& -,..

Rcraho1 ~kveen dn.a dose and responre.

'00- - lOO USfcH~

o 0 .... ----- - - 0011.

... ----- -

- '°8 00.£- -.-p Sf&HOIO.

t advanfap -= ·LINGAf? Ovtfl 11c:JT~ cou23E.

- - . {oY1fDC cJIt.XIl tJJt th I~ d,/f. IYJ p:>#t!nt".

-----

I., E. 0

f ... -E

-I ~-..... --.. -I 0 +. I., doSe

E/1t1X =: hV x eff~t

e := tespor>rJC at dJ{f dose kveJs.

I; doJII, ~qJOnSe CUI\e IS HtPEacUe ... ,.,11' Plot " UN.Aft / t ~I.CP& I, ~ ~

",,, ~1t,.1.

tHE 8ASIl OF attJl!s ACTION

_ f)fVes can act In 3 liXJ.4S !

I f'H YSI COCI-tEl1Ic/tL _ _ .2 INHIBI1. ENZYMES

_ _ 3 ItT ON 'KEc&TORS .

_"'YJlCOCII'If,cAL _ _ _ __ _ _ _ _ __ __ _ _ _ ____________ _ 'ANTACltJS

_ _ . CflEUt10FeS - /en,ct/Iam,ne -fBbrr:olaia4Jn ptlX/ut:.fr! ---9 ~b, Cf), Jl8- -P(£/NE

- flYJICtllm - -_ -claIttm ralac.m edei:r:l'£ -P_ 'b, ~ __

__ _ _ _ _ _ - IACO/:alf ec/ctDft --1'" _UJ. _______ - /AZJ/bn()Xa(m~ ~ Fe __________ _

__ _ _ _ _ :- -IeffaCtfdlnes ~ Fe, CQ,HSI AI. _ _ _ __ _____ _ __ •

___ .'. l DCA( ~"iSrHETlCj ? ·1*,1t£IIm0lV~1J

.' 0IVB oflen. Q'lmdO/ 10 nC/vaA dL'hslrl'lfe

!lEVEtSIBtf .. '1tIt.E"E~'SLe

I &;ab/(; chanau CO?Iple/)( ]

~ ~ua,lUj nt:r.d fiEsYN'HESI S

"

1

;r

- - 0fU& N:lNAT&D (i) COl1Pt.e)C -- , -

~'1HE~ - - --,,------------_ .J~ J ~ _ _ _ _ ~

D/ltEGT CIIANfJ£ _ ~UlMATION AtrG~ED ION ~/LrtY 1N1Etlf!E.IJI/Irrf NtJaElC /fC1/J

~ 'AcJ, () . (jA8A

~(!) 18 the Q1

channel.

~seHCII.S SYIV7I1Es.s.

()cAt1P -=- _ _ ~,SIrJo,ds. @cGHP @NO

@ IfJ -I- OA6-

(eau)

- - ----~

cAMP

----.,tEcEn~

ATP

AMf

cAMP -";> All f3 = t cAMP

0<2 =- JCAHP

~x, can ttif.td J:oJ.aroJ, rJtnu - H2 -- J, c,A~ 'fJ I/) tt/tl.it·

-> cAHP level, ,aluM ~ ctb,." '"OSPHOO'f$TE~~ __ en .. s. - - -- -' - - /

- - - - ~ Dlftr:r.fMT ","ILaft. -.- - -

· of/tJ:rnt dJslr,bohon I r!£r>Slh 'I' hf . - ~ -'Phru,:bxJJeJtetaJe TJI: - HI- and v.l·M. - .felechve. G b'l £NO ¥ /HONe. _

(7' ,. J!l ann -lnfbmmaltAt 0 bfD()Chodlio/or _ __ ~ . I, _ _ _ y _ - anh - pJaleJeJ; aegtttPhcv\.

V. SlmlK¥ 10 CANt> Ol/()th b'" aee r«iaJaA

Hekelnmute.. v'

~ Gip" mo Ju:s" t::<SHt-./

~~ GTP cGMP

~ (i)Pk

l PhoJphJ4/DhoA

NrrJelC OXIDE

J. - 1-

(areJ()/ne

f~ ' N~lc OX/oe r~) t' J>'Nn1~.sE l' t · hf{dtCtt(arJ1nme

+01. t tJOS Gsnr -NO.; C'if P4-50 ....

r

-

.2 NOS ~ e~OS - Cotl3tJcJk..t.

\ L NOS - u\ouc.llh M {> /ACh \

'S1ca:J - 13rod4klnm ~ n No,:> ~ \~SIn::s5.

G-TN SNP

NO - altk> Gplat:Jct q~1 adhesion

-~Jnobcp/c - Rt[j.ia/t::J> p.1l. Cl fQJ/ohoJ... _

- t "1 : s·.,. ~ettandl • - -

-abo /ksM NAI\K;. nq~ -_. ---~ .. ~---~------~ f'olc"t vo~dcblur. - NO +31'4- =t> S~No~thlcl~- 1 l-~ JOu!1e 9»"~I~1 ~""'" ...J

I 6fP .-&t-.",c6HP

~ - - flt>1a* kmax:s a fltkm' Phr»phOtt,flohoJ.

~ - ~/OYCI*tlA V6M

- "" t'tf)()/ah'r) Jm<>tStJc. M .

- fderotd Pt.f Ht) - tAjlolOtl"1

NIIrr;tJc, l61r/anu. = v ClJIUble 6'C ~GGHP~ _

PHOlPHOINOS.TIOES arid CAtcIUM IONS \.... -., ---membl'Q~e phOrlphoilp1dJ contam'f) INollTOL '1. 8if.JCatlt! IJamer:

PIP%.

Calmcddm - mO/(J co blndl1!J p1fk1V\ srn. M -r non ,fJ1w cle

11'D(:Ot?ln C - maIn Ca J:Jlnd",s 1/t'Aft.T and J'k~Al M.

Ca -;; {ot1f(ytnohnU D In C(J/mcdullll

Denz.yme. octV1#l..f.

re'l anod ,ne @ = Ope" Co chortltr.Ao

( (f) ~ CICC, eoPfr,t"t, CAoPrlbK

~ht.nca.l caphrt9 14. F-h..h.k. sk.rn. DIHYotOPY'fO INE@).

achvakcl ctJnplf$ t/IJJOCJolu [!A:/J Jo nlJc/~

- memp. phOlphO/lp,cU

~&I<KOO){'hCOldS = t hpocorhn I - <3 f/xJ!ph<lllpaJeA '2 ~ e j _ -_ (Jhf;}lIdOntC aed.

k, - ASSOclahltl ,-ale. (DVfz;mt

p -t e 4( • PlC kl, /A.sY;)CtClnr.v yak~.

AJStme dno tnokcUe. ~blf1 C~IJtM/.) p.)IiII (!) ,(k,1P18 CfJlHplt:l)(

!rpJtllbflUM k, = It I Ify /awmossach(J/\ le, {-lC«1 = kZ (oa] New h:nn I<d -!5J. = [P][fi]

J /<, COR] OISSOCJA71ON ~rANr At' e-~UIU~/()M.

kd :::= 'ONrI~'~A"1ON fS I/ItOG '0 OCCuPY ''z C> SlfB AT .&ulc,.8e1lM

--=;> tef/ecb affin,/tf fIJ}/ch ~ bind.

~t ~ t6/;a1 nombe/ rf It:rtplol>.

f == f!!!..l = frachon qloo rx:cupta1. CRt)

---- -

37YP&S --< (lJIf'n"'~E -< . ( '~~ft6It$I.'" - Com,ele (A}c.bA 'f]XJ1fl (pmpe/e It-, ~ .Jr"~. ..;>S{.{)IJJ DISSX-IAT/ON

NlJH.ewtlWmfE ( ... {;JdoJno.@.

N61 Jame a/le I IltJIIt( ""chant'"" ~

If .' .. A",NI'''' ~ cxKnt Jo tu})Lch dl11J blndJ @

"'N7~'NtI" 1tc,*',V'''~ : AblllJv 10 prrdtXJ2, a I8SpOt?Je.

"1",cAC,y : /Voxlmal ~ t:ltlJ:imabie b.i R d'lIl I·~. h1of"{.hne JJ men: e!ftCQC/OUJ 'lhon codelt1e.

100

o I/OS~ (I?:J)

ChlrackAl:.d b.( f)Ojf I!ATlo - ~clor bet tVhJCh rrnfl f qp'1$/ 10 8fd J'ClIre 1f:Sf&Jde..

Of(. -/ ~ ~ or / 0/(,-1 = ~CAJ I kd SOIILD rGuATION.

/o.j CA)

o~ SCHIL.J) eGtYXflON - 10 CO~ !b1FI\JC.Y

pA 2.:: - ve I~,thm ef dole. of antqgon • .rl 10 pttX'JfJtIJ " dQlt:, fQho df 2-

l e. IAJfet> Kd = fA]

lI'fjhV pAz = mote potent . __

Anh .. cno//I?f/8ICS i

hYOSCINE J

IHIPf(AMINe 3·+

Compete (,()tJh O{JtnlJt M (j}fXA)/'I- dlJsOCIole.

£),splaced bJ6 . NON -PAI?Au£L . J HAXlrtAL t<ESPOrY!Sc.

Ef~ IJJIJalL'I ()NI?S.ATCD Jo PJabWIf). CtJn(&JlfDhaA .

. ItJrfl ~J tXI?o,r riil>hnchctA bd. Jm:.~k lr ~IIL

-? ~Y -It' 6p2te /eCf!/)1oo - lowc1oc. compehl1l£ ,rre~ tr1aI! ace ab a:mpe1d11.1!. Jf!YrAlble..

-- - - - - --

~I ,fiafJotnll1e -= P_ClJlriJaJ; mWL'&+'LnIC t!) o({lJ1I1rj-l& ~ - -- ~ - --

- . Uep:ucn = ~LdlC. (ful{i7ale~pJ. t:ecJro/J~d bit ~mlne. -- -- - - - - --

__ ' /!incnat'JaJ _ --;> _ blJiomlL')L! =: blrJn::hat:UJslnchoA _ tlnta~o"um _ _ AcL~IJ"e. - H dilalonaA

lL.~1~]·«~_-::-- ~ - ----

- '00- -

- Hare 1eceplar af{1LJIAJ- at~_ -

1tJ1r1DJ1C ;::> 0 <'1 -- aclwl/y_" ~_ ~~

-o- .. -...-~--.. -_ _ ~~ dQIC _ _ _ __ _ _ _

~ anltf}aollkLtr JI(}O-OJ.& k .' - tJe,t:en:J 11'78 ~ aatJlWdla/!1~ . -- - -

In ,DJ!,) c:IDtK! - aJJ)1JI./J..J 4f)On/&b _ _ 1f-(iilqgonl1fLptr:U!I1£~ m:ts &VJ {l':t'npd1h~ /&'A)lhlll. tlJ1~nld._ _

--------- ----- --

· Rece(Jhx affu?/~ J:Jt1, . N£tS-A,{)ve INrl?lIJSIC AC11 III TY.

~ / pi;rm2U)J/ CO" ptr:Juce OI1Nt:Aj Y anVlJJslons "

~ cell OfnSlhv/~ or tespo1slvt:.nf!SS 10 ~Ied / «¥>ht1uxJ ~.

~rAeHYPH"IAXIS· 0,. e -:;: Oil tt --oe

L ItJachtfJ. . CHItONlC : ·Iass /Jeq/A:l)"QhoA of. ~ - ' In/t;lr¥:lIJ201toA ('cndoatlosl &)

"rtew/rlbJe cuf6.'ma honoJ cIrlnfP-> . . (?) ~dQhOA.