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Pathology of Treated GI Neoplasia
Pathology section seminar
Liverpool DDF meeting
Tuesday 19th June 2012 at14:00-15:15
Venue: Hall 11c in the ACC
Presenters:
Phillip Kaye, Adrian Bateman,
Shaun Walsh, Norman Carr, Judy Wyatt
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Treated Barrett‟s
Philip Kaye
NUH
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55 year old man on long standing
Barrett‟s surveillance
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62 year old man – EMR for
HGD
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50 year old man- nodule post RFA
for LGD
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p53
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BSG/DDF 2012Pathology Slide Seminar
Dr Adrian C Bateman
Southampton University Hospitals NHS Foundation Trust
Southampton Cellular Pathology
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History
• 56 year old man
• Refractory dysphagia following treatment for upper GI malignancy
• Gastrectomy performed
• Sections are from stomach wall
Southampton Cellular Pathology
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Mucosal aspect
Southampton Cellular Pathology
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Serosal aspect
Southampton Cellular Pathology
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Muscularis propria
Southampton Cellular Pathology
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GIST treated with TKIs
Three cases
Dr Shaun Walsh
Ninewells Hospital
Dundee
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Case 1
• Male patient, age 43 yrs.
• Dx with gastric GIST 1 year ago
• KIT positive on biopsy.
• Tyrosine kinase therapy for 10 months to „shrink tumour‟ and avoid total gastrectomy
• Tumour decreased very little in size but limited gastrectomy achieved
• Any evidence of response and can you do mutation analysis now please?
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Resected tumour after TKI
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Resected tumour after TKI
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Case 2
• Female age 49yrs.
• Dx. with small bowel GIST 1 yr. ago
• R0 resection. Tumour focally KIT positive.
• Tx. with Tyrosine Kinase inhibitor for one
yr.
• Now has recurrence
• Can you do mutation analysis please?
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Resected tumour after TKI
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Resected tumour after TKI
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Case 3
• Female age 62 yrs.
• Large Gastric GIST. Liver metastases.
• KIT, DOG-1 positive core biopsy.
• Treated with TKI‟s 6 months, no response
• New peritoneal metastases sampled
• Any evidence of response?
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Primary tumour untreated
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New peritoneal metastasis
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Pathology of treated colorectal
carcinoma
Norman Carr
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Chemoradiation effects
• Fibrosis
• Necrosis
• Acellular mucin
• Calcification
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Modified RCRG grading system
(Bateman AC et al)
1. Malignant epithelium <5%
2. Malignant epithelium 5 to 50%
3. Malignant epithelium >50%
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RCPath guidelines – staging
• “For tumour staging following neoadjuvant
therapy, only the presence of tumour cells
in the surgical specimen is taken to
determine the stage. Fibrosis,
haemorrhage, necrosis, inflammation and
acellular mucus are ignored. Cases with
complete regression are therefore
recorded as … ypT0”
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References
• Bateman AC et al. Rectal cancer staging post neoadjuvant therapy – how should the changes be assessed? Histopathology 2009; 54:713-21
• Chetty R et al. A multi-centre pathologist survey on pathological processing and regression grading of colorectal cancer resection specimens treated by neoadjuvant chemoradiation. Virchows Arch 2012; 460:151-5
• Dworak O et al. Pathological features of rectal cancer after preoperative radiotherapy. Int J Colorectal Dis 1997; 12:19-23
• Williams GT et al. Dataset for Colorectal Cancer (2nd edition). London: Royal College of Pathologists, 2007
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Pathology of treated liver
tumours
Judy Wyatt
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Mrs KM 28F
Presented with bulky liver metastases,
CK20+ve subsequently sigmoid primary identified.
Treated with FOLFOXIRI – irinotecan, oxaliplatin, 5FU very good response.
Right trisectionectomy and segment 2&3 metastasectomies performed at
same time as anterior resection of rectum ypT3, ypN1, ypV1, ypR0, TRG2
Liver: Right trisectionectomy, segments 4-8, 1,170kg,
7 tumours 5-70mm.
Left metastasectomies x2, 1.2g and2.1g,
2 tumours, 7mm and 10mm lesions
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KM right
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KM rectum
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KM right
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KM left
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KM right
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KM right
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KM right VG
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Mr PE, 27M
• August 2008: inoperable carcinoma of upper rectum with bulky bilateral liver metastases.
• Sept – Feb 2008:Treated with oxaliplatin and cetuximab. Good response but still inoperable.
• March 2009: Candidate for SIRT treatment with aim of surgery if further response.
• June 2009: SIRT
• July 2009: nausea, vomiting, ascites, 3 weeks after treatment. Deteriorated and died 3 weeks later.
• Consent autopsy:
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PE
left right
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PE
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PE
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PE
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PE
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PE
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PE VG