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Biochemistry forTomorrow’s Medicine
Final programme
www.febs2011.it
Organised by
36th FEBS Congress 3
Torino, Italy - June 25-30, 2011
CONTENTS
Organisers and Committees ................................................................................................................ 4
Welcome message ............................................................................................................................... 5
FEBS 2011 Patronages......................................................................................................................... 5
FEBS 2011 Sponsors ........................................................................................................................... 8
FEBS 2011 Exhibitors ........................................................................................................................... 9
Key Information ................................................................................................................................... 10
Poster Presentations ........................................................................................................................... 11
Plenary Lectures ................................................................................................................................. 13
Congress Symposia ........................................................................................................................... 14
Programme at a Glance ..................................................................................................................... 16
Pre-Congress Event ........................................................................................................................... 18
Programme day by day ....................................................................................................................... 19
Poster Sessions .................................................................................................................................. 46
Exhibition Area - Poster Areas ............................................................................................................ 47
Turin (Torino)........................................................................................................................................ 48
Final Programme4
36th FEBS CONGRESS - “Biochemistry for Tomorrow’s Medicine”
Organised byFederation of European Biochemical Societies (FEBS)
Italian Society of Biochemistry and Molecular Biology (SIB)University of Torino (UNITO)
in collaboration withItalian Federation of Life Sciences (FISV)
Italian Society of Biophysics and Molecular Biology (SIBBM)Italian Society of Immunology, Clinical Immunology and Allergology (SIICA)
Italian Society of Pharmacology (SIF)Italian Proteome Association (ItPA)
Co-sponsored byDepartment of Life Sciences,
Italian Research Council Rome
Scientific Committee and International Advisory BoardChairman
Sergio Papa
Organising CommitteeChairman
Gianfranco Gilardi
Organising Secretariat
M.A.F. Servizi Srl - Congress DivisionCorso Svizzera 185 - Turin (Italy)
Phone +39 011 505900 - Fax +39 011 505976Via XX Settembre 23 - Genova (Italy)
www.mafservizi.it
Organisers and Committees
36th FEBS Congress 5
Torino, Italy - June 25-30, 2011
WELCOME TO THE 36th FEBS CONGRESS
Dear Colleagues,
On behalf of the Italian Society of Biochemistry and Molecular Biology, the co-organising Italian ScientificSocieties and the Scientific and Organising Committees of FEBS 2011-Torino, we are most pleased towelcome you all to the 36th FEBS Congress “Biochemistry for Tomorrow’s Medicine”. It is indeed significantthat our Congress takes places in Torino, the first capital city of Italy, coinciding this year with the celebra-tions of the 150th year of Italy’s unification.
The availability of the human genome with the exponential development of functional genomics and pro-teomics and other related fields have opened new paths in the elucidation of the molecular pathogenesisof major human diseases. The Congress brings together a forum of experts in the most advanced sectorsof Biochemistry and Molecular Biology, from fundamental aspects to applied ones aimed at human pa-thophysiology. The scientific achievements that will be presented in more than 1500 contributions willprovide a comprehensive view of the translational power of fundamental research and inspire the futureresearch activity of younger generations of biomedical investigators.
We hope that you will enjoy the Congress as well as the many touristic attractions and events in the city ofTorino and its surroundings.
Gianfranco GilardiChairman Organizing Committee
Sergio PapaChairman Scientific Committee
FEBS 2011 Patronages
Presidenza del Consiglio dei Ministri, Repubblica Italiana
Città di Torino
Presidenza Consiglio Nazionale delle Ricerche, CNR - Roma
36th FEBS Congress 7
Torino, Italy - June 25-30, 2011
International Scientific Advisory BoardPhilip Cohen (UK)Pascale Cossart (F)Stephanie Dimmeler (D)Paul Freemont (UK)Joseph Houstek (CZ)Sirpa Jalkanen (FIN)
Chairman Sergio Papa
Chairman Gianfranco Gilardi Deputy Chairman Fiorella Altruda
MembersMarco Arese (SIB)Luciana Avigliano (SIB)Maria Cavaletto (SIB)Tiziana Crepaldi (SIB)Silvia Deaglio (SIB)Ada FunaroDario Ghigo (SIB)Giuliana Giribaldi (SIB)Carlo Giunta (SIB)Andrea Graziani (SIB)Emilio Hirsch (ABCD)Evelin Keiling Schwarzer (SIB)
Mauro Patrone (SIB)Enrica Pessione (SIB)Marco Piccinini (SIB)Menico Rizzi (SIB)Sheila Sadeghi (SIB)Guido Serini (SIB)Francesca Silvagno (SIB)Fabiola Sinigaglia (SIB)Guido Tarone (ABCD)Franco Turrini (SIB)Francesca Valetti (SIB)Bruno Venerando (SIB)
Honorary Chairman Paolo Arese
MembersLilia Alberghina (SIB)Andrea Bellelli (SIB)Irene Bozzoni (SIB)Maurizio Brunori (SIB)Federico Bussolino (SIB)Felice Cervone (FISV)Filiberto Cimino (SIB)Daniela Corda (SIB)Riccardo Cortese (SIB)Paolo Comoglio (FISV)Vincenzo Cuomo (SIF)Antonio De Flora (SIB)Giorgio Lenaz (SIB)Giovanna Lucchini (FISV)Lucio Luzzatto (FISV)
Giulio Magni (SIB)Fabio Malavasi (SIB)Jacopo Meldolesi (FISV)Paolo Mocarelli (ItPa)Salvatore Oliviero (FISV)Valerio Orlando (FISV, SIBBM)Pier Giuseppe Pelicci (FISV)Carola Ponzetto (SIB)Piero Pucci (SIB, ItPA)Menico Rizzi (SIB)Maria Grazia Roncarolo (FISV)Giuseppe Rotilio (SIB)Francesco Salvatore (SIB)Roberto Sitia (FISV)Tommaso Russo (SIB)
Karl Küchler (A)Nils-Goran Larsson (S)Iain Mattaj (D)Gerry Melino (UK)Pier Paolo Pandolfi (USA)Israel Pecht (IL)
Francesco Ramirez (USA)Francisco Sanchez-Madrid (E)Anthony Schapira (UK)Kai Simons (D)Vladimir Skulachev (RUS)
FEBS Executive CommitteeTomas Zima, ChairmanWinnie Eskild, Vice ChairIsrael Pecht, Secretary GeneralJohn Mowbray, TreasurerAdam Szewczyk,Congress CounsellorJaak Järv, Chairman of the Advanced Courses CommitteeVicente Rubio, Chairman of the Fellowships CommitteeFélix M. Goñi, Chairman of the Publication CommitteeJacques-Henry Weil, Chairman of the Science and Society CommitteeGul Güner-Akdogan, Chair of the Education CommitteeClaudina Rodrigues-Pousada,Chair of the Working Group on the Career of Young ScientistsLea Sistonen, Chair of the Working Group on Women in Science
Organising Committee
Scientific Committee
Final Programme8
36th FEBS CONGRESS - “Biochemistry for Tomorrow’s Medicine”
FEBS 2011 Sponsors
FEBS
Department of Life Sciences, Italian Research Council, Rome
Regione Piemonte
Italian Association for Cancer Research, AIRC
Bracco
SMAT
GE Healthcare
Novartis Vaccines and Diagnostic
BioPmed
Aspect
Instruct
36th FEBS Congress 9
Torino, Italy - June 25-30, 2011
ABCAM
ACS PUBLICATION
BIOCHEMICAL SOCIETY
BIOLINE
CAYMAN CHEMICAL COMPANY
ELSEVIER
EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL)
EMBO
EUROPEAN RESEARCH COUNCIL
FEBS
JACKSON IMMUNORESEARCH EUROPE
KOMABIOTECH
LEICA MICROSYSTEM
NEW ENGLAND BIOLABS/CELL SIGNALING TECHNOLOGY
NOVUS BIOLOGICALS
POLYPLUS TRANSFECTION
PROTEINTECH GROUP
SCIENCES/AAAS
SPRINGER
ST. JUDE CHILDREN’S RESEARCH HOSPITAL
TOCRIS BIOSCIENCE
WILEY-BLACKWELL
WISEPRESS BOOKSHOP
FEBS 2011 Exhibitors
Final Programme10
36th FEBS CONGRESS - “Biochemistry for Tomorrow’s Medicine”
Key Information
VenueLingotto Conference CentreVia Nizza, 28010126 Torino
The Lingotto Con-gress Centre is 10minutes from thecentre of Turin andthe Porta Nuovatrain station.Connections canbe made by busand tram, and alsoby underground.The Lingotto train
station can be reached via the Olympic footbridge. Visitorsarriving from motorways or from city by-pass will be guideddirectly to the Lingotto’s underground car parks by road signs.
On Site RegistrationPlease register at the Registration Desk in front of theAuditorium. If you are pre-registered via on line system, pleasemake sure to take your registration confirmation with you toavoid any confusion.If you are not pre-registered via on line system, you canregister and pay directly at the registration desk.In case your payment was not recognised or did not reach usby June 20, 2011, copy of the bank transfer will not beconsidered as a proof of payment. Therefore, you will beasked to pay an onsite registration. All proven doublepayments will be refunded after the congress.
REGISTRATION FEES
ACADEMIC GRADUATE EUR 550
STUDENT EUR 200
NON-ACADEMIC EUR 700
ACCOMPANYING PERSON EUR 120
Participants applying for special fee must submit a proof oftheir age or their student status.The registration fee for participants includes: congressmaterial, abstract book, welcome reception.
Registration DeskThe registration desk is located on the ground floor of theLingotto Conference Centre.Opening Hours:June 25, 2011 08:00 – 19:00June 26, 2011 08:00 – 18:00June 27, 2011 08:00 – 18:00June 28, 2011 08:00 – 18:00June 29, 2011 08:00 – 18:00June 30, 2011 08:00 – 12:00
Emergency NumbersAmbulance: 118Police: 112 or 113Fire brigade: 115
The registration fee includes- Admission to all sessions, poster areas and exhibitions- Admission to Opening Ceremony and Welcome Reception- Congress documents in the Congress bag - Final Pro-
gramme Book, Abstract Book (Supplement of FEBSJournal), FEBS Letters Congress Special Issue, LateAbstract Book, Evaluation Form.
- Name badge
Accompanying persons fee includes:Admission to the Opening Ceremony and WelcomeReception.Please note that accompanying persons are not allowed to take partin the sessions.
Certificate of attendanceCertificate of attendance will be handed at the registrationdesk.
BadgesAlong with your registration, you will receive your badge. Thename badge must be worn when attending the sessions.Admittance to the sessions without the badge is not possible.Only full participants may attend the sessions.
Participants (Blue)
Accompanying Person (Magenta)
Speakers and Chairs (Red)
Executive Committee (Yellow)
Scientific and Organising Committees (Yellow)
Press (Grey)
Exhibitor (Violet)
Staff (Cyan)
YSF (Green)
One Day Badge (White)
Speakers preview roomIt is located in front of the Auditorium stairs. Please makesure to hand in your presentation at least 120 minutes priorto the start of your assigned session. Our staff in the speakerspreview room will be happy to assist you.
Presentation submissionOnly Power Point presentations (CD, USB stick) may be used.In the lecture rooms a video projector and laptop will be atyour disposal. Personal laptops are not permitted. Pleasetake your presentation to the Speakers preview room nolater than 120 minutes prior to your lecture and approach themedia technician. Presentation guidelines have beenprovided to all speakers prior to the congress.
MessagesA message board will be located in the registration area. Youcan post your messages here.
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LocationThe poster display area will be directly connected to theconference rooms and the exhibition area. Your posterboard will be marked with your Poster number. Thisnumber will be the same as in the FEBS JournalSupplement.
Poster mountingYou are asked to mount and discuss your poster on thedays as specified at page 46. Make sure to remove allposter-mounting materials from the board after the end
of your session. The Congress staff will remove postersnot taken down on time. However, the CongressOrganizers cannot ensure any further responsibility forthe material.
Poster materialThe size of your poster board is 120x90 cm (height xwidth) and will be marked with your poster number.Hanging material for the poster boards will be providedonsite.
AUDITORIUM
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Plenary Lectures
Pier Paolo PandolfiOpening Plenary Lecture PL-1
Co-sponsored by AIRCThe ceRNA hypothesis, the non-coding revolution and the future of cancer research and its therapy
Saturday June 25 - 18:00-19:00
Elena ContiSir Hans Krebs Lecture PL-2
Molecular mechanisms of RNA degradationSunday June 26 11:30-12:30
Pier Giuseppe PelicciTheodor Bücher Lecture PL-3
Regulation of self-renewal in Cancer Stem CellsSunday June 26 - 17:45-18:45
Luis SerranoEMBO Lecture PL-8
A quantitative systems biology study on a model bacteriumMonday June 27 -11:30-12:30
Sirpa JalkanenDatta Lecture PL-5
Homing-associated molecules as targets to prevent harmful inflammations and cancer spreadMonday June 27 - 17:45-18.45
John MattickIUBMB Lecture PL-6
Challenging the dogma: the central role of RNA in human development and cognitionTuesday June 28 - 11:30-12:30
Carol V. RobinsonWISE Plenary Lecture PL-7
Finding the right balance: from Rare Gases to Rotary motorsTuesday June 28 - 17:45-18:45
Hugo MaccioniPABMB Lecture PL-4
Organization of the synthesis of glycolipids in the Golgi complexWednesday June 29 - 11:30-12:30
Shiro SuetsuguFEBS Letters Award Lecture PL-9
Subcellular membrane curvature mediated by the BAR domain superfamily proteinsWednesday June 29 - 15:00-16:00
Karen van EunenFEBS Journal Prize Lecture PL-10
In vivo-like enzyme kinetics improve metabolic computer modelsWednesday June 29 - 15:00-16:00
Guido KroemerClosing Plenary Lecture PL-11
Autophagy, cytoprotection and longevityThursday June 30 - 11:15-12:15
Final Programme14
36th FEBS CONGRESS - “Biochemistry for Tomorrow’s Medicine”
Congress Symposia
S1 The genome in the 3rd milleniumCoordinators: Valerio Orlando, Roma, Giovanna Lucchini, Milano
o S 1.1 Coding and noncoding information in genome functiono S 1.2 Mechanisms controlling genome integrityo S 1.3 Epigenetic control of cell fate
S2 Complexity in RNA biologyCoordinators: Irene Bozzoni, Roma, Riccardo Cortese, Pomezia
o S 2.1 Non coding RNA: evolution, functiono S 2.2 Small RNA in disease
S3 Following the life of a proteinCoordinators: Maurizio Brunori, Roma, Menico Rizzi, Novara, Daniela Corda, Napoli
o S 3.1 Protein synthesis, traffic and turnover
o S 3.2 Protein folding and bindingo S 3.3 NAD-dependent post-translational modifications
S4 Cell-cell communicationCoordinators: Antonio De Flora, Genova, Fiorella Altruda, Torino
o S 4.1. Intercellular trafficking of signal molecules
o S 4.2 Regulation of cell functions by intercellular contact systems
S5 Membrane dynamicsCoordinators: Jacopo Meldolesi, Milano, Daniela Corda, Napoli
o S 5.1 Membrane dynamicso S 5.2 Organelle dynamics
o S 5.3 Membrane dynamics and disease
S6 Molecular basis of developmentCoordinators: Roberto Sitia, Milano, Vania Broccoli, Milano
o S 6.1 Stress adaptation and developmento S 6.2 Cell shape determination
o S 6.3 Development of cognition and language
S7 Systems biologyCoordinator: Lilia Alberghina, Milano
o S 7.1 Omics and bioinformaticso S 7.2 Networks and circuits
S8 Molecular engineering for medicineCoordinator: Gianfranco Gilardi, Torino
o S 8.1 Synthetic biology for medicineo S 8.2 Biomedical application of nanotechnology
S9 Prokaryote biochemistry: friends and foes in the microbial worldCoordinators: Gianni Dehò, Milano, Enrica Pessione, Torino
o S 9.1 Probiotics as health-promoting agents
o S 9.2 Antimicrobial drug discovery: a new challenge for the future
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S10 Metabolic control and disordersCoordinators: Luciana Avigliano, Roma, Giuseppe Rotilio, Roma, Giorgio Lenaz, Bologna
o S 10.1 Nuclear receptors and lipid metabolismo S 10.2 Molecular perspectives for diabeteso S 10.3 Redox balance and obesity
S11 Recent advances in cancer biologyCoordinators: Paolo Comoglio, Candiolo, Pier Giuseppe Pelicci, Milano, Carola Ponzetto, Torino
o S 11.1 Genes and pathways in cancero S 11.2 Cancer stem cells and metastasis
S12 Cellular senescence and agingCoordinators: Filiberto Cimino, Napoli, Antonio De Flora, Genova
o S 12.1 Plasticity of aging
o S 12.2 Cellular senescence
S13 Rare diseases reveal new biochemical mechanismsCoordinators: Sergio Papa, Bari, Francesco Salvatore, Napoli
o S 13.1 Rare metabolic diseaseso S 13.2 Mitochondrial diseases
S14 Biochemistry of the brain and neurodegenerative disordersCoordinators: Tommaso Russo, Napoli, Enzo Cuomo, Roma, Aldo Fasolo, Torino
o S 14.1 Recent advances in neurodegenerative disorderso S 14.2 Dopaminergic neurons and Parkinson’s disease
S15 Molecular basis of cardiovascular diseasesCoordinators: Federico Bussolino, Torino, Guido Tarone, Torino
o S 15.1 Development of vascular system
o S 15.2 Molecular basis of cardiovascular diseases
S16 Biochemistry of immunity and inflammationCoordinators: Gianpietro Semenzato, Padova, Fabio Malavasi, Torino, Alberto Mantovani, Milano
o S 16.1 Ectoenzyme network and diseaseso S 16.2 Structure and function of innate immunity receptors
o S 16.3 Receptors and signal transduction
S17 Biochemistry and molecular biology of malaria and tuberculosisCoordinators: Paolo Arese, Torino, Menico Rizzi, Novara
o S 17.1 Biochemistry and molecular biology of tuberculosiso S 17.2 Biochemistry and molecular biology of malaria
S18 Plant biochemistry for health and tomorrow’s medicineCoordinator: Felice Cervone, Roma
o S 18.1 Green factoryo S 18.2 Plant innate immunity
S19 Molecular and cellular therapeuticsCoordinators: Maria Grazia Roncarolo, Milano, Lucio Luzzatto, Firenze
o S 19.1 Vectors for therapeutic and experimental applications
o S 19.2 Gene and cell therapy for genetic diseases
Final Programme16
36th FEBS CONGRESS - “Biochemistry for Tomorrow’s Medicine”Programme at a GlanceSaturday, June 25, 2011 Sunday, June 26, 2011 Monday, June 27, 2011
PARALLEL SYMPOSIA
8:30-11:00 Auditorium S3.1Protein synthesis, traffic and turnover
8:30-11:00 Hall 500 S1.1Coding and noncoding information in
genome function
8:30-11:00 Hall Gialla S5.1Membrane dynamics
8:30-11:00 Hall Istanbul S7.1Omics and boinformatics
8:30-11:00 Hall Londra S4.1Intercellular trafficking of signal
molecules
11:00-11:30 BREAK
11:30-12:30 AuditoriumSir Hans Krebs Plenary Lecture PL-2
Elena Conti, Munich - D
12:30-13:00 BREAK
13:00-15:00 POSTER SESSION
PARALLEL EVENTS
13:00-15:00 Hall Gialla TW-1Advances in molecular and
functional MRI
13:00-15:00 Hall Londra Biochemical education
13:30-15:00 Hall IstanbulWise workshop
14:00-15:00 Hall 500Chiara D’Onofrio Lecture
Luca Scorrano
PARALLEL SYMPOSIA
15:00-17:30 Auditorium S1.2Mechanisms controlling genome
integrity
15:00-17:30 Hall 500 S3.2Protein folding and binding
15:00-17:30 Hall Gialla S5.2Organelle dynamics
15:00-17:30 Hall Istanbul S7.2Networks and circuits
15:00-17:30 Hall Londra S4.2Regulation of cell functions byintercellular contact systems
17:45-18:45 AuditoriumTheodor Bücher Plenary Lecture
PL-3Pier Giuseppe Pelicci, Milan - I
19:00-20:00 Hall 500Britton Chance Memorial Session
Les Dutton, Philadelphia, USA
PARALLEL SYMPOSIA
8:30-11:00 Auditorium S1.3 Epigenetic control of cell fate
8:30-11:00 Hall 500 S3.3NAD-Dependent
Post-translation modifications
8:30-11:00 Hall Gialla S5.3Membrane dynamics and disease
8:30-11:00 Hall Istanbul S8.1Synthetic biology for medicine
8:30-11:00 Hall Londra S9.1 Probiotics as health-promoting
agents
11:00-11:30 BREAK
11:30-12:30 AuditoriumEMBO Lecture PL-8
Luis Serrano, Barcelona - E
12:30-13:00 BREAK
13:00-15:00 POSTER SESSION
PARALLEL EVENTS
13:00-15:00 Hall Gialla TW-2Cellular events monitored by
in-cell NMR
13:00-15:00 Hall 500 Workshop PhD training in Europe:
where are we heading?
PARALLEL SYMPOSIA
15:00-17:30 Auditorium S14.1Recent advances in
neurodegenerative disorders
15:00-17:30 Hall 500 S10.1 Nuclear receptors and lipid
metabolism
15:00-17:30 Hall Gialla S6.1Stress adaptation and development
15:00-17:30 Hall Istanbul S8.2Biomedical application of
nanotechnology
15:00-17:30 Hall Londra S9.2Antimicrobial drug discovery: a new
challenge for the future
17:45-18:45 AuditoriumPrakash Datta Plenary Lecture PL-5
Sirpa Jalkanen, Turku - FIN
Pre-Congress Event
10:00-16:00 Hall Londra
Bio-NMR Satellite MeetingNMR in Biology
AUDITORIUM
16:30-17:30
Opening Ceremony
17:30-18:00
Musical interlude
18:00-19:00Opening Plenary Lecture PL-1
Co-sponsored by the ItalianAssociation for Cancer Research
(AIRC) Pier Paolo Pandolfi, Boston - USA
19:00-21:00Welcome Reception
Lingotto Hall
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Torino, Italy - June 25-30, 2011
Tuesday, June 28, 2011 Wednesday, June 29, 2011 Thursday, June 30, 2011
PARALLEL SYMPOSIA
8:30-11:00 Auditorium S14.2 Dopaminergic neurons and
Parkinson’s disease
8:30-11:00 Hall 500 S10.2Molecular perspectives
for diabetes
8:30-11:00 Hall Gialla S6.2Cell shape determination
8:30-11:00 Hall Istanbul S18.1 Green factory
8:30-11:00 Hall Londra S12.1 Plasticity of aging
11:00-11:30 BREAK
11:30-12:30 AuditoriumIUBMB Lecture PL-6
John Mattick, Brisbane - AUS
12:30-13:00 BREAK
13:00-15:00 POSTER SESSION
PARALLEL EVENTS
13:00-15:00 Hall 500Science and society
Session on genetic diseases
PARALLEL SYMPOSIA
15:00-17:30 Auditorium S2.1 Non coding RNA: evolution,
function
15:00-17:30 Hall 500 S10.3Redox balance and obesity
15:00-17:30 Hall Gialla S6.3Development of cognition and
language
15:00-17:30 Hall Istanbul S18.2Plant innate immunity
15:00-17:30 Hall Londra S12.2Cellular senescence
17:45-18:45 Auditorium WISE Plenary Lecture PL-7
Carol V. Robinson, Oxford - UK
20:30-22:00Centro di Biotecnologie MolecolariPublic Science and Society Forum on
Biochemistry for tomorrow’sMedicine
PARALLEL SYMPOSIA
8:30-11:00 Auditorium S2.2 Small RNA in disease
8:30-11:00 Hall 500 S11.1 Genes and pathways in cancer
8:30-11:00 Hall Gialla S16.1Ectoenzyme network and diseases
8:30-11:00 Hall Istanbul S13.1Rare metabolic diseases
8:30-11:00 Hall Londra S15.1Development of vascular system
11:00-11:30 BREAK
11:30-12:30 AuditoriumPABMB Plenary Lecture PL-4 Hugo Maccioni, Córdoba - RA
12:30-13:00 BREAK
13:00-15:00 POSTER SESSION
PARALLEL EVENTS
13:00-15:00 Hall 500Workshop:
Integrating molecular bioscienceeducation with medical training
13:00-15:00 Hall LondraWorkshop:
Fluorescence Spectroscopy: a toolfor protein chemistry
15:00-16:00 AuditoriumFEBS Publication Award Lectures
15:00-16:00 AuditoriumFEBS Letters Award Lecture PL-9
Shiro Suetsugu, Tokyo - J
15:00-16:00 AuditoriumFEBS Journal Prize Lecture PL-10Karen van Eunen, Groningen - NL
PARALLEL SYMPOSIA
16:15-18:45 Auditorium S19.1Vectors for therapeutic andexperimental applications
16:15-18:45 Hall 500 S11.2 Cancer stem cells and metastasis
16:15-18:45 Hall Gialla S16.2 Structure and function of innate
immunity receptors
16:15-18:45 Hall Istanbul S13.2Mitochondrial diseases
16:15-18:45 Hall Londra S17.1Biochemistry and molecular biology
of tubercolosis
20:30-23:00 Social Dinner
PARALLEL SYMPOSIA
8:30-11:00 Auditorium S19.2 Gene and cell therapy for genetic
diseases
8:30-11:00 Hall Gialla S16.3Receptors and signal transduction
8:30-11:00 Hall Istanbul S15.2 Molecular basis of cardiovascular
diseases
8:30-11:00 Hall Londra S17.2Biochemistry and molecular biology
of malaria
11:15-12:15Closing Plenary Lecture PL-11
Guido Kroemer, Villejuif - F
12:15 - 12:45CLOSING CEREMONY
FEBS COUNCIL MEETINGHotel Majestic, Torino
June 30th- July 1st
AUDITORIUM
Final Programme18
36th FEBS CONGRESS - “Biochemistry for Tomorrow’s Medicine”
Saturday June 25, 2011
Pre-Congress Event10:00 - 16:00
Bio-NMR Satellite MeetingNMR in Biology
This satellite meeting is intended to presentthe opportunities provided by NMR todayto the broad biological community. Theopportunity that biologists can exploit theEuropean programme for access to Bio-NMR (www.bio-nmr.net) researchinfrastructures is presented.
10:00Welcome by Israel PechtFEBS - Secretary GeneralWeizmann Institute of Science, Rehovot,Israel
10:10Ivano BertiniBio-NMR Project Coordinator CERM,Italy
Opening and Introduction
10:30Harald SchwalbeCenter for Biomolecular Magnetic Resonance,J. W. Goethe-University, Frankfurt am Main,Germany
NMR spectroscopic investigationsof RNA folding in vitro and in cells
11:10Rolf BoelensBijvoet Center for Biomolecular Research,Utrecht University, Netherlands
Structure and dynamics in generegulation and DNA repair
11:50Jacob AnglisterWeizmann Institute of Science, Israel
Observation of intermolecularinteractions in large proteincomplexes by 2D-double differenceNOESY: application to the 44 kDainterferon-receptor complex
12:30Lunch (kindly offered by Bruker)
13:50Roberta PierattelliCERM & Department of Chemistry, University ofFlorence, Italy
13C direct detection biomolecularNMR.
14:30Markus ZweckstetterMax Plank Institute for Biophysical Chemistry,Germany
Frontiers of structural biology:The dynamic structure of disorderedproteins and proteins in themembrane
15:10Mikael OlivebergDepartment of Biochemistry and Biophysics,Stockholm University, Sweden
In-cell NMR of the ALS-associatedprotein Cu/Zn SOD1
15:50Closing remarks
Organising CommitteeWiktor KozminskiWarsaw University, Poland
Miquel PonsIRB Barcelona, Spain
Isabella Caterina FelliCERM, University of Firenze, Italy
Scientific SecretariatChiara VenturiCERM, University of Firenze, Italy
HALL LONDRA
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Opening Ceremony16:30 - 17:30
AUDITORIUM
Opening PlenaryLecture PL-1Co-sponsored by the Italian Association forCancer Research
Chairpersons:Israel PechtRehovotSergio PapaBari
Pier Paolo PandolfiHarvard Medical School - Boston - USA
The ceRNA hypothesis, thenon-coding revolution and the futureof cancer research andits therapy
Plenary Lecture18:00 - 19:00
Welcome Reception19:30 - 21:30
AUDITORIUM
Gianfranco GilardiChairman Organizing Committee
Sergio PapaChairman Scientific Committee
Tomas ZimaFEBS Chairman
Filiberto CiminoPresident SIB
Israel PechtFEBS Secretary General“Presentation of FEBS Diplôme d’Honneurrecipients”
Welcome address by theAuthorities
LINGOTTO HALL
Musical interlude
Saturday June 25, 2011
Final Programme20
36th FEBS CONGRESS - “Biochemistry for Tomorrow’s Medicine”
Sunday June 26, 2011
Parallel Symposia 8:30 - 11:00
AUDITORIUM
SymposiaS1.1 Coding and noncodinginformation in genome functionChairpersons:Thomas GingerasNew York
Valerio OrlandoRoma
8:30 - 9:00 S1.1.1Thomas JenuweinFreiburg
Epigenetic control by histonemethylation.
9:00 - 9:30 S1.1.2Job DekkerWorcester
Three-dimensional architecture ofthe human genome.
9:30 - 10:00 S1.1.3Thomas R. GingerasNew York
Important lessons from a complexgenome.
10:00 - 10:30 S1.1.4Geoff FaulknerEdinburgh
Retrotransposition and the geneticidentity of human neurons.
10:30 - 10:45 S1.1.5Beatrice BodegaRoma
Repetitive elements transcription andmobilization contribute to humanskeletal muscle differentiation andduchenne muscular dystrophyprogression.
10:45 - 11:00 S1.1.6Giorgio DieciParma
Non-canonical termination signalrecognition by RNA polymerase III inthe human genome.
HALL 500 HALL GIALLA
Symposia
S3.1 Protein synthesis, trafficand turnoverChairpersons:Aaron CiechanoverHaifa
Menico RizziNovara
8:30 - 9:00 S3.1.1Aaron CiechanoverNobel Laureate, Haifa
The Ubiquitin Proteolytic System -From Basic Mechanisms throughHuman Diseases and onto DrugDevelopment.
9:00 - 9:30 S3.1.2Mark SafroRehovot
Structural diversity amongcytoplasmic and organellar aaRSsmay lead to incorporation of free-radical damaged amino acids intoproteins.
9:30 - 10:00 S3.1.3Hidde PloeghCambridge MA
Quality control in the endoplasmicreticulum: removal of unwantedproteins.
10:00 - 10:30 S3.1.4Peter-Michael KloetzelBerlin
The proteasome and the ubiquitinsystem: The two faces of one enzyme.
17:00 - 17:15 S3.2.5Gert BangeHeidelberg
New insights into the coordination ofprotein export by the flagellar type 3secretion system.
17:15 - 17:30 S3.2.6Katerina ChatziHeraclion, CreteThe signal peptides and the earlymature domain cooperate for efficientsecretion.
SymposiaS 5.1 Membrane dynamicsChairpersons:Vivek MalhotraBarcelona
Jacopo MeldolesiMilano
8:30 - 9:00 S5.1.1Alberto LuiniNapoli
Control systems of the secretorypathway.
9:00 - 9:30 S5.1.2Vivek MalhotraBarcelona
Protein sorting and packing alongthe secretory pathway.
9:30 - 10:00 S5.1.3Marino ZerialDresden
Systems analysis of endocytosis andsignalling.
10:00 - 10:30 S5.1.4Enrique Rodriguez-BoulanNew York
Clathrin adaptors and polarizedtrafficking in epithelia.
10:30 - 10:45 S5.1.5Sarah CarpentierBruxelles
A reappraisal of the role ofphosphoinositide 3-kinase in apicalreceptor-mediated endocytosis bykidney proximal tubular cells.
10:45 - 11:00 S5.1.6Gregory D FairnToronto
Phosphatidylserine polarization isrequired for proper Cdc42localization and for development ofcell polarity.
36th FEBS Congress 21
Torino, Italy - June 25-30, 2011
SymposiaS4.1. Intercellular trafficking ofsignal moleculesChairpersons:Shin-ichiro ImaiSt. Louis
Antonio De FloraGenova
8:30 - 9:00 S4.1.1Elena ZocchiGenova
Abscisic acid and cyclic ADP-riboseare first and second messenger ininflammatory cells, hemopoieticprogenitors and pancreatic beta-cells.
9:00 - 9:30 S4.1.2Friedrich Koch-NolteHamburg
New tools for activating and blockingthe P2X7 ion channel - a key sensorof NAD and ATP released from cells. 9:30 - 10:00 S4.1.3Alberto DarszonCuernavaca
How sperm find the egg.
10:00 - 10:30 S4.1.4Shin-ichiro ImaiSt. Louis
The pathophysiological importanceof NAMPT-mediated NAD+biosynthesis in the regulation ofmetabolism and aging in mammals.
10:30 - 11:00 S4.1.5Egor PlotnikovMoscow
Cell-to-cell crosstalk betweenmesenchymal multipotent stromalcells and renal tubular cellsin co-culture.
HALL ISTANBUL HALL LONDRA
AUDITORIUM
Symposia
S 7.1 Omics and bioinformaticsChairpersons:Sampsa HautaniemiHelsinki
Cecilia SacconeBari
8:30 - 9:00 S7.1.1Sampsa HautaniemiHelsinki
Efficient bioinformatics approachesfor large-scale data analysis.
9:00 - 9:30 S7.1.2Alfonso ValenciaMadrid
Challenging Our Understanding ofProtein Interaction Networks.
9:30 - 10:00 S7.1.3Peer BorkHeidelberg
Extracting phylogenetic andfunctional signals frommetagenomics data.
10:00 - 10:30 S7.1.4Søren BrunakKongens Lyngby
Integrating phenotypic data fromelectronic patient records withmolecular level systems biology.
10:30 - 10:45 S7.1.5Andrei DrabovichToronto
Targeted Mass Spectrometry forQuantitative Proteomic Analysis ofEnergy Metabolic Pathways in BreastCancer Cells
10:45 - 11:00 S7.1.6Enzo ScifoHelsinki
Systems biology approachestowards Neuronal ceroidlipofuscinoses interactome.
Sir Hans KrebsPlenary Lecture PL-2Chairpersons:Adam SzewczykWarsawMenico RizziNovara
Elena ContiMax Planck Institute of Biochemistry - Munich - D
Molecular mechanisms of RNAdegradation
Plenary Lecture11:30 - 12:30
Parallel Symposia08:30 - 11:00
➜
Break 11:00 - 11:30
Final Programme22
36th FEBS CONGRESS - “Biochemistry for Tomorrow’s Medicine”
Technical Workshop TW-1
13:00 - 15:00Advances in Molecular andFunctional MRISponsored by Aspect Imaging Ltd
13:00 - 13:30Klaas NicolayBiomedical NMR,Technical University Eindhoven,The Netherlands
Quantitative MRI techniques formolecular and cellular imaging
13:30 - 14:00Ayelet Akselrod-BallinDepartment of Biological Regulation, WeizmannInstitute, Israel
MRI-Optical multimodal imaging
14:00 - 14:30Simonetta Geninatti CrichCenter of Molecular Imaging, University ofTorino, Italy
Design and testing of Targeting andResponsive probes for MRIpreclinical applications
14:30 - 15:00Pernille Rose JensenAlbeda Research Ltd., Denmark
Imaging of metabolic reactions byhyperpolarized 13C DNP-MR
13:00 - 15:00Biochemical Education
High School Scientific Education: aBridge towards Medicine, Biologyand Biotechnology UniversityCoursesEducazione Scientifica nella Scuola Mediasuperiore: un Ponte verso i Corsi Universitari diMedicina, Biologia e Biotecnologie
Organised by Italian Society of Biochemistryand Molecular Biology
CULTURA SCIENTIFICA DI BASEED ACCESSO ALLA FORMAZIONEUNIVERSITARIA IN AREABIOMEDICACoordinatori:Paola IzzoUniversità di NapoliAmalia BosiaUniversità di Torino
13:00Giovanni BonioloUniversità di Milano
Ruolo di una formazione scientificadi base nella Società della Scienza
13:15Alberto CalatroniUniversità di Messina
Il ruolo della Chimica Medicanell’attuale processo di formazionedel Medico
13:30Roberto CirioUniversità di Torino-INFN Torino
Il ruolo della Fisica nell’attualeprocesso di formazione del Medico
13:45Carla MigliavaccaLiceo Scientifico Statale Antonelli - Novara
Didattica delle ScienzeBiomolecolari nella Scuola MediaItaliana: stato dell’arte e prospettive
13:50Discussion
NUOVI APPROCCIALL’INSEGNAMENTO DELLEDISCIPLINE BIOMOLECOLARINELLA SCUOLA MEDIACoordinatori:Fiorella AltrudaUniversità di TorinoFabiola SinigagliaUniversità del Piemonte Orientale “A.Avogadro”
14:00 - 14:10Lanfranco MasottiLife Learning Center - Bologna
Il Life Learning Center: un centro diformazione e aggiornamentoculturale per studenti e docenti delleScuole medie”
14:10 - 14:20Elena SpoldiEnrica FavaroLife Learning Center - Torino
L’esperienza maturata al LifeLearning Center di Torino
14:20 - 14:30Giovanni PaolellaUniversità di Napoli Federico II - CEINGE Napoli
E-learning: un metodo innovativo perla didattica delle ScienzeBiomolecolari
14:30 - 14:40Rita TrisoglioLiceo Scientifico Statale Antonelli - Novara
Apprendere le Scienze della Vita conapproccio di tipo sperimentale
14:40 - 14:55Elisabetta GaitaMaria Chiara RossiI.S.A. Sobrero - Casale Monferrato
Nuove proposte di formazione inambito degli Istituti di FormazioneTecnica superiore (IFTS)
15:00End Session
HALL LONDRA
Sunday June 26, 2011
Break 12:30-13:00
POSTER AREA
13:00 - 15:00Poster Sessions
P01, P03, P04, P05, P06, P07, P08,P09, P18, P20, P21, P22, P23-P27,P24, P25, P26, P28, P32.
HALL GIALLA
The sessionsbetween
13:00 and 15.00are held in parallel
36th FEBS Congress 23
Torino, Italy - June 25-30, 2011
CHIARA D’ONOFRIOLECTUREChairperson:Valerio OrlandoRoma
Luca ScorranoDulbecco-Telethon Institute at the VenetianInstitute of Molecular Medicine - Genève
Keeping mitochondria in shape: amatter of life, differentiation and death
WISE Workshop
13:30 - 15:00“Future in science and Science inFuture: Ideas and Expectations ofWomen Scientists”Presentation byMaria Laura Scarinofollowed by a panel discussion
HALL 500
Special Lecture14:00 - 15:00
HALL ISTANBUL
Final Programme24
36th FEBS CONGRESS - “Biochemistry for Tomorrow’s Medicine”
Sunday June 26, 2011
Parallel Symposia 15:00 - 17:30
SymposiaS1.2 Mechanisms controllinggenome integrityChairpersons:
John F.X. DiffleyHerts
Maria Pia LongheseMilano
15:00 - 15:30 S1.2.1John F.X. DiffleyHerts
Early Events in Eukaryotic DNAReplication.
15:30 - 16:00 S1.2.2Yosef ShilohTel Aviv
The ATM-Mediated DNA DamageResponse: The System and thePathways.
16:00 - 16:30 S1.2.3Julia Promisel CooperLondon
Telomeres and the challenges tochromosomal integrity.
16:30 - 17:00 S1.2.4Andrea MusacchioMilano
The structural basis of chromosomesegregation.
SymposiaS 3.2 Protein folding andbindingChairpersons:William A. EatonBethesda
Maurizio BrunoriRoma
15:00 - 15:30 S3.2.1William A. EatonBethesda
Single-Molecule FRET and TransitionPaths in Protein Folding.
15:30 - 16:00 S3.2.2Alan R. FershtCambridge UK
Folding approaching the speed limit.
16:00 - 16:30 S3.2.3Joel L. SussmanRehovot
Intrinsically Disordered Proteins: ARole in Nervous SystemDevelopment.
16:30 - 17:00 S3.2.4Peter TompaBudapest
Unusual binding modes ofintrinsically disordered proteins.
10:30 - 10:45 S3.1.5Michael GriffinParkville
Methionine oxidation inducesamyloid fibril formation byapolipoprotein A-I.
10:45 - 11:00 S3.1.6Stefano GianniRoma
The folding problem simplified:protein families, circular permutantsand heteromorphic pairs.
Symposia
S 5.2 Organelle dynamicsChairpersons:Luca ScorranoGenève
Sharon ToozeLondon
15:00 - 15:30 S5.2.1Ligia C. GomesPadova
Autophagy and mitochondrialelongation: sustaining cell viabilityunder difficult conditions.
15:30 - 16:00 S5.2.2Graça RaposoParis
Endosome dynamics in thebiogenesis of Lysosome RelatedOrganelles.
16:00 - 16:30 S5.2.3Sharon ToozeLondon
Molecular insights into autophagy.
16:30 - 17:00 S5.2.4Graham WarrenVienna
Golgi Biogenesis.
17:00 - 17:15 S5.2.5Alexey M. BelkinBaltimore
Unconventional secretion of tissuetransglutaminase involvesphospholipid- dependent deliveryinto recycling endosomes.
17:15 - 17:30 S5.2.6Nurit Pereg-AzouzTel Aviv
Rab GTPases and Mast CellExocytosis.
AUDITORIUM HALL 500 HALL GIALLA
36th FEBS Congress 25
Torino, Italy - June 25-30, 2011
AUDITORIUM
SymposiaS 4.2 Regulation of cellfunctions by intercellularcontact systemsChairpersons:Charles StreuliManchester
Fiorella AltrudaTorino
15:00 - 15:30 S4.2.1Charles StreuliManchester
How integrins control breastdevelopment and function.
15:30 - 16:00 S4.2.2Ugo CavallaroMilano
Neural adhesion molecules as novelplayers in cancer progression.
16:00 - 16:30 S4.2.3Walter BirchmeierBerlin
Wnt/beta-catenin signaling in stemand cancer stem cells.
16:30 - 17:00 S4.2.4Tomitake TsukiharaHyogo
Structural studies of connexin-26 gapjunction channel.
Symposia
S 7.2 Networks and circuitsChairpersons:Thomas HöferHeidelberg
Lilia AlberghinaMilano
15:00 - 15:30 S7.2.1Barbara BakkerGroningen
System organization of mammalianfatty-acid metabolism.
15:30 - 16:00 S7.2.2Carstern CarlbergLuxembourg
Systems biology approaches tonuclear receptor signaling.
16:00 - 16:30 S7.2.3Thomas HöferHeidelberg
A recruitment-reaction model forchromatin-associated regulatoryprocesses.
16:30 - 17:00 S7.2.4Thomas KirkwoodNewcastle upon Tyne
All Our Tomorrows: The Science ofHuman Ageing.
17:00 - 17:15 S7.2.5Michele CaselleTorino
The role of incoherent microRNA-mediated feedforward loops in noisebuffering.
17:15 - 17:30 S7.2.6Lucia NapioneTorino
Unraveling the influence ofendothelial cell density on VEGF-Asignalling.
THEODOR BÜCHERLECTURE PL-3Chairpersons:Tomas ZimaPrague
Paolo AreseTorino
Pier Giuseppe PelicciEuropean Institute of Oncology - Milano - I
Regulation of self-renewal in CancerStem Cells
Plenary Lecture17:45 - 18:45
Parallel Symposia15:00 - 17:30
➜
"Britton ChanceMemorial Session"
19:00 - 20:00Chair introduction:Angelo AzziBoston
Israel PechtRehovot
Sergio PapaBari
Memorial LectureLes DuttonPhiladelphia
Reflections inBiochemistry
HALL ISTANBUL HALL LONDRA
ROOM 500
Final Programme26
36th FEBS CONGRESS - “Biochemistry for Tomorrow’s Medicine”
Monday June 27, 2011
Parallel Symposia 08:30 - 11:00
SymposiaS1.3 Epigenetic controlof cell fateChairpersons:Geneviève AlmouzniParis
Salvatore OlivieroSiena
8:30 - 9:00 S1.3.1Geneviève AlmouzniParis
Epigenetic challenges in centromereinheritance during the cell cycle.
9:00 - 9:30 S1.3.2Dirk SchübelerBaselGenetic determinants of generepression.
9:30 - 10:00 S1.3.3Renato ParoBasel
Epigenetic reprogramming duringtissue regeneration.
10:00 - 10:30 S1.3.4Amanda FisherLondon
Pluripotent stem cells and epigeneticreprogramming.
10:30 - 10:45 S1.3.5Maryam ShahhoseiniTehran
Evidence for a dynamic role of thehistone variant H2A.Z in epigeneticregulation of normal/carcinomaswitch.
10:45 - 11:00 S1.3.6Chiara LanzuoloRoma
PcG complexes set the stage forinheritance of epigenetic genesilencing in early S phase beforereplication.
SymposiaS 3.3 NAD-dependentpost-translational modificationsChairpersons:Fritz NolteHamburg
Daniela CordaNapoli
8:30 - 9:00 S3.3.1Andreas LadurnerHeidelberg
Macrodomains mediate NADmetabolite-dependent nucleardynamics.
9:00 - 9:30 S3.3.2Daniela CordaNapoli
Novel developments in proteinmono-ADP-ribosylation.
9:30 - 10:00 S3.3.3Mathias ZieglerBergen
NAD+ - a key molecule in cellularsignalling.
10:00 - 10:30 S3.3.4Michael HottigerZurich
ARTD1/PARP1 ADP-ribosylateslysine residues of the core histonetails.
10:30 - 10:45 S3.3.5Silvia GaravagliaNovara
High-resolution crystal structure ofperiplasmic Haemophilus influenzaeNAD nucleotidase, lead to reveal anovel enzymatic function of humanCD73.
10:45 - 11:00 S3.3.6Valentina AudritoTorino
Nicotinamide blocks proliferation andinduces apoptosis of chroniclymphocytic leukemia cells throughactivation of the p53/miR-34a/SIRT1tumor suppressor network.
SymposiaS 5.3 Membrane dynamics anddiseaseChairpersons:Sergio GrinsteinToronto
Giorgio LenazBologna
8:30 - 9:00 S5.3.1William BalchLa Jolla
Proteostasis, Folding and MembraneTraffic- Protecting the Proteome inHuman Disease.
9:00 - 9:30 S5.3.2Ari HeleniusZürich
Role of endosomes in virus entry.
9:30 - 10:00 S5.3.3Sergio GrinsteinToronto
Membrane dynamics duringphagocytosis.
10:00 - 10:30 S5.3.4Ira MilosevicNew Haven
Endocytic mechanisms at neuronalsynapses.
10:30 - 10:45 S5.3.5Joao FreireLisboa
Assigning a role to the Dengue VirusCapsid Protein during cellularinfection.
10:45 - 11:00 S5.3.6Paulina Podszywalow-bartnickaWarsaw
Quantitative proteomics analysis ofsecretome and secretedmicrovesicles of chronic myeloidleukemia cells using SILAC method.
AUDITORIUM HALL 500 HALL GIALLA
36th FEBS Congress 27
Torino, Italy - June 25-30, 2011
AUDITORIUM
SymposiaS 8.1 Synthetic biology formedicineChairpersons:Anthony CassLondon
Gianfranco GilardiTorino
8:30 - 9:00 S8.1.1Anthony CassLondon
Exploiting Conformational Change inBiosensor Design.
9:00 - 9:30 S8.1.2Rita BernhardtSaarbrücken
Bacterial hydroxylases and theirpotential to synthesize pharmaceutical products.
9:30 - 10:00 S8.1.3Debashis GhoshNew York
Ligand-Binding Interactions andQuaternary Association In HumanAromatase.
10:00 - 10:30 S8.1.4Mark HowarthOxford
From flesh-eating bacteria to proteinsuperglue.
10:30 - 10:45 S8.1.5Rocío de MiguelViscasillas Zaragoza
Ferritin: nanotechnology at theservice of the new biomedicine.
10:45 - 11:00 S8.1.6Sergii GrebinykKyiv
Modulation of ROS production andcytosolic Ca2+ homeostasis byfullerenes C60 in oncotrasformed T-cells.
SymposiaS 9.1 Probiotics as health-promoting agentsChairpersons:Katharina RiedelBraunschweig
Enrica PessioneTorino
8:30 - 9:00 S9.1.1Katharina RiedelBraunschweig
Moonlighting proteins as biomarkersfor probiotic safety.
9:00 - 9:30 S9.1.2Brian HendersonLondon
Bacteria-Host Dual CommunicationUses Molecular Chaperones.
9:30 - 10:00 S9.1.3Effie TsakalidouAthens
Milk protein fragments inducebacteriocin biosynthesis inStreptococcus macedonicus:perspectives in food preservation andinfection control.
10:00 - 10:30 S9.1.4Yves Le LoirFrance
Interactions between Lactic acidbacteria and Staphylococcus aureus:an old story with new healthperspectives.
10:30 - 10:45 S9.2.5Halil DundarAnkara
Purification, characterization andpartial amino acid sequence ofmesentericin W3, a new anti-ListeriaBacteriocin.
10:45 - 11:00 S9.2.6Renato GennaroTrieste
Reduced phosphorylation of LPSdecreases E.coli susceptibility to thehuman antimicrobial peptide LL-37.
Plenary Lecture11:30-12:30
Parallel Symposia08:30 - 11:00
Break 11:00 - 11:30
➜HALL ISTANBUL HALL LONDRA
EMBO LECTURE PL-8Chairperson:Maurizio BrunoriRoma
Luis SerranoCentre for GenomicRegulation - Barcelona - E
A quantitative systems biology studyon a model bacterium
Final Programme28
36th FEBS CONGRESS - “Biochemistry for Tomorrow’s Medicine”
Monday June 27, 2011
13:00 - 15:00Poster Sessions
P01, P03, P04, P05, P06, P07, P08,P09, P18, P20, P21, P22, P23-P27,P24, P25, P26, P28, P32
POSTER AREA
HALL 500
HALL GIALLA
13:00 - 15:00WORKSHOPPhD Training in Europe:Where Are We Heading?
Chairpersons:Gül Akdogan GünerTurkeyJason PerretBelgium
Organised by the FEBS EducationCommittee
Gül Akdogan GünerTurkey
Jason PerretBelgium
Introduction to the Workshop
Michael J MulvanyDenmarkGraduate School of Health Sciences, AarhusUniversity, and Vice-President, ORPHEUS
European Vision in PhD Education
Detlef RiesnerGermanyDüsseldorf University Co-Founder, Chairman ofthe Supervisory Board Qiagen NV
What industry, in particular BiotecIndustry expects?
Panel Discussion
Break 12:30 - 13:00
The sessionsbetween
13:00 and 15.00are held in parallel
13:00 - 15:00Technical Workshop TW-2
Cellular events monitoredby in-cell NMR
13:00 - 13:30 Ivano BertiniMagnetic Resonance Center (CERM),University of Firenze, Italy
13:30 - 14:00 Volker DötschCenter for Biomolecular Magnetic Resonance(BMRZ), Goethe University, Germany
14:00 - 14:30 Philip SelenkoLeibniz Institute of MolecularPharmacology (FMP), Germany
14:30 - 15:00 Open discussion
Final Programme30
36th FEBS CONGRESS - “Biochemistry for Tomorrow’s Medicine”
SymposiaS 6.1 Stress adaptation anddevelopmentChairpersons:David RonCambridge UK
Roberto SitiaMilano
15:00 - 15:30 S6.1.1David RonCambridge, UK
Protein folding homeostasis in theendoplasmic reticulum.
15:30 - 16:00 S6.1.2Roberto SitiaMilano
ERp44 acts as a pH-dependentchaperone to retrieve client proteinsfrom the Golgi complex.
16:00 - 16:30 S6.1.3Naihe JingShanghai
BMP signaling and neurogenesis ofdeveloping spinal cord.
16:30 - 17:00 S6.1.4Richard I MorimotoEvanston
The Stress of Misfolded Proteins inAging and Disease.
17:00 - 17:15 S6.1.5Ester ZitoCambrigde
Oxidative protein folding by anendoplasmic reticulum localizedperoxiredoxin.
17:15 - 17:30 S6.1.6Fulvio SaccocciaRoma
Crystal structure of Schistosomamansoni Peroxiredoxin I: insights intoa general mechanism of assembly ofstress-regulated chaperones.
Monday June 27, 2011
Parallel Symposia 15:00 - 17:30
SymposiaS 10.1 Nuclear receptors andlipid metabolismChairpersons:Nagy LaszloDebrecen
Luciana AviglianoRoma
15:00 - 15:30 S10.1.1Nagy LaszloDebrecen
Decision-making by macrophagesand dendritic cells using RXRheterodimeric receptors to sense theirlipid environment.
15:30 - 16:00 S10.1.2Peter TontonozLos Angeles
Nuclear Receptor Regulation ofCholesterol Metabolism.
16:00 - 16:30 S10.1.3Bart StaelsLille
Role of PPAR signalling in diabeticdyslipidemia.
16:30 - 17:00 S10.1.4Susanne MandrupOdense
The transcriptional network of PPARgamma in adipocyte developmentand function.
17:00 - 17:15 S10.1.5Nico MitroMilano
Liver x receptor activation protectsfrom diabetic neuropathy by restoringfatty acid biosynthesis.
17:15 - 17:30 S10.1.6Santina BruzzoneGenova
Glucose-induced increase of abscisicacid (aba) levels in human plasmaand aba- stimulated glucose uptakeby adipocytes.
SymposiaS 14.1 Recent advances inneurodegenerative disordersChairpersons:Maria Grazia SpillantiniCambridge, UK
Tommaso RussoNapoli
15:00 - 15:30 S14.1.1Luca SteardoRoma
Astrocytes in neurodegeneration:potential target for Alzheimer’sdisease treatment.
15:30 - 16:00 S14.1.2Maria Grazia SpillantiniCambridge, UK
Parkinson’s disease, a dying backpathology associated with synapticalpha-synuclein aggregation.
16:00 - 16:30 S14.1.3Dominic WalshDublin
Aβ dimers, non-infectious prion andtherapeutic antibodies.
16:30 - 17:00 S14.1.4Inna SlutskyTel Aviv
Amyloid-beta: from release tosynaptic function.
17:00 - 17:15 S14.1.5Ilaria CanobbioPavia
The Alzheimer’s disease associatedamyloid beta-peptide supportsplatelet adhesion and activation.
17:15 - 17:30 S14.1.6Christian Lefebvre d’hellencourtSaint Denis
Anti-inflammatory effects of autotaxinon microglial cells.
AUDITORIUM HALL 500 HALL GIALLA
36th FEBS Congress 31
Torino, Italy - June 25-30, 2011
SymposiaS 8.2 Biomedical application ofnanotechnologyChairperson:Nicola RosatoRoma
15:00 - 15:30 S8.2.1Silke KrolMilanoFunctionalized Nanoparticles - At theborder between drug and deliverysystem.
15:30 - 16:00 S8.2.2Ruth DuncanCardiff
Clinical status of lysosomotropic/endosomotropic polymer conjugatesdesigned as nanomedicines.
16:00 - 16:30 S8.2.3Fernando PalacioSaragozza
Multifunctional coating platform forthe biomedical applications ofmagnetic nanoparticles.
16:30 - 17:00 S8.2.4Cornelia PalivanBasel
Artificial Organelles Based onPolymer Nanoreactors.
17:00 - 17:15 S8.2.5Ekaterina SouslovaMoscow
Near infrared fluorescent proteins.
17:15 - 17:30 S8.2.6Alessandra BalduiniPavia
Silk fibroin engineered 3D System forthe Study of Megakaryocytes andFunctional Platelet Production.
SymposiaS 9.2 Antimicrobial drugdiscovery: a new challenge forthe futureChairpersons:Jean Marie PagèsMarseille
Gianni DehòMilano
15:00 - 15:30 S9.2.1Claudio O. GualerziCamerino
The quest for antibiotics andcharacterization of new inhibitorstargeting the translational apparatus.
15:30 - 16:00 S9.2.2Lloyd CzaplewskiOxfordshire
Inhibitors of bacterial cell division.
16:00 - 16:30 S9.2.3Jean Marie PagèsMarseille
Bypass the membrane barrierstrategy in multidrug resistant Gram-negative bacteria.
16:30 - 17:00 S9.2.4Vanessa SperandioDallas
Inter-kingdom chemical signaling inhost-bacterial associations.
17:00 - 17:15 S9.1.5Flaminia AlaleonaRoma
The bacterial high affinity Zn-uptakesystem: a possible target for novelantibiotics.
17:15 - 17:30 S9.1.6Valentina StelitanoRoma
Characterization of proteins fromPseudomonas aeruginosa involvedin c-di-GMP turnover.
AUDITORIUM
Plenary Lecture17:45 - 18:45
PRAKASH DATTALECTURE PL-5Chairpersons:Ian MowbrayLondon
Carola PonzettoTorino
Sirpa JalkanenUniversity of Turku - Turku - FIN
Homing-associated molecules astargets to prevent harmfulinflammations and cancer spread.
Parallel Symposia15:00 - 17:30
Break 17:30 - 17:45
➜HALL ISTANBUL HALL LONDRA
Final Programme32
36th FEBS CONGRESS - “Biochemistry for Tomorrow’s Medicine”
Tuesday June 28, 2011
Parallel Symposia 08:30 - 11:00
SymposiaS 6.2 Cell shape determinationChairpersons:Frank CostantiniNew York
Vania BroccoliMilano
8:30 - 9:00 S6.2.1Frank CostantiniNew York
Cellular behaviours during renalbranching morphogenesis.
9:00 - 9:30 S6.2.2Carl-Philipp HeisenbergKlosterneuburg
Cell and tissue mechanics inzebrafish gastrulation.
9:30 - 10:00 S6.2.3Sandrine Etienne-MannevilleParis
Adherens junctions and astrocytepolarity.
10:00 - 10:30 S6.2.4Ian G. MacaraVirginia
Polarity Proteins in Morphogenesisand Metastasis.
10:30 - 10:45 S6.2.5Tania IncittiTrento
Turning stem cells into retina:possible strategies for the cure ofretinal degenerations.
10:45 - 11:00 S6.2.6Benedetta CerrutiTorino
Polarity and coordinated cell divisionin epithelial morphogenesis.
SymposiaS 10.2 Molecular perspectivesfor diabetesChairpersons:Johan AuwerxLausanne
Massimo FedericiRoma
8:30 - 9:00 S10.2.1Johan AuwerxLausanne
Transcriptional cofactors and NAD+ inthe control of metabolism.
9:00 - 9:30 S10.2.2Massimo FedericiRoma
Ectodomain shedding proteasesacting at the interface of metabolicand vascular disorders.
9:30 - 10:00 S10.2.3Agnieszka DobrzynWarsaw
Regulation of cardiac energymetabolism - the role of long-chainfatty acids.
10:00 - 10:30 S10.2.4Jiarui WuShanghai
Systems Biology for diabeticbiomarker discovery.
10:30 - 10:45 S10.2.5Maurizio CrestaniMilano
Class I histone deacetylases andenergy metabolism: new players in“diabesity?
10:45 - 11:00 S10.2.6Lorena Ivona StefanCraiova
Evaluation of metabolic status in type2 diabetes mellitus patients by protonnuclear magnetic resonancespectroscopy method (1H-NMR).
SymposiaS 14.2 Dopaminergic neuronsand Parkinson’s diseaseChairpersons:Alain ProchiantzParis
Aldo FasoloTorino
8:30 - 9:00 S14.2.1Antonio SimeoneNapoli
Otx2 in adult meso-diencephalicdopaminergic neurons.
9:00 - 9:30 S14.2.2Anders BjörklundLund
Use of stem cells for cell replacementin Parkinson´s disease.
9:30 - 10:00 S14.2.3Alain ProchiantzParis
Engrailed Homeoproteins protectmesencephalic dopaminergicneurons in animal models ofParkinson disease.
10:00 - 10:30 S14.2.4Marten SmidtUtrecht
A Pitx3 regulatory network indevelopment and maintenance ofmesodiencephalic dopamineneurons.
10:30 - 10:45 S14.2.5Beatriz Alvarez-CastelaoMadrid
Synphilin-1 inhibits alpha-synucleindegradation by the proteasome.
10:45 - 11:00 S14.2.6Anna Maria SardanelliBari
Mitochondrial respiratory dysfunctionin PARK6 and PARK2 familialParkinsonism.
AUDITORIUM HALL 500 HALL GIALLA
36th FEBS Congress 33
Torino, Italy - June 25-30, 2011
AUDITORIUM
SymposiaS 12.1 Plasticity of agingChairpersons:Luigi FontanaSt. Louis
Ariela BenigniBergamo
8:30 - 9:00 S12.1.1Rafael de CaboBaltimore
Sirtuin activating compounds,resveratrol and SRT1720, extendhealthspan and lifespan of C57BL6male mice.
9:00 - 9:30 S12.1.2David Gems-Linda PartridgeLondon
Nutrient-sensing pathways and aging.
9:30 - 10:00 S12.1.3Michael HallBasel
TOR signaling, from yeast to human.
10:00 - 10:30 S12.1.4Fontana LuigiSt. Louis
Caloric restriction and aging.
10:30 - 11:00 S12.1.5Sarah HempenstallAberdeen
Effects of dietary restriction andageing on mitochondrial function inmale C57BL/6 mice.
SymposiaS 18.1 Green factoryChairpersons:Cathie MartinNorwich
Alessandro VitaleMilano
8:30 - 9:00 S18.1.1Cathie MartinNorwich
Engineering phenylpropanoidproduction in crops for healthy foods.
9:00 - 9:30 S18.1.2Eva StögerVienna
Plant-made pharmaceuticalantibodies.
9:30 - 10:00 S18.1.3Roberto BassiVerona
Domestication of wild unicellularalgae for growth in photobioreactors.
10:00 - 10:30 S18.1.4Jules BeekwilderWageningen
Metabolic engineering of terpenoidsfor green pharmaceuticals.
10:30 - 10:45 S18.1.5Monika SztajnertWroclaw
Flax produces biologically activecannabinoids.
10:45 - 11:00 S18.1.6Kwok Wai LaiHong Kong SAR
The occurrence of ACC- dependentethylene biosynthesis might haveplayed important role in thespeciation of β-cyanoalaninesynthase (CAS) from the O-acetylserine sulfhydrylase (OASS)family proteins during land plantevolution.
Plenary Lecture11:30-12:30
IUBMBLECTURE PL-6
Chairpersons:Angelo AzziPresident IUBMP, Boston
Antonio De FloraGenova
John MattickUniversity of Queensland - Brisbane - AUS
Challenging the dogma: the centralrole of RNA in human developmentand cognition
Parallel Symposia08:30 - 11:00
Break 11:00 - 11:30
➜HALL ISTANBUL HALL LONDRA
Final Programme34
36th FEBS CONGRESS - “Biochemistry for Tomorrow’s Medicine”
«Science & Society»Session on genetic Diseases
13:00 - 15:00Chairpersons:Jacques-Henry WeilStrasbourg
Patrizia GallettiNapoli
Marina Cavazzana CalvoDepartment of Biotherapy, Hopital NeckerEnfants Malades, Université Paris Descartes,France
Gene therapy: Acquired results,expected advances and obstacles
Gert-Jan B. van OmmenDept of Human Genetics, Leiden UniversityMedical Centre, The Nethederlands
Progress in exon skipping therapy forDuchenne muscular dystrophy andthe future of RNA-based genetictherapy
Bart LoeysAntwerp University Hospital, Belgium
Connective tissue diseases andcytokines: A pathway to treatment
Milan MacekInstitute of Biology and Medical Genetics,University Hospital Motol and 2nd School ofMedicine, Charles University, Czech Republic
Organization of care for geneticdiseases in a diverse Europe
HALL 500
Tuesday June 28, 2011
13:00 - 15:00Poster Sessions
P02, P10, P11, P12, P13, P14, P15,P16, P17, P19, P29, P30, P31 P33
POSTER AREA
Break 12:30 - 13:00
The sessionsbetween
13:00 and 15.00are held in parallel
Final Programme36
36th FEBS CONGRESS - “Biochemistry for Tomorrow’s Medicine”
Tuesday June 28, 2011
Parallel Symposia 15:00 - 17:30
SymposiaS 6.3 Development of cognitionand languageChairpersons:Pico CaroniBasel
Wieland B. HuttnerDresden
15:00 - 15:30 S6.3.1Wieland B. HuttnerDresden
Neural stem cells and the evolution ofthe cerebral cortex.
15:30 - 16:00 S6.3.2Alexander DityatevNovgorod/Genova
From recognition molecules tocognition.
16:00 - 16:30 S6.3.3Edvard I. MoserTrondheim
Neural mechanisms for mapping ofspace.
16:30 - 17:00 S6.3.4Pico CaroniBasel
Structural traces of learning andmemory in the hippocampus.
17:00 - 17:30 S6.3.5Cecile PaganParis
Alterations of the melatonin Pathwayas a susceptibility factor to Autism.
SymposiaS 10.3 Redox balance andobesityChairpersons:Vladimir SkulachevMoscowGiuseppe RotilioRoma
15:00 - 15:30 S10.3.1Louis CasteillaToulouse
Redox balance and adipogenesis.
15:30 - 16:00 S10.3.2Paul HolvoetLeuven
Interaction between oxidative stressand inflammation in obesity.
16:00 - 16:30 S10.3.3Vladimir SkulachevMoscow
Mitochondria-targeted penetratingions as inhibitors of the agingprogramme and obesity.
16:30 - 17:00 S10.3.4Gerry MelinoRomap53 family, involvement of p73 inmetabolism and senescence: why weneed it?
17:00 - 17:15 S10.3.5Jun-Yuan HuangTaipei
Haematopoietic haeme oxygenase-1impacts obesity-induced adiposemacrophage infiltration and insulinresistance.
17:15 - 17:30 S10.3.6Jin-Kyung ChoGyeonggi-do
Effects of exercise intensity on globalhepatic mRNA expression in high fat-induced obese mice.
SymposiaS 2.1 Non coding RNA:evolution, functionChairpersons:Pier Paolo PandolfiBoston
Irene BozzoniRoma
15:00 - 15:30 S2.1.1Witold FilipowiczBasel
Regulation of microRNA Repressionand microRNA Turnover inMammalian Cells.
15:30 - 16:00 S2.1.2Caroline DeanNorwich
Non-coding RNAs in the control offlowering time.
16:00 - 16:30 S2.1.3Lucas KaaijUtrecht
Functional analysis of Tdrd1 andTdrd6 in the zebrafish Piwi pathway.
16:30 - 17:00 S2.1.4Olga DontsovaMoscow
Functional role of ribosomal RNAmethylation.
17:00 - 17:15 S2.1.5Marcella CesanaRoma
Role of microRNAs in DuchenneMuscular Dystrophy and in muscledifferentiation.
17:15 - 17:30 S2.1.6Ranjan PereraOrlando
The melanoma-upregulated longnoncoding RNA SPRY4-IN1modulates apoptosis and invasion.
AUDITORIUM HALL 500 HALL GIALLA
36th FEBS Congress 37
Torino, Italy - June 25-30, 2011
Symposia12.2 Cellular senescenceChairpersons:Lenhard K. RudolphUlm
Filiberto CiminoNapoli
15:00 - 15:30 S12.2.1Daniel PeeperAmsterdam
Senescence and tumor suppression.
15:30 - 16:00 S12.2.2Lenhard K. Rudolph Ulm
Checkpoint responses to telomeredysfunction in stem cells.
16:00 - 16:30 S12.2.3Fabrizio d’Adda di FagagnaMilano
Molecular mechanisms of cellularsenescence.
16:30 - 17:00 S12.2.4Judith Campisi - Marco DemariaBerkeley
Cellular senescence linksinflammation and aging.
17:00 - 17:15 S12.2.5Zbigniew KorwekWarsaw
Does activation of DNA damageresponse in human T cells lead tocellular senescence?
17:15 - 17:30 S12.2.6Raffaella FaraonioNapoli
Adoptive expression of a set ofmiRNAs induces cellular senescencein human fibroblasts.
SymposiaS 18.2 Plant innate immunityChairpersons:Ulla BonasHalle
Felice CervoneRoma
15:00 - 15:30 S18.2.1Ulla BonasHalle
How bacterial pathogen effectorproteins manipulate the plant cell.
15:30 - 16:00 S18.2.2Brian StaskawiczBerkeley
Role of pathogen effectors in plantinnate immunity.
16:00 - 16:30 S18.2.3Jonathan JonesNorwich
Discovering and validating plantpathogen effectoromes.
16:30 - 17:00 S18.2.4Giulia De LorenzoRoma
Healthy food for a healthy life:engineering resistance byconstructing chimeric receptors forpathogen recognition.
17:00 - 17:15 S18.2.5Marcel ZamockyVienna
Bifunctional catalase-peroxidase issecreted by the rice blast fungusMagnaporthe grisea during oxidativeburst.
17:15 - 17:30 S18.2.6Eugene RogozhinMoscow
Novel antifungal defensins fromseeds of wild plants.
AUDITORIUM
Parallel Symposia15:00 - 17:30
➜HALL ISTANBUL HALL LONDRA
20:30 - 22:00
Public Science &Society Forum on“Biochemistry forTomorrow’sMedicine”MBC - Centro di Biotecnologie Molecolari,Via Nizza 52 - Torino
The contribution of biochemicalresearch for major humandiseases.
Il contributo della ricercabiochimica per le maggiori malattieumane.
WISE/EMBOWoman in ScienceAward 2011Laudation by the Nominator for theAwardee
17:45 - 18:45Wolfgang BaumeisterMax-Planck-insitute of Biochemistry,Martinsried, Germany
Plenary Lecture17:45-18:45
WISE LECTURE PL-7Chairperson:Lea SistonenTurkuLuciana AviglianoNapoli
Carol V. RobinsonDepartment of Chemistry Universityof Oxford - UK
Finding the right balance: From RareGases to Rotary motors.
Final Programme38
36th FEBS CONGRESS - “Biochemistry for Tomorrow’s Medicine”
Wednesday June 29, 2011
Parallel Symposia 08:30 - 11:00
SymposiaS 2.2 Small RNA in diseaseChairpersons:John RossiDuarte
Riccardo CortesePomezia
8:30 - 9:00 S2.2.1Reuven AgamiAmsterdam
Selective inhibition of miRNAaccessibility is required for p53tumour suppressive activity.
9:00 - 9:30 S2.2.2John RossiDuarte
Aptamer and dendrimer mediateddelivery of therapeutics small RNAs.
9:30 - 10:00 S2.2.3Adrian KrainerNew York
Oligonucleotide Therapeutics forCorrecting Defective RNA Splicing.
10:00 - 10:30 S2.2.4Maria Carmo-FonsecaLisboa
Co-transcriptional RNA checkpoints.
10:30 - 10:45 S2.2.5Constance CiaudoZurich
Characterisation of new small RNApopulations in mouse EmbryonicStem cells.
10:45 - 11:00 S2.2.6Mary-jessica LaguetteCape Town
Sequence Variants within the 3’-UTRof the COL5A1 gene alters mRNAstability: Implications for musculoskeletal soft tissue injuries.
SymposiaS 11.1 Genes and pathways incancerChairpersons:René BernardsAmsterdam
Carola PonzettoTorino
8:30 - 9:00 S11.1.1René BernardsAmsterdam
Dissecting mechanisms of cancerdrug resistance through functionalgenetics.
9:00 - 9:30 S11.1.2Chris J. MarshallLondon
Rho GTPase signalling in invasionand metastasis.
9:30 - 10:00 S11.1.3Michael StrattonCambridge
Evolution of the Cancer Genome.
10:00 - 10:30 S11.1.4Grahame HardieDundee
AMP-activated protein kinase, atumour suppressor that opposesthe metabolic changes in cancercells.
10:30 - 10:45 S11.1.5Hanna KryhGothenburg
Characterisation of amplicon junctionsequences in genomic regionssurrounding the MYCN gene inneuroblastoma tumors; Implicationsfor clinical follow-up of high-riskpatients.
10:45 - 11:00 S11.1.6Emanuela PupoTorino
Hydrogen sulphide promotes calciumsignals and migration in tumour-derived endothelial cells.
SymposiaS16.1 Ectoenzyme network anddiseasesChairpersons:Simon RobsonBoston
Fabio MalavasiTorino
8:30 - 9:00 S16.1.1Simon RobsonBoston
Ectonucleotidases, regulatory T cellsand the conditioning of vascular andimmune responses in inflammatorybowel disease.
9:00 - 9:30 S16.1.2Laura AirasTurku
CD73 as a regulator of CNSinflammation.
9:30 - 10:00 S16.1.3Silvia DeaglioTorino
Nucleotide-metabolising enzymes intumour-host interactions: the chroniclymphocytic leukemia model.
10:00 - 10:30 S16.1.4Richard EbsteinJerusalem
CD38 mediates social behaviour inclinical and non-clinical subjects.
10:30 - 10:45 S16.1.5Irini EvnouchidouAgia Paraskevi Attikis
Specific ER aminopeptidase 1 SNPsaffect antigen processing in vitro anddemonstrate substrate inhibitionkinetics.
10:45 - 11:00 S16.1.6Alejandra Ochoa-ZarzosaMorelia
Prolactin and Staphylococcus aureusinhibit nuclear factor kappa Bactivation in bovine mammaryepithelial cells.
AUDITORIUM HALL 500 HALL GIALLA
36th FEBS Congress 39
Torino, Italy - June 25-30, 2011
AUDITORIUM
SymposiaS 13.1 Rare metabolic diseasesChairpersons:Stylianos E. AntonarakisGenève
Francesco SalvatoreNapoli
8:30 - 9:00 S13.1.1Stylianos E. AntonarakisGeneva
The Connectivity of GenomicElements.
9:00 - 9:30 S13.1.2Miguel C. SeabraLondon
Pathogenesis of diseases involvingdefects in Rab GTPase function andmembrane traffic.
9:30 - 10:00 S13.1.3Francesco SalvatoreNapoli
Nature and nurture in geneticdiseases: the cases of hereditaryfructose intolerance andhyperphenylalaninemias.
10:00 - 10:30 S13.1.4Santiago Rodríguez de CórdobaMadrid
Pathogenic mechanisms in Lafora’sdisease.
10:30 - 10:45 S13.1.5Giulia NacciTorino
Isolation and cloning of stimulatoryanti-PDGF receptor auto-antibodiesfrom the immunological repertoire ofpatients with systemic sclerosis.
10:45 - 11:00 S13.1.6Mirko PinottiFerrara
Aberrant splicing reverts a potentiallylethal coagulation deficiency causedby A+1G/T splicing mutation.
SymposiaS 15.1 Development of vascularsystemChairpersons:Ralf AdamsMünster
Massimo SantoroTorino
8:30 - 9:00 S15.1.1Lena Claesson WelshUppsala
VEGF in control of vascular function
9:00 - 9:30 S15.1.2Ralf AdamsMuenster
Angiogenesis - growth of new bloodvessels and beyond.
9:30 - 10:00 S15.1.3Deepak SrivastavaSan Francisco
Regulatory networks controllingcardiac cell fate.
10:00 - 10:30 S.15.1.4Guido SeriniTorino
Regulation of integrin function inendothelial cells: a matter ofconformation and traffic.
10:30 - 10:45 S15.1.5María Soledad AlvarezValencia
Effect of Cycloxygenase 2 in cardiacischemia-reperfusion injury.
10:45 - 11:00 S15.1.6Olena SemenykhinaKyiv
Exogenous hydrogen sulphide as amodulator of the mitochondrialpermeability transition pore openingin rat heart.
Plenary Lecture11:30 - 12:30
Parallel Symposia08:30 - 11:00
Break 11:00 - 11:30
➜HALL ISTANBUL HALL LONDRA
PABMBLECTURE PL-4Chairpersons:Jorge BabulPresident PABMB, Santiago
Rubio VicenteValencia
Hugo J.F. MaccioniNational University of Córdoba - Córdoba- RA
Organization of the synthesis ofglycolipids in the Golgi complex
Final Programme40
36th FEBS CONGRESS - “Biochemistry for Tomorrow’s Medicine”
HALL 500
13:00 - 15:00Poster SessionsP02, P10, P11, P12, P13, P14, P15,P16, P17, P19, P29, P30, P31 P33
13:00 - 15:00Workshop:Integrating MolecularBioscience Educationwith Medical Training
Organised byFEBS Education Committee
Chairpersons:Karmela BarisicCroatiaKeith ElliottUK
Introduction to the Workshop
13:00 - 13:30Karmela BarisicCroatia
Keith ElliottUK
Why integrate? The evidence tosupport integration of scientific andclinical learning within undergraduatemedical curricula”
13:30 - 14:00Karen MattichPeninsula College of Medicine and Dentistry,Universities of Exeter and Plymouth, UK
”Integrating Molecular Bioscienceswithin the Medical Curriculum: theMaastricht Approach”
14:00 - 14:30Jan F. C. GlatzDirector of Education, BiomedicalSciences Maastricht University, The Netherlands”How to Integrate MolecularBioscience in Medical Training”
14:30 - 15:00Tomáš ZimaDean of the 1st Medical Faculty, CharlesUniversity Prague, Czech Republic
Panel Discussion
Plenary Lecture15:00 - 16:00
FEBS PublicationsAward LectureChairpersons:Felix WielandManaging Editor FEBS LettersRichard PerhamEditor in Chief of FEBS Journal
FEBS Letters AwardLecture PL-9Shiro SuetsuguUniversity of Tokyo, Japan
Subcellular membrane curvaturemediated by the BAR domainsuperfamily proteins.
FEBSJournal PrizeLecture PL-10Karen van EunenUniversity Medical Centre Groningen,The Netherlands
In vivo-like enzyme kinetics improvemetabolic computer models
Wednesday June 29, 2011
AUDITORIUM
POSTER AREA
The sessionsbetween
13:00 and 15:00are held in parallel
HALL LONDRA
13:00 - 15:00Workshop:FluorescenceSpectroscopy: a toolfor protein chemistrySponsored by Perkin Elmer Ltd
13:00 - 15:00Steve UpstonePerkin Elmer Ltd, UK
Theory and applications offluorescence spectroscopy in proteinstructure-function
Final Programme42
36th FEBS CONGRESS - “Biochemistry for Tomorrow’s Medicine”
Wednesday June 29, 2011
Parallel Symposia 16:15 - 18:45
SymposiaS 11.2 Cancer stem cells andmetastasisChairpersons:Peter FriedlNijmegen
Paolo ComoglioTorino
16:15 - 16:45 S11.2.1Juliane HannemannHamburg
Circulating tumour cells and cancermicrometastasis.
16:45 - 17:15 S11.2.2Peter FriedlNijmegen
Intravital imaging of cancer invasionand experimental therapy response:role of integrins.
17:15 - 17:45 S11.2.3Paolo ComoglioTorino
MET and invasive growth: a geneticprogramme for stem and cancer stemcells.
17:45 - 18:15 S11.2.4Stefano PiccoloPadova
Mechanisms of metastasissuppression.
18:15 - 18:30 S11.2.5Giulio Di MininTriesteA genome-scale protein interactionprofile of Drosophila p53 uncoversadditional nodes of the human p53network.
8:30 - 18:45 S11.2.6Arkaitz CarracedoDerio
Regulation of metabolism in healthand disease by cancer genes: a newfunction for the promyelocyticleukaemia protein.
SymposiaS 16.2 Structure and function ofinnate immunity receptorsChairpersons:Luke O'NeillDublin
Lorenzo MorettaGenova
16:15 - 16:45 S16.2.1Luke O’NeillDublin
Toll-like receptor and NOD-likereceptor signaling in inflammationand infection.
16:45 - 17:15 S16.2.2Veit HornungBonn
Intracellular sensing of DNA by theinnate immune system.
17:15 - 17:45 S16.2.3Lorenzo MorettaGenova
Human NK receptors: functionalcharacteristics and clinicalapplications.
17:45 - 18:15 S16.2.4Olaf GrossEpalinges
Inflammasomes: IL-1beta cleavageand beyond.
18:15 - 18:30 S16.2.5Sara SerraTorino
Ectoenzyme-generated extracellularadenosine creates local conditionsfavouring growth and survival ofchronic lymphocytic leukaemia cells.
8:30 - 18:45 S16.2.6Serdar DoganAntalya
Polymorphism in the TNF-alpha genepromoter at position -1031 isassociated with increased circulatinglevels of TNF-alpha, myeloperoxidaseand nitrotyrosine in primary Sjogren’sSyndrome.
SymposiaS 19.1 Vectors for therapeuticand experimental applicationsChairpersons:Maria Grazia RoncaroloMilano
Lucio LuzzattoFirenze
16:15 - 16:45 S19.1.1Lucio LuzzattoFirenze
Prospects and problems of genetherapy of haemoglobinopathies.
16:45 - 17:15 S19.1.2Thierry VandenDriesscheLeuven
Haemophilia as trailblazer for genetherapy.
17:15 - 17:45 S19.1.3Tony CathomenHannover
Development and application ofdesigner nucleases.
17:45 - 18:15 S19.1.4Luigi NaldiniMilano
Targeting gene transfer to improvethe efficiency and safety of genetherapy.
AUDITORIUM HALL 500 HALL GIALLA
36th FEBS Congress 43
Torino, Italy - June 25-30, 2011
SymposiaS 13.2 Mitochondrial diseasesChairpersons:Douglas WallaceIrvine
Sergio PapaBari
16:15 - 16:45 S13.2.1Massimo ZevianiMilano
OXPHOS-related mechanisms andpathways unraveled by newmitochondrial disorders.
16:45 - 17:15 S13.2.2Arnold MunnichParis
Human diseases with impairedmitochondrial translation.
17:15 - 17:45 S13.2.3Douglas WallacePhiladelphia
Energyomics-energenomics: amitochondrial etiology of commondiseases.
17:45 - 18:15 S13.2.4Michael RyanMelbourne
Understanding mitochondrialcomplex I assembly and misassemblyin disease.
18:15 - 18:30 S13.2.5Vittoria PetruzzellaBari
Survey of genes involved inmitochondrial biogenesis in earlydevelopment of zebrafish ascandidates for mitochondrialpathologies.
8:30 - 18:45 S13.2.6Cláudio M. GomesOeiras
Pathogenesis mechanisms inmitochondrial beta oxidationdiseases: protein misfolding, functionand small molecules.
SymposiaS 17.1 Biochemistry andmolecular biology oftuberculosisChairpersons:Roland BroschParis
Giovanna RiccardiPavia
16:15 - 16:45 S17.1.1Clifton E. BarryBethesda
The biochemistry of activation ofnitroimidazole antibiotics inMycobacterium tuberculosis.
16:45 - 17:15 S17.1.2Stewart ColeLausanne
New medicines for tuberculosis:benzothiazinones.
17:15 - 17:45 S17.1.3Roland BroschParis
ESX/Type VII secretion in tuberclebacilli - a key factor in virulence andprotection.
17:45 - 18:15 S17.1.4Katarina MikusovaBratislava
Playing biochemistrywith mycobacterial cell wall - an oldgood drug target.
18:15 - 18:30 S17.1.5Vadim NikitushkinMoscow
Muropeptides of mycobacterialpeptidoglycan are the factors ofdormant mycobacteria resuscitation.
8:30 - 18:45 S17.1.6Franca RossiNovara
Structural investigations on M.tuberculosis proteins involved in DNArepair.
HALL ISTANBUL HALL LONDRA
20:30 - 23:00
Social Dinner
Parallel Symposia16:15 - 18:45
➜
Final Programme44
36th FEBS CONGRESS - “Biochemistry for Tomorrow’s Medicine”
Thursday June 30, 2011
Parallel Symposia 08:30 - 11:00
SymposiaS 15.2 Molecular basis ofcardiovascular diseasesChairpersons:Federico BussolinoTorino
Guido TaroneTorino
8:30 - 9:00 S15.2.1Stefan EngelhardtMuenchen
Cardiac muscle microRNAs.
9:00 - 9:30 S15.2.2Emilio HirschTorino
Genetic modeling of PI3K inhibition.
9:30 - 10:00 S15.2.3Alain TedguiParis
Role of innate and adaptive immunityin atherosclerosis.
10:00 - 10:30 S15.2.4Eli KeshetJerusalem
Adaptive responses in the ischemicmyocardium.
10:30 - 11:00 S15.2.5Muhammad AslamGiessen
Adrenomedullin 2 enhancesmacrovascular endothelial barrierfunction while it disrupts coronarymicrovascular barrier via differentialregulation of Rac1.
SymposiaS 16.3 Receptors and signaltransductionChairpersons:Hua Eleanor YuDuarte
Alberto MantovaniMilano
8:30 - 9:00 S16.3.1Oreste AcutoOxford
T cell antigen receptor signalling.
9:00 - 9:30 S16.3.2Ada FunaroTorino
Clinical and biological significance ofCD157 in ovarian carcinoma.
9:30 - 10:00 S16.3.3Manolis PasparakisCologne
Intracellular signalling pathwaysregulating epithelial homeostasis andinflammation.
10:00 - 10:30 S16.3.4Hua Eleanor YuDuarte
STAT3 in cancer inflammation andimmunity.
10:30 - 10:45 S16.3.5Christina ThomasEpalinges
NLR expression and inflammasomeactivation in neutrophils.
10:45 - 11:00 S16.3.6Antonio InforzatoRozzano
Modular organisation andglycosylation of the long petraxinPTX3 dictate its biological functions.
SymposiaS 19.2 Gene and cell therapy forgenetic diseasesChairpersons:Natalie CartierParis
Alessandro AiutiMilano
8:30 - 9:00 S19.2.1Natalie CartierParis
Gene therapy strategies for geneticleukodystrophies.
9:00 - 9:30 S19.2.2Alessandro AiutiMilano
Gene Therapy for PrimaryImmunodeficiencies.
9:30 - 10:00 S19.2.3Juan BuerenMadrid
New Approaches for the GeneTherapy of Inherited Bone MarrowFailure Syndromes: The FanconiAnaemia Model.
10:00 - 10:30 S19.2.4Shin-ichi MuramatsuTochigi
Gene therapy for Parkinson’s disease:Strategies for the local production ofdopamine.
10:30 - 10:45 S19.2.5Mikhail A. RubtsovMoscow
Treatment of lymphoid cells with thetopoisomerase II poison etoposideleads to an increased juxtaposition ofAML1 and ETO genes on the surfaceof nucleoli.
10:45 - 11:00 S19.2.6Giuseppina CovelloTrento
Antisense RNA-induced exon-skipping for the gene therapy offrontotemporal dementia andparkinsonism associated withchromosome 17 (FTDP-17).
AUDITORIUM HALL GIALLA HALL ISTANBUL
36th FEBS Congress 45
Torino, Italy - June 25-30, 2011
AUDITORIUM
SymposiaS 17.2 Biochemistry andmolecular biology of malariaChairpersons:Maria MotaLisboa
Paolo AreseTorino
8:30 - 9:00 S17.2.1Maria MotaLisboa
Plasmodium-Host-Plasmodiuminteractions: how is malariasuperinfection controlled?
9:00 - 9:30 S17.2.2Dominique Soldati-FavreGenève
Molecular events governing the lyticcycle in apicomplexa.
9:30 - 10:00 S17.2.3Michael LanzerHeidelberg
Transporters as mediators of drugresistance in the human malariaparasite Plasmodium falciparum.
10:00 - 10:30 S17.2.4Artur ScherfParis
The study of antigenic variation inPlasmodium falciparum: Mind gamesor a novel therapeutic approach.
10:30 - 10:45 S17.2.5Rachel CerdanMontpellier
Membrane biosynthesis enzyme ofPlasmodium falciparum erythrocyticstages as a putative antimalarialtarget.
10:45 - 11:00 S17.2.6Oleksii SkorokhodTorino
Role of malaria pigment hemozoinand hemozoin-generated4-hydroxynonenal on inhibition oferythropoiesis in malaria anaemia.
Closing PlenaryLecture PL-11Chairpersons:Jaak JärvTallinLucio LuzzattoFirenze
Guido KroemerGustave Roussy Institut - Villejuif - FR
Autophagy, cytoprotection andlongevity
Plenary Lecture11:15 - 12:15
Parallel Symposia08:30 - 11:00
➜
Closing Ceremony
Closing remarks by
Sergio PapaChairman Scientific Committee of the36th FEBS Congress
Israel PechtFEBS Secretary General
Presentation of the37th FEBS/22nd IUBMBCongress 2012 SevillaMiguel Angel de la Rosa
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Final Programme46
36th FEBS CONGRESS - “Biochemistry for Tomorrow’s Medicine”
Poster Sessions
Group 18:30 am June 26 - 6:00 pm June 27
P01 Genomes: structure, information and epigenetic controlP03 Protein structure, functional mechanisms, turnoverP04 Cell-cell communicationP05 Membrane dynamicsP06 Molecular basis of developmentP07 Systems biologyP08 Molecular engineering for medicineP09 Prokaryote biochemistryP18 Plant biochemistryP20 ApoptosisP21 Signal transductionP22 BioinformaticsP23-P27 BioenergeticsP24 Membrane phospholipidsP25 Protein kinases and phosphatasesP26 Free radical balance and oxidative stressP28 ProteomicsP32 Metals in biology
Group 28:30 am June 28 - 6:00 pm June 29
P02 RNA biologyP10 Metabolic control and disordersP11 Cancer biologyP12 Cellular senescence and agingP13 Rare diseasesP14 Biochemistry of the brain and neurodegenerative disordersP15 Molecular basis of cardiovascular diseasesP16 Biochemistry of immunity and inflammationP17 Biochemistry and molecular biology of malaria and tuberculosisP19 Molecular and cellular therapeuticsP29 Cell organelle dynamicsP30 GlycobiologyP31 Developmental biologyP33 Varia
36th FEBS Congress 47
Torino, Italy - June 25-30, 2011
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Final Programme48
36th FEBS CONGRESS - “Biochemistry for Tomorrow’s Medicine”
Turin (Torino)
Turin is a major city as well as a business and cul-tural centre in northern Italy, capital of the Piedmontregion, located mainly on the left bank of the Po Riversurrounded by the Alpine arch. The population of thecity proper is 909,193 (November 2008) while the popu-lation of the urban area is estimated by Eurostat to be1.7 million inhabitants; the Turin metropolitan area isestimated by OECD to have a population of 2.2 million.
Turin is a flourishing, industrious and cosmopolitanEuropean city, which enjoys state-of-the-art technologyand architectural developments. The city boasts a richculture and history, and is known for its numerous artgalleries, restaurants, churches, palaces, operahouses, piazzas, parks, gardens, theatres, libraries,museums and other venues. Turin is well-known for itsbaroque, rococo, neo-classical, and Art Nouveau ar-chitecture. Much of the city's public squares, cas-tles, gardens and elegant palazzi (such as PalazzoMadama), were built by Sicilian architect FilippoJuvarra, who modelled these buildings on the Baroqueand classical style of Versailles. Examples of theseFrench-themed edifices include the Royal Palace ofTurin, the Palazzina di caccia of Stupinigi and theBasilica di Superga. Turin is sometimes called the "cra-dle of Italian liberty", due to its having been the birth-place and home of notable politicians and people whocontributed to the Risorgimento, such as Cavour. Pres-tigious and important museums, such as the MuseoEgizio and the Mole Antonelliana are also found in thecity. Turin's several monuments and sights make it oneof the world's top 250 tourist destinations, and the tenthmost visited city in Italy in 2008.
Turin used to be a major European political centre, be-ing Italy's first capital city in 1861 and being home to theHouse of Savoy, Italy's royal family. Even though muchof its political significance and importance had been lostby World War II, it became a major European crossroadfor industry, commerce and trade, and currently is one ofItaly's main industrial centres, being part of the famous"industrial triangle", along with Milan and Genoa.
Turin is well known as the home of the Shroud of Tu-rin, the football teams Juventus F.C. and Torino F.C.,the headquarters of automobile manufacturers Fiat,Lancia and Alfa Romeo, and as host of the 2006 WinterOlympics. Several International Space Station mod-ules, such as Harmony and Columbus, were also manu-factured in Turin. It was the capital of the Duchy of Sa-voy from 1563, then of the Kingdom of Sardinia ruledby the Royal House of Savoy and finally the first capitalof a unified Italy.