Download - Y. Pestis
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YERSINIA PESTISFormerly Pasteurella pestis
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What is Yersinia pestis?
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GOOD QUESTION!
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This
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End of slideshow, click to exit
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• Gram negative
• Coccobacillus
• Obligate intracellular pathogen
• Fermentative
• A facultative anaerobe
• Non-motile inside of host but motile when isolated. (different!)
It is
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NOT SO INTERESTING BUT FUNDATORY HISTORY
Yersinia pestis was discovered in Hong Kong in 1894 by a Swiss physician
Alexandre Yersin during the Chinese epidemic of plague!
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Y. Pestis interacts with mostly rodents and fleas.
This is how it is able to invade humans and create
Diseases
Bubonic PlaguePneumonic Plague
Y. Pestis inside flea
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• Sudden high fever
• Swelling of lymph glands
• Chills
• “General Discomfort”
• Muscular pain
• Headaches
• Seizures
Symptoms of Bubonic PLague
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SYMPTOMS OF Pneumonic Plague
• Trouble Breathing• Chest pain• Cough• Fever• Headache• General Weakness• Bloody saliva and mucus
Y. Pesits
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INFECTION CYCLE
Flea feeding off blood
Blood meal
Direct Contact
Resevoir
Vector
Victim
Techinally True, if you eat mice.
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IN ITS PNEUMONIC FORM,
Human – human transmission
Cough/sneeze
INFECTEDMAN
HEALTHY MAN
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Fun overviewBUBONIC PLAGUE
Entry (inflected flea bite)
Spread (Lymphatic & systemic)
Disease
Exit (highly contagious)
PNEUMONIC PLAGUE
Exit (airborne)
Disease
Entry (airborne)
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HOW TO NOT GET INFECTED• Don’t touch dead rodents
• Don’t eat/roll around in live rodents
• COOK your meat correctly
• Use bug repellent for fleas with DEET or permethrin
• Treat pets for fleas
• Wear long sleeves
• Give money to vaccine researchers BECAUSE THERE ISNT a vaccine YET
• Avoid the sick
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BIOLOGICAL WARFARE
•1347- Plague victims catapulted by mongols.
1940- Japanese plane releasing rice and rat fleas containing Y. pestis
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You guys didn’t read the article
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ProteaseNo
Protease
Fas-FasL Signalli
ng
Caspase-3
Mutant Wild Type
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WORKS CITED
Caulfield, A., Walker, M., Gielda, L., Lathem, W. (2014) The Pla Protease of Yersinia pestis Degrades Fas Ligand to Manipulate
Host Cell Death and Inflammation. Cell Host and Microbe 15(4) (424-434)"Plague." Centers for Disease Control and Prevention. Centers for
Disease Control and Prevention, 28 Nov. 2012. Web. 14 July 2014.
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•ANY QUESTIONS?