![Page 1: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/1.jpg)
Lecture in INF5890 April 13th 2015
Critical Perspectives on Management,
Governance and Control of ICT
Margunn Aanestad
![Page 2: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/2.jpg)
Today:
• Critique of traditional management approaches • Too much reliance on «command and control» • Alternative approaches
• Readings • Ciborra, C. U. (2000): “A Critical Review of the Literature
on the Management of Corporate Information Infrastructure”. Chapter 2 in "From Control to Drift", Oxford University Press
• Ciborra, C.U (2004): “Encountering information systems as a phenomenon” Chapter 1 in "The Social Study of Information and Communication Technology". Oxford University Press
![Page 3: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/3.jpg)
Ciborra in «From Control to Drift»
Chapter 2: A Critical Review of the Literature on the Management of Corporate Information Infrastructure
![Page 4: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/4.jpg)
• Arguing against other literature on how to manage/govern the information infrastructure of a company, specifically this book:
– Weill and Broadbent (1998): «Leveraging the New Infrastructure. How Market Leaders Capitalize on Information Technology”
• They claim: IT infrastructure is an asset, manage it as other assets in your investments portfolio
• The recommendations are «based on proven and familiar principles of financial portfolio management»
Asset: «A resource with economic value that an individual, corporation or country owns or controls with the expectation that it will provide future benefit”
![Page 5: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/5.jpg)
• Different understandings of what «Information Infrastructures» are • ‘common sense’ versus theoretical notion
• The complexity of the existing IT and the interplay between IT and organization makes the information infrastructure much more complex to deal with than other assets • There are limitations to control-based approaches
• Central terms: • The «installed base»: IIs are never developed from
scratch, always already exists
• «Cultivation of installed base»
![Page 6: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/6.jpg)
![Page 7: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/7.jpg)
Chapter 8 (by Hanseth and Braa): “Who’s in control: Designers, Managers
– or Technology?
• Norsk Hydro established in 1905
• Fertilizer Division: Hydro Agri Europe
– 19 production sites & 72 locations
• Diversification, large acquisitions, but “hands off” management (independent national divisions)
• 1992: Crisis – decided tighter integration of European divisions
![Page 8: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/8.jpg)
Phase 1: Reengineering (without IT) • A swift integration was planned
– “Synergy between processes through global organizing”
• A lot of resistance in the organization, not successful
• Detected a lot of very different IT systems – decided to standardize (necessary for organisational integration)
– Defined the “Hydro Bridge” standard
• HAE choose SAP as a company wide standard ERP system in 1994
• Implementation started in 1995 and should continue to 1999
![Page 9: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/9.jpg)
Phase 2: SAP Implementation • First step:
– Develop a common, uniform SAP installation that supports joint processes across the organisation
• Second step: – Shared processes -> tighter integration
• Plan: Pilot (Germany), then validation and roll-out of final version – More complicated than expected – pilot demanded 3
months of massive support, > 1000 issues identified, not all could be corrected in final version
• Management did achieve (via SAP) more control (through definitions of standard processes)
![Page 10: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/10.jpg)
Phase 3: Fragmentation during roll-out
• Validation before local implementations: Lokal users involved in several regionale projects, ca. 100 participants in scandinavian project
• Fragmentation of the SAP solution – Different national regulation (accounting, tax, environmental impact)
– Different market models and business cultures
• From a uniform, joint system to a heterogeneous information infrastructure
– Customized for every division
• SAP now became the “ally” of the local divisions (resisting management’s standardization efforts)
![Page 11: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/11.jpg)
HAE’s emerging information infrastructure
• SAP installation in HAE had to be integrated with the other divisions (e.g. Oil and Gas)
• … and it had to be integrated with the underlying infrastructure and other applications – The “Hydro Bridge” standard
– Lotus Notes, spreadsheets
– Notes and web-based interfaces to SAP
• Result: not a neat, layered, but a complex, matrix formed information infrastructure
![Page 12: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/12.jpg)
Support services
Network, OS, PC’s
Desktop- applications
SAP
Lotus Notes user interface
Web-browsere
Lotus Notes database
Complex –further changes may be difficult: “SAP is like concrete, it is very flexible until it sets. Then there is nothing you can do to change it”
![Page 13: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/13.jpg)
Summing up the case: • From visions of shared, uniform system to a
complex, heterogeneous information infrastructure
• The II was “emergent” rather than designed and planned
• Chapter title: “Who is in control? Designers, Managers – or Technology?” – First – SAP is the ally of top management
– Then: the ally of the local divisions
– Then: blocks future changes – SAP “in control”?
![Page 14: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/14.jpg)
Alternative to control
• The «From Control to Drift» book contains cases with similar outcomes , showing the limitations (or even counter-productivity) of traditional managerial approaches (control-based)
• Alternatives to control:
– Cultivation of the installed base:
• Less control (the plant must grow)
• Less detached control, more involved «care»
• Selection based on proven results (learning process)
![Page 15: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/15.jpg)
Similar argument:
• Ole Hanseth and Claudio Ciborra:
• «Risk, Complexity and ICT»
• Focus: integration
– Solution or problem?
• Increased integration -> increased risk
![Page 16: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/16.jpg)
Naturally, managers and consultants tend to downplay challenges and emphasize achievements. But what about researchers? Do we need to «go deeper»?
![Page 17: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/17.jpg)
The second reading
• Ciborra, C.U (2004): “Encountering information systems as a phenomenon”
• A methodological argument: how to approach (study, understand, deal with) these phenomena?
![Page 18: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/18.jpg)
Some quotes:
• «Managers… lack the words to describe… the unexpeced consequences, serendipitous occurrences, and emergent, disappointing features of the new technological systems… A key reason for managers’ bafflement and uncertainty lies in the ungrounded expectations created by widely used managerial and consulting models… The vacuity and boastfulness of these promises should not fool anyone...The recommendation is: ‘more command and control’»
![Page 19: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/19.jpg)
Argument
• We need to think differently about IT than what managerial/consultant approaches advocate
• Phenomenology (Husserl, Heidegger):
– «go back to the basics and enounter the world as it presents itself in our everyday experiences»
– «rely on evidence, intuition, and empathy»
– In «the murly world of informal, worldly, and everyday modes of operations and practice, It is the realm of hacking, practical intelligence,…, the shortcut and the transgressions…»
![Page 20: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/20.jpg)
With a phenomenological lense we might see that:
• Technology tend to surprise us when it is put into use
– «drift» as metaphor
• Implementation requires ongoing work
– «care» as metaphor
• Technology doesn’t evolve according to rational implementation plans
– «cultivation» as metaphor (bricolage, improvisation)
• Technology comes with promises and threats
– «hospitality» as metaphor
![Page 21: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/21.jpg)
Other points in Ciborra (2000)
• Tensions/differences between:
– Formulation and implementation
– Espoused theory versus theory in use
– Single-loop learning or double-loop learning
– Management politics vs. politics of non-humans
![Page 22: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/22.jpg)
Challenging assumptions
Traditional managerial approach (Deming)
Double loop learning (Argyris)
![Page 23: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/23.jpg)
Why double loop?
Organisational complexity analytic processes not sufficient, exploration required Rapid technological change new affordances, new potentialities, constraints continuously relaxed Striking a balance between global and local – planned and emergent – short term and long term
![Page 24: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/24.jpg)
How to handle the challenge
Governance vs project management vs maintenance Creating a common basis for: operating logics, technology principles, socialisation processes, distribution of decisions Timeboxing (projects) only when relevant and realistic in close relationship with maintaining – cultivating Projects are good for monitoring and managing but they create a sense that IIs can be compartmentalised
![Page 25: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/25.jpg)
Recent Norwegian Cases
NAV: Large and long-term ICT projects: halted when the assumptions had to be adjusted Genap: Explorative building through a pragmatic approach (assumptions challenged) “One citizen – one record”: the challenges of making a project out of a vision
![Page 26: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/26.jpg)
Example: NAV
• Social insurance/benefits, social welfare,
employment (2006 merger)
• Administers 1/3 of national budget (<320 billion
NOK/year), 30 mill. transactions/year
• >19000 employees
• NAV ICT:
– Runs > 300 applications
– 425 employees
– + ca. 200 consultants
– ICT renewal projects
![Page 27: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/27.jpg)
NAV’s ICT renewal projects
• Projects: (2012 numbers)
– Arena: 225-300 mill. NOK (over six years)
– Infotrygd: 150-210 mill. NOK (over six years)
– New «vedtaksløsning»: 340-460 mill. NOK (over seven
years)
– Self service solution: 350-460 mill. NOK (over seven
years)
– Info-platform/resource- and production mng: 260-360
mill. (seven years)
– Agreement for customer side: 600-850 mill. NOK (over
six years)
• 15-20 years’ perspective (3,3 billion NOK)
![Page 28: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/28.jpg)
Some of the external parties that NAV systems communicate with
![Page 29: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/29.jpg)
Progress with ICT renewal:
• Work planned from 2010, initiated in 2012
• Project 1, 2 and 3
– Project 1: 1,75 bNOK allocated
– Spring 2013: Halted – to be «re-organized»
– Prioritized disability pension reform 1.1.15
– Estimated losses: 110-170 mill. NOK
• Increased overall costs ~ 1,5 bNOK (?)
• Parliament hearings
– November 28th 2014 and February 2nd 2015
![Page 30: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/30.jpg)
«in hindsight we see
that we were too
ambitious, and that we
did not realize the
complexity of
harmonizing the new
platform with the
existing solutions»
![Page 31: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/31.jpg)
• «National DNA sequencing data platform for
healthcare»
• Cross-disciplinary research project
• UiO and Oslo University Hospital
• Goals: Learn about/develop IT support for
«personalized medicine»
• From september 2011 until summer 2015
genAP
![Page 32: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/32.jpg)
”Strawman” architecture (Sept 2011)
(The system as initially imagined)
EXOM
base med
varians
filer
EXOM base
funksjonell
annotering
Klinisk
algoritme/
Ekspert
system
Gradert
tilgang
avhengig
av klinisk
spørsmål/
bruk og
tillatelser
Brukere PASIENTER
Pleietjeneste?
Allmennlege
Spesialister
•Pediater
•Nevrolog
•Etc
Spesial IT systemer
Ekspert/ Med.
genetiker
Tillatelse
til bruk fra
pasient
LOGG for
queries, bruker
og tillatelser
![Page 33: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/33.jpg)
Vision for «automated system»:
Genom-data
Hva er CYP3A5, CYP3A4 og POR?
CYP3A5 *1/*3 CYP3A4 *18/*1b POR *28/*28
![Page 34: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/34.jpg)
Help to design treatment
Genom-data
Hvordan doserer jeg Marevan for akkurat denne
pasienten?
Et øyeblikk Bzzbzz.. CYP2C9..bzzbzz..
VCORKC1
Bzzbzz.. CYP2C9*1..bzzbz
z..VCORKC1*3
A simple example
Almenpraktiker
![Page 35: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/35.jpg)
Assisted diagnostics
Genom-data
Er dette den arvelige formen
for kardio-myopati?
Et øyeblikk Bzzbzz.. MYH7..bzzbzz… TNNT2..TPM1…
Bzzbzz.. MYH7..bzzbzz… TNNT2..TPM1…
Hei! Den varianten har jeg aldri sett før!
Hjelp meg, Kjære genetiker!
Hm… stoppkodon midt i myomet, det kan umulig gå bra
Ok.
A more complicated example
Almenpraktiker
Genetiker
![Page 36: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/36.jpg)
Status for genAP
• Secure High-Performace Computing infrastructure at USIT (TSD)
– Secure computational storage
![Page 37: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/37.jpg)
USIT (UiO)
Tungregne-gruppa
TSD2: Tjeneste
Sensitive Data
Forsknings-
infrastruktur
for prosjekter
underlagt:
Helseforsknings-,
Bioteknologi-,
Helseregister-
eller Person-
opplysningsloven
![Page 38: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/38.jpg)
Status for genAP
• Secure High-Performace Computing infrastructure at USIT
– TSD - Secure computational storage
• Presentation of genetic information to clinicians:
– Prototype evaluated (Lærum m.fl., JAMIA 2014), (domain: pharmacogenetics)
• Improve the interpretation capacity in the lab
– Partial automatisation/better IT support in the interpretation process
![Page 39: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/39.jpg)
Sample loading
and QC
Frequency and
inheritance External databases
References
Pathogenicity
prediction
Final evaluation
and report
Matching against
in-house DB
Mapping of the interpretation prosess:
![Page 40: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/40.jpg)
Redesign of IT systems in use
![Page 41: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/41.jpg)
Gene Variant (HGVS) Norvariome ESP6500 1000G Contradictory information Filter out :
Select all
BRCA1 c.434A>C 0.0234 - - -
BRCA1 c.2311T>C - 0.0446 - -
Gene Variant (HGVS) Norvariome ESP6500 1000G Contradictory information Filter out :
Select all
BRCA1 c.873T>C - 0.0079 - -
BRCA1 c.1067A>G - 0.0053 - Warning: entry found in HGMD Pro
Details
for variant BRCA1 c.1067A>G
HGVS cDNA c.1067A>G
Observed genotype CA
HGMD Pro Disease-associated
polymorphism
Effect Missense
SIFT TOLERATED
MutationTaster Polymorphism
View raw
View all
View external record
genAP analysis workbench
VarDB Sample Options | Sign out | Help External DB Prediction References Report
Next Previous
Frequency
Neutral variants (>0.008)
Sample 000001A loaded | Gene panel: Breast and ovarial cancer v1.0
Probably neutral variants (0.001-0.008)
Only variants with frequency >0.008 are shown.
Filter
Mockup v0.1
Removes checked
variants from further
analysis, adds to report.
Pathogenicity
prediction tools
Extracting, adding
and scoring of
references
Report with all details,
suggested classification
and export tools
External
databases
In-house
database Sample loading
BIC ClinVar dbSNP HGMD Pro
SeqScape
Analysis workbench
Details for selected
variant.
![Page 42: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/42.jpg)
Updated overview of system (from Feb 2014)
![Page 43: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/43.jpg)
Scaling down of ambitions
• From an exclusive focus on HTS
– To building solutions for «old» sequencing technologies
• From a national scope
– to a regional scope
– to a hospital scope
– to a departmental scope
• From generic expert system
– To a system for specific ‘gene panels’ (for simple and well mapped areas, i.e. monogenic & dominant)
• From a ‘common infrastructure’ (or platform)
– To a support system for interpretation (improved production rate and quality)
![Page 44: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/44.jpg)
The emerging architecture:
• Bottom-up (from the concrete setting) and
shaped by what is possible to do:
– Who (clinicians) are interested to join?
– In what clinical domains are there low-hanging
fruits, with low risk and high gain?
• The HTS performance for that domain
• The knowledge about gene-disease relations
• The volume and ‘status’ of patients affected
– What do others (externals) do? And not do?
– What do project members want to do…etc.
![Page 45: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/45.jpg)
National strategy for health IT
• «One citizen – one record»
• Situation today:
– Each GP and hospital maintains separete patient records
– Limited digital communication (standardised messages and discharge reports exchanged, not full record information)
![Page 46: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/46.jpg)
The State Project Model
• Quality Assurance (external) for major public investment projects (above 750 mNOK)
– Checkpoints (of documentation quality)
– Conceptual appraisal (KVU)
– QA1 before Cabinet’s decision on the solution:
• QA of the choice of concept (KS1)
– QA 2 before Parliament’s approval of cost frame:
• QA of costs, estimation and cost control (KS2)
![Page 47: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/47.jpg)
![Page 48: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/48.jpg)
• (Some slides removed)
![Page 49: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/49.jpg)
(”The Cynefin framework”)
![Page 50: Lecture in INF5890 April 13th 2015 Critical Perspectives ... · Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad . Today: ... •The «installed](https://reader031.vdocuments.net/reader031/viewer/2022020319/5c7c249309d3f2ac4e8c3c04/html5/thumbnails/50.jpg)