Cover legend: This image shows a wide-field view ofdeconvolved hippocampal synapses, defined by thepostsynaptic protein PSD-95 (green). A subgroup of

these synapses co-express visible levels of RhoA (red),and thus appear yellow. RhoA is a member of the

Rho-GTPase family of enzymes and contributes to thestability of the actin skeleton of synapses and

dendritic spines. During multiple acute stresses, thecombined actions of the adrenal stress hormone

corticosterone and hippocampal-origin CRH reducethe levels of active RhoA within hippocampalsynapses, promoting their collapse. For more

information, see the article by Chen et al.(pages 11295–11307).

i This Week in The Journal

Dual Perspectives

11151 The Role of GluN2C-Containing NMDA Receptors in Ketamine’s PsychotogenicAction and in Schizophrenia ModelsElizaveta Khlestova, Jon W. Johnson, John H. Krystal, and John Lisman

11158 Ketamine: NMDA Receptors and BeyondCharles F. Zorumski, Yukitoshi Izumi, and Steven Mennerick

Journal Club

11165 Seeking an In Vivo Neuronal Context for the PINK1/Parkin PathwayNicholas R. Ader

11168 Identifying Functional Subdivisions in the Medial Frontal CortexPedro Silva Moreira, Paulo Marques, and Ricardo Magalhaes

Research Articles

CELLULAR/MOLECULAR

11196 Long-Term Potentiation at the Mossy Fiber–Granule Cell Relay Invokes PostsynapticSecond-Messenger Regulation of Kv4 ChannelsArsalan P. Rizwan, Xiaoqin Zhan, Gerald W. Zamponi, and Ray W. Turner

11208 Dynamic Partitioning of Synaptic Vesicle Pools by the SNARE-Binding ProteinTomosynVictor A. Cazares, Meredith M. Njus, Amanda Manly, Johnny J. Saldate,Arasakumar Subramani, Yoav Ben-Simon, Michael A. Sutton, Uri Ashery,and Edward L. Stuenkel

11283 p39 Is Responsible for Increasing Cdk5 Activity during Postnatal NeuronDifferentiation and Governs Neuronal Network Formation and EpilepticResponsesWenqi Li, Megan E. Allen, Yanfang Rui, Li Ku, Guanglu Liu,Andrew N. Bankston, James Q. Zheng, and Yue Feng

11320 Nitric Oxide Modulates HCN Channels in Magnocellular Neurons of the SupraopticNucleus of Rats by an S-Nitrosylation-Dependent MechanismMelina Pires da Silva, Davi Jose de Almeida Moraes, Andre de Souza Mecawi,Jose Antunes Rodrigues, and Wamberto Antonio Varanda

November 2, 2016 • Volume 36 Number 44 • www.jneurosci.org

11362 HIV Tat Impairs Neurogenesis through Functioning As a Notch Ligandand Activation of Notch Signaling PathwayYan Fan, Xiang Gao, Jinhui Chen, Ying Liu, and Johnny J. He

DEVELOPMENT/PLASTICITY/REPAIR

� 11238 Natural Firing Patterns Imply Low Sensitivity of Synaptic Plasticity to Spike TimingCompared with Firing RateMichael Graupner, Pascal Wallisch, and Srdjan Ostojic

11295 Converging, Synergistic Actions of Multiple Stress Hormones Mediate EnduringMemory Impairments after Acute Simultaneous StressesYuncai Chen, Jenny Molet, Julie C. Lauterborn, Brian H. Trieu, Jessica L. Bolton,Katelin P. Patterson, Christine M. Gall, Gary Lynch, and Tallie Z. Baram

SYSTEMS/CIRCUITS

11171 Bottom-Up versus Top-Down Induction of Sleep by Zolpidem Acting onHistaminergic and Neocortex NeuronsDavid S. Uygun, Zhiwen Ye, Anna Y. Zecharia, Edward C. Harding, Xiao Yu,Raquel Yustos, Alexei L. Vyssotski, Stephen G. Brickley, Nicholas P. Franks,and William Wisden

� 11185 An Inhibitory Septum to Lateral Hypothalamus Circuit That Suppresses FeedingPatrick Sweeney and Yunlei Yang

11338 Consistency of Border-Ownership Cells across Artificial Stimuli, Natural Stimuli,and Stimuli with Ambiguous ContoursJanis K. Hesse and Doris Y. Tsao

BEHAVIORAL/COGNITIVE

11223 Rule Encoding in Orbitofrontal Cortex and Striatum Guides SelectionBrianna J. Sleezer, Meghan D. Castagno, and Benjamin Y. Hayden

11259 A Two-Stage Process Model of Sensory Discrimination: An Alternative toDrift-DiffusionPeng Sun and Michael S. Landy

11275 A Defensive Kicking Behavior in Response to Mechanical Stimuli Mediated byDrosophila Wing Margin BristlesJiefu Li, Wei Zhang, Zhenhao Guo, Sophia Wu, Lily Yeh Jan, and Yuh-Nung Jan

11331 Correlation between Pupil Size and Subjective Passage of Time in Non-HumanPrimatesTomoki W. Suzuki, Jun Kunimatsu, and Masaki Tanaka

NEUROBIOLOGY OF DISEASE

11308 Effects of Long-Term Exercise on Age-Related Hearing Loss in MiceChul Han, Dalian Ding, Maria-Cecilia Lopez, Senthilvelan Manohar,Yanping Zhang, Mi-Jung Kim, Hyo-Jin Park, Karessa White, Yong Hwan Kim,Paul Linser, Masaru Tanokura, Christiaan Leeuwenburgh, Henry V. Baker,Richard J. Salvi, and Shinichi Someya

11350 Ablation of Perk in Schwann Cells Improves Myelination in the S63del Charcot-Marie-Tooth 1B MouseMariapaola Sidoli, Nicolo Musner, Nicholas Silvestri, Daniela Ungaro,Maurizio D’Antonio, Douglas R. Cavener, M. Laura Feltri, and Lawrence Wrabetz

11374 Correction: The article “Functional Imaging of Denate Granule Cells in the Adult MouseHippocampus” by Gregor-Alexander Pilz, Stefano Carta, Andreas Stäuble, Asll Ayaz,Sebastian Jessberger, and Fritjof Helmchen, appeared on pages 7407–7414 of the July 13,2016 issue. A correction for this article appears on page 11374.

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