8/18/2019 Drug Study- Belladonna and Opium

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 Trade Name: B & O SuppositoriesGeneric Name: Belladonna alkaloids and opiumClassifcation: Narcotic analgesic and anti-spasmodic combination

medicationMechanism: Belladonna relaes smooth muscles and stops muscle

spasms! Opium is con"erted to morphine #hich is anopioid pain relie"er! Opioids can reduce gastrointestinalmotilit$% propulsion% secretions% and increasegastrointestinal muscle tone! Opioids also stimulatereceptors on ner"es in the brain to increase the thresholdto pain increasing the amount o' stimulation it takes to'eel pain( and reduce the perception o' pain thepercei"ed importance o' the pain(! These e)ects help incontrolling pain and relie"ing spasms% especiall$ bladderspasms! Belladonna*opium is a controlled substance!

+ses: Treat moderate to se"ere pain 'rom spasm o' the urinar$

tract!,oute: ,ectalosage: .nsert / suppositor$ rectall$ once or t#ice dail$! Not to

eceed 01 suppositories*da$ or as directed b$ ph$sician!Side e)ects ro#siness% di22iness% blurred "ision% dr$ mouth% urine

retention% nausea% "omiting% constipation% itching% andhi"es!

3d"erse4)ects:

Slo# shallo# breathing5 se"ere dro#siness or di22iness!Can be habit 'orming and has abuse potential because o'its opium content!

Contraindicatio

ns:

Not recommended 'or children /6 $ears or $ounger

7recautionsandinteractions

• 3l"imopan 4ntereg( 8increases belladonna and

opium le"els in the bod$5 opioid must be stopped 9da$s prior to starting 3l"imopan!

• M3O inhibitors like phenel2ine Nardil(% selegiline

elapar% 4msam% 4ldepr$l(% and isocarboa2idMarplan( as #ell as line2olid $"o( antibiotic 8ma$ lead to serious changes in blood pressure%'e"er% sleepiness% agitation% con'usion and in se"erecases% death! Must be stopped or separated b$ /1

da$s be'ore administering B&O!• Naltreone ,e"ia( 8decreases le"els and

therapeutic e)ects o' B&O% leading to treatment'ailure!

• Narcotic analgesics 8increased risks o' di22iness%

sedation% and respirator$ depression!

• Cimetidine% Butorphanol% Nalbuphine% 7otassium

tablets% 7ramlimtide% ,i'ampin

8/18/2019 Drug Study- Belladonna and Opium

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;ealth Teaching

• o not stop abruptl$ as it ma$ cause #ithdra#al

s$mptoms!

• o not increase dose!

• Ma$ cause addiction!

• Store at room temperature a#a$ 'rom light and

moisture!• o not re'rigerate!

• o not store in the bathroom!

•