2
Outline for Lectures 2 & 3
The immune system is designed to eliminate pathogens.
Who are the infectious agents?Overview of the two arms of the immune system: innate immunity & adaptive immunity.
What are the cell types involved with immune responses?What are the important immunological tissues?
3
What barriers are present in the human body to prevent entry/infection by pathogens?
Parham, p. 3How do pathogens enter into the human body?
8
The innate immune response is essentialfor elimination of a pathogen but notsufficient.
The adaptive immune response requires certain key players of the innate immune response to become activated.
10
Where do the cells of the immune system come from?
Leukocytes-Hematopoiesis:
Hematopoietic stem cells from the bone marrow
UndifferentiatedPluripotentSelf-renewing
13
What stimulates the differentiation of stem cells & progenitor cells?
Hematopoietic Inducing Microenvironment:
Requires bone marrow stromal cells & growth factors (cytokines).
Kuby, Immunology, fig. 2-2
16
Lymphocytes:
B lymphocytes (B cells)T lymphocytes (T cells)Important for the adaptive immune response.