Download - STK1113 Group 10 - Chemistry of Vitamin B12
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Presented by: Wong How ChuTan Shing Cheng Jacqueline Tiong Liq
Lin
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Andrew Dino Anak Najib(20658 WS47)
Diyanah Musfirah bt Jamal(20873 WS47)
Jacqueline Tiong Liq Lin(21099 WS47)
Marly Matleen Anak Augustine Agoh(21412 WS47)
Nabile binti Satibi(21643 WS50)
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Nur Amiza bt Matsah(21896 WS47)
Nurul Ikma binti Razali(22056 WS50)
Siti Kamilah bt Mohamed(22339 WS50)
Tan Shing Cheng(22501 WS47)
Wong How Chu(22635 WS50)
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Project Manager:
Jacqueline Tiong Liq Lin
Note Taker:Siti Kamilah bt Mohamed
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Explain what tetradentate and hexadentate ligands are.
Determine the shape and the coordination number for tetradentate and hexadentate
Answering questions posted by the Medical Committee
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INTRODUCTIONINTRODUCTION
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Vitamin B12 is a water soluble vitamin with a key role in the normal functioning of the brain and nervous system, especially the formation of blood.
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It is structurally the most complicated vitamin
• Vitamin B12 is a collection of cobalt and corrin ring molecules which are defined by their particular vitamin function in the body.
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Chemical structure of Vitamin B12
• Systemic IUPAC name is α-(5,6-dimethylbenzimi-dazolyl) cobomidcyanide
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Porphyrin group in the structure of Vitamin B12
The diagram shows the structure of Vitamin B12 with the porphyrin group being highlighted.
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In the structure of vitamin B12, it has a metal (Co) complexed to a tetradentate porphyrin group, nitrogen and a psedonucleotide.
The diagram above shows the structure of porphyrin.
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LIGANDSLIGANDS
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Charged or uncharged molecule, with one or more unshared pairs of electrons, that can attach to a central metallic atom or ion to form an aggregate known as a complex ion (Huheey et al., 1993)
Latin: ligare = “to bind”
In forming a complex, a ligand is said to coordinate to the metal.
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Prefix Meaning
Mono- 1
Di- or Bi- 2
Tri- 3
Prefix Meaning
Tetra- 4
Penta- 5
Hexa- 6
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A chelating agent which has four groups capable of attachment to a metal ion
Also known as quadridentate ligand
Has 4 lone pairs of electrons
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• important for the chelation of iron on hemoglobin
• a tetradentate ligand
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Hexadentate ligand is a chelating agent which has 6 groups capable of attachment to a metal ion
Also known as sexadentate ligand
Has 6 lone pairs of electrons
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Ethylenediaminetetracetic acid
Used for the removal of heavy metals from animal tissues
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The EDTA ion entirely wraps up a metal ion using all the 6 positions
Coordination number = 6, because 6 coordinate bonds are formed by the central metal ion
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Tetradentate Hexadentate
Shape Square planarTetrahedral
OctahedralTrigonal prismatic
Coordination number
4 6
Number of lone pairs of electrons 4 6
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Square planar
Tetrahedral
Octahedral
Trigonal prismatic
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ANSWERS TO ANSWERS TO QUESTIONS POSTED QUESTIONS POSTED FROM THE MEDICAL FROM THE MEDICAL
COMMITTEECOMMITTEE
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[Fe(C2O4)3]2-
Trioxalateferrate(III) ion
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K4[Fe(CN)6]
(i) Potassium hexacyanoferrate (II)
Roman numeral represents oxidation number
(ii) Potassium hexacyanoferrate (4-) Arabic numbers represents net charge
(iii) Tetrapotassium hexacyanoferrate
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(1) Leigh, G. J., ed., Nomenclature of Inorganic Chemistry (1990). IUPAC. Blackwell Scientific Publications, England. p 152 - 157.
(2) Huheey, J.E., Keiter, E.A., Keiter, R.L.(1993). Inorganic Chemistry-Principles of Structure and Reactivity. Fourth Edition. HapperCollins College Publishers, New York.
(3) Rawn, J.D., Kask, U. (1993). General Chemistry. Wm. C. Brown Communication. p 812-840.
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(4) Brown, T.L., LeMay, H.E., Jr., Bursten, B.E., Murphy, C.J. (2009) Chemistry – the Central Science. Eleventh Edition. Pearson Education, Inc., New Jersey. p 1015 – 1041.
(5) Wikipedia. Vitamin B12. Retrieved on 9 Feb 2009 from http://en.wikipedia.org/wiki/Vitamin _B12
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QUESTIONS?QUESTIONS?
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Thank you !