THROXINE (T4) AND TRIIODOTHYRONINE (T3)
Presentation by:
Sofia Vitale
Francesca Canepa
Alexandra Aguero
Sarah Morin
W H E R E I S T H E H O R M O N E P R O D U C E D ?
Thyroid hormone is a metabolic hormone secreted by the thyroid
gland. There are two types of thyroid hormones, thyroxine (T4),
and triiodothyronine (T3).
W H A T A R E T H E T A R G E T O R G A N S / S T R U C T U R E S O F T 3 A N D T 4 ?
T3 and T4 affect every cell and all the organs of the body. Too
much of either of these speeds things up and too little of these
slows things down.
H O W I S T H E S E C R E T I O N O F T H E H O R M O N E R E G U L AT E D / C O N T R O L L E D ?
Too much of TSH result in increased thyroid hormone synthesis and
release into the blood stream, and too little of TSH result in decreased
synthesis and that releases into the blood stream. The amount of TSH
secreted is controlled by the thyroid-releasing hormone, which is
produced by an organ called the hypothalamus. When the amount of
thyroid hormones in the blood reaches a certain level, the hypothalamus
stops secreting thyroid-releasing hormone. This stops the secretion of
TSH, which stops the secretion of T3 and T4.
W H AT I S T H E N O R M A L F U N C T I O N O F T H E H O R M O N E ?
The function for both T4 and T3 would be to regulate Metabolism.
The hormone are basically are specialized substances that
coordinate the activities of specific cells in certain areas of the
body. The hormone are produced by cells in glands, which they’re
secreted by the gland into the bloodstream. After that, the
bloodstream then transports the hormone to certain tissues, where
the hormone has its effect.
H O W D O E S T H E H O R M O N E C O N T R I B U T E T O H O M E O S TA S I S ?
The hormone alter the metabolism of target organs by increasing or
decreasing their activity. Changes in activity are strictly balanced
to maintain homeostasis.
W H AT A R E T H E C A U S E S A N D S Y M P T O M S O F H Y P O S E C R E T I O N O F T H E H O R M O N E
( O R R E C E P T O R B L O C K A G E ) ?
Hyposecretion of ADH is called the syndrome of inappropriate
antidiuretic hormone. This can cause the symptoms retention of
fluid, headache, disorientation, weight gain and also blood
concentration goes down. Hyposecretion of ADH is diabetes
insipidus, which can cause an increase in urine output and
excessive thirst.
W H AT A R E T H E T R E AT M E N T S F O R U N D E R O R O V E R A C T I VAT I O N O F T H E
H O R M O N E PAT H WAY
Hypersecretion are used to treat the underlying causes when
possible, monitor fluid intake, and for very symptomatic patients,
get hypertonic saline.
Hyposecretion are treated with a synthetic hormone called
desmopressin.
H O W, I F AT A L L , I S T H E H O R M O N E U S E D C L I N I C A L O R C O M M E R C I A L LY
ADH is neither used clinically or commercially. ADH is actually a
naturally produced hormone.
RESOURCES
http://emedicine.medscape.com/
http://www.yourhormones.info/
http://www.unomaha.edu/hpa/abnormal.html
http://
www.rightdiagnosis.com/sym/hypersecretion_of_gro
wth_hormone.htm
http://www.dummies.com/how-to/content/general-f
unctions-of-hormones-in-living-creatures.html