Download - Lecture 18 Yersinia
![Page 1: Lecture 18 Yersinia](https://reader035.vdocuments.net/reader035/viewer/2022062419/5584eacad8b42a73618b48bb/html5/thumbnails/1.jpg)
بسم الله الرحمن الرحيمبسم الله الرحمن الرحيم
GENUS: GENUS: YERSINIAYERSINIAProf. Khalifa Sifaw Ghenghesh
![Page 2: Lecture 18 Yersinia](https://reader035.vdocuments.net/reader035/viewer/2022062419/5584eacad8b42a73618b48bb/html5/thumbnails/2.jpg)
Yersinia pestisYersinia pestis
PlaguePlague Infected Fleas (Infected Fleas (Xenopsylla cheopisXenopsylla cheopis) )
are the Major Mechanism of are the Major Mechanism of
Transmission.Transmission.
Rodents >>Rodents >>
![Page 3: Lecture 18 Yersinia](https://reader035.vdocuments.net/reader035/viewer/2022062419/5584eacad8b42a73618b48bb/html5/thumbnails/3.jpg)
Clinical SyndromesClinical Syndromes
i. i. Bubonic PlagueBubonic Plague:: Incubation period: Incubation period:
– << 7 days after flea bite. 7 days after flea bite. High fever and painful bubo in the groin and High fever and painful bubo in the groin and
axilla.axilla. Untreated Untreated Bacteremia > 75% mortality Bacteremia > 75% mortality
raterate
![Page 4: Lecture 18 Yersinia](https://reader035.vdocuments.net/reader035/viewer/2022062419/5584eacad8b42a73618b48bb/html5/thumbnails/4.jpg)
ii. ii. Pneumonic PlaguePneumonic Plague:: Bubonic Disease >Pneumonic Plague > Bubonic Disease >Pneumonic Plague >
Exhales the Organism in Droplets.Exhales the Organism in Droplets.
Highly infectiousHighly infectious Incubation period:Incubation period:
– 2 to 3 days, with fever and malaise2 to 3 days, with fever and malaise– pulmonary signs within one daypulmonary signs within one day
Untreated Untreated > 90% mortality rate> 90% mortality rate
![Page 5: Lecture 18 Yersinia](https://reader035.vdocuments.net/reader035/viewer/2022062419/5584eacad8b42a73618b48bb/html5/thumbnails/5.jpg)
Yersinia pestisPuss from bubo/Gram-negative rods
![Page 6: Lecture 18 Yersinia](https://reader035.vdocuments.net/reader035/viewer/2022062419/5584eacad8b42a73618b48bb/html5/thumbnails/6.jpg)
LABORATORY DIAGNOSIS
Aspirate from Buboes, Aspirate from Buboes, Pus from the Area of Flea Bite, Pus from the Area of Flea Bite, Sputum, Throat Swab or Blood.Sputum, Throat Swab or Blood.
Transport Media >>Transport Media >>
![Page 7: Lecture 18 Yersinia](https://reader035.vdocuments.net/reader035/viewer/2022062419/5584eacad8b42a73618b48bb/html5/thumbnails/7.jpg)
Yersinia pestis on Sheep Blood Agar (72hrs)
![Page 8: Lecture 18 Yersinia](https://reader035.vdocuments.net/reader035/viewer/2022062419/5584eacad8b42a73618b48bb/html5/thumbnails/8.jpg)
TREATMENT– StreptomycinStreptomycin
CONTROL– A Quarantinable Disease.– Control of Urban Plague:– Garbage Disposal.
![Page 9: Lecture 18 Yersinia](https://reader035.vdocuments.net/reader035/viewer/2022062419/5584eacad8b42a73618b48bb/html5/thumbnails/9.jpg)
Y. enterocolitica Y. pseudotuberculosis
– Enterocolitis: Diarrhea, fever and abdominal painInfection can mimic acute appendicitisMore common in children
– Other infections:Septicemia, arthritis, hepatitis, and osteomyelitis
– Epidemic outbreaks due to Y. enterocolitica:
Contaminated meat and milk