Functional role of enzyme AMPK

April Irums

GRANT PROPOSAL

What is AMPK?

AMP-activated protein Kinase

More On AMPK…

What Does AMPK Really DO?

• AMPK aids in efficient fatty acid oxidation. (FAT LOSS!)

Heart & Liver • protein synthesis

• insulin resistance

How Can We Benefit From AMPK?

Activated with exercise

Facilitates stronger heart muscles

How Can We Benefit From AMPK?

Cardiac Hypertrophy

Diabetes

Faulty hormone signalling

What Do We Already Know?

We Also know That….

Mitochondria

Hypothesis

Increased AMPK levels in the body will

increase mitochondrial density in type 1 muscle fibres and

myocytes

How Are We Going To Test This?

Examine Samples

AMPK Levels within Samples

Prolonged Exercise

Control Group

NO exercise!Sedimentary Lifestyle

Experimental Group

Use of Biopsy equipment

30 days to exerciseIncrease Heart Rate

Measure AMPK Levels

Rat Food

How Will We Do This?

Muscle and Heart Biopsy

Procedure

SUPER TINY SCAR!

Main Goal

Figuring out the functional role of AMPK in the body!

What We Expect To See

Heart Patients

Problems With Weight

Significance