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Study of bacteria isolated from urinary
tract infections and determination oftheir susceptibility to antibiotics
Pembimbing :
dr. Dasril Nizam, Sp.PD, KGEH
Disusun oleh :Maya Andriana
07120080048
FK UNIVERSITAS PELITA HARAPAN
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INTRODUCTION
Urinary tract infection (UTI) is the second mostcommon infectious in community medicalpractice.
150 million people are diagnosed UTI each year. UTI are classified :
Uncomplicated healthy female patients with structurally and functionally
normal urinary tracts.
Complicated abnormalities of the urinary tract that impede urine flow,
the existence of a foreign body (e.g., indwelling catheter,stone), or infection with multi- drug resistant pathogens.
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UTI
the lower urinary tract or both theupper and the lower tracts.
Cystitis : dysuria, frequency, and occasionally
suprapubic tenderness.
Acute pyelonephritis : flank pain or tenderness, or
both, and fever, often associated with dysuria,
urgency, and frequency.
> 95% of urinary tract infections are caused bya single bacterial species (E. coli).
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Corynebacterium urealyticum important
nosocomial pathogen.
Anaerobic organisms are rarely pathogens in
the urinary tract.
Coagulase Negative Staphylococci are a
common cause of UTI in some reports.
Staphylococci saprophyticus in young
women of a sexually active age.
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MATERIALS AND METHODS
- Sampling-
In total, 7056 patients with clinical symptoms
of UTI referred to Imam Khomeini hospital
Ahvaz, Iran, were investigated. 4209 (50.7%) females and 2847 (40.3%) males.
age range of 25-60 years (mean, 43.7 years).
Clean-Catch midstream urine of the patients wascollected in a sterile tube (4-5 ml).
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MATERIALS AND METHODS
- Antimicrobial susceptibility testing -
Study antimicrobial susceptibility testing wasdone on Mueller- Hinton agar.
ampicilin (10g), kanamicin (30g),cephalothin (30g), ciprofleoxacin (5g),tetracycline (30g), nalidixic acid (30g),nitofurantoin (300g), amikacin (30g),
tobramicin (10g), ceftriaxone (30g),cefotaxime (10g)and gentamicin (10g)andtrimethoprim-sulfamethoxazole (25g)
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RESULTS
In this study, 553(8.7%) patients out of 7056
were showed to be urine culture positive
(their colony count was equal or more than104).
There were 376(68%) females and 177(32%)
males in patients with urine positive culture.
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RESULTS
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RESULTS
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DISCUSSION
Approximately 1 in 3 women will require
antimicrobial treatment for a UTI before age
24, and 40% - 50% of women will have a UTIduring their lifetime.
The elevated incidence of UTI among females
(between male) is related to genitourinarysystems in anatomy and microflora.
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DISCUSSION
The prevalence of Gram-positive cocci was not high inour study ; this is similar to other studies in differentcountries.
E. coli was the most predominant bacteria. In present study a high level of bacterial resistance
ampicillin and cephalothin. (similar to previous studiesin the United States).
The most effective antimicrobial agents in our studyand other reported researchesamikacin andciprofleoxacin for Gram- negative bacilli (81%-100%).
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TERIMA KASIH