Drugs containing

Carboxylic acid

INTRODUCTION

are organic acids characterized by the presence of at least one carboxyl group. The general formula of a carboxylic acid is R-COOH

General characters

Boiling point:Carboxylic acids tend to have higher boiling

points

Acidity:Carboxylic acids are typically weak acids

Odor :

Carboxylic acids often have strong odors,

especially the volatile derivatives. Most

common are acetic acid (vinegar) and butyric

acid (rancid butter) .

Solubility:Carboxylic acids

are polar .the Smaller carboxylic acids are soluble

with water, whereas higher carboxylic acids are less soluble

EXAMPLES FOR CARBOXYLIC ACIDS INCLUDED IN SOME DRUG:

1 .

Salicylic acid

.

2.

Fusidic acid

.

3 .

Citric acid

.

4 .

Ascorbic acid

.

5 .

Benzoic acid

.

6.

Lactic acid

.

7.

Tartaric acid

.

For Example

:1 -

Aspocid . ( shewable

tablets)

2 -

Rivo ( tablets)

3 -

Rivo ped ( supp) 4 -

aspocid buffer( eff)

5-

Aspegic( vial)

It is Acetyl salicylic acid which have many trade names in the Egyptian market

Aspirin

synthesis

Aspocid

Indications

Side effects

contraindications

Precautions

1- headache. ( the 1st drug in treatment of migraine) 2- pain( muscle, cramps ,skin irritation)3-prevention of heart

attacks and strokes . 4-for fever and pains associated with common cold 5-for joint pain of acute rheumatic fever

Indications

• Dyspepsia, heartburn, anorexia, nausea, occult blood loss, epigastric discomfort, massive GI bleeding, potentiation of peptic ulcer

GIT

• Bronchospasm, asthma-like symptoms, anaphylaxis, skin rashes, urticarial, rhinitis

Allergic

• Prolongation of bleeding time, thrombocytopenia, leukopenia, purpura, shortened erythrocyte survival time, decreased plasma iron levels.

Hematologic

Side

Effects:

Contraindications:

1-Hypersensitivity to salicylates 2-

Clients with asthma, hay fever3 -Severe anemia

4 -history of blood coagulation defects

, 5-in conjunction with anticoagulant

therapy 6-In pregnancy, especially the last

trimester as the drug may cause

problems in the newborn child or

complications during delivery.

Precautions

1-

Use with caution during

lactation

.

2-

gastric or peptic ulcers

,

3 -

in cardiac disease

.

4- in liver or kidney

disease.

Heel Forte ointment

Composition;

Salicylic acid 12 g

Urea 8 g

Dose:

A thin film of the ointment should

be applied twice daily to cover the

affected area completely

PROPERTIES :Salicylic acid has keratolytic property

which causes the cornified tissues to

swell, soften, macerate and

desquamate. Urea moisturizes and softens severely

dry, rough skin

SOINDICATIONS :

1-Removal of callus and corns

2-Smoothing of intensely rough

heels3-Helps in treatment of warts

contraindications

Hyper sensitivity to any of the

components of the ointment

Side effects

May cause dermatitis or

irritation

Precaution

Protect surrounding skin

and avoid application to

broken or inflamed skin.

Avoid contact with the eye.

Not to be used for diabetic patients and

those with poor blood circulation .

Scabinol soap

INGREDIANTS

benzyl benzoate

15%sulpher15%

USES:

For scabies and

pediculosis.

Dermacid soapINGREDIANTS benzoic a .1 % tartaric

a .7% salicylic

a .2%

 •Acidic Soap. •  Restores and maintains the

natural acidity of the skin. 

•  Used for mycotic skin

infections, prickly heat, sweat and diaper rashes,

acne, etc.

Salicylic acid soap

INGREDIANT

S : 2% salysilic acid.

USES :for infectious skin disease.

Examples for soaps containing carboxylic acids

Faw

ar F

ruit

PRESENTATION FORM :

Sachet

COMPOSITION :

Citric acid 16 gm

Flavor and color to 100

gm

Sodium bicarbonate 56 gm

Tartaric acid 26.7 gm

USES :

Antacids in the gastrointestinal

system.

Eva Spotless Cream

Components:

Special formula facial cream rich in lactic acid and lemon juice.

USES

the ideal solution to deal with black spots and other problems of teenage skin and not only.

Cream gently removes the top layer of dead cells and cleans pores, preventing problems.

The cream also lightens the skin and contributes to the disappearance of freckles.

What is fucidic acid??

fucidic acid is a

bacteriostatic antibiotic that is often used topically in

creams and eyedrops, but may also be given

systemically as tablets or injections. Fusidic acid is

often found in topical skin and eye preparations .

Drugs containing

fusidic acid:

Structure:

Fusi

derm

oin

tmen

t

Components:

Each 100 gm Fusiderm ointment containsSodium fusidate2 gm

USES:

Fusiderm is an antibiotic having a potent antimicrobial activity against many Gram-positive organisms such as, Streptococci,

Corynebacterium minutissimum and particularly Staphylococci, including the strains resistant to

penicillin or other antibiotics.

Fusiderm provides highly effective topical treatment in primary and secondary bacterial

infections of the skin and has a unique ability to penetrate intact skin

Bet

afuc

in c

ream

COMPOSITION:

Each gram contains :

Fucidic acid 20 mg

Betamethasone 1mg

PROPERTIES

: Betafucin cream combines the

potent topical antibacterial

action of fusidic acid with the

anti-inflammatory and

antipruritic effect of

betamethasone

VITACID C

Are e

ffervesc

ent

granule

s of s

ingle

vita

min

( asc

orbic

acid)

COMPOSIT

ION

:

1 -

sach

ets:

eac

h 4 g

m

sach

et con

tain

500

mg a

scor

bic a

cid

2 -1

gm e

fferve

scen

t

table

ts con

tain

1 g

m

asco

rbic a

cid

VITAMIN C PROPERTIES

:

1-

Vitamin C is an essential co-enzyme

for collagen formation

2-

tissue repair and synthesis of lipids

and proteins

.

3-

It acts both as a reducing agent and

as antioxidant

.

4-

It is necessary for many physiologic

functions

e.g. metabolism of iron, carbohydrate

and folic acid, resistance to infection,

cellular respiration and preservation of

blood vessel integrity

.

1-Prevention and

treatment of scurvy.

2-Symptomatic relief of

common cold and influenza

3-Pregnancy and lactation.

4-in certain diseases and

conditions such as:

hyperthyroidism, peptic

ulcer, chronic illness and

infections (whooping

cough, pneumonia, sinusitis and

rheumatic fever).

History of hyper sensitivity to

vitamin CIndication

s Contraindecations

REFERENCES:

1 -Organic chemistry (5th Edition),Paula Yurkanis Bruice.

2-2nd Edition Therapeutic drugs, Colin Dollergy,

Vol 1.3 -2nd Edition therapeutic drugs,

Colin Dollergy,vol2.

4-Drug Index ,Master on therapeutic Drugs,

Dr. Henein Wely & Dr. Usama Tharwat.5 -Mina El Bostany pharmacy .

BY:

1 -

Aya

Ahm

ed S

aber

2 -

Geh

an E

ssam

Mah

moo

d

3 -

Eman

Ala

a El

Sha

my

4-

Eman

Moh

amed

Mos

tafa

Facu

lty

of p

harm

acy

ASU

Phar

mac

eutica

l

Chem

istr

y de

part

men

t

1st Y

ear

Se

ctio

n 2