Molecular characterization of new Homologous Recombination factors during DNA replication stress
Growing evidence suggests that replicative stress-induced genomic
instability underlies the cancer predisposition in individuals with sporadic
or hereditary mutations in specific Homologous Recombination (HR) and Fanconi Anemia (FA) genes, besides their well-established role in Double-Strand Break (DSB) and interstrand-
crosslink (ICL) repair.
The student will join a group of 10 researchers and – under the direct
supervision of a postdoc - will focus on investigating the molecular role in
replication stress of new HR factors, recently identified by a high-content microscopy-based genetic screen.
The student will learn and performindependently a number of different approaches, ranging from standard
molecular and cell biology methods tomore specialized techniques such as
Quantitative Imaging-based Microscopy(QIBC), in vivo DNA labelling and
chromosome spreading, and ElectronMicroscopy of replication intermediates.
Institute of Molecular Cancer Research
24h Cdc25A
Application: [email protected] brief motivation letter + CV
Starting date: September 2016
Duration: 12 months
www.imcr.uzh.ch
MSc/Diploma positionDNA Replication and Genome Instability Group
Prof. Massimo Lopes
