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Promoting Adherence and Retention in ARV-based
Prevention
Dr. Seema Sahay, Ph.D
Division of Social and Behavioral Research
National AIDS Research Institute
Indian Council of Medical Research, Pune (India)
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Overview• Defining and measuring adherence• Issues around adherence
• The adherence framework– Individual, Product, Provider and Community
• Lessons learnt from treatment adherence
• Adherence in HIV prevention trials
• Known drivers of adherence
• Meeting the adherence challenges
• Addressing retention
• The CLUB message
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What is adherence?
• WHO defines adherence:• ‘The extent to which a person’s behavior – taking
medication, following a diet, and/or executing lifestyle changes – corresponds with agreed recommendations from a health care provider’ .
• Multidimensional: Interplay of participant behavior, adverse effect profiles, patient fatigue, and integration of therapy into the routine of daily living.
Adherence in HIV prevention – To take / use the drug as prescribed in order to achieve optimal drug levels at the time of exposure to virus.
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Measuring adherence
• Self-report use / recall• Direct measures
• Smart applicators• Wise Pill/Bags• Unannounced product count
• Biomarkers – drug levels• Triangulation of measures – combination of different
measures
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Issues around ARV based prevention
• How do we ensure that the drug/ product is available at the time of potential HIV exposure (when it relies on self-directed use)?
• Who would be the potential users? Key populations?
• In real life scenarios, how should PrEP products be positioned?
• How do we promote adherence to drugs/ interventions in non-therapeutic situations?
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Adherence Framework
Adherence
Individual
Product Provider
Community
Environmental Economic
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Individual
• Motivations for using the product – perception of self risk
• Time when product use might be most desirable: Example: desire to conceive
• Convenient to incorporate into lifestyle• Is the product empowering?• Relationship dynamics• Attitudes and beliefs towards the product
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Product
• Delivery vehicle• Oral – tablets• Vaginal - gels, rings, films
• Regimen• Dosing and timing• Daily vs coitally
• Product characteristics• Sticky, drippy, dry, smell, color, taste, too large to
swallow
• Potential side effects
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Provider
• Is the provider equipped with necessary information? – Training / Skills
• Is the provider community literate?• Are appropriate educational aids available?• Support of strengthened health care system• How would linkages between ARV delivery and
prevention programs be established?
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Community
• Disclosure to partner and families• For TasP: partner’s support would be useful
• Stigma / discrimination • Example: ARVs and TB drugs
• Community understanding of product • Buy-in at all levels of government / DoH is
critical • Country, province, states, district, municipality
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Lessons learnt from treatment adherence
• Buddy system – providing support• Treatment clubs – delivery of drugs to patient’s homes
and discussing experiences• Prescription and drug dispensing for longer period• Partner support • Peer involvement and community education• Empowered health educators, nurses or community
health workers• Cell phone reminders• Unannounced pill counts
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Effectiveness in PrEP trials is strongly correlated with adherence levels
0 20 40 60 80 100-60
-40
-20
0
20
40
60
80
Adherence by drug levels
Eff
ec
tiv
en
es
s (
%)
Pearson correlation = 0.86, p=0.003
Source: Prof Salim Abdool Karim, CAPRISA
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Lessons learnt from ARV prevention trials
• * Respect the individual *• Identify barriers to adherence and help the
individual come up with solutions • Product must suit the individual's lifestyle,
i.e. if sex is infrequent then a daily dose may not suit the need
• Encourage honesty – providers should not be judgemental
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Known drivers of adherence
Risk perceptionHealth seeking behavior
Followingprotcolsfor changing risk
behaviors
CommunityInvolvement
Social supportHealth caresystemAccess to health
resources
Diseasecharacteristcs
Illness-relevantcognition,
perceptions ofdisease factors, and
beliefs
Attributesof patient
Patient'senvironment
Adherence
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Risk perception: a key indicator of adherence
• Short message surveys for PrEP [K. Curran et al, 2013]
• Missed doses were correlated with sexual abstinence
• Unprotected sex was not associated with decreased PrEP adherence
• Low perception of HIV risk could explain low PrEP adherence [Van Damme et al, 2012]
• Self-perception of risk might increase PrEP use [Grant et al, 2010]
Perceived self risk would be an indicator of adherence
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Promoting adherence: challenges ahead• Individual:
• Self-perceived HIV risk: generally healthy! • Personal needs, priorities, motivations, and behavior • How do we promote adherence to drug in non-therapeutic condition?
• Products: • Unknown efficacy and incomplete safety profile• Frequency and timing of drug/product delivery• Do we have options available?
• Provider:• Are providers empowered to educate their patients?• Are providers working within a strengthened health care system?• Are there linkages between ARV delivery and prevention program?
• Community:• Addressing stigma and discrimination• Do we have buy-in at all levels of government?
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Adherence: Meet the challenge• Social science research:
• For understanding stigma• Learn about the social process that sustains stigma• Impact of stigma on health-related behavior.
• Develop and systematically test enhanced adherence counseling interventions
• Identify drivers of adherence to ARV based prevention to provide reliable explanation of variable adherence
• There is a need to leverage upon existing routines and establish client-centered relationships/ environments to support promote adherence and accurate reporting [Vitamin pills…]
• Development of products that do not depend on human behaviors: Injectable PrEP.
• Strategies to identify target population
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Retention
• Retention and adherence should go beyond individual boundaries
• Lessons from Link ART centre [LAC] program for retention might be useful
• At program level, linkages between ARV for prevention and ARV for treatment needs to be planned
• Identify individual, individual’s behavioral, family, societal and environment factors that can prevent retention in prevention program.
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CLUB Message
• Commitment to remain HIV free• Live and prevent• Understand personal challenges• Believe in yourself to adhere