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Social Cognition:Mu Rhythms and Mirror Neurons
Jaime A. Pineda, Ph.D.Cognitive Neuroscience Laboratory
COGS1 class
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Research Interest
! Understanding the behavior of others
The capacity to achieve internal descriptions of actions
and use them to organize one’s own future behaviors
! Neural mechanisms for understanding actions and their intentions
! The effects on learning and social interactions
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Motivating Questions
! How do we understand the actions of others?! Rationally? ! Intuitively?
! How do we understand first- and third-person experiences?! Perspective-taking?
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Questions
! What are mirror neurons?! Can they help us understand actions
and their intentions?! Are they important for social
interactions?! How do we study mirror neurons
noninvasively?! What happens when mirroring systems
become dysfunctional?
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Classic Explanation
! Theory-Theory(argument from analogy; disembodied knowledge; visual hypothesis)
! Involves striate, extrastriate, inferotemporallobe and superior temporal sulcus, among others
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A New Perspective
! Simulation Theory(Direct-matching hypothesis; embodied knowledge)! Map visual information onto
motor representations of the same action
! Mirroring systems! bridges between perception and
action that allow for simulation ! Mirror neurons! Mu rhythms
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Mirror Neurons and Mu Rhythms
Inferior frontal gyrus
Superior temporalsulcus
Inferior parietallobule
Sensorimotorcortex normal
suppressed
Iacoboni and Dapretto, Nature Reviews, 2006,7:942-951 Visual input
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An Observation/Execution Matching System?
! A dysfunctional “mirror system” produces problems in understanding actions
Inferior frontal gyrus
Superior temporalsulcus
Sensorimotorcortex
Inferior parietallobule
Visual input
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Biological Motion
! Visual system's ability to recover object information from sparse input
! Gender! Activity engaged in! Emotional state
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Biological Motion Perception: Monkeys
! Perret and colleagues(1989; 1990; 1994)
Cells in superior temporal polysensoryarea (STPa) of the macaque temporal cortex appear sensitive to biological motion
Oram & Perrett, J. Cog. Neurosci., 1994, 6(2), 99-116
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Biological Motion Perception: Humans
! An area in the superior temporal sulcus (STS) in humans responds to biological motion
! Other areas do as well, including frontal cortex, SMA, insula, thalamus, amygdala
Grossman et al. J. Cog. Neurosci., 2000, 12(5), 711-720
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Brain Circuit for Social Perception (SP)
Allison et al., Trends in Cog. Sci., 2000, 4, 267-272
• SP is processing of information that results in the accurate analysis of the intentions of others
• STS involved in the processing of a variety of social signals
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Mirror Neurons
! Found in:! area F5 of monkey (homolog of Broca’s
area)! STSa! inferior parietal cortex (7b)
! Activated by:! Goal directed actions (reaching,
grasping, holding)! Observation of similar actions
performed by “biological” agents
! Do not respond to target alone or intransitive gestures (i.e., nonobjectdirected)
! Do not respond to mechanical movements
Di Pellegrino et al., Exp. Brain Res., 1992, 91, 176-80
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Rizzolatti et al., Cogn. Brain Res., 1996, 3:131-141
Mirror Neuron Activity
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Perception-to-Action Mapping
Action
Logically-RelatedCongruent
Perception
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Understanding Intentions
Umilta et al. Neuron, 2001, 32: 91-101
Iacoboni et al., PLoS Biol., 2005, 3(3): e79
Grasping Mimicking
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! Response facilitation! Mimicry! Simulation! Imitation learning ! Understanding actions ! Understanding
intentions! Empathy! Theory of Mind! Language
Functional Significance
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MNS Activity No MNS Activity
intentionality?anthropomorphism?
biological realism?motivational significance?
transitive/intransitive actions?
generalizability?
Characterizing the System
learning?
social relevance?
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Mu Suppression No Mu Suppression
intentionality?anthropomorphism?
biological realism?motivational significance?
transitive/intransitive actions?
generalizability?
Characterizing the System
learning?
social relevance?
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Rolandic “en arceau” rhythm(7-11 Hz)
“…blocked when the subject performs a movement or simply when he changes his postural tone.”
“…disappears when the subject identifies himself with an active person represented on the screen.”
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Mu Rhythm Characteristics
! Analog of the feline SMR (12-16 Hz)
! Maximal over sensorimotor areas
! Attenuated or blocked by movement
! Not affected by opening/closing the eyes
! Not affected by auditory/visual stimulation in the absence of movement
Kuhlman, W.N., Electroenceph. Clin. Neurophys., 1978, 44: 83-93
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Frequency Analysis of Mu Rhythm
Power
Frequency
(8-13 Hz)
(10-14 Hz)
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Pineda et al., IEEE Trans. Rehab. Engr., 2000, 8(2): 219-222
Does Mu Suppression Reflect Mirror Activity?
Baseline
Move
Observe
Imagine
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Action Observation and Social Interaction
! To what degree do mu rhythms, like mirror neurons, reflect social interaction?
Oberman et al., Social Cognitive and Affective Neuroscience, 2007, 2, 62-66
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! Measured mu power (2 min of EEG) in normals (n=20) ages 18-34 (mean=21.1, SD=3.40 ) under different observation conditions:
! Non-interacting! Social Action - Spectator ! Social Action - Interactive! Visual white noise
! Engaged in continuous performance task during observation
Experimental Paradigm
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Non-interacting Social Action - Spectator
Social Action - Interactive
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0
0.5
1
1.5
2
2.5
3
3.5
4
Non-Interacting Social Action,Spectator
Social Action,Interactive
Deg
ree
of S
ocia
l Int
erac
tion
Results
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Results
-0.4
-0.3
-0.2
-0.1
0
0.1
Social Action, InteractiveSocial Action, SpectatorNon-Interacting
C3 CZ C4
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! Are mu rhythms sensitive to processing of facial expressions?
Thurman and Pineda, in prep
Understanding Facial Expressions
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Understanding Facial Expressions
Emotion versus gender discrimination task
Disgust Anger Happy
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Results
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Results (cont.)
r = -0.5 r = -0.04
r = 0.73
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Autism: A Dysfunctional Mirror System?
! Autistic spectrum disorders are characterized by:! Impairments in social interaction! Delayed/abnormal language
development! Impaired imagination! Impaired imitation! Repetitive and restricted patterns of
behavior
! No common underlying mechanism has been identified! Deficits in imitation learning –
Rogers and Pennington, 1991
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Hypothesis
! If mu rhythms reflect MNS activity and the capacity to understand actions as well as learn through imitation, then autistics should show differences in mu rhythms compared to controls
Oberman et al., Cog. Brain Res. 2005, 24: 190-198
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Experimental Paradigm
! Measured mu power (2 min of EEG) in normals (n=12) and autistics (n=10) under different conditions:
! Self-movement of hand
! Watching video of someone moving their hand
! Watching a video of a ball moving up and down
Oberman et al., Brain Res Cogn Brain Res. 2005, 24(2):190-8.
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Results
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Creating a Temporary “Autistic” Brain
! Do sensorimotor mu rhythms reflect downstream modulation from cells in premotor cortex?
Pineda et al., in prep
RATIONALEIf mirror neurons in IFG are involved in the direct modulation of mu rhythms, then temporary inhibition of these neurons should prevent suppression of mu rhythms and cause “autistic-like” behaviors.
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Method
! Measured EEG mu power in typically developing adults (n=8) under different conditions before and after IFG stimulation
! Observation of movement (4 videos)! Simple (hand movements) and complex (social
interactions)
! Baron-Cohen’s Eyes Task! Emotion and gender discrimination
! 1 Hz rTMS (5 min at ~ 40-50% MEP threshold) targeted at left IFG
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Results
ACCURACY
0
0.2
0.4
0.6
0.8
1
1.2
ET-EMOTION ET-GENDERCONDITIONS
PER
CEN
T C
OR
REC
T
PRE
POST
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Results
IFG STIMULATION
-0.1
-0.08
-0.06
-0.04
-0.02
0
0.02
0.04
0.06
0.08
0.1
C3 C4 C3 C4
SIMPLE COMPLEXMOVEMENT TYPE
MU
SU
PPR
ESSI
ON
PRE
POST
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Reversing Autism?
! Operant conditioning of the mu rhythm (10 weeks)! HF ASD: 7-17 yr olds; n=20
! Rationale! Changes in mu rhythm dynamics
produces changes in MNS activity and in behaviors mediated by this system
! Experimental/Control groups ! Mu activity above threshold (E)! EMG activity below threshold
(E/C) Pineda et al., in prep
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Assessments
! Verification of diagnosis (IQ, ADI, ADOS)
! Quantitative EEG (QEEG)! Test of Variable Attention (TOVA)! Imitation ability (De Renzi’s
Apraxia imitation test)! Mu suppression index (MSI)! Autism Treatment Evaluation
Checklist (ATEC - parental assessment)
! Neuroimaging (fMRI, DTI, fcMRI)
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Sustained Attention
! Reduction trend in ADHD score for experimental group
ADHD SCORES FROM TOVA
-5.00
-4.60
-4.20
-3.80
-3.40
-3.00
Experimentals Controls
Z-SC
OR
ES PrePost
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Mu Suppression Index
MU SUPPRESSION INDEX
-0.1
-0.08
-0.06
-0.04
-0.02
0
0.02
0.04
0.06
HAND SOCIAL HAND SOCIAL
PRE-TRAINING POST-TRAINING
LOG
[CO
ND
ITIO
N/B
ASE
LIN
E]
CONTROLS
EXPERIMENTALS
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A Fundamental Organizational Feature of the Brain?
“Understanding others as intentional agents may be groundedin the relational nature of our interactions with the world”
! Beyond understanding actions! emotions: the root of empathy?! sounds and other senses ! language
! Other problems in “mirroring”! Aberrant imitation learning: addiction?
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What Is It Like To Be…?
Thomas Nagel, The Philosophical Review 83 (1974).
Can aspects of subjective experience be reduced to brain activity?
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Collaborators and Students
! Vilayanur Ramachandran! Lindsay Oberman! Eric Altschuler! Andrey Vankov! Bill Skinner! Chulie Ulloa! Brendan Allison! Ed Hubbard! Joe McCleery! Erin Hecht! David Brang
([email protected])! Scott Carey
! Adrienne Moore! Rajiv Rao! Chris Robinson! Hanie Elfenbein! Alex Bressler! Steven Thurman! Jena Davis! John Hestenes! Dong Suk! Christa Futagaki! Judith Kaye! Lee Edwards