Download - Vitamin d presentation
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Vitamin DSpikes in testing and miracle cures
PFC Eaker
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What is Vitamin D?
• Fat Soluble Vitamin• Found in food• Absorbed through sunlight exposure• Converted to hormone form through liver and
kidney
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Two Major Forms of Vitamin D
• Vitamin D2, ergocalciferol
• Vitamin D3, cholecalciferol
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Other Forms of Vitamin D
• Vitamin D1: molecular compound of ergocalciferol with lumisterol, 1:1
• Vitamin D4: 22-dihydroergocalciferol
• Vitamin D5: sitocalciferol (made from 7-dehydrosisterol)
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What are the sources?
• Cod Liver Oil, 1 Tbs: 1,360 IU• Salmon, cooked, 3 1/2 oz: 360 IU• Mackerel, cooked, 3 1/2 oz: 345 IU• Sardines, canned in oil, drained, 3 1/2 oz: 270 IU• Milk, nonfat, reduced fat, and whole, vitamin D fortified, 1 c: 98
IU• Margarine, fortified, 1 Tbs: 60 IU• Pudding, 1/2 c prepared from mix and made with vitamin D
fortified milk: 50 IU• Dry cereal, Vitamin D fortified w/10% of the recommended
daily value, 3/4 c: 40-50 IU (other cereals may be fortified with more or less vitamin D)
• Liver, beef, cooked, 3 1/2 oz: 30 IU• Egg, 1 whole (vitamin D is present in the yolk): 25 IU
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Exposure to sunlight
• Important source of vitamin D• Season, latitude, time of day
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What does Vitamin D do?
• Maintain normal blood levels of Calcium and Phosphorus
• Aids in absorption of calcium• Promotes bone mineralization• Prevents rickets in children and Osteomalacia in
adults
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Role in immunomodulation
• Binds to nuclear Vitamin D receptors (VDR)• Immune enhancing and immunosuppressive
effects• Increase activity of NKCs• Increased production of cathelicidin• Therepeutic Clinical Applications
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How much Vitamin D do we need?
• Ages 19-50: 200 International Units (IU)• Ages 51-69: 400 IU• Age 70 and older: 600 IU
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When can vitamin D deficiency occur?
• Rickets• Osteomalacia
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Rickets/Osteomalacia
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Who may need extra vitamin D to prevent a deficiency?
• Older Americans (greater than age 50) • individuals with limited sun exposure • occupations that prevent exposure to sunlight • reduced ability to absorb dietary fat • exclusively breast-fed infants
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What is the health risk of too much vitamin D?
• nausea • vomiting • poor appetite • constipation • weakness • weight loss
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When is it ordered?
• 25 OH Vitamin D test • 1,25 di OH Vitamin D test
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Testing
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What does the test result mean?
• 25 OH Vitamin D test
Low blood levels = not getting enough exposure
to sunlight
problem with absorption from the intestines
High levels = supplementation from vitamin pills
or other nutritional supplements
• 1,25 di OH Vitamin D test
Low levels = kidney disease
one of the earliest changes to occur in persons
with early kidney failure.
High levels = excess parathryoid hormone
diseases such as sarcoidosis or some lymphomas, that can make 1,25 di OH Vitamin D outside of the kidneys
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Spike in Vitamin D testing
• ABC NEWS - NEW YORK, NY, USA
“Sunshine Vitamin May Cut Death Risk”• BBC NEWS - UNITED KINGDOM
“Pain Linked With Low Vitamin D”• BLOOMBERG.COM
“Death May Be Nearer For People Who lack
Vitamin D”• BRITTANIA RADIO
“Vitamin D Can Heal Tuberculosis?”
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Current Research
• Cancers• Heart Disease • Stroke• Diabetes• Depression• Muscle Weakness• Birth Defects• Obesity
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Role in cancer prevention and recovery
• Calcitriol – Induces
death of cancer cells
• Regulates Cell growth,
Differentiation etc.
• Daily intake of 1,000IU/day
reduces risks
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Vitamin D and Obesity
• Seasons• Altitude• Calcium• Link between other
diseases• Treatable
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Vitamin D and Diabetes
• Low serum levels at greater risk• Lack of Vitamin D interferes with insulin secretion
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Vitamin D and depression
• SAD• 130 patients• 600 or 4,000 IU supplements• Re-evaluated 1 year later
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Conclusion
• Vitamin D – The wonder drug?• LabCorp – Testing volume doubled every ear for
the past four years• Quest Diagnostics – Testing volume tripled
between May 2006 and May 2008
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Questions?