Studying the international way
IMC University of Applied Sciences Krems, Austria
Bernhard Klausgraber
The University of
Applied Sciences Krems
Guiding Principles
We are an Austrian university with an international focus. We offer practice-oriented degree programmes according to the needs of the industry which fulfil international university standards.
Location – close to Vienna
2 venues in Krems:
International Campus Piaristengasse
Campus Krems
Around 1.800 students
Around 2.500 graduates
KREMS
Three Schools
School of Business
School of Health
School of Life Sciences
School of Life Sciences
Bachelor & Master programmes (in English)
Medical & Pharmaceutical Biotechnology
(BSc und MSc)
Regulatory Affairs (MSc)
Universities:
Danube Univ. Krems
BOKU Vienna
Med. University of Vienna
University of Technology
Vienna University of Economics
University of Linz
University of Rostock
University of Greifswald
University of Augusta
University of Boston
Universities of Applied Sciences:
FH Tulln
FH Hagenberg
FH Lübeck
FH Biberach
Rentselear Polytechnic Institute Troy
Research Centers:
FZ Karlsruhe
Czech Acad. Sc. Nove Hrady
Fraunhofer Institute Leipzig
Ludwig Boltzmann Institute Wien
Clinics:
AKH Vienna
Hospital Tulln
European Patent Office
Munich
Nat. & internat. Lecturers
Companies: Topics:
Sanofi/Aventis, Vienna => Drug Law
Baxter Bioscience, Vienna => Project Management
Boehringer Ingelheim, Vienna => Quality Management
Fresenius Medical Care, B. Homburg => Scientific Marketing
Membrana, Wuppertal => Spec. Material Science
Miltenyi, Teterow => Pharm. Expression
Octapharma, Wien => Pharm. Production
Pfizer, Wien => Medical Products
Roche, Basel => Pharma. Marketing
Sandoz/Novartis, Kundl => Pharma. Production
ViruSure GmbH => Quality Management
Technology Companies:
ArsArthro GmbH, Krems => Medical Biotechnol.
ARWIG GmbH, Vienna => Biostatistics
Biotec Systems GmbH, Krems => Adsorber Technologies
InterCell GmbH, Vienna => Patent Law
DOT GmbH, Rostock => Implant Material Science
Rational GmbH, Rostock => Process Technology
WSB GmbH, Krems => Material Science
Ministry and Agencies => Clinical Studies
=> GMP / GCP
Lecturers from LifeScience Companies
9
Biotechnology at IMC stands for a balanced practical orientation
• The balanced interdisciplinary study program covers the whole „Value Chain“ from R&D to the approval of new drugs or medical products
• The methodical orientation and problem-solving abilities as first educational principle
• A full-time lecturer team with significant practical experiences – International education :
Austria => Med Univ. Vienna, Univ. Salzburg
Germany => Univ. Rostock
Slovakia => Univ. Bratislava
GB => Strathclyde Univ. Glasgow
USA => Cornell Univ. Medical Scholl, New York
Japan => Jikei Univ, Tokyo
- International research projects:
Germany => Zeiss Jena, Fresenius Homburg
USA => Beckman, PenKem New York
Japan => JMS Hiroshima
- International networking
Scandinavia => EU – Life Science Region
EC-Projects => Assessment procedure for innovative start-ups
-
• Broad and practical orientation
• Teaching contents based on a survey including the
pharmaceutical industry
• Balanced program between biomedicine and technology covers
the whole “value chain” from R&D up to approval of new drugs or
medical product
• High percentage of quality elements incorporated in lectures and
various laboratory course
• Methodical orientation and problem-solving abilities as first
educational ....
• Modular design of the study program
• Flexibility for participation in international joint programs
Our concept stands out against the classical (biotechnology) education
11
Bachelor program: 6 Semesters
Focus on basic knowledge to understand complex processes and
training of practical skills in:
• Basic Bio-Sciences
Biophysics, Mathematics, Chemistry, Biochemistry, Microbiology, Physiology, Diseases, Genetics, Pharmacology, Bioinformatics, Physiology, Medicine
• Special Laboratory Techniques
Cell Culture, Genetic Engineering, Fermentation,
Instrumental Analytics, Clean Room Training
• Quality Management
Project Management, GLP, GMP, GCP, Industrial Hygiene
• Bioprocess Technologies
Bioengineering, Pharmaceutical Production Systems
• Practical Training 8 months (mostly abroad)
12
Specialisation in:
• Pharmaceutical Production Technologies
Recombinant Protein Production, Fermentation, Bioseparation,
Quality Management and Validation
• Medical Biotechnology / Regenerative Medicine
Tissue Engineering, Cancer, Aging, Artificial Organs,
Nanobiotechnology
• Management
Business Administration, Quality and Project M., Regulatory
Affairs, Patenting, Licensing, Marketing
• Research Semester in Universities and Industry in 25 countries
Master program: 4 Semesters
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International … ?!
International students
International Visiting Professors and guest lecturers
60 % of students for bachelor/master thesis abroad
9. International Life Science Meeting of IMC FH Krems
EC-project Interreg
EC-IP-Course
ESAO Summer School „Biomaterials and Regenerative Medicine“
Lectures, posters and chairmanship at international conferences
Prof. Ivar Giaever, USA Nobel Prize in 1973
together with Esaki and Josephson
“Electron Tunneling”
Lecturer at FH Krems
Keratinozyten
Fibrinmatrix
Fibroblasten und/oder
Endothelzellen
Richtung der Migration
Elektrode
e.g.
Wound Healing Assay
Giaever´s Company:
R&D Profil of the Inst. Biotechnology New cell-based technologies for testing of bioactive substances Coop with Industry, Universities, EU 3.6 Mio. Project volume
16
• Current projects
• Students in research
• Scientific work
• Publications
• Conferences
• Cooperations
Our Research Concept:
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Our Research Concept:
1. Development of unique methods and technologies
2. Cooperation with partners:
Application research and service
Development of new methods
Participation in life science programms
3. Use of methods and technologies in education
4. Partner in international scientific networks
5. Foundation of start-up company or research center
18
Research Focus Medical Biotechnology:
1. Drug Discovery and Therapeutic
Strategies in Cancer, Inflammation and Regenerative
Medicine
2. Bioprocess Technology
Our Research Concept:
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Cancer Research
Cell Biology
Tissue
Regeneration
Instrument Development
Core Competences of Group Leaders
Innovative Assay Development
Biochemistry
Regenerative
Medicine
Drug Discovery
Our Research Concept
20 20
Potential for Synergy: Cooperation between the working teams
Drug Discovery
Tissue Engineering
Cell-based Testsystems
Ultimate Goal: Development of Lead
Compounds, Therapeutics and Diagnostics
Novel experimental methods
Our Research Concept
Our Research Concept
Target
Identification
Target Validation
Lead Identification
Lead Optimization
Phases of the drug
discovery process:
Preclinical and
Clinical
development
Organotypic Tumor Models in the Drug Discovery Process
Non-invasive assay
development to detect drug
induced reversions of the
hallmarks of cancer
- Inhibition of Proliferation
- Induction of Apoptosis
- Induction of Senescence
- Induction of Differentiation
- Inhibition of Invasion
Signaling Pathway Analysis
Genotype-Drug Response
Analysis
RNAi based Screening Techniques
Phenotype Based Drug Discovery
MDA-MB-231 MDA-MB-415 MDA-MB-468 MCF7 ZR-75-1
2D
Spheroids
Breast Cancer Cells
Dendritic Cell Based Cancer Therapy
Dendritic Cell Based Cancer Therapy
Personalized Medicine in Cancer
Screening of Marine Substances
Hanging Drop Rotory Wall Vessel
Establishment of 3D Tumor-Speroids
30µg
0 h 24 h 48 h 120
h
n.c.
3mg
30µg
Screening of marine Substances
Cultivation of
marine Organisms Pre-Screening of marine
Substances 2D Assays
rela
tive
flu
ore
sce
nce
0
0,2
0,4
0,6
0,8
1
1,2
Isolation of bioactive
Substances
Tumor-Immuntherapy
29
-downregulationof cbl b silencing
-isolation ofwhite blood
cells
-injection of activated cells
Establishment of organotypic 3D Tumor Sphäroids in vitro
32
Drug Discovery Systems
• Drug screening methods
Tumor models
Inflammation models
• Cooperation with Industrial Partners
Development of a new detection platform techniques
=> Support of scientific marketing world-wide
33
Pharmaceutical Process Technology
• Fermentation optimization
Oxygen Transfer
Calculation models
Index numbers
• Cooperation with Industrial Partners
=> Development of new production technologies
Presentation of first results in San Diego
34
Biotechnology at IMC Krems
• The balanced program covers the whole „Value Chain“ from R&D to the approval of new drugs or medical products
• Methodical orientation and problem-solving abilities as first educational principle
• Lecturer team with experience in international education and research projects
• International networks with Life Science industry and universities
=> The graduates starting their career in:
Industrial R&D 40%
Institutions 20%
PhD-programs 40% (Harvard, Cambridge, London, Oxford, Singapore, Hongkong, Antwerpen, Hannover, Aachen, Gent, Vienna, Graz, Innsbruck, Dublin, Stockholm, ..…)
Krems´s Specials in Numbers
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Nat & International Practical Training
Further PhD – Studies
Jobs
Acambis Cambridge, USA AGES, Wien Austrian Academy of Sciences, Wien Baxter Bioscience, Wien Baxter International, USA Biomin, Österreich Boehringer Ingelheim, Wien Chemistry School of Pharmacy, AUS Danube University, Krems Hagedorn Research Institute, DK ICRM Montreal, Kanada IMC, Krems LCT, Australia LKH Klagenfurt, Klagenfurt LMU München, Tansania/Deutschland McMaster University, Kanada Morphosys, Deutschland Octapharma, Wien Sandoz, Tirol Bundeskriminalamt, St.Pölten Vaxine Pty. Ltd. Sydney, Australia Tissue Genesis Inc., Hawai
National Laboratory of Berkeley
Sanquin Research, Niederlande
University of Alabama
University of Antwerp
University of British Columbia Vancouver
University of Brussels
University of Groningen
University of Homburg
University of Melbourne
University of Okago
University of Pecs
University of Queensland
University of Sidney
UTSW Medical Centre Dallas
Cancer Cell Inst., Madrid
University of London
University of Oxford
Univeristy of Cambridge
University of Sussex
University of Singapore
University of Hongkong
New York University
Pratical Training Semester BA and Applied Research Training Semester MA
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Practical Training Semester BA and Applied Research Training Semester MA
Since 2005: 358 Students in 25 countries
65% abroad
Universities 187
Industry 87
SMEs 31
Research Centers 29
Gov. Offices 10
IMC Krems 14
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Practical Training Semester BA and MA: Cooperation world-wide
Europe: 104 Germany 32
Great Britain 19
Netherlands 9
Sweden 8
Ireland 7 ….
Australia, New Z. 46 Australia 41
New Zealand 5
Amerika 40 USA 30
Canada 10
Asia 6 Singapore 4
Hongkong 1
Shanghai 1
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Pratical Training Semester: Cooperation in Austria
Industry 47 Baxter 21
Boehringer 16
Octapharma 4
Universities 44 MedUni
Graz
Innsbruck
Salzburg
VetMed
SMEs 28
Research Centers 18
AGES 7
40
Pratical Training Semester: Cooperation in Lower Austria
Industry 35 Baxter
SMEs 22 SeaLife Pharma 8
Biomin 5
Cell Danube 5
TMB 3
Arthro Kinetics 1
Danube University 13
IMC FH Krems 14
The intensive personal interaction of our IMC team with the external coaches worldwide shows a positive feedback about:
=> Performance of our students regarding:
structured problem solving abilities
open mind for interdisciplinary projects
flexibility
engagement
team work and management abilities
=> Possible further improvement of our educational concept
Bologna process
=> Use of our students activities for the establishment of new cooperation for research projects
=> Presentations of thesis at international conferences by the graduates
many of our students are invited to give talks at international conference or
are authors of peer-reviewed articles
The positive outcome of international practical training
42
Jobs of our Graduates (Known to us)
from this in Lower Austria:
Industry 57 19
SMEs 13 5
Universitys 40 6
Gov. Offices 4
from this in PhD-program:
42
Additional Studies: 5
(Medicine, Pharmacology, Diplomacy,…)
43
Further PhD Studies in:
Austria: Med. Univ. Vienna 8
Techn. Univ. Vienna 4
Univ. Vienna 1
Univ. Graz 3
Univ. Salzburg 1
Med. Univ. Innsbruck 2
BOKU Vienna 2
USA: Boston Univ. 1
Univ. Honolulu 1
Great Britain: Univ. London 1
Royal Institution 1
Univ. Cambridge 2
Univ. Oxford 2
Kings College London 2
Belgium: Univ. Gent 1
Univ. Antwerp 1
Ireland: Univ. Dublin 3
Germany : Univ. Hannover 1
Univ. Leipzig 1
Univ. Munich 1
Univ. Kassel 1
Univ. Aachen 1
Justus Liebig Univ. Giessen 1
China: Univ. Fudan, Shanghai 1
Univ. Hongkong 1
Sweden: Karolinska Institute 1
• Strong educational program
• Preparation for interdisciplinary projects in research and industry
• Team with strong experiences in education and research
• Interesting research profile: financial support (actual 3.5 Mio. €)
• Incorporation of representatives from industry and universities teaching newest
developments in biomedicine and biotechnology
• Close personal relation with industry, research institutions and universities
worldwide brings on a vast variety for the preparation of the practical training
semester
• Until today, our biotechnology students successfully finished their 9- months-
training in more than 25 countries, e.g.:
Universities: Harvard, Cambridge, Antwerp, Dallas, Lund
Leipzig, Singapore, Honking, Sydney
Industry Europa, America, Asia, Australia, Africa
• No unemployed graduates, 40% in PhD-programs world-wide
Attraction for students with clear and dedicated minds: A Summary !