dr. hazem al-mandeel ob/gyn rotation-course 481 multiple pregnancy
TRANSCRIPT
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DR. HAZEM AL-MANDEELOB/GYN ROTATION-COURSE 481
Multiple Pregnancy
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Introduction
A pregnancy with two or more embryos/fetuses that exist simultaneously
The perinatal mortality and morbidity are increased disproportionately with number of fetuses
Maternal mortality and morbidity are also increased
Twin gestation is the most common type
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Etiology and Classification of Twinning
Occurs as result of the division of one fertilized egg (monozygotic) or fertilization of two eggs (dizygotic). Both processes can occur in other multiple gestation
Dizygotic (Fraternal) twins will always have two amnions and two chorions
In Monozygotic (Identical) twins, the number of membranes depend on the time of cleavage of the fertilized egg
70% of MZ twins are monochorionic (mostly diamniotic) and 30% are diamniotic dichorionic
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Incidence of Twin Preganacy
Not constant throughout the world (varies according to race, hereditary factors, maternal age, parity, and the use of fertility agents)
Incidence of MZ twins is ≈ 1 per 250 birthsDZ twins increases with increased family Hx of
twinning, maternal age, and increased parityMultiple gestation occurs in 10%-30% of women
following the use of induction of ovulation agentsSpontaneous triplets is 1 in 8000 pregnancies
and quadruplets I in 800,000. In ART: 1 in 3000 births
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Determination of Zygosity
Obstetrical ultrasound can often determine zygosity (esp. if done before 14 weeks)
Determination of number of amnions and chorions are VERY important for management
After delivery, zygosity should be confirmedNo. of membranes, no. of placentas and
gender are essential in determining zygosity
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Abnormalities of Twinning Process
Occurs only in monochorionic (MZ) twins
Conjoined Twins
Twin-Twin Transfusion Syndrome (TTTS)
Umbilical Cord Abnormalities
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Complications of Multiple Gestation
AnemiaHydramniosPreeclampsiaPreterm labourPostpartum
hemorrhageCesarean delivery
MalpresentationPlacenta previaAbruptio placentaePremature rupture of
the membranesPrematurityUmbilical cord
prolapseIntrauterine growth
restrictionCongenital anomalies
Maternal Fetal
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Diagnosis of Multiple gestation
Signs and Symptoms: maternal sensation of larger abdomen, sensation of excessive fetal movement, excessive weight gain, palpation of more fetal parts, ausculation of more than one fetal heart
Ultrasound should be done routinely in all pregnancies (usually between 18-20 weeks)
Failure of early Dx of multiple gestation leads to increased perinatal morbidity and mortality
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Antepartum Management
Goal is to minimize perinatal mortality and morbidity and to prevent maternal complications
More frequent visits for antenatal careAssessment of the cervical length
frequently Bed rest for the mother in the late
pregnancy is suggestedFetal surveillance is essential: monthly
obstetrical ultrasound in the late pregnancy period and non stress test in the last month
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Intrapartum Management
Prevention and treatment of preterm labourPatient should be delivered in a hospital
with NICU facilityMode of delivery for twins depends on the
fetal presentations (Vx/Vx, Vx/Br, Br/Vx, or Br/Br)
Time interval between twin delivery is controversial (less than 30min)
For other multiple pregnancy, caesarean section is the safest mode of delivery
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Causes of Perinatal Morbidity and Mortality
Congenital anomaliesPrematurityBirth hypoxia/AsphyxiaRespiratory Distress SyndromeCerebral hemorrhageBirth TraumaStillbirthsRetained dead fetus Syndrome