![Page 1: The Recurrence of Helicobacter pylori Infection: Incidence and Variables Influencing It. A Critical Review Ph.D. candidate: Tian-yi Wang Gisbert J P. The](https://reader036.vdocuments.net/reader036/viewer/2022070401/56649f205503460f94c38fda/html5/thumbnails/1.jpg)
The Recurrence of Helicobacter pylori Infection: Incidence and
Variables Influencing It. A Critical Review
Ph.D. candidate: Tian-yi Wang
Gisbert J P. The recurrence of Helicobacter pylori infection: incidence and variables influencing it. A critical review[J]. The American journal of gastroenterology, 2005, 100(9): 2083-2099.
![Page 2: The Recurrence of Helicobacter pylori Infection: Incidence and Variables Influencing It. A Critical Review Ph.D. candidate: Tian-yi Wang Gisbert J P. The](https://reader036.vdocuments.net/reader036/viewer/2022070401/56649f205503460f94c38fda/html5/thumbnails/2.jpg)
Index
2
![Page 3: The Recurrence of Helicobacter pylori Infection: Incidence and Variables Influencing It. A Critical Review Ph.D. candidate: Tian-yi Wang Gisbert J P. The](https://reader036.vdocuments.net/reader036/viewer/2022070401/56649f205503460f94c38fda/html5/thumbnails/3.jpg)
Background
3
![Page 4: The Recurrence of Helicobacter pylori Infection: Incidence and Variables Influencing It. A Critical Review Ph.D. candidate: Tian-yi Wang Gisbert J P. The](https://reader036.vdocuments.net/reader036/viewer/2022070401/56649f205503460f94c38fda/html5/thumbnails/4.jpg)
•H. pylori infection has been a worldwide health, medical, and economics problem as a chronic bacterial infection.
•The eradication of H. pylori could significantly reduce the prevalence of various gastric diseases.
Background
![Page 5: The Recurrence of Helicobacter pylori Infection: Incidence and Variables Influencing It. A Critical Review Ph.D. candidate: Tian-yi Wang Gisbert J P. The](https://reader036.vdocuments.net/reader036/viewer/2022070401/56649f205503460f94c38fda/html5/thumbnails/5.jpg)
Background
•The long-term effectiveness of H. pylori eradication programs will also depend on recurrence risk.
![Page 6: The Recurrence of Helicobacter pylori Infection: Incidence and Variables Influencing It. A Critical Review Ph.D. candidate: Tian-yi Wang Gisbert J P. The](https://reader036.vdocuments.net/reader036/viewer/2022070401/56649f205503460f94c38fda/html5/thumbnails/6.jpg)
Definitions
![Page 7: The Recurrence of Helicobacter pylori Infection: Incidence and Variables Influencing It. A Critical Review Ph.D. candidate: Tian-yi Wang Gisbert J P. The](https://reader036.vdocuments.net/reader036/viewer/2022070401/56649f205503460f94c38fda/html5/thumbnails/7.jpg)
Recurrence
Hp(+)Pretreatment
Hp(-)6-8 weeks after
treatment
Hp(+)Posttreatment( e.g. 1 year or
later)
![Page 8: The Recurrence of Helicobacter pylori Infection: Incidence and Variables Influencing It. A Critical Review Ph.D. candidate: Tian-yi Wang Gisbert J P. The](https://reader036.vdocuments.net/reader036/viewer/2022070401/56649f205503460f94c38fda/html5/thumbnails/8.jpg)
8
![Page 9: The Recurrence of Helicobacter pylori Infection: Incidence and Variables Influencing It. A Critical Review Ph.D. candidate: Tian-yi Wang Gisbert J P. The](https://reader036.vdocuments.net/reader036/viewer/2022070401/56649f205503460f94c38fda/html5/thumbnails/9.jpg)
Recrudescence
Reinfection
Treatment 6-8 weeks 1 year or later
limit of detection
limit of detection
![Page 10: The Recurrence of Helicobacter pylori Infection: Incidence and Variables Influencing It. A Critical Review Ph.D. candidate: Tian-yi Wang Gisbert J P. The](https://reader036.vdocuments.net/reader036/viewer/2022070401/56649f205503460f94c38fda/html5/thumbnails/10.jpg)
Objective
![Page 11: The Recurrence of Helicobacter pylori Infection: Incidence and Variables Influencing It. A Critical Review Ph.D. candidate: Tian-yi Wang Gisbert J P. The](https://reader036.vdocuments.net/reader036/viewer/2022070401/56649f205503460f94c38fda/html5/thumbnails/11.jpg)
Objective
•To estimate risk of H. pylori recurrence
•To examine the different variables that may influence its reappearance
![Page 12: The Recurrence of Helicobacter pylori Infection: Incidence and Variables Influencing It. A Critical Review Ph.D. candidate: Tian-yi Wang Gisbert J P. The](https://reader036.vdocuments.net/reader036/viewer/2022070401/56649f205503460f94c38fda/html5/thumbnails/12.jpg)
Methods
![Page 13: The Recurrence of Helicobacter pylori Infection: Incidence and Variables Influencing It. A Critical Review Ph.D. candidate: Tian-yi Wang Gisbert J P. The](https://reader036.vdocuments.net/reader036/viewer/2022070401/56649f205503460f94c38fda/html5/thumbnails/13.jpg)
Methods
•Bibliographical searches in MEDLINE electronic database
•Key Words “Helicobacter pylori” or “H. pylori” “recurrence” or “recurred” or
“recrudescence” or “reinfection” or “reinfection” or “reinfected”
![Page 14: The Recurrence of Helicobacter pylori Infection: Incidence and Variables Influencing It. A Critical Review Ph.D. candidate: Tian-yi Wang Gisbert J P. The](https://reader036.vdocuments.net/reader036/viewer/2022070401/56649f205503460f94c38fda/html5/thumbnails/14.jpg)
Methods
•Variables extracted ▫author, population, country, eradication
treatment, waiting time to define eradication, diagnostic methods, follow-up time of the study patients, number of reinfections per total patients.
![Page 15: The Recurrence of Helicobacter pylori Infection: Incidence and Variables Influencing It. A Critical Review Ph.D. candidate: Tian-yi Wang Gisbert J P. The](https://reader036.vdocuments.net/reader036/viewer/2022070401/56649f205503460f94c38fda/html5/thumbnails/15.jpg)
Results
![Page 16: The Recurrence of Helicobacter pylori Infection: Incidence and Variables Influencing It. A Critical Review Ph.D. candidate: Tian-yi Wang Gisbert J P. The](https://reader036.vdocuments.net/reader036/viewer/2022070401/56649f205503460f94c38fda/html5/thumbnails/16.jpg)
Results_ incidence of recurrence•117 literatures satisfy the conditions
•the recurrence rate of H. pylori infection varied from 0% to more than 50%.
•mean annual recurrence rate (per patient-year of follow up) was 4.5% (95% CI, 4.2–4.8%).
![Page 17: The Recurrence of Helicobacter pylori Infection: Incidence and Variables Influencing It. A Critical Review Ph.D. candidate: Tian-yi Wang Gisbert J P. The](https://reader036.vdocuments.net/reader036/viewer/2022070401/56649f205503460f94c38fda/html5/thumbnails/17.jpg)
Results_ incidence of recurrence•mean annual recurrence rate
▫Developed countries 3.4%▫Developing countries 8.7%
•Nevertheless, the recurrence rates are not always consistent with the prevalence of infection in some regions such as Japan and Korea.
![Page 18: The Recurrence of Helicobacter pylori Infection: Incidence and Variables Influencing It. A Critical Review Ph.D. candidate: Tian-yi Wang Gisbert J P. The](https://reader036.vdocuments.net/reader036/viewer/2022070401/56649f205503460f94c38fda/html5/thumbnails/18.jpg)
Results_ variables influencing recurrence
•The time to confirm successful treatment▫4 wk after completing treatment 4.6%▫8 wk after completing treatment 3.5%
•Efficacy of eradication treatment▫The choice of antibiotic, bismuth, proton
pump inhibitor or H2-antagonist
![Page 19: The Recurrence of Helicobacter pylori Infection: Incidence and Variables Influencing It. A Critical Review Ph.D. candidate: Tian-yi Wang Gisbert J P. The](https://reader036.vdocuments.net/reader036/viewer/2022070401/56649f205503460f94c38fda/html5/thumbnails/19.jpg)
•Diagnostic methods to check for H. pylori eradication
▫the rapid urease test, the urea breath test, gastric biopsy etc.
▫sensitivity of techniques
Results_ variables influencing recurrence
![Page 20: The Recurrence of Helicobacter pylori Infection: Incidence and Variables Influencing It. A Critical Review Ph.D. candidate: Tian-yi Wang Gisbert J P. The](https://reader036.vdocuments.net/reader036/viewer/2022070401/56649f205503460f94c38fda/html5/thumbnails/20.jpg)
•Cut-off point for the urea breath test ▫the value of the breath test after treatment
for patients suffering a recurrence is higher.
▫Selection of a lower cut-off value may be helpful to maintain the diagnostic accuracy.
Results_ variables influencing recurrence
![Page 21: The Recurrence of Helicobacter pylori Infection: Incidence and Variables Influencing It. A Critical Review Ph.D. candidate: Tian-yi Wang Gisbert J P. The](https://reader036.vdocuments.net/reader036/viewer/2022070401/56649f205503460f94c38fda/html5/thumbnails/21.jpg)
Results_ variables influencing recurrence
• Infection status of Family members and partners
▫intrafamilial clustering▫children are important in the transmission▫But the patient’s partner may not act as a
reservoir for the reinfection.
![Page 22: The Recurrence of Helicobacter pylori Infection: Incidence and Variables Influencing It. A Critical Review Ph.D. candidate: Tian-yi Wang Gisbert J P. The](https://reader036.vdocuments.net/reader036/viewer/2022070401/56649f205503460f94c38fda/html5/thumbnails/22.jpg)
Conclusion
![Page 23: The Recurrence of Helicobacter pylori Infection: Incidence and Variables Influencing It. A Critical Review Ph.D. candidate: Tian-yi Wang Gisbert J P. The](https://reader036.vdocuments.net/reader036/viewer/2022070401/56649f205503460f94c38fda/html5/thumbnails/23.jpg)
Conclusion
• mean annual recurrence rate was 4.5% globally.
• Annual recurrence rate in developed countries is lower than that in developing countries.
• The time to confirm successful treatment, efficacy of eradication treatment, diagnostic methods, cut-off point for the urea breath test are all variables influencing recurrence.
![Page 24: The Recurrence of Helicobacter pylori Infection: Incidence and Variables Influencing It. A Critical Review Ph.D. candidate: Tian-yi Wang Gisbert J P. The](https://reader036.vdocuments.net/reader036/viewer/2022070401/56649f205503460f94c38fda/html5/thumbnails/24.jpg)
Thank you !
24