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PUB L I C A T I O NS – Dr Dinah Parums Books: Parums, D .V . (Editor). Essential Clinical Pathology. Blackwell Science Ltd. Oxford. 1996. ISBN 0-632-03088-7. This is a 700 page book containing 500 full colour figures. It represents a complete clinical pathology (laboratory medicine) !core& course text,ook for medical students5 ,ased on the Editor&s teachin8 experience running the Oxford clinical pathology teaching over 3 years. One third of this book is written by the Editor with contributions in Haematology, Biochemistry, Immunology and Microbiology from 14 other authors. http://www.amazon.com/Essential-Clinical-Pathology-Series/dp/0865427518 http://www.fishpond.co.uk/Books/Essential-Clinical-Pathology-Dr-Dinah-Parums-Edited-by/9780632030880 http://www.alibris.co.uk/search/books/author/Dr.-Dinah-Parums http://books.google.co.uk/books?id=I7HLrkJz2XgC&pg=PA6&lpg=PA6&dq=dr+dinah+parums&source=bl&ots=1S8VIs8WFn&sig=YWkVqtr8TSnHa_McGLmaAw4eqXA&hl=en&sa=X&ei=FiACUvPmN6Tm7Aas1IGIDw&ved=0CDAQ6AEwBg#v=onepage&q=dr%20dinah%20parums&f=false Peer Reviewed C linical and Research Papers: Donovan MJ, Kotsianti A, Bayer-Zubek V, Verbel D, Teverovskiy M, Cordon-Cardo C, Costa J, Greco FA, Hainsworth JD, Parums D V . A systems pathology model for predicting overall survival in patients with refractory, advanced non-small-cell lung cancer treated with gefitinib. Eur J Cancer. 2009 May;45(8):1518-26.

http://www.ncbi.nlm.nih.gov/pubmed/19272767 Hirsch FR, Dziadziuszko R, Thatcher N, Mann H, Watkins C, Parums D V , Speake G, Holloway B, Bunn Jr PA, Franklin WA. Epidermal Growth Factor Receptor Immunohistochemistry: Comparison of Antibodies and Cut-off Points to Predict Benefit from Gefitinib in a Phase III Placebo-Controlled Study in Advanced Non-Small Cell Lung Cancer. Cancer, 2008, 112(5):1114-21. http://www.ncbi.nlm.nih.gov/pubmed/18219661 and http://onlinelibrary.wiley.com/doi/10.1002/cncr.23282/abstract Hirsch FR, Varella-Garcia M, Bunn PA Jr, Franklin WA, Dziadziuszko R, Thatcher N, Chang A, Parikh P, Pereira JR, Ciuleanu T, von Pawel J, Watkins C, Flannery A, Ellison G, Donald E, Knight L, Parums D , Botwood N, Holloway B. Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non-small-cell lung cancer. J Clin Oncol. 2006 Nov 1;24(31):5034-42. http://www.ncbi.nlm.nih.gov/pubmed/17075123

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Wookey, A, Ellison, G, Donald, E, McCormick, R, Smith, J, Parums, D, Flannery, A, Gibson, N, March, R. Genetic Heterogeneity of Tumours and implications for Epidermal Growth Factor Receptor Mutation Detection in Non Small Cell Lung Cancer Patients. Abstract and Poster 3390. AACR, April 2005. http://www.abstractsonline.com/viewer/viewAbstract.asp?CKey={B74B45DA-99A5-4496-A2EA-8A525AD0A1C3}&MKey={218FF7E7-9F17-4030-9BB4-8C029B0C9B4E}&AKey={728BCE9C-121B-46B9-A8EE-DC51FDFC6C15}&SKey={7CE4DF10-EEC9-4132-B659-5BBF3C75C385} Lindop, G.B.M., Burke, M.M., Ogston, S., Bishop, P., Corbishley, C., Goddard, M., Harrison, R., Kjellstrom, C., McPhaden, A., Malone, M., Parums, D., Suvarna, K., Stewart, S. Inter-observer variability in grading acute rejection in endomyocardial biopsies. J Heart and Lung Transplantation 2003; Supp v22 n1 S96. http://www.worldcat.org/title/inter-observer-variability-in-grading-acute-rejection-in-endomyocardial-biopsies/oclc/4933925381&referer=brief_results Torsney E, Charlton R, Parums D V , Collis M, Arthur HM. Inducible expression of human endoglin during inflammation and wound healing in vivo. Inflamm Res 2002;51:464-70. http://www.ncbi.nlm.nih.gov/pubmed/12365720 Katz, S.D., Parums, D .V . Sympathetic activation by sildenafil. Circulation 2001;104:119-200. http://www.ncbi.nlm.nih.gov/pubmed/11723034 Ray-Chaudhuri N, Kine DA, Tijani SO, Parums D V , Cartlidge N, Strong NP, Dayan MR. Effect of prior steroid treatment on temporal artery biopsy findings in giant cell arteritis. Br J Ophthalmol. 2002;86:530-2. http://www.ncbi.nlm.nih.gov/pubmed/11973248 Luckraz H, Parums D V , Dunning J. Reverse saphenous interposition vein graft repair of a giant atherosclerotic aneurysm of the left anterior descending coronary artery. J Thorac Cardiovasc Surg 2002;123:817-20. http://www.ncbi.nlm.nih.gov/pubmed/11986613 De Soyza, A.G., Dark, J.H., Parums, D .V ., Curtis, A., Corris, P.A. Donor-acquired small cell lung cancer following pulmonary transplantation. Chest 2001;120:1030-1. http://publications.chestnet.org/data/Journals/CHEST/21966/1027.pdf Katz, S.D., Parums, D .V . Sympathetic activation by sildenafil. Circulation 2001;104:119-200. http://circ.ahajournals.org/content/104/22/e119.full Arthur, H., Torsney, E., Ure, J., Smith, A., Wilson, D., Charlton, R.G., Parums, D .V ., Jowett, T., Burn, J., Diamond, A. Endoglin, a ancillary TGF Beta Receptor, is Required for Extraembryonic Angiogenesis and Plays a Key Role in Heart Development. Developmental Biology 2000;217:42-53. http://www.ncbi.nlm.nih.gov/pubmed/10625534

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Pagano, D., Townend, J.N., Parums, D .V ., Bonser, R.S., Camici, P.G. Hibernating Myocardium: Morphological Correlates of Inotropic Stimulation and Glucose Uptake. Heart 2000;83:456-461. http://www.ncbi.nlm.nih.gov/pubmed/10722551 Kumar, R.P.Smith, D.A., Hilton, C.J. and Parums, D .V . A Case of Epithelioid Haemangioendothelioma (EHE) of the Lung with Bronchial Brushing Cytology. Cytopathology 1999;10:132-6. http://www.ncbi.nlm.nih.gov/pubmed/10211620 and http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2303.1999.00111.x/abstract Crilley, J.G., Owens, W.A., Parums, D .V . A Dissection with a Difference: An Unusual Case of Ascending Aortic Dissection Secondary to Granulomatous Aortitis. Hosp Med 1998;59:892-3. http://www.ncbi.nlm.nih.gov/pubmed/10197126 Parums, D .V . :n;ited Commentary> ?@istiocytosis ABC Thorax 1998;53:322-323. http://link.springer.com/chapter/10.1007%2F978-1-4615-1959-1_21 and http://www.ncbi.nlm.nih.gov/pubmed/9741379 Gorog, D.A., Rakhit, R., Parums, D .V ., Laffan, M., Davies, G.J. Raised Factor VIII is Associated with Coronary Thrombotic Events. Heart 1998;80:415-7. http://www.ncbi.nlm.nih.gov/pubmed/9875127 Marchbank, A.J., Parums, D .V ., Westaby, S. Tricuspid Valve Repair in a Mountaineer. Ann Thorac Surg 1998;65:537-9. http://www.ncbi.nlm.nih.gov/pubmed/9485262 Leonard A, Corris P, Parums, D .V . Amiodarone pulmonary toxicity. BMJ 1997;314:1831-1832. http://www.ncbi.nlm.nih.gov/pubmed/9224103 Walton, L.J., Powell, J.T., Parums, D .V . Unrestricted Usage of Immunoglobulin Heavy Chain Genes in B Cells Infiltrating the Wall of Atherosclerotic Abdominal Aortic Aneurysms. Atherosclerosis 1997 135: 65-71. http://www.ncbi.nlm.nih.gov/pubmed/9395274 Douek, M., Kitson, J.L., Parums, D.V., Coombs, R.R.H. The value of modern imaging in the diagnosis of foot swellings. The Foot 1996;6:152-157. http://www.worldcat.org/title/the-value-of-modern-imaging-techniques-in-the-diagnosis-of-foot-swellings/oclc/4933650049&referer=brief_results Buttery, L.D.K., Springall, D.R., Chester, A.H., Evans T.J., Standfield, N, Parums, D .V ., Yacoub, M.H., Polak, J.M. Inducible Nitric Oxide Synthase is Present within Human Atherosclerotic Lesions and Promotes the Formation and Activity of Peroxynitrite. Lab Invest 1996;75:77-85. http://www.ncbi.nlm.nih.gov/pubmed/8683942

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Kennedy, P., Parry, A.J., Parums, D .V ., Pillai, R. Myxoma of the aortic valve. Ann Thorac Surg. 1995; 59: 1221-3. http://www.ncbi.nlm.nih.gov/pubmed/7733728 Ramshaw, A.L., Roskell, D.E., Parums, D .V . Cytokine gene expression in aortic adventitial inflammation associated with advanced atherosclerosis (chronic periaortitis). J Clin Pathol 1994;47: 721-727. http://www.ncbi.nlm.nih.gov/pubmed/7962625 Parums, D .V . Invited review; the arteritides. Histopathology 1994;25:1-20. http://www.ncbi.nlm.nih.gov/pubmed/7959641 Potter, C.G., Ramshaw, A.L., Stickland, J.E., Parums, D .V ., McGee, J.O'D. Quantification of specific mRNA by flat-bed scintillation counting of dual-labelled dot blots. Biotechniques 1993;15:738-43. http://www.ncbi.nlm.nih.gov/pubmed/8251177 Wood, K.M., Cadogan, M.D., Ramshaw, A.L., Parums, D .V . The distribution of adhesion molecules in human atherosclerosis. Histopathology 1993;22: 437-444. http://www.ncbi.nlm.nih.gov/pubmed/7688340 Ramshaw, A.L., Parums, D .V . The distribution of adhesion molecules in chronic periaortitis. Histopathology 1994;24:23-32. http://www.ncbi.nlm.nih.gov/pubmed/7511559 Paul, J., Baigrie, C., Parums, D .V . A fatal case of disseminated infection with the turtle bacillus, Mycobacterium chelonae. J.Clin Pathol 1992;45:528-530. http://www.ncbi.nlm.nih.gov/pubmed/1624602 Davies, A.H., Parums, D .V . Storage of donor long saphenous vein for coronary artery bypass surgery. J Cardiovascular Surgery 1992;33:92-97. http://www.ncbi.nlm.nih.gov/pubmed/1545005 Ramshaw, A.L., Parums, D . V . Combined immunohistochemical and immunofluorescence method to determine the phenotype of proliferating cell populations. J Clin Pathol 1992;45:1015-1017. http://www.ncbi.nlm.nih.gov/pubmed/1485903 Parums, D .V ., Choudhury, R.P., Shields, S.A., Davies, A.H. Characterization of inflammatory cells associated with "idiopathic retroperitoneal fibrosis". Br J Urol 1991;67:564-568. http://www.ncbi.nlm.nih.gov/pubmed/2070198 McKee, G., Parums D . V . False positive cytodiagnosis in fibrosing alveolitis. Acta Cytologica 1990;34:105 107. http://www.ncbi.nlm.nih.gov/pubmed/2296835

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Cawthorn, S.J., Parums, D .V ., Gibbs, N.M., A'Hern, R.P., Caffarey, S.M., Broughton, C.I.M., Marks C.G. Extent of mesorectal spread and involvement of lateral resection margin as prognostic factors after surgery for rectal carcinoma. Lancet 1990;335:1055-1059. http://www.ncbi.nlm.nih.gov/pubmed/1691810\ Parums, D .V ., Dunn, D.C, Dixon, A.K, Mitchinson, M.J. Characterization of inflammatory cells in a patient with chronic periaortitis. Am J Cardiovascular Pathol 1990;3:121-129. http://www.ncbi.nlm.nih.gov/pubmed/2264985 Parums, D . V . Inflammatory mediators and atherosclerosis. Biochem Soc Trans 1990;18:1069-1072. http://www.biochemsoctrans.org/bst/018/bst0181069.htm and http://www.ncbi.nlm.nih.gov/pubmed/2088809 Parums, D . V ., Brown, D.L., Mitchinson, M.J. Serum antibodies to oxidized LDL and ceroid in chronic periaortitis. Arch Pathol Lab Med 1990;114:383-387. http://www.ncbi.nlm.nih.gov/pubmed/2322097 Parums, D .V . The spectrum of chronic periaortitis. Histopathology 1990;16:423-431. http://www.ncbi.nlm.nih.gov/pubmed/2193863 Ramshaw, A.L., Parums, D . V . Immunohistochemical characterization of inflammatory cells associated with advanced atherosclerosis. Histopathology 1990;17:543-552. http://www.ncbi.nlm.nih.gov/pubmed/2076887 Parums, D .V ., Cordell, J.L., Micklem, K., Heryet, A.R., Gatter, K.C., Mason, D.Y. JC70 : A new monoclonal antibody that detects vascular endothelium-associated antigen on routinely processed tissue sections. J Clin Pathol 1990;43:752-757. http://www.ncbi.nlm.nih.gov/pubmed/2212067 Parums, D .V . Studies on Inflammation in Atherosclerosis. PhD thesis, University of Cambridge, 1987. http://ulmss-newton.lib.cam.ac.uk/vwebv/holdingsInfo?bibId=12418 Parums, D . V ., Chadwick, D.R., Mitchinson, M.J. The localisation of immunoglobulin in chronic periaortitis. Atherosclerosis 1986;61:117-123. http://www.sciencedirect.com/science/article/pii/0021915086900705 and www.ncbi.nlm.nih.gov/pubmed/3530262 Parums, D . V ., Mitchinson, M.J. Demonstration of immunoglobulin in the neighbourhood of advanced atherosclerotic plaques. Atherosclerosis 1981;38:211-216. http://www.ncbi.nlm.nih.gov/pubmed/7470201

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Patents: 1) Inventors: Parums; Dinah (Cambridge, GB); Phillips; Stephen Charles (Kent, GB); Ridden; John (Kent, GB) Assignee: Pfizer Inc. (New York, NY); Application No. 894743; Filed: June 28, 2001 Abstract The present invention relates to an isolated target sequence. The target sequence is a splice variant of PDE5 called a PDE5a1, a component of which is presented as SEQ ID No 1. The identified target sequence of the present invention may be used to as a target to identify agents (such as modulators) useful in the prevention and/or treatment of a disease associated with scarring and/or fibrosis or to selectively identify smooth muscle cells and myofibroblasts and myoepithelial cells in samples of normal and diseased tissue from individuals. http://patent.ipexl.com/inventor/Dinah_Parums_1.html 2) Inventors: Davies, Michael John; Huggins, Jonathan Paul; Parums, Dinah Velta. Assignee:Pfizer Inc., (Groton, CT).Application No. 20050148585 (USPTO); Filed: 7th July, 2002. Abstract: This invention relates to the use of cyclic guanosine 3',5'-monophosphate type five (cGMP PDE5) inhibitors (hereinafter PDE5 inhibitors), including in particular the compound sildenafil, for the treatment of chronic wounds of a non-diabetic origin including in particular chronic venous ulcers, chronic decubitus (pressure sores) and arterial ulcers; and acute wounds. http://patents.justia.com/inventor/dinah-parums http://www.patentbuddy.com/Inventor/Parums-Dinah/5778826 Contributions to Books and Periodicals: Mitchinson, M.J., Ball, R.Y., Carpenter, K.L.H., Parums, D . V . Macrophages and ceroid in atherosclerosis. In: Hyperlipidaemia and atherosclerosis, Suckling, K.E., Groot, P.H.E. (Eds.), Academic Press, London, 1988 p.117-134. www.sciencedirect.com/science/article/pii/0014579392813894 Parums, D . V . Aortic atherosclerosis: pathogenesis and local complications. Oxford Textbook of Pathology. Eds. J.O'D, McGee, P.G. Isaacson, N.A. Wright, Oxford University Press, 1992 Chapt. 12.3, p.812-22. http://www.amazon.co.uk/Oxford-Textbook-Pathology-Principles-Publications/dp/0192619721 Parums, D .V . Macrophages in cardiovascular disease. Chapter 9 In: The Natural Immune System - Volume II : The Macrophage. Ed. C.E. Lewis & J.O'D. McGee. Oxford University Press. 1992, p.361-390. http://www.fishpond.co.uk/Books/Natural-Killer-Cell-Claire-E-Lewis-Edited-by-JOD-McGee-Edited-by/9780199632336

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Parums, D .V . The pathobiology of atherosclerosis. Oxford Textbook of Surgery. Eds. Morris, P.J. & Malt, R.A. Oxford University Press. 1994. pp. 319-324. http://onlinelibrary.wiley.com/doi/10.1002/bjs.1800820362/abstract Parums, D .V . The pathobiology of vasculitis. Oxford Textbook of Surgery. Eds. Morris, P.J. & Malt, R.A. Oxford University Press. 1994, pp. 325-328. http://onlinelibrary.wiley.com/doi/10.1002/bjs.1800820362/abstract Parums, D . V . Chronic periaortitis. Oxford Textbook of Surgery. Eds. Morris, P.J. & Malt, R.A. Oxford University Press. 1994, pp. 329-331. http://onlinelibrary.wiley.com/doi/10.1002/bjs.1800820362/abstract Parums, D .V . The Distribution of Adhesion Molecules in Normal and Atherosclerotic Arteries and Aortas. In: Cardiovascular Disease: Cellular and Molecular Mechanisms, Prevention and Treatment. Ed. L. Gallo. Plenum Publishing Corporation, 1994. http://www.worldcat.org/title/cardiovascular-disease-2-cellular-and-molecular-mechanisms-prevention-and-treatment-proceedings-of-the-fourteenth-washington-international-spring-symposium-at-the-george-washington-university-held-june-6-10-1994-in-washington-dc/oclc/722347805?ht=edition&referer=di Parums, D . V . Histochemistry and immunochemistry of vascular diseases. In: Pathology of Blood Vessels. Eds. Stehbens, W.E. & Lie, J.T. Chapman and Hall. 1995, pp 313-329. http://www.amazon.com/books/dp/0412486407 Parums, D .V . Inflammation and atherosclerosis. In: Pathology of Blood Vessels. Eds. Stehbens, W.E. & Lie, J.T. Chapman and Hall. 1995, pp329-353. http://www.amazon.com/books/dp/0412486407 N O T E : http://pubget.com/author/dinah-parums and http://www.worldcat.org/title/dinah-velta parums/oclc/4779366614&referer=brief_results