Download - Papillary thyroid cancer
![Page 1: Papillary thyroid cancer](https://reader036.vdocuments.net/reader036/viewer/2022081801/55a73bab1a28abd5258b46a0/html5/thumbnails/1.jpg)
Papillary Thyroid Cancer
M.A.Khachatryan
![Page 2: Papillary thyroid cancer](https://reader036.vdocuments.net/reader036/viewer/2022081801/55a73bab1a28abd5258b46a0/html5/thumbnails/2.jpg)
The anatomo-histological structure of Thyroid Gland
![Page 3: Papillary thyroid cancer](https://reader036.vdocuments.net/reader036/viewer/2022081801/55a73bab1a28abd5258b46a0/html5/thumbnails/3.jpg)
Characteristics of Papillary Thyroid Cancer
• 80% of TC
• Common in females
• Peak onset ages 30-50
• Follicular cell genesis
• Well-differentiated
• Minimally invasive
• Lymphogenic spread
![Page 4: Papillary thyroid cancer](https://reader036.vdocuments.net/reader036/viewer/2022081801/55a73bab1a28abd5258b46a0/html5/thumbnails/4.jpg)
Causes/ Risk Factors
• Family history/genetic defect maybe involved
• Radiation
• Men
• Older persons
AACE/AME/ETA Thyroid Nodule Guidelines, Endocr Pract.2010;16(Suppl1
![Page 5: Papillary thyroid cancer](https://reader036.vdocuments.net/reader036/viewer/2022081801/55a73bab1a28abd5258b46a0/html5/thumbnails/5.jpg)
Symptoms and Signs
• Few or no symptoms
• Small lump(nodule)
• Painless during palpation
![Page 6: Papillary thyroid cancer](https://reader036.vdocuments.net/reader036/viewer/2022081801/55a73bab1a28abd5258b46a0/html5/thumbnails/6.jpg)
Exams and Tests
• History
• Physical examination
• US
• FNA
• Thyroid function tests
![Page 7: Papillary thyroid cancer](https://reader036.vdocuments.net/reader036/viewer/2022081801/55a73bab1a28abd5258b46a0/html5/thumbnails/7.jpg)
PTC US Features
• Hypoechogenicity
• Inhomogeneous echo pattern
• Microcalcifications
• Absence of peripheral halo
• Irregular borders, blurred margins
• Often intranodular hypervascularity
• Regional lymphadenopathy
![Page 8: Papillary thyroid cancer](https://reader036.vdocuments.net/reader036/viewer/2022081801/55a73bab1a28abd5258b46a0/html5/thumbnails/8.jpg)
![Page 9: Papillary thyroid cancer](https://reader036.vdocuments.net/reader036/viewer/2022081801/55a73bab1a28abd5258b46a0/html5/thumbnails/9.jpg)
![Page 10: Papillary thyroid cancer](https://reader036.vdocuments.net/reader036/viewer/2022081801/55a73bab1a28abd5258b46a0/html5/thumbnails/10.jpg)
Cytology of PTC; Nuclear inclusion.
![Page 11: Papillary thyroid cancer](https://reader036.vdocuments.net/reader036/viewer/2022081801/55a73bab1a28abd5258b46a0/html5/thumbnails/11.jpg)
Primary treatment
• No prospective clinical trials have clearly determined the “best treatment” of patients with PTC
• Appropiate surgical planning
202 ENDOCRINE PRACTICE Vol. 7 No. 3 May/June 2001
![Page 12: Papillary thyroid cancer](https://reader036.vdocuments.net/reader036/viewer/2022081801/55a73bab1a28abd5258b46a0/html5/thumbnails/12.jpg)
Macroscopic pathology-photograph
![Page 13: Papillary thyroid cancer](https://reader036.vdocuments.net/reader036/viewer/2022081801/55a73bab1a28abd5258b46a0/html5/thumbnails/13.jpg)
Microscopic examination
![Page 14: Papillary thyroid cancer](https://reader036.vdocuments.net/reader036/viewer/2022081801/55a73bab1a28abd5258b46a0/html5/thumbnails/14.jpg)
Adjuvant Therapy
• Thyroid Hormone-suppresive therapy
• Radioiodine Remnant Ablation(131J)
202 ENDOCRINE PRACTICE Vol. 7 No. 3 May/June 2001
![Page 15: Papillary thyroid cancer](https://reader036.vdocuments.net/reader036/viewer/2022081801/55a73bab1a28abd5258b46a0/html5/thumbnails/15.jpg)
M.A.Khachatryan