dr. william olalia matias maulion medenilla medina
TRANSCRIPT
Extrahepatic Biliary Obstruction
DR. WILLIAM OLALIAMATIAS MAULION MEDENILLA MEDINA
A 58-year-old male with Progressive Jaundice
HISTORY Two months PTC
Vague abdominal pain and anorexia One month PTC
Progressive yellowish discoloration of the sclera
Tea-colored urine Pruritus Acholic stools 20% Weight loss
PAST PERSONAL HISTORY Heavy smoker (3 pack years) Occasional beverage drinker No history of hepatitis Known hypertensive (10 years)
Captopril Metoprolol
No history of DM
A 58-year-old male with Progressive Jaundice
PE FINDINGS Vital Signs: Normal Icteric sclerae (-) Palpable cervical or supraclavicular LN Heart & Lungs: Normal Abdomen
Globular with vague ballotable mass at RUQ Smooth, non tender and moves with
respiration (-) Fluid wave Rectal Exam: Acholic stools
A 58-year-old male with Progressive Jaundice
Diagnostic Algorithm
A 58-year-old male with Progressive Jaundice
Lab Findings
Normal Value
CBC NormalCreatinine 2 mg/dL 0.6 –
1.5mg/dLAlk. Phosphatase
500 u/L 32 – 110 u/L
Total Protein 6.5 g/dL 5 – 9 g/dLAlbumin 3.5 g/dL 3.5 – 5.0
g/dLGlobulin 2.5g/dLCA 19-9 350
units/mL< 37 units/mL
DIAGNOSTIC WORK-UP
A 58-year-old male with Progressive
JaundiceDIAGNOSTIC WORK-UP Chest X-ray: Normal Ultrasound
Distended gallbladder with no stones CBD 2.5 cm Dilated intrahepatic ducts Enlarged head of the pancreas Normal Liver
A 58-year-old male with Progressive Jaundice
ANCILLARY DIAGNOSTIC TOOLS ERCP CT Scan MRI EUS
UltraSound
Homogenous echotexture No hyperechoic structures were noted Presence of dilated intrahepatic ducts
Ultrasound
(L) Dilated gallbladder . No stones or calcifications/posterior shadowing present.
(R) Dilated CBD
Ultrasound
Hyperechoic masses: Presence of extrahepatic mass
ERCP
CT Scan
MRI
MRI
MRI
EUS
A 58-year-old male with Progressive
JaundiceSALIENT
FEATURES Progressive
jaundice Tea-colored urine Acholic stools Pruritus
Vague abdominal pain
Anorexia Weight loss
Icteric sclerae Abdomen
Globular with vague ballotable mass at RUQ
Smooth, non tender and moves with respiration
Rectal Exam: Acholic stools
Biliary Tract Obstruction secondary to Pancreatic Head Malignancy
Clinical Impression
Pancreatic Cancer
Head 80%, body 15%, tail 5%
Types Ductal adenocarcinoma, most common Intraductal papillary mucinous carcinoma Mucinous cystadenocarcinoma
Age Peak age incidence: 65-75 years old 40-45% locally advanced 40-45% metastatic 10-20% localized resectable
Pancreatic Cancer
CLINICAL PRESENTATION Jaundice (progressive), pruritus Anorexia, weight loss Back pain
an indication of advance disease because retroperitoneal nerves may have already been affected
Palpable GB (Courvoisier’s sign) Virchow’s node (left supraclavicular node),
Sister Joseph’s sign (nodules in the umbilicus) denote advanced malignancy
Pancreatic Cancer
RISK FACTORS Tobacco smoking Familial background Peutz-Jeghers syndrome HNPCC Li-Fraumeni syndromeFAP Chronic pancreatitis
PROGNOSIS Advanced disease: overall median survival <6 months;
5-year survival rate 0.4-5% 2.6-9% undergo pancreatic resection OMS 11-20 months 5-year survival rate 7-25%: relatively fatal since it
presents usually at an advance stage All patients die within 7 years of diagnosis
Differential Diagnosis
Pancreatic Cancer Management Algorithm
No
NoYes
Yes
Clinical, US, CT, ERCP, EUC, MRCP
Multidisciplinary team
SurgeonNursing staffAnesthetistsRadiologyIntensivistGastroenterologyDieticiansPathologyOncology
Biopsy
Palliative care
StentingSurgical bypassPain reliefChemotxRadiotcNew Rx
Dx of pancreatic cancer
Is patient fit for resection?
Resection
Kausch-WhippleKW-PPLeft resection
Assess respectability CECT, EUS
Adjuvant treatment
Enzyme supplementsChemotherapyNovel treatments
Treatment
Resectable?
Yes No
Good risk Good risk Poor risk Poor risk
Whipple’s
PPPD
Endoscopic drainage Bypass
Cholecystojejunostomy with Gastrojejunostomy
Hepaticojejunostomy with Gastrojejunostomy
ERCP
PrognosisStaging of Pancreatic Cancer
Primary Tumor (T)
T1 Limited to pancreas, < 2 cm
T2 Limited to pancreas, > 2 cm
T3 Extension into duodenum or bile duct
T4 Extension into portal vein, SMV, SMA, Stomach, Spleen, Colon
Regional Lymph Nodes (N)
N0 No nodal metastases
N1 Regional nodal metastases
Distant Metastases (M)
M0 No distant metastases
M1 Distant metastases (Liver, Lung)
Prognosis
Stage
T N M Description
I 1,2 0 0 Tumor confined to pancreas
II 3 0 0 Tumor invades duodenum &/or bile duct, no nodal involvement
III 1,2,3
1 0 Tumor has not spread beyond duodenum or bile duct but includes regional lymph nodes
IVA 4 Any
0 Locally advanced tumor growing into blood vessels, stomach, spleen, and colon with or without lymph node involvement
IVB Any Any
1 Distant metastases (liver, lungs) present
THANK YOU!