Download - Tuberculin test aman maurya
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TUBERCULIN TEST
AMAN MAURYA
ROLL NO.-10
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INTRODUCTION• HISTORY• ROBERT KOCH PREPARED A PROTEIN
EXTRACT OF TUBERCLE BACILLUS BY
CONCENTRATING TENFOLD BY EVAPORATION
, A 6-8 WEEK CULTURE FILTRATE OF THE
BACILLUS GROWN IN 5% GLYCEROL BROTH.
THIS WAS CALLED “ORIGINAL” OR “OLD
TUBERCULIN”
• FIRST USED FOR ALLERGING TESTING BY
VON PIRQUET (1906)
ROBERT KOCH
VON PIRQUET
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PRINCIPLE
• RESPONSES
ANTITUBERCULAR IMMUNITY
TUBERCULIN HYPERSENSTIVITY
BOTH RESPONSES MEDIATED BY T-
LYMPHOCYTE SENSITISED TO THE
BACTERIAL ANTIGEN .
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REAGENTS
• OLD TUBERCULIN (OT)
• ROBERT KOCH
• 6-8 WEEK CULTURE
• CONCENTRATED BY EVAPORATION ON A
HEATED WATER BATH.
• NOW RARELY USED
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REAGENTS PURIFIED PROTEIN DERIVATIVE (PPD)
SEIBERT (1941)
Prepared by M.tuberculosis In semisynthetic
medium
1 TU = 0.01 ml of OT
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MANTOUX Test-
0.1 ml of PPD is injected intradermally
into flexor aspect of forearm.
METHOD
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METHODHEAF Test-
• multiple puncture apparatus
• A drop of undiluted PPD is spread on the
area of skin
• The apparatus is pressed against this
area of skin.
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RESULT
In MANTOUX test the site of injection is
examined after 48-72 hrs
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RESULT
Positive test-
local oedema- 10 mm diameter
confirms past infection
helpful in children under 5 years
indicate active infection
becomes positive 4-6 weeks after
infection or BCG vaccination.
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FALSE negative
Miliary tuberculosis
Infection of measles
Hodgkin”s disease
Sarcoidosis
Lepromatous leprosy
Malnutrition
Administration of immunosuppressive
agents and corticosteroids
RESULT
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RESULT
FALSE positive
atypical mycobacteria
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USES To measure prevalence of infection in a
community
To diagnose active infection in young
children
It is used as an indicator of successful
BCG vaccination
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