Download - Results
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Presented At The Workshop On Clinical Research From HCor, São Paulo, Brasil, As Part Of The Clinical Research National Program Of The Brazilian Health Ministry (December 4, 2009)
Critical Appraisal of LiteratureEstimate of Clinical Benefits
The Roadmap for Evidence Based Clinical Practice
Suzana Alves da Silva, MD, MScCoordinator of Research & Development
Teaching and Research Center of Pró-Cardíaco
1domingo, 16 de maio de 2010
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Center for Education Research and Evaluation
CLARITY Group
Teaching and Research Center of Pró-Cardíaco
2domingo, 16 de maio de 2010
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Clinical Action DomainsTHERAPY DIAGNOSIS PROGNOSIS HARM
Ask
Acquire
Appraise
Ask
Acquire
Appraise
Ask
Acquire
Appraise
Ask
Acquire
Appraise
Apply Apply Apply Apply
The Action Domains
3domingo, 16 de maio de 2010
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4domingo, 16 de maio de 2010
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What are the most important results?
5domingo, 16 de maio de 2010
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Critical Appraisal of the Results
TherapyDiagnosisDiagnosisDiagnosis PrognosisPrognosis
HarmTherapyPerformancePerformance Utility Performance Utility
Harm
Frequency
Effect
Impact
Precision
Pre-test prob Risk
RR, OR, HR LR RR, OR, HR
RR, OR, HR
RR, OR, HR
RR, OR, HR
RR, OR, HR
RD, NNT Pos-test prob RDRD RD RD, NNH
CI CI CICI CI CI CI
6domingo, 16 de maio de 2010
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Absolute Risk at 1 yearControl Intervention
7domingo, 16 de maio de 2010
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Absolute Risk at 1 year
0
0,2
0,4
0,6
0,8
Population A Population B Population C Population D
Control Intervention
7domingo, 16 de maio de 2010
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Absolute Risk at 1 year
0
0,2
0,4
0,6
0,8
80%Population A Population B Population C Population D
Control Intervention
7domingo, 16 de maio de 2010
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Absolute Risk at 1 year
0
0,2
0,4
0,6
0,8
80% 40%Population A Population B Population C Population D
Control Intervention
7domingo, 16 de maio de 2010
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Absolute Risk at 1 year
0
0,2
0,4
0,6
0,8
80% 40% 20%
Population A Population B Population C Population D
Control Intervention
7domingo, 16 de maio de 2010
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Absolute Risk at 1 year
0
0,2
0,4
0,6
0,8
80% 40% 20% 10%
Population A Population B Population C Population D
Control Intervention
7domingo, 16 de maio de 2010
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Absolute Risk at 1 year
0
0,2
0,4
0,6
0,8
80% 40% 20% 10%60,0%
Population A Population B Population C Population D
Control Intervention
7domingo, 16 de maio de 2010
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Absolute Risk at 1 year
0
0,2
0,4
0,6
0,8
80% 40% 20% 10%60,0% 30,0%
Population A Population B Population C Population D
Control Intervention
7domingo, 16 de maio de 2010
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Absolute Risk at 1 year
0
0,2
0,4
0,6
0,8
80% 40% 20% 10%60,0% 30,0% 15,0%
Population A Population B Population C Population D
Control Intervention
7domingo, 16 de maio de 2010
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Absolute Risk at 1 year
0
0,2
0,4
0,6
0,8
80% 40% 20% 10%60,0% 30,0% 15,0% 7,5%
Population A Population B Population C Population D
Control Intervention
7domingo, 16 de maio de 2010
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Risk DifferenceControle Intervenção
Impact Measure
8domingo, 16 de maio de 2010
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Risk Difference
0
0,2
0,4
0,6
0,8
População A População B População C População D
Controle Intervenção
Impact Measure
8domingo, 16 de maio de 2010
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Risk Difference
0
0,2
0,4
0,6
0,8
80% 60,0%População A População B População C População D
Controle Intervenção
Impact Measure
8domingo, 16 de maio de 2010
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Risk Difference
0
0,2
0,4
0,6
0,8
80% 60,0%População A População B População C População D
Controle Intervenção
20%
Impact Measure
8domingo, 16 de maio de 2010
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Risk Difference
0
0,2
0,4
0,6
0,8
80% 40%60,0% 30,0%População A População B População C População D
Controle Intervenção
20%
Impact Measure
8domingo, 16 de maio de 2010
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Risk Difference
0
0,2
0,4
0,6
0,8
80% 40%60,0% 30,0%População A População B População C População D
Controle Intervenção
20%
10%
Impact Measure
8domingo, 16 de maio de 2010
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Risk Difference
0
0,2
0,4
0,6
0,8
80% 40% 20%60,0% 30,0% 15,0%
População A População B População C População D
Controle Intervenção
20%
10%
Impact Measure
8domingo, 16 de maio de 2010
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Risk Difference
0
0,2
0,4
0,6
0,8
80% 40% 20%60,0% 30,0% 15,0%
População A População B População C População D
Controle Intervenção
20%
10%
5%
Impact Measure
8domingo, 16 de maio de 2010
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Risk Difference
0
0,2
0,4
0,6
0,8
80% 40% 20% 10%60,0% 30,0% 15,0% 7,5%
População A População B População C População D
Controle Intervenção
20%
10%
5%
Impact Measure
8domingo, 16 de maio de 2010
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Risk Difference
0
0,2
0,4
0,6
0,8
80% 40% 20% 10%60,0% 30,0% 15,0% 7,5%
População A População B População C População D
Controle Intervenção
20%
10%
5% 2,5%
Impact Measure
8domingo, 16 de maio de 2010
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0
0,2
0,4
0,6
0,8
80% 40% 20% 10%60,0% 30,0% 15,0% 7,5%
População A População B População C População D
Controle Intervenção
20%
10%
5% 2,5%
Impact Measure
8domingo, 16 de maio de 2010
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Other ways to express impact measures
9domingo, 16 de maio de 2010
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Other ways to express impact measures
ARR NNT20% 100 20 5
X 1
10% 100 10 10
5% 100 5 20
2,5% 100 2,5 40
9domingo, 16 de maio de 2010
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Other ways to express impact measures
ARR NNT20% 100 20 5
X 1
10% 100 10 10
5% 100 5 20
2,5% 100 2,5 40
9domingo, 16 de maio de 2010
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Other ways to express impact measures
ARR NNT20% 100 20 5
X 1
10% 100 10 10
5% 100 5 20
2,5% 100 2,5 40
9domingo, 16 de maio de 2010
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Other ways to express impact measures
ARR NNT20% 100 20 5
X 1
10% 100 10 10
5% 100 5 20
2,5% 100 2,5 40
9domingo, 16 de maio de 2010
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Other ways to express impact measures
ARR NNT20% 100 20 5
X 1
10% 100 10 10
5% 100 5 20
2,5% 100 2,5 40
9domingo, 16 de maio de 2010
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Other ways to express impact measures
ARR NNT20% 100 20 5
X 1
10% 100 10 10
5% 100 5 20
2,5% 100 2,5 40
9domingo, 16 de maio de 2010
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Other ways to express impact measures
ARR NNT20% 100 20 5
X 1
10% 100 10 10
5% 100 5 20
2,5% 100 2,5 40
9domingo, 16 de maio de 2010
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Other ways to express impact measures
ARR NNT20% 100 20 5
X 1
10% 100 10 10
5% 100 5 20
2,5% 100 2,5 40
9domingo, 16 de maio de 2010
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Other ways to express impact measures
ARR NNT20% 100 20 5
X 1
10% 100 10 10
5% 100 5 20
2,5% 100 2,5 40
9domingo, 16 de maio de 2010
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Other ways to express impact measures
ARR NNT20% 100 20 5
X 1
10% 100 10 10
5% 100 5 20
2,5% 100 2,5 40
9domingo, 16 de maio de 2010
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Other ways to express impact measures
ARR NNT20% 100 20 5
X 1
10% 100 10 10
5% 100 5 20
2,5% 100 2,5 40
9domingo, 16 de maio de 2010
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Other ways to express impact measures
ARR NNT20% 100 20 5
X 1
10% 100 10 10
5% 100 5 20
2,5% 100 2,5 40
9domingo, 16 de maio de 2010
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Other ways to express impact measures
ARR NNT20% 100 20 5
X 1
10% 100 10 10
5% 100 5 20
2,5% 100 2,5 40
9domingo, 16 de maio de 2010
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Measures of Effect or Association
✤Relative Risk✤Odds Ratio✤Harzard Ratio
10domingo, 16 de maio de 2010
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What is Relative Risk then?
0
0,2
0,4
0,6
0,8
80% 40% 20% 10%60,0% 30,0% 15,0% 7,5%
Population A Population B Population C Population D
Control Intervention
20%
10%
5% 2,5%
11domingo, 16 de maio de 2010
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What is Relative Risk then?
0
0,2
0,4
0,6
0,8
80% 40% 20% 10%60,0% 30,0% 15,0% 7,5%
Population A Population B Population C Population D
Control Intervention
20%
10%
5% 2,5%
60 / 80 = 0,75
11domingo, 16 de maio de 2010
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What is Relative Risk then?
0
0,2
0,4
0,6
0,8
80% 40% 20% 10%60,0% 30,0% 15,0% 7,5%
Population A Population B Population C Population D
Control Intervention
20%
10%
5% 2,5%
60 / 80 = 0,75
30 / 40 = 0,75
11domingo, 16 de maio de 2010
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What is Relative Risk then?
0
0,2
0,4
0,6
0,8
80% 40% 20% 10%60,0% 30,0% 15,0% 7,5%
Population A Population B Population C Population D
Control Intervention
20%
10%
5% 2,5%
60 / 80 = 0,75
30 / 40 = 0,75
15 / 20= 0,75
11domingo, 16 de maio de 2010
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What is Relative Risk then?
0
0,2
0,4
0,6
0,8
80% 40% 20% 10%60,0% 30,0% 15,0% 7,5%
Population A Population B Population C Population D
Control Intervention
20%
10%
5% 2,5%
60 / 80 = 0,75
30 / 40 = 0,75
15 / 20= 0,75 7,5 / 10
= 0,75
11domingo, 16 de maio de 2010
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And Relative Risk Reduction?Control Intervention RR= 0,75
12domingo, 16 de maio de 2010
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And Relative Risk Reduction?
0
0,2
0,4
0,6
0,8
Population A Population B Population C Population D
Control Intervention RR= 0,75
12domingo, 16 de maio de 2010
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And Relative Risk Reduction?
0
0,2
0,4
0,6
0,8
80% 60,0%Population A Population B Population C Population D
Control Intervention RR= 0,75
12domingo, 16 de maio de 2010
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And Relative Risk Reduction?
0
0,2
0,4
0,6
0,8
80% 60,0%Population A Population B Population C Population D
Control Intervention
20 / 80
RR= 0,75
RRR = 0,25
12domingo, 16 de maio de 2010
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And Relative Risk Reduction?
0
0,2
0,4
0,6
0,8
80% 40%60,0% 30,0%Population A Population B Population C Population D
Control Intervention
20 / 80
RR= 0,75
RRR = 0,25
12domingo, 16 de maio de 2010
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And Relative Risk Reduction?
0
0,2
0,4
0,6
0,8
80% 40%60,0% 30,0%Population A Population B Population C Population D
Control Intervention
20 / 80
10 / 40
RR= 0,75
RRR = 0,25
RRR = 0,25
12domingo, 16 de maio de 2010
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And Relative Risk Reduction?
0
0,2
0,4
0,6
0,8
80% 40% 20%60,0% 30,0% 15,0%
Population A Population B Population C Population D
Control Intervention
20 / 80
10 / 40
RR= 0,75
RRR = 0,25
RRR = 0,25
12domingo, 16 de maio de 2010
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And Relative Risk Reduction?
0
0,2
0,4
0,6
0,8
80% 40% 20%60,0% 30,0% 15,0%
Population A Population B Population C Population D
Control Intervention
20 / 80
10 / 40 5 / 20
RR= 0,75
RRR = 0,25
RRR = 0,25
RRR = 0,25
12domingo, 16 de maio de 2010
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And Relative Risk Reduction?
0
0,2
0,4
0,6
0,8
80% 40% 20% 10%60,0% 30,0% 15,0% 7,5%
Population A Population B Population C Population D
Control Intervention
20 / 80
10 / 40 5 / 20
RR= 0,75
RRR = 0,25
RRR = 0,25
RRR = 0,25
12domingo, 16 de maio de 2010
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And Relative Risk Reduction?
0
0,2
0,4
0,6
0,8
80% 40% 20% 10%60,0% 30,0% 15,0% 7,5%
Population A Population B Population C Population D
Control Intervention
20 / 80
10 / 40 5 / 20
2,5 / 10RR= 0,75
RRR = 0,25
RRR = 0,25
RRR = 0,25RRR = 0,25
12domingo, 16 de maio de 2010
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And Relative Risk Reduction?
0
0,2
0,4
0,6
0,8
80% 40% 20% 10%60,0% 30,0% 15,0% 7,5%
Population A Population B Population C Population D
Control Intervention
20 / 80
10 / 40 5 / 20
2,5 / 10RR= 0,75
RRR = 0,25
RRR = 0,25
RRR = 0,25RRR = 0,25
RRR= 0,25
12domingo, 16 de maio de 2010
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And Relative Risk Reduction?
0
0,2
0,4
0,6
0,8
80% 40% 20% 10%60,0% 30,0% 15,0% 7,5%
Population A Population B Population C Population D
Control Intervention
20 / 80
10 / 40 5 / 20
2,5 / 10RR= 0,75
RRR = 0,25
RRR = 0,25
RRR = 0,25RRR = 0,25
RRR= 0,25+
12domingo, 16 de maio de 2010
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And Relative Risk Reduction?
0
0,2
0,4
0,6
0,8
80% 40% 20% 10%60,0% 30,0% 15,0% 7,5%
Population A Population B Population C Population D
Control Intervention
20 / 80
10 / 40 5 / 20
2,5 / 10RR= 0,75
RRR = 0,25
RRR = 0,25
RRR = 0,25RRR = 0,25
RRR= 0,25+ = 1
12domingo, 16 de maio de 2010
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Why the measures of association are more frequently used in Systematic Reviews?5 year mortality rate in the drug eluting stents trials: All Sirius - Sirius - Ravel
All - Sirius
Pache
Ravel
RR (95% CI) % Weight
48
19,9
32,1
1,32(0,63-2,78)
1,40(0,45-4,35)
1,72(0,75-3,95)
1,47 (0,89-241)
4,350,23
Overall 95% CI
Studies
1
Int J Epidemiol 2002;31:72-6.
13domingo, 16 de maio de 2010
![Page 62: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/62.jpg)
Measures of EffectOdds Ratio
✤What is Odds?
14domingo, 16 de maio de 2010
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Difference between Risk and Odds
15domingo, 16 de maio de 2010
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Difference between Risk and Odds
Probability of Occurring
Probability of not Occurring Odds
P 1 - P P/(1-P)
Risk of occurring the number 1:
1/6
Risk of not occurring the
number 1:
5/61/5
15domingo, 16 de maio de 2010
![Page 65: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/65.jpg)
Difference between Risk and Odds
Probability of Occurring
Probability of not Occurring Odds
P 1 - P P/(1-P)
Risk of occurring the number 1:
1/6
Risk of not occurring the
number 1:
5/61/5
15domingo, 16 de maio de 2010
![Page 66: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/66.jpg)
Difference between Risk and Odds
Probability of Occurring
Probability of not Occurring Odds
P 1 - P P/(1-P)
Risk of occurring the number 1:
1/6
Risk of not occurring the
number 1:
5/61/5
15domingo, 16 de maio de 2010
![Page 67: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/67.jpg)
Difference between Risk and Odds
Probability of Occurring
Probability of not Occurring Odds
P 1 - P P/(1-P)
Risk of occurring the number 1:
1/6
Risk of not occurring the
number 1:
5/61/5
15domingo, 16 de maio de 2010
![Page 68: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/68.jpg)
Difference between Risk and Odds
Probability of Occurring
Probability of not Occurring Odds
P 1 - P P/(1-P)
Risk of occurring the number 1:
1/6
Risk of not occurring the
number 1:
5/61/5
15domingo, 16 de maio de 2010
![Page 69: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/69.jpg)
Difference between Risk and Odds
16domingo, 16 de maio de 2010
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Risk of occurring... Risk of not occurring... Odds
P 1 - P P/(1-P)
50% 50% 1
40% 60% 0,66
30% 70% 0,43
20% 80% 0,25
10% 90% 0,11
5% 95% 0,052
Difference between Risk and Odds
16domingo, 16 de maio de 2010
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Risk of occurring... Risk of not occurring... Odds
P 1 - P P/(1-P)
50% 50% 1
40% 60% 0,66
30% 70% 0,43
20% 80% 0,25
10% 90% 0,11
5% 95% 0,052
Difference between Risk and Odds
16domingo, 16 de maio de 2010
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Risk of occurring... Risk of not occurring... Odds
P 1 - P P/(1-P)
50% 50% 1
40% 60% 0,66
30% 70% 0,43
20% 80% 0,25
10% 90% 0,11
5% 95% 0,052
Difference between Risk and Odds
16domingo, 16 de maio de 2010
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Risk of occurring... Risk of not occurring... Odds
P 1 - P P/(1-P)
50% 50% 1
40% 60% 0,66
30% 70% 0,43
20% 80% 0,25
10% 90% 0,11
5% 95% 0,052
Difference between Risk and Odds
16domingo, 16 de maio de 2010
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Risk of occurring... Risk of not occurring... Odds
P 1 - P P/(1-P)
50% 50% 1
40% 60% 0,66
30% 70% 0,43
20% 80% 0,25
10% 90% 0,11
5% 95% 0,052
Difference between Risk and Odds
16domingo, 16 de maio de 2010
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Risk of occurring... Risk of not occurring... Odds
P 1 - P P/(1-P)
50% 50% 1
40% 60% 0,66
30% 70% 0,43
20% 80% 0,25
10% 90% 0,11
5% 95% 0,052
Difference between Risk and Odds
16domingo, 16 de maio de 2010
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Risk of occurring... Risk of not occurring... Odds
P 1 - P P/(1-P)
50% 50% 1
40% 60% 0,66
30% 70% 0,43
20% 80% 0,25
10% 90% 0,11
5% 95% 0,052
Difference between Risk and Odds
16domingo, 16 de maio de 2010
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Risk of occurring... Risk of not occurring... Odds
P 1 - P P/(1-P)
50% 50% 1
40% 60% 0,66
30% 70% 0,43
20% 80% 0,25
10% 90% 0,11
5% 95% 0,052
Difference between Risk and Odds
16domingo, 16 de maio de 2010
![Page 78: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/78.jpg)
Risk of occurring... Risk of not occurring... Odds
P 1 - P P/(1-P)
50% 50% 1
40% 60% 0,66
30% 70% 0,43
20% 80% 0,25
10% 90% 0,11
5% 95% 0,052
Difference between Risk and Odds
16domingo, 16 de maio de 2010
![Page 79: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/79.jpg)
Risk of occurring... Risk of not occurring... Odds
P 1 - P P/(1-P)
50% 50% 1
40% 60% 0,66
30% 70% 0,43
20% 80% 0,25
10% 90% 0,11
5% 95% 0,052
Difference between Risk and Odds
16domingo, 16 de maio de 2010
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Risk of occurring... Risk of not occurring... Odds
P 1 - P P/(1-P)
50% 50% 1
40% 60% 0,66
30% 70% 0,43
20% 80% 0,25
10% 90% 0,11
5% 95% 0,052
Difference between Risk and Odds
16domingo, 16 de maio de 2010
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Risk of occurring... Risk of not occurring... Odds
P 1 - P P/(1-P)
50% 50% 1
40% 60% 0,66
30% 70% 0,43
20% 80% 0,25
10% 90% 0,11
5% 95% 0,052
Difference between Risk and Odds
16domingo, 16 de maio de 2010
![Page 82: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/82.jpg)
Risk of occurring... Risk of not occurring... Odds
P 1 - P P/(1-P)
50% 50% 1
40% 60% 0,66
30% 70% 0,43
20% 80% 0,25
10% 90% 0,11
5% 95% 0,052
Difference between Risk and Odds
16domingo, 16 de maio de 2010
![Page 83: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/83.jpg)
Risk of occurring... Risk of not occurring... Odds
P 1 - P P/(1-P)
50% 50% 1
40% 60% 0,66
30% 70% 0,43
20% 80% 0,25
10% 90% 0,11
5% 95% 0,052
Difference between Risk and Odds
16domingo, 16 de maio de 2010
![Page 84: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/84.jpg)
Risk of occurring... Risk of not occurring... Odds
P 1 - P P/(1-P)
50% 50% 1
40% 60% 0,66
30% 70% 0,43
20% 80% 0,25
10% 90% 0,11
5% 95% 0,052
Difference between Risk and Odds
16domingo, 16 de maio de 2010
![Page 85: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/85.jpg)
Risk of occurring... Risk of not occurring... Odds
P 1 - P P/(1-P)
50% 50% 1
40% 60% 0,66
30% 70% 0,43
20% 80% 0,25
10% 90% 0,11
5% 95% 0,052
Difference between Risk and Odds
16domingo, 16 de maio de 2010
![Page 86: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/86.jpg)
Risk of occurring... Risk of not occurring... Odds
P 1 - P P/(1-P)
50% 50% 1
40% 60% 0,66
30% 70% 0,43
20% 80% 0,25
10% 90% 0,11
5% 95% 0,052
Difference between Risk and Odds
16domingo, 16 de maio de 2010
![Page 87: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/87.jpg)
Risk of occurring... Risk of not occurring... Odds
P 1 - P P/(1-P)
50% 50% 1
40% 60% 0,66
30% 70% 0,43
20% 80% 0,25
10% 90% 0,11
5% 95% 0,052
Difference between Risk and Odds
16domingo, 16 de maio de 2010
![Page 88: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/88.jpg)
Risk of occurring... Risk of not occurring... Odds
P 1 - P P/(1-P)
50% 50% 1
40% 60% 0,66
30% 70% 0,43
20% 80% 0,25
10% 90% 0,11
5% 95% 0,052
Difference between Risk and Odds
16domingo, 16 de maio de 2010
![Page 89: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/89.jpg)
Difference between Risk and OddsRisk of occurring... Risk of not occurring... Odds
P 1 - P P/(1-P)
0,5 50% 1
0,4 60% 0,66
0,3 70% 0,43
0,2 80% 0,25
0,1 90% 0,11
0,05 95% 0,05217domingo, 16 de maio de 2010
![Page 90: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/90.jpg)
18domingo, 16 de maio de 2010
![Page 91: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/91.jpg)
Outcome +
Outcome - Risk Odds
Intervention 10 90 10% 10%/90%
Control 20 80 20% 20%/80%
RR = 0,5
OR = 0,4
18domingo, 16 de maio de 2010
![Page 92: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/92.jpg)
Outcome +
Outcome - Risk Odds
Intervention 10 90 10% 10%/90%
Control 20 80 20% 20%/80%
RR = 0,5
OR = 0,4
18domingo, 16 de maio de 2010
![Page 93: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/93.jpg)
Outcome +
Outcome - Risk Odds
Intervention 10 90 10% 10%/90%
Control 20 80 20% 20%/80%
RR = 0,5
OR = 0,4
18domingo, 16 de maio de 2010
![Page 94: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/94.jpg)
Outcome +
Outcome - Risk Odds
Intervention 10 90 10% 10%/90%
Control 20 80 20% 20%/80%
RR = 0,5
OR = 0,4
RR = RA I/C
18domingo, 16 de maio de 2010
![Page 95: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/95.jpg)
Outcome +
Outcome - Risk Odds
Intervention 10 90 10% 10%/90%
Control 20 80 20% 20%/80%
RR = 0,5
OR = 0,4
RR = RA I/C OR = Odds I/C
18domingo, 16 de maio de 2010
![Page 96: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/96.jpg)
Outcome +
Outcome - Risk Odds
Intervention 10 90 10% 10%/90%
Control 20 80 20% 20%/80%
RR = 0,5
OR = 0,4
RR = RA I/C OR = Odds I/C
18domingo, 16 de maio de 2010
![Page 97: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/97.jpg)
Measures of EffectHarzard Ratio
0
25
50
75
100100
9590
80
70
30
100
70
50
4035
30
2005 2006 2007 2008 2009 2010
Intervention Control
Surv
ival
(%
)
19domingo, 16 de maio de 2010
![Page 98: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/98.jpg)
Measures of EffectHarzard Ratio
0
25
50
75
100100
9590
80
70
30
100
70
50
4035
30
2005 2006 2007 2008 2009 2010
Intervention Control
RR = 5/30
Surv
ival
(%
)
19domingo, 16 de maio de 2010
![Page 99: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/99.jpg)
Measures of EffectHarzard Ratio
0
25
50
75
100100
9590
80
70
30
100
70
50
4035
30
2005 2006 2007 2008 2009 2010
Intervention Control
0,17
Surv
ival
(%
)
19domingo, 16 de maio de 2010
![Page 100: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/100.jpg)
Measures of EffectHarzard Ratio
0
25
50
75
100100
9590
80
70
30
100
70
50
4035
30
2005 2006 2007 2008 2009 2010
Intervention Control
RR = 10/50
0,17
Surv
ival
(%
)
19domingo, 16 de maio de 2010
![Page 101: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/101.jpg)
Measures of EffectHarzard Ratio
0
25
50
75
100100
9590
80
70
30
100
70
50
4035
30
2005 2006 2007 2008 2009 2010
Intervention Control
0,17
0,2Surv
ival
(%
)
19domingo, 16 de maio de 2010
![Page 102: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/102.jpg)
Measures of EffectHarzard Ratio
0
25
50
75
100100
9590
80
70
30
100
70
50
4035
30
2005 2006 2007 2008 2009 2010
Intervention Control
RR = 20/60
0,17
0,2Surv
ival
(%
)
19domingo, 16 de maio de 2010
![Page 103: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/103.jpg)
Measures of EffectHarzard Ratio
0
25
50
75
100100
9590
80
70
30
100
70
50
4035
30
2005 2006 2007 2008 2009 2010
Intervention Control
0,17
0,20,33
Surv
ival
(%
)
19domingo, 16 de maio de 2010
![Page 104: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/104.jpg)
Measures of EffectHarzard Ratio
0
25
50
75
100100
9590
80
70
30
100
70
50
4035
30
2005 2006 2007 2008 2009 2010
Intervention Control
RR = 30/65
0,17
0,20,33
Surv
ival
(%
)
19domingo, 16 de maio de 2010
![Page 105: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/105.jpg)
Measures of EffectHarzard Ratio
0
25
50
75
100100
9590
80
70
30
100
70
50
4035
30
2005 2006 2007 2008 2009 2010
Intervention Control
0,17
0,20,33 0,46
Surv
ival
(%
)
19domingo, 16 de maio de 2010
![Page 106: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/106.jpg)
Measures of EffectHarzard Ratio
0
25
50
75
100100
9590
80
70
30
100
70
50
4035
30
2005 2006 2007 2008 2009 2010
Intervention Control
RR = 70/70
0,17
0,20,33 0,46
Surv
ival
(%
)
19domingo, 16 de maio de 2010
![Page 107: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/107.jpg)
Measures of EffectHarzard Ratio
0
25
50
75
100100
9590
80
70
30
100
70
50
4035
30
2005 2006 2007 2008 2009 2010
Intervention Control
0,17
0,20,33 0,46 1
Surv
ival
(%
)
19domingo, 16 de maio de 2010
![Page 108: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/108.jpg)
Measures of EffectHarzard Ratio
0
25
50
75
100100
9590
80
70
30
100
70
50
4035
30
2005 2006 2007 2008 2009 2010
Intervention Control
0,17
0,20,33 0,46 1
HR ≃ Average RR ≃ 0,43
Surv
ival
(%
)
19domingo, 16 de maio de 2010
![Page 109: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/109.jpg)
Measures of PrecisionConfidence Intervals
95% dos
valores f(x)
! ! - 2" ! + 2" 0-1,96 +1,96
................
............
.........
......n re
sulta
dos
Medidas de Frequência
Medidas de Associação
Medidas de Impacto
Estimate Effect
Inferior Limit of 95% CI | | Superior Limit of 95% CI
Médias
20domingo, 16 de maio de 2010
![Page 110: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/110.jpg)
Confidence Intervals5 year mortality in the drug-eluting stents trials: All Sirius - Sirius - Ravel
All - Sirius
Pache
Ravel
RR (95% CI) % Weight
48
19,9
32,1
1,32(0,63-2,78)
1,40(0,45-4,35)
1,72(0,75-3,95)
1,47 (0,89-241)
4,350,23
Overall 95% CI
Studies
1
RR Int J Epidemiol 2002;31:72-6.
21domingo, 16 de maio de 2010
![Page 111: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/111.jpg)
Confidence Intervals5 year mortality in the drug-eluting stents trials: All Sirius - Sirius - Ravel
All - Sirius
Pache
Ravel
RR (95% CI) % Weight
48
19,9
32,1
1,32(0,63-2,78)
1,40(0,45-4,35)
1,72(0,75-3,95)
1,47 (0,89-241)
4,350,23
Overall 95% CI
Studies
1
! ! - 2" ! + 2"
RR Int J Epidemiol 2002;31:72-6.
21domingo, 16 de maio de 2010
![Page 112: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/112.jpg)
Confidence Intervals5 year mortality in the drug-eluting stents trials: All Sirius - Sirius - Ravel
All - Sirius
Pache
Ravel
RR (95% CI) % Weight
48
19,9
32,1
1,32(0,63-2,78)
1,40(0,45-4,35)
1,72(0,75-3,95)
1,47 (0,89-241)
4,350,23
Overall 95% CI
Studies
1
! ! - 2" ! + 2"
! ! - 2" ! + 2"
RR Int J Epidemiol 2002;31:72-6.
21domingo, 16 de maio de 2010
![Page 113: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/113.jpg)
Confidence Intervals5 year mortality in the drug-eluting stents trials: All Sirius - Sirius - Ravel
All - Sirius
Pache
Ravel
RR (95% CI) % Weight
48
19,9
32,1
1,32(0,63-2,78)
1,40(0,45-4,35)
1,72(0,75-3,95)
1,47 (0,89-241)
4,350,23
Overall 95% CI
Studies
1
! ! - 2" ! + 2"
! ! - 2" ! + 2"
! ! - 2" ! + 2"
RR Int J Epidemiol 2002;31:72-6.
21domingo, 16 de maio de 2010
![Page 114: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/114.jpg)
Confidence Intervals5 year mortality in the drug-eluting stents trials: All Sirius - Sirius - Ravel
All - Sirius
Pache
Ravel
RR (95% CI) % Weight
48
19,9
32,1
1,32(0,63-2,78)
1,40(0,45-4,35)
1,72(0,75-3,95)
1,47 (0,89-241)
4,350,23
Overall 95% CI
Studies
1
! ! - 2" ! + 2"
! ! - 2" ! + 2"
! ! - 2" ! + 2"
! ! - 2" ! + 2"
RR Int J Epidemiol 2002;31:72-6.
21domingo, 16 de maio de 2010
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22domingo, 16 de maio de 2010
![Page 116: Results](https://reader036.vdocuments.net/reader036/viewer/2022070503/568c37361a28ab02359ad1e5/html5/thumbnails/116.jpg)
23domingo, 16 de maio de 2010
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Thank You!
24domingo, 16 de maio de 2010