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Inflammation and RepairInflammation and Repair
(Keeping your genes in the gene pool.)(Keeping your genes in the gene pool.)
The Shallow End of the Gene PoolThe Shallow End of the Gene Pool Grand Old TermsGrand Old Terms
TumorTumor RuborRubor CalorCalor DolorDolor Functio laesaFunctio laesa
Exudate and TransudateExudate and Transudate
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Vascularized TissueVascularized Tissue
The Invisible UniverseThe Invisible Universe
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The portal to the other side.The portal to the other side.
Allow Fluid to ExitAllow Fluid to Exit
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Sometimes the vessels are injured too.Sometimes the vessels are injured too. Warriors causing troubleWarriors causing trouble
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NeutrophilsNeutrophils
PMNs in tissuePMNs in tissue
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Red QueenRed Queen
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Mast Cells in OmentumMast Cells in Omentum(red blobs are fat cells)(red blobs are fat cells)
Though they are dead, yet they beckonThough they are dead, yet they beckon
ArachidonicArachidonic Acid Acid DerivativesDerivatives
ShortShort--livedlived Locally actingLocally acting CyclooxygenaseCyclooxygenase Moby DickMoby Dick
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Necrosis vs. ApoptosisNecrosis vs. Apoptosis
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Chronic Chronic inflamationinflamation Three aspectsThree aspects
Cell typeCell type DurationDuration FibrosisFibrosis
Abscess = acuteAbscess = acute Abscess = acuteAbscess = acute GranulomaGranuloma = chronic= chronic
Insoluble antigenInsoluble antigen Can’t destroyCan’t destroy Wall it offWall it off
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Clone your warriors on the battlefieldClone your warriors on the battlefield
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SignalingSignaling
Extracellular GoopExtracellular Goop
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Liver regeneration, human and rat.Liver regeneration, human and rat.
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Serous ExudateSerous Exudate
ExudateExudate Chemically may Chemically may
fool you and look fool you and look like a transudate.like a transudate. Paucity of cellsPaucity of cells Lower than Lower than
expected SPexpected SP At the site of At the site of
injury, because injury, because of injury.of injury.
Fibrinous ExudateFibrinous Exudate
Lots of proteinLots of protein Not just fibrinNot just fibrin No bugs, so no Ab No bugs, so no Ab g ,g ,
and C’and C’ Very few cellsVery few cells Still, it’s and exudateStill, it’s and exudate Site of injury, because Site of injury, because
of injuryof injury
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Suppurative or Purulent ExudateSuppurative or Purulent Exudate
PusPus BugsBugs HerterolysisHerterolysis Zit juiceZit juice Zit juiceZit juice AbscessAbscess
Rubor, Dolor, Tumor…Rubor, Dolor, Tumor…
Local ChangesLocal Changes
Vascular changesVascular changes HistamineHistamine
Nearly Local ChangesNearly Local Changes
Lymphatic Lymphatic drainagedrainage
LymphangitisLymphangitis LymphadenitisLymphadenitisy py p What does the What does the
‘itis’ tell us?‘itis’ tell us?
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Sedimentation RateSedimentation Rate
Rouleaux formationRouleaux formation Serum ProteinsSerum Proteins
C’ Reactive ProteinC’ Reactive Protein
Liver proteinLiver protein BloodBlood Aids complement Aids complement
binding tobinding tobinding to binding to damaged or damaged or foreign cells.foreign cells.
Rises quicklyRises quickly Follows ESRFollows ESR
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Wound DehiscenceWound Dehiscence
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