Medicines Differentiation Analysis
MyCore
18 January 2011
Asset Overview
© Medicines Differentiation Analytics 2010
As a Patient, I want to extend/slow down the onset of Alzheimer's.
As a Payer, The cost of adverse events (high blood pressure, weight gain, increased pulse rate) are costing us additional money. An alternative treatment that addresses these adverse effects would gain access. In 2014, current Lilly rug ALZ-In-Comp1 will go off patent and be available generically. The efficacy of any new drug must be significantly better (with no additional safety risks) then that to gain access and get reimbursement – otherwise only the generic Lilly drug will be provided to patients. Generic Lilly drug estimated at $100 per month.
As a Provider, Many of the patients have adverse reactions while on the current SOC - such as increased blood pressure & body weight. I would liek to give patients a safer alternative. Many of my patients complain of being tired a lot, not having energy that they used to have while on the current standard of care. They are not exercising, as they should. I would like to give them an alternative treatment that does not have this side effect.
Alzheimer Disease Unmet Needs -Customer Value Statements
As a Approver, Any medicine that slows down the onset of Alzheimer's will get approval over other alternatives. Safety must meet current levels.
As a Caregiver, My spouse's onset of Alzheimer's must be slowed down.
© Medicines Differentiation Analytics 2010
Alzheimer Disease Competitive Positioning
In-Line (When approved) – estimated LOE – how administered – how frequently)
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Pipe-Line: (ADD STAGE) Est Launch Date - how administered – how frequently.
• LillyAlz-In-Comp1• MerckAlz-In-Comp2
• NovartisAlz-Pipe-Comp1• PfizerAlz-Pipe-Comp2
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MyCore Healthcare Differentiation Instrument
Target Perf.
Observed
SOC
Competitors
KEY
Months of Disease Progression.
SOC100 95 90 75 185 80
% with Adverse events. SOC30 17.5 5 3
% of patients with decreased energy
levels.SOC
75 60 45 15 130
Monthly Cost. SOC100 87.5 75 1
© Medicines Differentiation Analytics 2010 6
REAL
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Win
© Medicines Differentiation Analytics 2010 8
Worth
© Medicines Differentiation Analytics 2010
MyCore Real, Win, Worth Summary
Is the Market & Opportunity REAL? What is the unmet medical need? What is the
likelihood that Stakeholders will: Take, Prescribe, Approve, & Pay For. What are the hurdles that must be overcome for stakeholders to actually take action?
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Can we WIN? Is our Asset Differentiated, safe and effective to meet the Customer Need? Can we leverage our differentiated position? How strong is our competitive position? Are our internal capabilities well aligned with asset?
Is the Opportunity WORTH the investment? Are the Sales & Profit attractive?How high is the Cost of entry?
• Pharm Sci, Sales force, etc.Is there Strategic Fit?
• Reputation, Tie to Strategy, etc.Can we leverage multiple indications?
Value Score Rigor Score
1
1
1
3.6
1.4
1
1 2Average
© Medicines Differentiation Analytics 2010
Understand needs and desired outcomes of this Asset/Project
Finalize competitive landscape & parameters
Build differentiation instrument & competitive label position statements
Prepare Differentiated Commercialization Package
Next Steps