Download - Simulation by Design - A Healthcare Focus
© 2011 ANSYS, Inc. October 10, 20111
Simulation by Design
A healthcare focusDr. Mike Slack
ANSYS Technical Services
© 2011 ANSYS, Inc. October 10, 20112
© 2011 ANSYS, Inc. October 10, 20113
What does simulation promise?
© 2011 ANSYS, Inc. October 10, 20114
ANSYS
• ANSYS have been around for 40 years.
• Has the biggest and most diverse customer base in simulation.
• A simulation company succeeds by evolving the way our products work to meet the needs of our customers.
© 2011 ANSYS, Inc. October 10, 20115
Presentation objectives
Why simulation
–Business drivers for simulation.
–How ANSYS simulation fits a healthcare business
–How it enables virtual prototyping
–The Future
© 2011 ANSYS, Inc. October 10, 20116
But First ...
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Conservation of Mass
Conservation of Momentum
The Navier-Stokes Equation for fluid flow
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• Eqn. is complex so lets make things easier
• You can either simplify the equation or the shape of the domain.
• We discretise our domain into simple shapes - a computational mesh.
• We now need a computer to calculate how each shapeinteracts with its neighbours.
Using a computer to solve flow eqns.
control volume
CFD - ComputationalFluid Dynamics
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So now we can model a race car
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Business Drivers for simulation
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The healthcare sector
• A high value growth sector– Increased spending on Health
– Aging more active presentation – Customised patient specific treatment
• Regulatory and technological demands have seen simulation tools playing an increasingly vital role.
– Design, development and understanding of medical devices, effective drug delivery and bio processing
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The importance of Innovation
• It is critical to not only maintain but to accelerate and innovate.
• Innovation brings game changing technology.
Ipad tablet. A brand new concept. Sweeps into the market
Joseph Lister's reduced death rate from 45.7%. To 15% with the introduction of his new antiseptic treatment.
© 2011 ANSYS, Inc. October 10, 201112
Top Health Care Companies Rely on ANSYS Simulation
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Business Driver - Risk
Admired companies, known for their good products, experience trouble because a lack of product Integrity!
“The cost of getting it wrong and the value of getting in right have never been greater.”
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Innovation
“ I’m not in the business of predicting, I’m in the business of innovating. We need the tools to predict with confidence so our product is right the first time. ”
David Stanbridge, CEO at Swift Technology Group
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Accuracy
“By using an anisotropic hyperelastic material model in ANSYS Mechanical we are able to accurately predict the quality of motion of the natural and the implanted spine.
Using ANSYS software allows us to perform hundreds of design iterations in the same amount of time it would take to run a single cadaveric test.”
Jorge A. Ochoa, Ph.D., P.E., CTO - Archus Orthopedics
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Time
"The ability to evaluate different designs with CFD without building prototypes drastically reduced the amount of time needed to bring the glucose monitor to market.“
Dr. Ron Kurnik - Cygnus Therapeutic Systems
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Top Product Design Challenges
47%
41%
36%
28%
24%
0% 10% 20% 30% 40% 50%
Problems/errors found too late
Making trade-offs for cost, performance and quality
Frequent design changes
Predicitng product behavior in a real world environment
Workforce reductions / lack of technical experts
Top Product Design Challenges
Source: Aberdeen Group. April 2010
Percentage of Respondants; n=157
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The process of testing Ideas
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Co
st o
f ch
ange
Concept Design
Review
Prototype Production Operation
Its better to make mistakes early
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1990’s
History of simulation in design
Today
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Test Your Concepts
Evaluate the current
– Develop your knowledge and experience in new technology areas.
Try out your ideas
– Establish what works and understand why
– Understand the impact of scale
– Review your best concepts
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Testing and healthcare
• Why?
– Biomechanical testing is required before implanting in the human body
– Preclinical tests help protect patients from ineffective devices
– Experimental and computational models provide insight about what happens in the real system, provide focus and therefore reduce more costly tests
Simulation
PhysicalModels
AnimalExperiments
Increasing Cost
Incr
easi
ng
Bio
logi
cal
Rel
evan
ce
* Prendergrast and Maher J Mat Proc Tech (2001)
Preclinical Testing
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Have Confidence in your design
Provide evidence to back up your concept.
Communication
3D visualisation and numerical data will demonstrate and provide confidence to your internal and external customers.
Simulation provides evidence to differentiate your design.
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Range of Healthcare Applications
© 2011 ANSYS, Inc. October 10, 201127
The FCC ruled in February, 2011 that the finite element method (FEM) is a valid technique to simulate a medical device that must communicate with other similar devices.
Electromagnetic implants
E field produced by Implant Antenna
Far Field of Implant Antenna
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ANSYS Solutions for Process and manufacture
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Virtual prototyping
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Virtual prototyping
• Refine the design - establish the most sensitive parameters.
• Satisfy regulatory demands by demonstration and explanation, simulation can support and document compliance.
• Investigate the robustness of your product ensuring it achieves all of its promise.
© 2011 ANSYS, Inc. October 10, 201131
Central to Simulation Driven Product Development
• Move from a single design point solution to understanding the design space so simulation can guide design
• Design exploration answers the big questions
Single point What if?Response surface
?
??
Go Beyond the Single Design Point…
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Dyson Reinvents the Fan
• Safe device...
• Explored 10x design variations per day.
• Improved performance 250% over original design
• Continuous airflow!
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New Technology and R&D Activities
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Old Paradigms
Single Physics
Single Component Simulation by a Single Person
Idealized geometries
Few Design Points Studied
Long Pre-Clinical/Clinical Testing
New Paradigms
Multiphysics Simulation(flow, thermal, structural, electromagnetic, acoustic, etc.)
Collaborative MultidomainSimulation (component and system)
Patient-Specific Testing on Large Patient Database
Extensive Design Exploration
In Silico Testing Validated through Few (pre-)Clinical Checks
ANSYS Vision for Healthcare Industry
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Assess your design in a multiple physics environment
Power loss distribution
Radio FrequencyVibration stress
Flow and Cooling
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System Design - ANSYS Simplorer
Simulink
IcePak Simulation
ANSYS Mechanical
Maxwell
Q3DFluent
CustomModel, C
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HBM full physics
Application areas:• Coronary stents• Peripheral stents• Artificial organs
Application areas:• Orthopaedic implants• Exercise equipment
Application areas:• Transdermal• Inhalers• Oral• Intrathecal
Application areas:• Medical imaging• Cardiology products• Drug delivery
CARDIOVASCULAR DRUG DELIVERYMUSCULOSKELETAL ELECTROMAGNETICS
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Summary
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Summary
Simulation
• Do the what if’s
• Refine through virtual Prototyping
• Have confidence in your design
• Compliments regulatory approval