Lymphoma / Leukaemia Biobanks
Melanie Oates
• 2 diseases • 1 issue: collect material involved in disease
Circulating within the blood Lymphatic tissues
Leukaemia/Lymphoma Biobanking
in Liverpool
University of Liverpool
Leukaemia Bank
LLR funded
2005-15
Leukaemia Biobanking in Liverpool
2005
2002
1988 No formal Biobank, samples were collected by PIs for their own research group
University of Liverpool
Leukaemia Bank
The coordinated collection of lymphoproliferative disorders was started with clinical annotation
2013
University of Liverpool Leukaemia Bank
•Purpose: Local & LLR funded Researchers
•Disease(s): Leukaemias and Lymphomas
•Collection: Local cohort
•Samples: cryopreserved PBMCs, plasma,
germline DNA
•Run to local and HTA standards
Leukaemia Biobanking in Liverpool
Leukaemia Biobanking in Liverpool
University of Liverpool Leukaemia Bank
- > 32,640 vials of patient material
- Data/ material from more than 600 CLL patients
- Material/data from 151 other leukaemias and lymphomas
- Released material to help support projects in
Newcastle University Hull Royal Marsden Manchester Royal Inf.
Birmingham University Oxford University
Leukaemia Biobanking in Liverpool
UK CLL Trials Biobank (2008)
• Purpose: National sample repository
• Disease: CLL
• Collection: patients entering national clinical trials
• Samples: PBMCs, plasma, serum, germline DNA
• Run to GCP for Laboratories and HTA standards
LIVERPOOL
GCLP
Leukaemia Biobanking in Liverpool
UK CLL Trials Biobank
• Has historical clinical trial material transferred
CLL201, CLL202, CLL206, CLL4
Trials Phase I Phase II Phase III
Closed RESPeCT
Closed to recruitment
AdMIRE ARCTIC
Open CLEAR, CLL210, COSMIC, CHOP-OR CyCLLe
RIAltO
Lymphoma Biobanking in Liverpool
PACIFICO Phase III trial (2009)
• Purpose: Research sample collection
• Disease: Follicular Lymphoma
• Collection: Patients entering national clinical trials
• Samples: PBMCs, plasma, serum, germline DNA &
FFPE tissue blocks
• Run to GCP for Laboratories standards and HTA
Purine-Alkylator Combination In Follicular lymphoma Immuno-Chemotherapy for
Older patients: a phase III comparison of R-CVP versus R-FC
LIVERPOOL
GCLP
Lymphoma Biobanking in Liverpool
PACIFICO Phase III (2009)
• Recruitment -680 patients
• 226 patients, given 352 blood samples for PBMCs,
plasma & serum
• 178 FFPE blocks from 136 patients
• Supporting research within Liverpool and nationally
University of Liverpool
Leukaemia Bank
•Lymphoma research groups
are expanding
•Different material required
•Logistical problems
Liverpool Tissue Bank
•Expertise in solid tissue
collection
•Collects material from other
sites
Leukaemia/Lymphoma Biobanking
in Liverpool
• To build on the lymphoma collection with LTB to include freshly isolated cells from tissue
• Support the national collection of Mantle Cell Lymphoma
The Future for Leukaemia/
Lymphoma Biobanking in Liverpool