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•La leucocitosis inducida por el ejercicio puede ser atribuida principalmente a:
-NEUTROFILIA
-Linfocitosis.
-Monocitosis.
Mackinnon LT. Advances in exercise immunology. Champaign (IL): Human Kinetics, 1999
•Después de un ejercicio prolongado el número de leucocitos puededescender por debajo del recuento de reposodescender por debajo del recuento de reposo.
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Benschop RJ, Rodriguez-Feuerhahn M, Schedlowski M. Catecholamine-induced leukocytosis: early observations, current research, and future directions. Brain Behav Immun 1996; 10 (2): 77-91.
Pedersen BK, Hoffman-Goetz L. Exercise and the immune system: regulation, integration, and adaptation. Physiol Rev 2000; 80 (3): 1055-81
Catecolaminas.
Cortisol.
Recuento de Leucocitos
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Meager A. Cytokine regulation of cellular adhesion molecule expression in inflammation. Cytokine Growth Factor Rev 1999; 10 (1): 27-39.
Malm C, Nyberg P, Engstrom M, et al. Immunological changes in human skeletal muscle and blood after eccentric exercise and multiple biopsies. J Physiol 2000; 529 (Pt 1): 243-62.
Citoquinas.
Adhesión molecular.
Factores de crecimiento.
Cortisol.
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¿Cual es la fuente de
leucocitosis?
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Benschop RJ, Rodriguez-Feuerhahn M, Schedlowski M. Catecholamine-induced leukocytosis: early observations, current research, and future directions. Brain Behav Immun 1996; 10 (2): 77-91.
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Pedersen BK, Hoffman-Goetz L. Exercise and the immune system: regulation, integration, and adaptation. Physiol Rev 2000; 80 (3): 1055-81
•Las células circulantes no son movilizadasno son movilizadas desde la medula óseamedula ósea o el timotimo.
•Suzuki et al sugieren que los neutrófilos son liberados desde la médula ósea después del ejercicio físico.
Suzuki K, Nakaji S, Yamada M, et al. Impact of a competitive marathon race on systemic cytokine and neutrophilresponses. Med Sci Sports Exerc 2003; 35 (2): 348-55.
IL-6
M-CSF
NEUTROFILOSNEUTROFILOS
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¿Dónde emigran los leucocitos cuando
disminuye su número?
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Malm C. Exercise immunology: a skeletal muscle perspective. Exerc Immunol Rev 2002; 8: 116-67
Espersen GT, Stamp I, Lidang Jensen M, et al. Lymphocyte redistribution in connection with physical activity in the rat. Acta Physiol Scand 1995; 155 (3): 313-21
•Adhesión pared endotelial.
•Piel.
•Bazo.
•Pulmones.
•No migran al músculo esquelético.
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1. Monocitos
Woods J, Lu Q, Ceddia MA, et al. Special feature for the Olympics: effects of exercise on the immune system: exercise-induced modulation of macrophage function. Immunol Cell Biol 2000; 78 (5): 545-53.
Mackinnon LT. Advances in exercise immunology. Champaign (IL): Human Kinetics, 1999.
•Después de ejercicio agudoejercicio agudo pueden ↑ o = .
•Después de períodos prolongados de entrenamiento de resistenciaperíodos prolongados de entrenamiento de resistenciapueden ↓.
Malm C. Exercise immunology: a skeletal muscle perspective. Exerc Immunol Rev 2002; 8: 116-67.
Starkie RL, Angus DJ, Rolland J, et al. Effect of prolonged, submaximal exercise and carbohydrate ingestion on monocyteintracellular cytokine production in humans. J Physiol 2000;528 (Pt 3): 647-55.
•La función “in vitro” y la expresión “invivo” del receptor de superficie puede estar alterada por el ejercicio .
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Suzuki K, Nakaji S, Yamada M, et al. Impact of a competitive marathon race on systemic cytokine and neutrophilresponses. Med Sci Sports Exerc 2003; 35 (2): 348-55.
•La función de monocitos y neutrófilos aumenta después de una maratón.
•Su actividad biológica fue inhibida por un incremento de las defensas antioxidativas.
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Woods JA. Exercise and neuroendocrine modulation of macrophage function. Int J Sports Med 2000; 21 Suppl. 1: S24-30
• Durante períodos de ↓ del entrenamiento en atletas de resistencia ↑ función monocitos.
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2. Linfocitos
• Catecolaminas ↑ linfocitos circulantes durante el ejercicio.
•Pocas horas después del ejercicio retorno a niveles basalesretorno a niveles basales.
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Gabriel H, Kindermann W. The acute immune response to exercise: what does it mean? Int J Sports Med 1997; 18 Suppl.1: S28-45
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Gabriel H, Kindermann W. The acute immune response to exercise: what does it mean? Int J Sports Med 1997; 18 Suppl.1: S28-45
•Si el ejercicio es de duración extrema recuento de leucocitos por debajo de los niveles de reposo.
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Pedersen BK, Hoffman-Goetz L. Exercise and the immune system: regulation, integration, and adaptation. Physiol Rev 2000; 80 (3): 1055-81.
Nieman DC. Special feature for the Olympics: effects of exercise on the immune system: exercise effects on systemic immunity. Immunol Cell Biol 2000; 78 (5): 496-501.
Rowbottom DG, Green KJ. Acute exercise effects on the immune system. Med Sci Sports Exerc 2000; 32 (7 Suppl.):S396-405.
Jonsdottir IH. Exercise immunology: neuroendocrine regulation of NK-cells. Int J Sports Med 2000; 21 Suppl. 1: S20-3 .
• NK presentan una respuesta homogénea al ejercicio:
↑ ejercicio.
↓ postejercicio.
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Malm C, Nyberg P, Engstrom M, et al. Immunological changes in human skeletal muscle and blood after eccentric exercise and multiple biopsies. J Physiol 2000; 529 (Pt 1): 243-62.
• Los linfocitos T son mas pródigos al cambio con el ejercicio que las células B.
•Cambios en el número de linfocitos T producción Ig células B.
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¿Influye el entrenamiento sobre
el recuento de linfocitos en reposo?
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Dressendorfer RH, Petersen SR, Moss Lovshin SE, et al. Performance enhancement with maintenance of restingimmunestatus after intensified cycle training. Clin J Sport Med 2002;12 (5): 301-7.
Mackinnon LT. Chronic exercise training effects on immune function. Med Sci Sports Exerc 2000; 32 (7 Suppl.): S369-76
• Parece ser que el entrenamiento no afecta al recuento basal de linfocitos.
Gabriel HH, Urhausen A, Valet G, et al. Overtraining and immune system: a prospective longitudinal study in endurance athletes. Med Sci Sports Exerc 1998; 30 (7): 1151-7
• Individuos con sobreentrenamiento pueden tener un recuento basal de linfocitos normal.
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•En ejercicio extenuante:
tumour necrosis factor-a.IL-1β.IL-6 IL-1
•Se liberan de manera secuencial semejante a lo que ocurre en un trauma físico.
Pedersen BK, Ostrowski K, Rhode T, et al. Strenuous exercise a model of the cytokine response to trauma and sepsis. CanJ Physiol Pharmacol 1998; 76: 505-11
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David C. Nieman DC, Pedersen BK. Exercise and Immune Function.Recent Developments Sports Med 1999; 27 (2): 73-80.
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LEUCOCITOS:
GRANULOCITOS 60 %
LINFOCITOS 20-25 %
MONOCITOS.
SUB GRUPOS DE LINFOCITOS:
CD (Cluster Designators}
Células T (CD3)
T helper (CD4)
T citotóxico/supresor (CD8)
Células B (CD 19)
NK (CD 16)
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FACTORES SOLUBLES:INMUNOGLOBULINAS (Ig A, Ig G, Ig M, Ig D, Ig E)
ANTICUERPOS:-Facilitan la fagocitosis.-Activan el complemento.-Producen opsoninas.-Neutralizan las toxinas bacterianas.
CITOKINAS : Comunicación entre células.-Interleukinas.-Interferón.-Factor de necrosis tumoral.-Factor estimulante de colonias.COMPLEMENTO:-Fagocitosis.-Presentación del antígeno.-Muerte de la célula infectada.
PROTEÍNAS DE F ASE AGUDA:-Estimulan la migración celular al lugar de la infección.-Activan el complemento.-Estimulan la fagocitosis.-Minimizan la lesión tisular.