, and Auto-Archive (UV and HPLC) available with the MultiFill and include Teflon sample tubing, PEEK valves and accessories as listed. Order dissolution baths and sample probe kits separately. CE Approved. U.S. Patents.
The DissoScan is a low-cost yet rugged workhorse for basic 1-bath routines. Media replace is not required because rinse media is returned to the vessel by the Sample and Return Probes with a Return Harness. DissoScan systems include 1 Teflon tubing harness (for 1 bath); 8-sample systems also include stainless probes for standard and blank.
The Maximizer is designed for extensive methods and applications, providing maximum versatility and throughput. It’s an ideal system for QC/QA, formulations and R&D, including multi-bath routines, multiple standards, PEEK valves, media replace, off-line dilutions, and system rinse and wash. Maximizer systems include 3 Teflon tubing harnesses (for 3 baths or sources) and stainless probes for media replace and waste. 8-sample systems also include stainless probes for standard and blank.
AutoPlus DissoScan & Maximizer Autosamplersp/n Description
60-302-006 DissoScan 6-Sample System (DS-6), 115/230 V
60-302-008 DissoScan 8-Sample System (DS-8), 115/230 V
60-300-006 Maximizer 6-Sample System (MX-6), 115/230 V
60-300-008 Maximizer 8-Sample System (MX-8), 115/230 V AutoPlus Accessoriesp/n Description
60-200-805 Q-Pak IQ/OQ/PQ for AutoPlus
60-200-851 Q-Pak IQ/OQ/PQ for Vision-Enabled AutoPlus
60-200-706 Teflon Tubing Harness, 6 Sample, 3 ft
60-200-708 Teflon Tubing Harness, 8 Sample, 3 ft
60-200-101 Validation Printer for Autosampler, 115 V
60-200-102 Validation Printer for Autosampler, 230 V
47-200-703 Printer Paper Rolls (5/pk)
47-200-704 Printer Ribbon (2/pk)
60-200-700 AutoPlus 2-Year Spare Parts Kit, 115/230 V
91-902-020 Electro-Mechanical Tool Kit
81-200-025 Hanson/Agilent Dissolution Systems Driver ver. 4.0 (on CD)
60-200-724 AutoPlus Firmware ver. 3.20 Upgrade Kit for SR8-Plus
60-200-725 AutoPlus Firmware ver. 4.0 Upgrade Kit for Vision (field installed)
AutoPlus Maximizer
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hansonresearch.com | 99-300-001 Rev. 3-11 | AutoPlus��
AutoPlus Autosampling Systems
Retrieval Reservoir Assembly60-200-022
AutoPlus MultiFill Collector(collection rack sold separately)
AutoPlus System ComponentsAutoPlus Retrieval SystemThe AutoPlus Retrieval System is an accessory add-on to the AutoPlus Maximizer that eliminates autosampling waste volume. The “retrieval” accessory returns rinse media back to the vessel after UV analysis and/or collection. Easy field retrofit.p/n Description
60-200-022 Retrieval Reservoir Assembly and Bench Mount Base
AutoPlus MultiFill Collection & Sample ArchiveThe AutoPlus MultiFill 8-Channel “X-Y” collection system for archive of dissolution samples. Includes AutoPlus interface and 1 Teflon tubing harness (output to waste or return). Order collection racks (1 required), tubes, vials and caps separately. Caps/septums are required to be pre-cut. Specify voltage when ordering.p/n Description
60-200-490 AutoPlus MultiFill Collector (MF-8), 115 V
60-200-491 AutoPlus MultiFill Collector (MF-8), 230 V
PEEK Needle Optionp/n Description
60-200-497 PEEK Needle Option (factory installed; replaces stainless steel needles)
60-200-496 PEEK Needle Kit (field retrofit; replaces stainless steel needles.)
AutoPlus MultiFill Collection Racks & AccessoriesMultifill Collector requires 1 collection rack and 1 pack of test tubes to complete installation.p/n Description
91-030-053 Collection Rack for 16 mm x 100 mm Test Tubes
91-030-063 Collection Rack for 12 mm x 32 mm HPLC Vials (pre-cut septum vials required)
91-030-071 Collection Rack for 13 mm x 100 mm Test Tubes
91-030-074 Collection Rack for 1 mL Vials, 192 Position (for Waters WISP 96 carousel, 8 mm x 43 mm)
91-030-051 Test Tubes, 16 mm x 100 mm (250/pk)
27-800-714 Evaporation Caps for 16 mm Test Tubes (50/pk) (pre-cut caps)
91-030-150 HPLC Vials w/ Pre-Cut Septums, 12 mm x 32 mm (100/pk)
27-800-633 Test Tubes, 13 mm x 100 mm (250/pk)
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�� UV-Vis System | 99-300-001 Rev. 3-11 | hansonresearch.com
UV-Vis System
uV-ViS SySteMUV Detection & Data Analysis with AgilentThe Hanson AutoPlus system is designed for seamless integration with the Agilent 8453 UV-Vis Spectrophotometer and ChemStation analytical software system. All required Agilent equipment and software is available with the AutoPlus through our worldwide OEM partnership with Agilent Technologies. All items listed below are required for on-line UV dissolution testing with Hanson and Agilent. Specify voltage when ordering.
Agilent UV-Vis System p/n Description
60-200-040 * Agilent—Pharmaceutical UV-Vis System (G1815AA) Includes:
Agilent-8453 SpectrophotometerAgilent ChemStation with General, Advanced & Security Pack UV-Vis softwareComputer, monitor, and color printer (PC specs at time of order)
•••
60-200-032 * Dissolution Software for Agilent 8453 (G1118AA)
60-200-031 * 8-Position Multicell Transport (G1120A) (choose 8 optional flow cells from below)
60-200-484 Flow Cell Tubing Kit (set/8)
60-200-708 Teflon Tubing Harness, 8 Sample, 3 ft (requires 2)
81-200-025 Hanson/Agilent Dissolution System Drivers ver. 4.0 (on CD)
Optional Flow Cells (requires 8)p/n Description
91-215-033 * Flow Cell, 1 mm (5061-3396)
91-215-034 * Flow Cell, 2 mm (5061-3397)
91-215-035 * Flow Cell 10 mm (5062-2476)
Standards & Accessories for System Validationp/n Description
60-200-043 * OQ/PV Standard Kit—1 for UV-Vis (5063-6503) (required)
60-200-044 * OQ/PV Standard Kit—2 for UV-Vis (5063-6521) (required)
60-200-045 * OQ/PV Hardware Kit for UV-Vis (5063-6523)
60-200-046 * IQ Test Sample for UV-Vis Spectrophotometer (5063-6524)
91-951-026 OQ/PV Caffeine Standard sample (for service validation only)
60-200-049 * Multicell Adjustment Tool (89075-23800) * Current prices and specifications are available at time of quote for all Agilent products.
Agilent 8453 ChemStation
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hansonresearch.com | 99-300-001 Rev. 3-11 | Legacy DDS��
Legacy DDS
Legacy DDS™ (Dissolution Data System)The Hanson Legacy DDS Dissolution Data System is a productivity software program for the Hanson SR8-Plus and AutoPlus system. It is designed for a diverse range of analytical techniques for USP I & II oral dosage dissolution testing, providing management of protocols and methods, automated sampling, collection, detection, data acquisition, calculations, and reporting. Legacy DDS includes client-server architecture for networking and data management, and 21CFR11 compliant security, and audit trail.
Legacy DDS is built on IDIS (Automated Lab Systems, formerly Icalis) tablet dissolution data management software. IDIS, first launched in 1992, is installed in over 400 laboratory sites worldwide, including GSK, AstraZeneca, Novartis, Merck, Patheon, Solvay, Aventis, and others. With Legacy DDS, versatile user methodology is achieved using exclusive ALS Solution Path Technology whereby dissolution testing, sampling, collection, and detection systems are readily configured.
Legacy DDS software includes an array of drivers for many popular spectrophotometers (Agilent, PerkinElmer, Varian, Shimadzu, Thermo), providing for online UV analysis with the Hanson AutoPlus autosampling system. Data manipulation, statistical analysis, and report writing are easily customized to meet specific customer documentation requirements. Data management and system connectivity are expandable for laboratory networking and corporate LIMS interfacing.
On-site training for Legacy DDS is customized and quoted per user requirement.
Legacy DDS Stand-Alone Workstationsp/n Description
82-601-101 Stand-Alone Workstation Legacy DDS SoftwareSupports:
SR8-Plus dissolution testers connected to AutoPlus, MultiFill, and choice of UV spectrophotometerIncludes:
1 workstation license, Oracle license & software, Solution Path Technology, 21CFR11 compliant security, drivers for popular UV spectrophotometers, drivers for other dissolution testers, and drivers for MAP & AFC*
•
•
82-601-301 Validation Document Package for Stand-Alone Workstation Legacy DDS
82-601-501 Validation Performance for Stand-Alone Workstation Legacy DDS
Legacy DDS Multi-System Networksp/n Description
82-602-101 Multi-System Network Legacy DDS Software (includes multi-system network license to support up to 5 stand-alone workstations)
82-602-301 Validation Document Package for Multi-System Network Legacy DDS
82-602-501 Validation Performance for Multi-System Network Legacy DDS
Legacy DDS Network Client Access Onlyp/n Description
82-603-101 Network Client Access Only Legacy DDS Software (supports PC client access to network operations and data)
82-603-301 Validation Document Package for Network Client Access Only Legacy DDS
82-603-501 Validation Performance for Network Client Access Only Legacy DDS
* Media Addition Pump (MAP) and Auto Filter Changer (AFC) are available on special order. Please consult Hanson for details.
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�� Legacy DDS | 99-300-001 Rev. 3-11 | hansonresearch.com
Legacy DDS
Legacy DDS System Configurations(stand-alone and multi-system)
Legacy DDS Multi-Lab Network System(local or wide-area)
legacy DDS™ (DiSSolution Data SySteM)
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hansonresearch.com | 99-300-001 Rev. 3-11 | Bill DDS��
Bill DDS
bill™ DDS™ (DiSSolution Data SySteM)
Client-Server Architecture
Bill DDS System Diagrams
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�� Bill DDS | 99-300-001 Rev. 3-11 | hansonresearch.com
Bill DDS
Bill™ DDS™ for SR8-Plus™The informatics productivity tool that provides secure control of methods, protocols and data, with easy download to your Hanson SR8-Plus and AutoPlus dissolution instruments. Bill DDS allows you to start small (with Lite), and to build your DDS as you grow (expand with Pro).
Bill DDS Lite is ideal for 1 laboratory site and may be expanded later with Pro.
Bill DDS Pro is required for multi-lab networks and for LIMS-interfacing (with Labtronics LimsLink™).
Both packages include required software and full 1-year technical support.
Add-on packages provide a Com-Switch interface for each dissolution instrument system.
HRCare IQ/OQ validation and maintenance contracts are available.
Each Com-Switch can handle either (a) 1 AutoPlus with MultiFill and up to 3 SR8-Plus dissolution testers, or (b) up to 8 SR8-Plus dissolution testers
without AutoPlus. Bill DDS client-server architecture provides interfacing to multi-user PC workstations.
Bill DDS (Lite and Pro) requires MS Sequel for database management (either Sequel Express or Standard) and Labtronics LimsLink for LIMS interfacing. Computer workstations, MS Sequel, LimsLink, and firmware upgrade kits are purchased separately.
HRCare IQ/OQ validation, additional (Add-on) installation and training, and after-sales support contracts are also available. Please consult Hanson with requirements.
Bill DDS Start-up & Add-on Packagesp/n Description
81-500-115 Bill DDS Lite Start-Up Package (requires Add-On Package p/n 81-500-111) Includes:
Bill DDS software package Multi-user license for 1 laboratory site 1-year technical support
•••
81-500-110 Bill DDS Pro Start-up Package Includes:
Bill DDS software package Multi-user license for multi-lab networks and LIMS-interfacing 1 Bill Com-Switch p/n 81-500-105 1-year technical support
••••
81-500-111 Bill DDS Add-on Package (includes one Bill DDS Com-Switch p/n 81-500-105)
Bill DDS Accessories p/n Description
81-500-120 Bill DDS/SR8-Plus License & Firmware Upgrade Kit ver.10.0 (field retrofit)
81-500-420 Bill DDS/SR8-Plus License & Firmware Upgrade Kit ver.10.0 (factory installed)
81-500-122 Bill DDS/AutoPlus License & Firmware Upgrade Kit ver.10.2 (field retrofit)
81-500-422 Bill DDS/AutoPlus License & Firmware Upgrade Kit ver.10.2 (factory installed)
81-500-150 Com-Switch Printer
81-500-305 Printer Plug Retrofit for Existing Printers (requires installation)
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•
•
•
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hansonresearch.com | 99-300-001 Rev. 3-11 | On-Line HPLC��
On-Line HPLC
on-line Hplc DiSSolution SySteM Hanson Research is pleased to support the On-Line HPLC Dissolution System from Waters Corporation. The Transfer Module, OEM manufactured exclusively for Waters, has been designed for direct interfacing with the Alliance HPLC system with Millennium software. This complete dissolution test system package is being distributed and supported by Waters worldwide. Full specifications and pricing are available from your local Waters representative.The Waters Alliance System for Dissolution offers on-line sampling, transfer, and HPLC analysis for 6- and 8-sample dissolution baths. In addition, the Millennium dissolution software can provide fast, accurate data reduction and documentation of results. Both the system and the software comply with accepted USP protocols to facilitate meeting regulatory requirements.
The Waters HPLC Dissolution System is fully functional with Hanson SR8-Plus dissolution testers. Complete dissolution test protocols are provided with the Waters software, and communications with the SR8-Plus are built-in for validation of critical dissolution test parameters. The Hanson SR8-Plus is distributed and supported by Hanson Research worldwide. Please consult Hanson for further details and SR8-Plus firmware requirements.
Required Accessoryp/n Description
47-200-759 Cable, RS232 Communication, 9 ft.
Waters On-Line HPLC(pictured with an SR8-Plus dissolution tester)
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�0 Diffusion Cell Test Systems | 99-300-001 Rev. 3-11 | hansonresearch.com
Diffusion Cell Test Systems
hansonresearch.com | 99-300-001 Rev. 3-11 | Diffusion Cell Test Systems��
Diffusion Cell Test Systems
DiffuSion cell teSt SySteMS“Start-up” 6-Cell Manual Test SystemA “start-up” vertical diffusion cell test system for manual use and sampling. This expanded package includes a 6-cell drive system with stainless stand, 6 vertical diffusion cells (see choices below), convenient manual sampling syringe, jacketed media replace beaker, and supply kit. The circulating waterbath must be ordered separately. The “start-up” manual test system is adaptable for later addition of the MicroettePlus autosampler. Please specify voltage when ordering.
Start-up 6-Cell Manual Test System (58-6M) - Including Cells Please specify choice of Vertical Diffusion Cells when ordering:
Circulating Waterbath System & Accessoriesp/n Description
58-001-430 Programmable Circulating Waterbath, 115 V (recommended)
58-001-431 Programmable Circulating Waterbath, 230 V (recommended)
58-001-721 Start-up Tool Kit, 115 V (recommended)Includes vacuum pump, service vessel assembly, and applicator
58-001-722 Start-up Tool Kit, 230 V (recommended) Includes vacuum pump, service vessel assembly, and applicator
91-030-138 Applicator/Mixer, Polyethylene
91-030-155 Manual Sampling Syringe
91-030-150 HPLC Vials w/ Pre-Cut Septums, 12 mm x 32 mm (100/pk) (recommended)
58-001-716 Check Valves (100/pk) (recommended)
58-001-815 Q-Pak IQ/OQ/PQ for Manual Diffusion Cell System (recommended)
91-030-062 Membrane for Cells, 25 mm dia x 0.45 micron (100/pk) (recommended)
6-Cell Manual Test System(pictured with recommended circulating bath option)
58-6M System with: p/n with Clear Cells p/n with Amber Cells
4 mL Cells, “Small” 58-001-401 58-001-411
7 mL Cells, “Standard” (FDA-recommended for topicals)
58-001-402 58-001-412
12 mL Cells, “Large” 58-001-403 58-001-413
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�0 Diffusion Cell Test Systems | 99-300-001 Rev. 3-11 | hansonresearch.com
Diffusion Cell Test Systems
hansonresearch.com | 99-300-001 Rev. 3-11 | Diffusion Cell Test Systems��
Diffusion Cell Test Systems
MicroettePlus™ Automated Test SystemThe MicroettePlus system provides automatic sampling from topical and transdermal percutaneous diffusion cells and collection into HPLC vials for sample analysis. (For reference, see FDA Guideline SUPAC-SS.) The MicroettePlus system automates sampling from groups of 6 diffusion cells for extensive unattended tests and handles surfactants, saline, and hydroalcoholic receptor solutions. The MicroettePlus is an ideal research tool for the study of topical and transdermal drug delivery formulations, as well as opthalmics, cosmetics, skin care products, and pesticides.
The MicroettePlus autosampler incorporates Hanson “AutoPlus” technology, including precision 6-channel syringe pump, PEEK valves and sample tubing, user-friendly programming with graphical display, up to 25 test protocols, “Com-Switch” for system and Multi-Group communications, automatic media replace at time of sampling, jacketed media replace beaker, and supply kit. MultiFill Collector, vertical
diffusion cells, and cell drive systems must be ordered with each system; circulating waterbaths and other accessories are available as options. U.S. Patents. CE Approved. Please specify voltage when ordering.
MicroettePlus Autosamplerp/n Description
58-001-100 MicroettePlus Autosampler (58-6A), 115/230 V (for up to 3 groups)
MultiFill Collector (required with system)The AutoPlus MultiFill 8-Channel “X-Y” collection system for archive of dissolution samples. Includes AutoPlus interface and one Teflon tubing harness (output to waste or return). Order collection racks (1 required), tubes, vials, and caps separately. Specify voltage when ordering.p/n Description
60-200-490 AutoPlus MultiFill Collector (MF-8), 115 V (1 per group)
60-200-491 AutoPlus MultiFill Collector (MF-8), 230 V (1 per group)
91-030-063 Collection Rack for 12 mm x 32 mm HPLC Vials
91-030-150 HPLC Vials w/ Pre-Cut Septums, 12 mm x 32 mm (100/pk) (recommended)
Cell Drive System (required with system)Includes precision electronic “Variomag” 6-Cell Drive System with control and stainless stand.p/n Description
58-001-420 6-Cell Drive System for MicroettePlus (1 per group)
Circulating Waterbath System (recommended with system)p/n Description
58-001-430 Programmable Circulating Waterbath, 115 V (for up to 3 groups)
58-001-431 Programmable Circulating Waterbath, 230 V (for up to 3 groups)
MicroettePlus Autosampler
MicroettePlus Automated Test System—Single Group Setup
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�� Diffusion Cell Test Systems | 99-300-001 Rev. 3-11 | hansonresearch.com
Diffusion Cell Test Systems
hansonresearch.com | 99-300-001 Rev. 3-11 | Diffusion Cell Test Systems��
Diffusion Cell Test Systems
MicroettePlus Multi-Group The MicroettePlus autosampler can be expanded to handle up to 3 groups of cell experiments for a total of 18 cells (6 cells per group). To expand the system, each group requres an additional 6-cell drive, cells, and MultiFill.
MicroettePlus Multi-Group Expansion Kitp/n Description
58-001-720 Multi-Group Expansion Kit (order 1 per additional 6-cell group)
Upgrade Original MicroettePlus to MicroettePlus Multi-GroupOriginal MicroettePlus systems may be upgraded for Multi-Group usage by adding a Com-Switch, Firmware 2.01 (or higher), and a Jacketed Beaker, plus Multi-Group components as indicated above.p/n Description
58-001-416 MicroettePlus Com-Switch (required)
58-001-728 MicroettePlus Firmware ver. 2.01 (required)
58-002-440 Jacketed Beaker Assembly w/ Waterbath Tubing Harness (required)
Contact your Hanson representative for a quote on upgrades and expansions.
Single Group SetupMicroettePlus system automates sampling from 1 group of 6 diffusion cells.
Multi-Group Setup—12 CellsMicroettePlus system automates sampling from 2 groups of 6 diffusion cells (12 total).
Multi-Group Setup—18 CellsMicroettePlus system automates sampling from 3 groups of 6 diffusion cells (18 total).
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�� Diffusion Cell Test Systems | 99-300-001 Rev. 3-11 | hansonresearch.com
Diffusion Cell Test Systems
hansonresearch.com | 99-300-001 Rev. 3-11 | Diffusion Cell Test Systems��
Diffusion Cell Test Systems
Vertical Diffusion Cells (required with system)Precision vertical diffusion cells designed for ease of use and accuracy. Complete cell assemblies include receptor chamber and clamp, dosage wafer (300 mg “infinite dose”), sampling and media replace ports, outside jacket for temperature control, and Helix stirrer. Each cell includes an individual serial number; volumes listed are nominal value. Ordering 1 extra cell with each group of 6 is strongly recommended. Please consult Hanson for special cell requirements.
Vertical Diffusion Cellsp/n Description
58-001-451 Vertical Diffusion Cell, 9 mm Orifice, 4 mL vol, “Small”
58-001-455 Vertical Diffusion Cell, 15 mm Orifice, 7 mL vol, “Standard” (recommended by FDA for topicals)
58-001-459 Vertical Diffusion Cell, 15 mm Orifice, 12 mL vol, “Large”
58-001-452 Vertical Diffusion Cell, 9 mm Orifice, 4 mL vol, Amber, “Small”
58-001-456 Vertical Diffusion Cell, 15 mm Orifice, 7 mL vol, Amber, “Standard” (recommended by FDA for topicals)
58-001-460 Vertical Diffusion Cell, 15 mm Orifice, 12 mL vol, Amber, “Large”
For Cell Type
Description 4 mL 7 mL 12 mL
Complete Clear Cell with Std Top, Clamp, and Helix
58-001-451 58-001-455 58-001-459
Complete Amber Cell with Std Top, Clamp, and Helix
58-001-452 58-001-456 58-001-460
Clear Vertical Diffusion Cell 58-001-453 58-001-457 58-001-461
Amber Vertical Diffusion Cell 58-001-454 58-001-458 58-001-462
Clamp Assembly 58-001-450 58-001-450 58-001-450
Helix Kit 58-001-467 58-001-467 58-001-468
For Cell Type
DIM 4 mL 7 mL 12 mL
A Ø38 mm Ø38 mm Ø38 mm
B Ø9 mm Ø15 mm Ø15 mm
C Ø9 mm Ø9 mm Ø15 mm
D Ø30 mm Ø30 mm Ø30 mm
E 61 mm 61 mm 61 mm
Clamp Assembly
A
B
DC
E
Cell 15 mm x 7 mL
Vertical Diffusion Cell with Helix
Helix 9 mm
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�� Diffusion Cell Test Systems | 99-300-001 Rev. 3-11 | hansonresearch.com
Diffusion Cell Test Systems
hansonresearch.com | 99-300-001 Rev. 3-11 | Diffusion Cell Test Systems��
Diffusion Cell Test Systems
Standard Cell Tops (included with cell)This top style is included with the complete cell assembly. It is occluded to minimize back diffusion during the sampling process. It is suggested to use this top style when testing more viscose materials, such as creams, gels, and ointments.
For Cell Type
Description 4 mL 7 mL 12 mL
Cell Ring 58-001-507 58-001-507 58-001-507
Glass Disk 58-001-506 58-001-506 58-001-506
Dosage Wafer 501-001-518 58-001-521 58-001-521
For Cell Type
DIM 4 m