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Page 1: PROF. DR D. F. SWAAB NEDERLANDS ... - trauma.nl · axis. Partial empty sella syndrome with an atrophied pituitary gland is seen in primary neuroendocrino- pathies such as growth hormone

PROF. DR D. F. SWAAB NEDERLANDS HERSENINSTITUUT, KNAW,

AMSTERDAM

Hoofdbrekers

Page 2: PROF. DR D. F. SWAAB NEDERLANDS ... - trauma.nl · axis. Partial empty sella syndrome with an atrophied pituitary gland is seen in primary neuroendocrino- pathies such as growth hormone
Page 3: PROF. DR D. F. SWAAB NEDERLANDS ... - trauma.nl · axis. Partial empty sella syndrome with an atrophied pituitary gland is seen in primary neuroendocrino- pathies such as growth hormone
Page 4: PROF. DR D. F. SWAAB NEDERLANDS ... - trauma.nl · axis. Partial empty sella syndrome with an atrophied pituitary gland is seen in primary neuroendocrino- pathies such as growth hormone

Hersenletsels bij boksen • Sinds WO II: 400 boksers dood • Subduraal haematoom, hersenbloeding/ infarct • Verscheurd septum /fornix • Atrofie hersengebieden, witte stof laesies • Hypothalamus en hypofyse laesies (GH) • Reuk vermogen verminderd • Cavum septum pelucidum • chronische traumatische encephalopathie (CTE):

40-80% van de profboksers, AD, PD, ontstekingen

Page 5: PROF. DR D. F. SWAAB NEDERLANDS ... - trauma.nl · axis. Partial empty sella syndrome with an atrophied pituitary gland is seen in primary neuroendocrino- pathies such as growth hormone
Page 6: PROF. DR D. F. SWAAB NEDERLANDS ... - trauma.nl · axis. Partial empty sella syndrome with an atrophied pituitary gland is seen in primary neuroendocrino- pathies such as growth hormone

Dementia pugalistica: AD, PD nu chronische traumatische encephalopathie (CTE)

Page 7: PROF. DR D. F. SWAAB NEDERLANDS ... - trauma.nl · axis. Partial empty sella syndrome with an atrophied pituitary gland is seen in primary neuroendocrino- pathies such as growth hormone

5) Parkinson’s disease

Page 8: PROF. DR D. F. SWAAB NEDERLANDS ... - trauma.nl · axis. Partial empty sella syndrome with an atrophied pituitary gland is seen in primary neuroendocrino- pathies such as growth hormone
Page 9: PROF. DR D. F. SWAAB NEDERLANDS ... - trauma.nl · axis. Partial empty sella syndrome with an atrophied pituitary gland is seen in primary neuroendocrino- pathies such as growth hormone

NHB 2006-058 (ADLL):

Lewy bodies and Lewy neurites in s. nigra, alpha-synuclein immunostaining

Page 10: PROF. DR D. F. SWAAB NEDERLANDS ... - trauma.nl · axis. Partial empty sella syndrome with an atrophied pituitary gland is seen in primary neuroendocrino- pathies such as growth hormone
Page 11: PROF. DR D. F. SWAAB NEDERLANDS ... - trauma.nl · axis. Partial empty sella syndrome with an atrophied pituitary gland is seen in primary neuroendocrino- pathies such as growth hormone
Page 12: PROF. DR D. F. SWAAB NEDERLANDS ... - trauma.nl · axis. Partial empty sella syndrome with an atrophied pituitary gland is seen in primary neuroendocrino- pathies such as growth hormone
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[email protected]

Young APOEe4 carriers low glucose metabolism

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• Football:

• Meer AD en ALS

• ALS of Dementia pugalistica/ chronische traumatische encephalopathie (CTE)?

• Ook voetbal, hockey en worstelen zijn risicosporten

Page 16: PROF. DR D. F. SWAAB NEDERLANDS ... - trauma.nl · axis. Partial empty sella syndrome with an atrophied pituitary gland is seen in primary neuroendocrino- pathies such as growth hormone
Page 17: PROF. DR D. F. SWAAB NEDERLANDS ... - trauma.nl · axis. Partial empty sella syndrome with an atrophied pituitary gland is seen in primary neuroendocrino- pathies such as growth hormone
Page 18: PROF. DR D. F. SWAAB NEDERLANDS ... - trauma.nl · axis. Partial empty sella syndrome with an atrophied pituitary gland is seen in primary neuroendocrino- pathies such as growth hormone
Page 19: PROF. DR D. F. SWAAB NEDERLANDS ... - trauma.nl · axis. Partial empty sella syndrome with an atrophied pituitary gland is seen in primary neuroendocrino- pathies such as growth hormone
Page 20: PROF. DR D. F. SWAAB NEDERLANDS ... - trauma.nl · axis. Partial empty sella syndrome with an atrophied pituitary gland is seen in primary neuroendocrino- pathies such as growth hormone
Page 21: PROF. DR D. F. SWAAB NEDERLANDS ... - trauma.nl · axis. Partial empty sella syndrome with an atrophied pituitary gland is seen in primary neuroendocrino- pathies such as growth hormone
Page 22: PROF. DR D. F. SWAAB NEDERLANDS ... - trauma.nl · axis. Partial empty sella syndrome with an atrophied pituitary gland is seen in primary neuroendocrino- pathies such as growth hormone
Page 23: PROF. DR D. F. SWAAB NEDERLANDS ... - trauma.nl · axis. Partial empty sella syndrome with an atrophied pituitary gland is seen in primary neuroendocrino- pathies such as growth hormone
Page 24: PROF. DR D. F. SWAAB NEDERLANDS ... - trauma.nl · axis. Partial empty sella syndrome with an atrophied pituitary gland is seen in primary neuroendocrino- pathies such as growth hormone
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Hofman, M.A. (1984) A biometric analysis of brain size in microencephalics. J. Neurol., 231: 87–93.

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Page 27: PROF. DR D. F. SWAAB NEDERLANDS ... - trauma.nl · axis. Partial empty sella syndrome with an atrophied pituitary gland is seen in primary neuroendocrino- pathies such as growth hormone
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