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Edinburgh Cancer Research UK Centre MRC Institute of Genetics and Molecular Medicine
www.igmm.ac.uk
Neil Carragher ([email protected])
Edinburgh Cancer Discovery Unit (ECDU) (Est.2011)
Edinburgh Phenotypic Assay Centre (E-PAC) (Est.2015)
University of Edinburgh
Returning to academia after a
career in big pharma
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Topics
1. My Career Path: (Industry to Academia to Industry to Academia)
1. Working Industry Vs Academia (personal view!)
2. Life in Industry: Examples of Day-to-day responsibility
3. Life in Academia: Examples of Day-to-day responsibility
4. A changing world in Industry and Academia
o Academic-Industry partnerships
o Academic-Academic partnerships
1. New initiatives in academic training (University of Edinburgh)
1. Tips ? & questions?
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Career Path:
Oxford (1993 -1996)
University of Washington, Seattle (1996-1999)
(Dept of Pathology: Atherosclerosis)
Beatson Institute for Cancer Research (1999-2004)
Advanced Science & Technology Lab (2004-2010)
Edinburgh Cancer Research Centre UoE (2010 - ?)
University of Aberdeen: cell & immunobiology (1992)
Glengordon Knitwear Factory, Aberdeen (pom-poms) (1992-1993)
Academia
Industry +PhD
Academia
Academia
Academia
Industry
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Industry Academia
Milestones
Timeline
Career development
Reward (bonus/promotion)
Management
Salary
Meetings
Milestones!
Timeline!
Career development
Reward?
Management
Teaching
Salary
Freedom
Continuity (staff & funding)
Meetings!
Publications!
Industry vs Academia Key words:
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Associate Principal Scientist:
AstraZeneca BAND D
1.Phenotypic Profiling: 5FTE, 1 contract, 1MSc (+4 collaborators Boston)
(+external collaborators)
2. Functional Profiling: 2FTE
(migration/invasion/angiogenesis)
3. In Vivo/Ex Vivo Imaging: 1FTE +external collaborators(1postdoc/1PhD)
(migration/invasion/angiogenesis)
-Project management (Planning/Reporting)
-Scoping, initiating and managing collaborations
-Technology Evaluation (visits, alliances with vendors/academics)
-Line Management
-PR
-Lab work
Project Management:
Day to day
Line Management: 5 FTE (matrix management)
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1.Phenotypic Profiling: 4FTE, 1 contract, 1MSc (+4 collaborators Boston)
(+external collaborators MIT)2. Functional Profiling: 2FTE
(migration/invasion/angiogenesis)
3. Drug combinations strategy: across all disease areas and all AstraZeneca sites.
Manage core matrix team of 16 FTE & 3 external collaborations (multi-million dollar budget!)
4. Cancer strategy matrix team:
-Project management (Planning/Reporting)
-Scoping, initiating and managing collaborations
-Strategy, Continuous Improvement: productivity/performance/innovation
-Technology Evaluation (visits, alliances with vendors/academics)
-Line Management
-PR
-Lots of travel and Lab work no more!
Project Management:
Day to day
Line Management: 5 FTE
Principal Scientist:
AstraZeneca BAND E
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Principal Investigator
University of Edinburgh
1. 4 major industry collaboration
2. ERC phenotypic screening projects
3. Co-applicant and supervisor in large brain cancer program
4. Co-applicant and supervisor in pro-drug/chemical biology program
-Project management (Planning/Reporting)
-Scoping, initiating and managing collaborations
-Technology Evaluation (visits, alliances with vendors/academics)
-Line Management
-PR (More publications and conference talks)
-Occasional teaching, essay marking.
-PhD studentship (second supervisor), Lab placements; Mentoring
Project Management:
Day to day
Line Management: 7 FTE (3 post doc; 3 Research assistants; 1 PhD studenship)
Start from bottom up: Laboratory space and £25,000
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Professor of Drug Discovery
University of Edinburgh
Principal Investigator responsibilities + New responsibilities:
• Head of Institute Biological Safety Committee
• Head of Institute Translation & Commercialization
• CSO Phenomics Discovery Initiative
• Director of the Edinburgh Cancer Discovery Unit
• Director of the Edinburgh Phenotypic Assay Centre
• School of Biological Sciences Research Committee
• College of Medicine/Vet Medicine Innovation Committee
Cancer Research UK:
• Small molecule expert review panel
• New Agents Committee
• Advisory panel for CRUK Centre for Drug Development
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ECDU: Western
General
College of Science &
Engineering
E-PAC: Royal infirmary
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… an opportunity for cross-disciplinary research
integrated approach
• basic biologists• geneticists• translational scientists• chemists• chemical biologists• physicists• engineers• computational biologists• mathematicians• pharmacologists• clinician scientists• phase 1 and phase 11
doctors• surgeons• pathologists• NHS consultants
‘smarter’ clinical trials
Interface between:Basic Research, Clinical research,
Health Service & Industry
better treatments
“ comprehensive translational centre” model of research and service
“filling the skills gap”
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Acknowledgements
Academic - Industry - Partnerships
Poster1015–findoutaboutjoiningPDI
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Academia PharmaIndustry
• Accesstoworld-classfacili es• Bestinclasscompoundlibrary• Needsdefinedbyindustry• Humandiseaserelevantassays• Assayssourcedfromacademia&clinic• Riskandcostsharingmodel• Wetdiligence• Accesstoprecompe vedata• Sharedconsor umdata&knowledge• Nego atedcontractandannualfee
Public–PrivatePartnershiptodevelopinnova ve,validated,
phenotypicassays
Foundingindustrialpartner
Poster1015–findoutaboutjoiningPDIhttp://npsc.ac.uk/pdi
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http://www.ed.ac.uk/medicine-vet-
medicine/research/edinburgh-scientific-academic-track
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http://www.ed.ac.uk/institute-academic-development
Proposed: Industry Academic Fellowship Scheme
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“Innovation” and “up-to-date”Embrace new approaches/technologies
Broad skill set (adaptability)
&
Hard work = Motivated
Tips:
Competitive CV:Relevant skills, Relevant work experience, Publications, References
Plan your training and your career path for your dream job:
-Look at Job description of current advertised posts-if you do not
have the skills required then seek training course/work experience
Science more fun than making pom-poms!
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ECDU/EPAC: Uni. of Edinburgh: Chemistry
John Dawson Margaret Frame, David Gray Asier Unciti-Broceta
Kenny Macleod Val Brunton Craig Fraser
Dahlia Doughty-Shenton Alan Serrels Jason Weiss
Ashraff Makda Bryan Serrels
Alison Munro Steve Pollard, Paul Brennan
Nils Lindstrom Dario Magnani
Ida Niklasson Siddharthan Chandran
Scott Warchal Duncan Sproul
Hitesh Patel Guido Sanguinetti
NPSC: Andrew Hopkins; Paul Andrews; Daniel Ebner; Denise Barrault
AcknowledgementsAcknowledgements
Centre for Drug Development
Carrick
Therapeutics, Ltd.
Paul Timpson