Prep/ Dr.wagdyPrep/ Dr.wagdy

Pharmaceutical PreparationPharmaceutical Preparation

Why we still use pharmaceutical Why we still use pharmaceutical

preparations? preparations?

1. Some drugs must be freshly prepared.2. Some people prefer the drug to be done

in a place they trust . 3. We can tailor the preparation according

to our needs.4. Lack of some commercial dosage forms.5. Needs of certain drug combination which

is not available.

Pharmaceutical compoundingPharmaceutical compounding

DefinitionDefinition

Preparation, mixing, assembling and packaging or labeling of certain medicine for internal or external use for human being or veterinary purpose in response to a prescription or from an official pharmacopoeia

Types of pharmaceutical Types of pharmaceutical compounded dosage formscompounded dosage forms::

• Injections

• Eye preparations

• Total parentral preparations

1-Sterile preparations1-Sterile preparations::

22--Non-sterile preparationsNon-sterile preparations::

• Solutions ,syrups ,suspension ,emulsions• Capsules ,powder ,granules • Rectal suppositories and enemas• Vaginal suppositories

Internal preparationsInternal preparations::

• Ointments, cream, lotions, paint, paste,…. Mouth wash and gargles Nasal and ear preparations Dusting powder , Medicated plasters

External preparationsExternal preparations::

Source of information for Source of information for compounding and dispensingcompounding and dispensing::

• BP British pharmacopoeia

• Pharmaceutical codex

• NF national formulary

• Martindale printed and electronic

Pharmaceutical calculationsPharmaceutical calculations::

• Dilution rules for concentrated solutions

• Ca X Va ═ Cb X Vb

• Where Ca ═ Concentration of Concentrate

• Va ═ volume of concentrate

• Cb ═ Concentration of dilute solution

• Vb ═ Volume of the dilute solution

Compounding PracticeCompounding Practice

1 .Personnel2 .The compounding area

3 .Equipments4 .Active ingredients and raw materials

5 .Packaging6 .Labeling and storage

7 .Stability and estimated expiration date8 .Recording

9 .Patient counseling10 .Pricing

Factors to be considered to achieve Factors to be considered to achieve good compounding practice aregood compounding practice are::

Personnel

Compounding areaCompounding area

EquipmentsEquipments

PackagingPackaging

Raw materialRaw material

labeling

labeling

RecordingRecording

Patient counselingPatient counseling

pricingpricing

How to price the preparationHow to price the preparation

The price of each material used in the preparation should be calculated and included in the price of the preparation for example the plastic bottles containing the preparation, the raw materials, also the drug used in the preparation

Example : • we used a 50 cc bottle--------1 pound• we used 5gms of salicylic acid powder i.e.500

gms of salicylic acid costs 250 pounds so the price of each gm will be 0.5 pound, so the 5 gms will cost 2.5 pounds

S O L U C A M P H RS O L U C A M P H R

0 1 2 3 4 5 6 7 8 90 1 2 3 4 5 6 7 8 9

If the price of the preparation is 20 £So we write LS/100 cc

• 3 to 5 pounds are added for entering the laboratory.

• finally , we fix the price on the preparation by the following method

PharmaceuticalPharmaceutical preparations in the market preparations in the market

Simple syrupSimple syrup: : Rx• Sugar.......................................192

• Warm water.............................108

Glycerin tannicGlycerin tannic: :

Rx• Tannic acid............................1 gm

• Glycerin.................................5

Strong lead sub Strong lead sub acetate(goulard`s extractacetate(goulard`s extract)

Rx• Pb acetate.............................250 gm

• Pb monoxide.........................175 gm

• Aqua distilled to.....................1000

Dilute solution:Dilute solution:

Strong solution.........................12.5 ml

Dist water recently boiled and cooled to 1000ml

Dissolve lead acetate in 60 ml of water , add to the lead monoxide in closed container. Allow standing for 48 H ,shake , filter and complete the volume with water.

ProcedureProcedure

shouldshould be be labeled labeled TOXICTOXIC

shouldshould be be labeled labeled TOXICTOXIC

Castallani`s paint Castallani`s paint (magenta paint)(magenta paint)

Rx• Basic fuschin..................................0.4

• Liquid phenol..................................4

• Boric acid.......................................0.8

• Resorcinol......................................8

• Acetone.........................................4

• Alcohol..........................................8

• Water to.....................................100

Fungal infection of the toenails

Glycerin aluminisGlycerin aluminis: :

Rx• Glycerin ..........................................120• Alum..................................................20• Dist water..........................................7.5

Uses : astringent and haemostaticastringent and haemostaticUses : astringent and haemostaticastringent and haemostatic

Mel boracisMel boracis: :

Rx• Borax..........................................10 gm• Glycerin.......................................5• Honey.........................................85

Thrush mouth

& candidiasis.

Thrush mouth

& candidiasis.

Glycerin magnesiaGlycerin magnesia: :

Rx• MgSO4.........................................400• Hot water......................................160• Glycerin.........................................480

Add MgSO4 to water, heat in a glass beaker

till dissolution then add glycerin

Add MgSO4 to water, heat in a glass beaker

till dissolution then add glycerin

FORFOR DIABETICDIABETIC

WOUNDSWOUNDS

Glycerin bicarbonate :Glycerin bicarbonate :Alkaline ear dropsAlkaline ear drops

Rx• Sod.bicarb.........................................5 gm

• Glycerin...........................................33 ml

• Water to ........................................100 ml

Ear wax Ear wax removerremoverEar wax Ear wax removerremover

Glycerin starch paste :Glycerin starch paste :Glycerin amyli(sand bathGlycerin amyli(sand bath)

Rx• Starch...............................................10 gm• Benzoic a`.......................................0.2 gm• Dist water.........................................20 ml• Glycerin add to ..............................100 gm

EmolientEmolientEmolientEmolient

Glycerin suppGlycerin supp: :

Rx• Gelatin.....................................14 gm• Glycerin...................................70 ml• Water to..................................100 ml

Glycerin icthamolGlycerin icthamol: :

Rx• Icthamol.....................................10 gm

• Glycerin......................................100 ml

Glycerin boraxGlycerin borax: :

Rx• Boric a`................................3 gm• Glycerin...............................10 ml

Glycerin boricGlycerin boric: :

Rx• Borax...................................1 gm• Glycerin.................................6 ml

Glycerin phenol : Glycerin phenol : Ear dropsEar drops

Rx• Phenol.........................................5 gm• Glycerin.......................................100 ml

Rx• Boric a .........................................2 gm

• Alcohol 90% to.........................100 ml

Alcoholic ear drops :Alcoholic ear drops :

Hamamelis ointmentHamamelis ointment::

Rx• Liquid extract of hamamelis…………10• Wool fat………………………………….50• Yellow soft paraffin…………………....50

Astringent ,haemostaticAstringent ,haemostatic& & Cooling effect forCooling effect for

haemorrhoidshaemorrhoids..

Astringent ,haemostaticAstringent ,haemostatic& & Cooling effect forCooling effect for

haemorrhoidshaemorrhoids..

Kaolin poulticeKaolin poultice::

Rx• Heavy kaolin………………52.7 gm

• Boric acid………………….4.5 gm

• Methyl salicylate………….0.2 ml

• Peppermint oil…………….0.05 ml

• Thymol…………………….50 mg

• Glycerin……………………42.5 gm

Topical dressing for boils& CarbunclesTopical dressing for boils& Carbuncles

Benzoin and menthol inhalationBenzoin and menthol inhalation::

Rx• Menthol…………………..2gm

• Tr. of benzoin co……….100ml

One teaspoonful to a glass of hot water and inhale the vapour.

One teaspoonful to a glass of hot water and inhale the vapour.

Alkaline nasal washAlkaline nasal wash: :

Rx• Sod.bicarb.....................................5 gm

• Sod chloride..................................5 gm

• Sod biborate(borax)......................5 gm

Nasal CongestionNasal Congestion & & allergic rhinitisallergic rhinitis..

Nasal CongestionNasal Congestion & & allergic rhinitisallergic rhinitis..

Argyrol ephedrine (nasal drops):

Rx• Argyrol.........................................15 gm

• Ephedrine....................................3 gm

• Water to..................................... 300 ml

•Argyrol is a mild silver protein.•Anti-bacterial effect.

•Argyrol is a mild silver protein.•Anti-bacterial effect.

Tincture iodineTincture iodine: Rx • Iodine....................................2.5 gm• KI...........................................3 gm• Alcohol 90% to......................100 ml

Rx• Iodine…………………...........10 gm• KI……………………………….6 gm• Water………………………….10 ml• Alcohol 90%..................... to 100 ml

Tr.Iodi` fortisTr.Iodi` fortis: :

Pot.iodide mixturePot.iodide mixture::

Rx• Pot. Iodide ……………………...1 gm

• liquid liqurice ……………………2.5 gm

• aromatic ammonia spirit………..0.5 ml

• chloroform water……………….. 0.5 ml

• water……………………… …to 100 ml

Expectorant

Talbut iodineTalbut iodine: :

Rx• Iodine..........................................2.5 gm• Zn iodide.....................................1.5 gm• Glycerin.......................................50 ml• Water to........... ..........................100 ml

gingival paint (ulcers)

gingival paint (ulcers)

Glycerin iodine (Throat swabGlycerin iodine (Throat swab):

Rx• Iodine..........................................0.25 gm• KI................................................0.6 gm• Water..........................................0.6 ml• Glycerin to ................................ 25 ml• Oil of peppermint.........................0.1 ml

To be shaken before useTo be shaken before use

Colourless iodine paint : ( white tr. Iodine)

Rx• Tr.iodine………………2.5%

• Strong solution of sodium thiosulphate

Solution to be added drop wise till endpoint.

Solution to be added drop wise till endpoint.

dibromohydroxymercurifluoresceindibromohydroxymercurifluorescein

Mercurochrome paintMercurochrome paint: :

Rx• Mercurochrome powder.............2 gm

• Hot water to................................100 ml

Alcoholic mercurochrome :Alcoholic mercurochrome :

Rx• Mercurochrome powder..............2 gm

• Alcohol 60%...............................100 ml

GENTIAN VIOLETGENTIAN VIOLET

Gentian violetGentian violet: :

Rx• Gentian violet..........................1gm

• water to...................................100 ml

Mouth candidiasis, chicken boxMouth candidiasis, chicken box

Rx• Gentian violet powder.................1gm• Alcohol........................................10 ml• Water to .....................................100 ml

Aqueous gentian violetAqueous gentian violet: :

Simple ointmentSimple ointment: :

Rx• Lanoline........................................10 gm

• White bees wax............................10 gm

• Soft paraffin...................................80 gm

Heat the white bees wax on a water bath, add the lanolin and finally

the soft paraffin, mix, stir until cold.

Heat the white bees wax on a water bath, add the lanolin and finally

the soft paraffin, mix, stir until cold.

Procedure

Icthamol ointIcthamol oint: .: .

Rx• Icthamol......................................10 gm

• Simple oint..................................100 gm

Salicylic a` oint. :Salicylic a` oint. :

Rx• Salicylic a` .................................2 gm

• Simple oint. ...............................100 gm

Sulfur ointSulfur oint: :

Rx• Sulphur.....................................2 gm

• Simple oint ..............................100 gm

ZnO ointZnO oint: :

Rx ZnO...............................................15 gm Simple ointment (Vaseline)......... 100 gm

Boric a` ointBoric a` oint: :

Rx• Boric a`........................................10 gm

• Simple oint ..................................100 gm

Astringent & Astringent & Antiseptic Antiseptic

Astringent & Astringent & Antiseptic Antiseptic

White ppt oint :White ppt oint : ((Ammoniated mercury oint)Ammoniated mercury oint)

Rx Ammoniated mercury 5% in simple ointment to be applied on anal areas.

For Pin WormsFor Pin WormsFor Pin WormsFor Pin Worms

Rx

• Benzoic a`...........................3 gm• Salicylic a`...........................1.5 gm• Vaseline to.......................... 50 gm

White field ointment:

AntifungalAntifungalAntifungalAntifungal

White field paint

Rx• Salicylic acid……….… 3 gm• Benzoic acid…….….… 6 gm• Glycerin………………… 8 ml• Alcohol 60% ………… to 100

( Taenia paint )( Taenia paint )

Oil of cade oint :Oil of cade oint :

Rx• Oil of cade..............................10 ml

• Hard paraffin...........................5 gm

• Yellow soft paraffin.................50 gm

PsoriasisPsoriasisPsoriasisPsoriasis

Mist ammonia & sengaMist ammonia & senga::

Rx• Amm.bicarb.........................0.2 gm

• Tr.ipeca.............................. 0.6 ml

• Tr.squill.............................. 0.5 ml

• Tr.senega...........................1.5 ml

• Syp.tolu..............................3 ml

• Aqua to..............................15 ml

Tablespoonful 3 times after meals

EXPECTORANT

Mist albaMist alba: :

االبيض • المزيج

Rx• MgSO4.......................................4 gm

• Light MgCO3..............................0.5 gm

• Peppermint water to...................10 ml

Laxative

Bisthmuth&chalk mixtureBisthmuth&chalk mixture:

Rx• Bismuth carbonate.......................4 gm

• Prep.chalk(CaCO3).....................2 gm

• Tragacanth..................................0.1 gm

• Tr.catechu...................................6 gm

• Glycerin........................................20 ml

• Chloroform water to.....................100 ml

Rx Tr.hyoscyamus........................1 Tr.belladonna....................... 0.2 Chloroform water................ .. 1.5 Syp to.................................... 5

Mist hyoscyamus & belladonna:

AntispasmodicAntispasmodic

Rx• Oil of anise.............................1 ml• Alcohol 90%..........................9 ml

Spirit anise:

Carminative& flavouring agent

Aqua chloro formi:

Rx

Oil of mentha..............................1 Aqua to........................................1000

Rx Chloroform.................................2.5 Aqua to.....................................1000

Aqua mentha:

Aqua cinnamon:

Rx Oil of cinnamon........................1

Alcohol....................................9

Rx Oil of cinnamon.........................1 Aqua.........................................500

Spirit of cinnamon :

Aqua calcis :(Lime Water)

Rx Calcium hydroxide..................1 gm

Water.....................................1000

in preparation ofin preparation of water- in-oil creamswater- in-oil creams & lotions.& lotions.

in preparation ofin preparation of water- in-oil creamswater- in-oil creams & lotions.& lotions.

Eusol solution:

Rx Boric a`....................................................12.5 Chlorinated lime(Bleaching powder)….125 Water to....................................................1000 (Leave 24 hrs before use)

Disinfectant lotion on wet dressing with equalpart of liquid paraffin, used within 2 weeks

Uses: Antiseptic

Disinfectant lotion on wet dressing with equalpart of liquid paraffin, used within 2 weeks

Uses: Antiseptic

Alum. acetate ear drops:

Rx• Aluminum Sulphate.............112.5• Acetic a`..............................12.5• CaC03..................................50• Tartaric a`............................22.5• Dist water............................375

Dissolve Al2(SO4)3 in 60cc dist water, add acetic acid + CaCO3 + rest of H2O stand 24 hours , then add tartaric acid.

The soln is diluted if used as lotion 1 to 20

Reduce

OticOdema

Rx Hydrogen peroxide 6% soln……….25ml

Water to……………………………..100ml

Hydrogen peroxide ear drops

EAR EAR WASH

WASH

Vaginal douche powderRx lanital powder:• Boric a`......................... ......70 gm• Alum.................................. 23.5 gm• Phenol.................................2 gm• Aromatic eucalyptus.........1.6 ml• Menthol...............................0.01 gm• Methyl salicylate................1.5 ml• Thymol................................0.02 ml

antiseptic, astringent & deodorant

Bendict`s reagent : sugar detection

Rx• Anhydrous sod.carbonate..........100 gm• Sod citrate..................................173 gm• Cu sulfate...................................17.5 gm• Aqua to.......................................1000 ml

Dissolve NaCO3+ Na citrate in 100 cc water add CuSO4 in 100 cc water to the solution

&complete to 1000 with water

Potion reviere mixture:

RX

NaHCO3.............................7 Syp...................................40 Water..............................300

1 .Alkaline mixture:

RX Citric a`...............................8 Syp of lemon.....................Q.S Water................................300

2 .acidic mixture: heart burn

& sour stomach

heart burn

& sour stomach

Calamine lotion:

Rx• Calamine..........................8 gm soothing • ZnO..................................8 gm effect• Glycerin............................6 ml • Lime water to...................100 ml

Sulphur in calamine:

Rx• Sulphur..............................1-5 gm

• Calamine lotion..................100 ml

CHICKENPOXCHICKENPOX

Calamine compound creamCalamine compound cream::

Rx• Calamine………………………6.25 gm• Zinc oxide……………………...6.25 gm• Solution of coal tar…………… 2 ml• Wool fat (lanolin)………………12 gm• Yellow soft paraffin…………… 50 gm

Soothing & antipruriticSoothing & antipruritic

Soothing & antipruriticSoothing & antipruritic

Karvol inhalationKarvol inhalation

Rx• Menthol……………………….36 mg• Chlorobutol…………………..30 mg• Cinnamon oil………………...12 mg• Pine oil………………………...86 mg• Turpentine oil………………...68 mg• Thymol…………………………3 mg

upper respiratory tract congestion )by inhalation(

upper respiratory tract congestion )by inhalation(

Cacao butter cream:

Rx• Oil of theobroma......................10 ml

• Liquid paraffin...........................5 ml

• Lanolin......................................15 ml

• Cold cream to............................50 ml

يوم بعد يوم للشعر يوم دهان بعد يوم للشعر دهان

PodophyllinPodophyllin

PLANTER WARTSPLANTER WARTS

Podophyllin paint:

Rx• Podophyllin powder……………20 gm

• Tr. Benzoin co………………to 100 ml

•warts in certain areas Harmful to the foetus

•should be freshly prepared

•warts in certain areas Harmful to the foetus

•should be freshly prepared

Rx• Podophyllin resin………………….20 gm.

• Salicylic acid………………………25 gm.

• Emulsifying ointment ……...…….100 gm.

Posalfilin

By stopping cell growth for

Callus & warts

By stopping cell growth for

Callus & warts

Rx• Salicylic acid…………………… 39%• Eucalyptus oil…………………....1%• Anhydrous lanolin to…………….100%

Scholl , corn & callus oint.

Topical application for corn & callus Topical application for corn & callus

Callus paint:

Rx• Salicylic acid…………. 2.5

• Lactic acid……………. 2.5

• Collodion………………. 15

Rx• Bergamot Oil ………………………25 ml

• Absolute Alcohol………………to 100 ml

Bergamot Oil / Alcohol

Photosensitizer for Vitiligo &

Hypopigmentation

Foot powder:

Rx• Alum…………………….….... 8 gm

• Starch………………….…….10 gm

• Calamine powder…………. 10 gm

• Oil of mentha……………... 0.5 ml

• Talc………………......…..to 100 gm

Dusting powder:

Rx• Phenol………………………2 gm

• ZnO…………………………2 gm

• Calamine…………….…….30 gm

• Talc………………..........to 100 gm

Prickly heat powder

Rx• Menthol………….................0.5

• ZnO………………...............20

• Talc………………...............50

• Calamine powder…………20

• Boric acid...........................20

Rx • Panthenol ………………..…….20 ml• NaHCO3 ………………………..0.5 gm• Oil of menthe ……………..…. 0.5 ml• Rose H2O …to……………..… 150 ml

Diaper Rash Preparation

كل • بعد سأسأةغيار

لتسلخات • تركيبهاألطفال

Acne preparations:

Rx• Sulphur...........................3 gm• Resorcinol..................... 1 gm• Zinc oxide...................... 20 gm• Talc…………………..…..20 gm• Glycerin……………….....20 gm• Rose water………….. to 200 ml

To be applied once at night

Rx• Salicylic acid………………….. 4 gm• Sulfur ………………………….. 6 gm • Resorcinol……………………... 4 gm• Zinc oxide……………………… 12 gm• Calamine……………………….. 8 gm• Glycerin………………………… 30 ml• Alcohol 70%..............................35 ml• Liposome base………………….35 ml

Preparation for AcnePreparation for Acne

Dalacin T lotion:

Rx• Dalacin caps……………….…..8 caps

• Distilled water………………… 45 ml

• Alcohol…………………….…...45 ml

Treatment of Acne

Acne preparation

• / عافية حسن د تركيبة

Rx• Menthol…………………….….0.5gm

• Resorcinol……………………. 2 gm

• Sulphur………………………...3 gm

• Dalacin T lotion…………….to 100 ml

REAL ALOPECIAREAL ALOPECIA

TOTALISTOTALIS

Alopecia paint:

Rx • Liquor ammonia fortis……….. 1• Tr. Cantharidas....................... 12 • Tr. Capsicum.......................... 12• Glycerin.................................. 10• Aqua rosa ..........………….To 50

Twice daily on the affected area.Twice daily on the affected area.

Rx• Minoxidil powder ……………2% • Liposome base………………30 ml

In case of females we use 2 % while in males we use 5 %.

Preparation for AlopeciaPreparation for Alopecia

Hair fall preparation(For men and women)

• / عيادة مصطفى د / تركيبة عيادة مصطفى د تركيبةRx

• Nopecia caps ……………..20 caps• Liposome base ………...to 30 ml

اسبوعيا مرتين دهانيوم بعد يوم او

Hair oil preparationHair oil preparation

Rx• Panthenol .........................250

• Almond oil ………….…….150

• Olive oil ……………….…..250

• Castor oil ……………..…..100

• Coconut oil …………….….250

• Lavender …………..…..….Q.S

H2O2 in Eucerine preparation:

Rx• H2O2 30 vol………….......... á

• Eucerine…………………........... á

• Cold cream (Eva base)…….…. 50

Should be done in ice bath or mortar kept in the

freezer 3 hours before use.

Should be done in ice bath or mortar kept in the

freezer 3 hours before use.

PeelingPeeling

Jessner's mixture:

Rx• Resorcinol………….…. 14 gm• Salicylic acid …………. 14 gm• Lactic acid …………..…14 ml• Alcohol …………….. to 100 ml

strong peeling agent.

strong peeling agent.

• Improve the appearance and health of skin.

• Diminish fine lines & wrinkles to smooth out the skin.

• Improve tone and elasticity.

• Reduce oil production & increase natural moisture.

• Reduce age spots & hyper pigmentation.

usesuses

Rx Trichloroacetic acid……………..1 part Salicylic acid……………………..6 parts Glycerin…………………………..q.s

Procedure:Procedure: Dissolve TCA in the least amount of glycerin

with gentle heat, add salicylic,triturate till smooth paste is obtained.

Corn callus, wartsCorn callus, warts & tattoo removal & tattoo removal Should be handled with extra careShould be handled with extra care

Trichloroacetic acid (TCA) paste

*The TCA peel is a chemicalThe TCA peel is a chemical.

*Generally left on the skin for 3-4 minutes.

*A covered ice pack or iced water can be used.

*The peeling process is taking 7- 10 days.

*People will generally require only 4-6 peels to achieve the desired results.

**TCA PeelTCA Peel treatment, healing & your new look, takes approximately two weeks from start to finish.

25% for medium.

50% very deep skin peel.

Chloral solution:

Rx• Chloral hydrate powder ………….10 gm• Simple syrup …………………...to 100 ml• Hypnotic dose :• Children aged 1 month to 12 years :

30 to 50 mg/kg

• Children aged 12 to 18 years:

0.5 to 1 gm

Driclor solution:

Rx

• Aluminum chloride ………….20 gm• Ethanol …………………...to 100 ml

Hyperhydrosis to be applied

at night on dry area, washed

in the morning , twice weekly.

Hyperhydrosis to be applied

at night on dry area, washed

in the morning , twice weekly.

Scott's ointment

Rx• Ammoniated mercury 40%..............100gm

• Yellow beeswax …………………….60gm

• Arachis oil……………………………60ml

• Camphor……………………………..30gm

Anti-rheumaticAnti-rheumatic

• Menthol………………………2.85 gm.• Camphor……………………..5.25 gm.• Turpentine oil ……………….4.77 gm.• Eucalyptus oil……………….1.35 gm.• Nutmeg oil…………………...0.48 gm.• Cedar wood oil………………0.45 gm.• Thymol………………………..0.1 gm.• Ointment base to…………….100 gm.

Vicks vapour- rub

Simple incorporation by melting

Simple incorporation by melting

• Benzoic acid……………………….0.03• Boric acid…………………………..2.35• Eucalyptol………………………….0.09• Menthol…………………………….0.04 • Methylsalicylate…………………...0.05• Thymol……………………………..0.06• Ethanol 95%.................................27• Water to……………………………100

Listerine antiseptic mouthwashListerine antiseptic mouthwash

Unnas paste:

Rx • ZnO …………...................... 15 gm• Gelatin ……………………… 15 gm• Glycerol ............................... 35 ml• Distilled water………………. 55 ml

soak gelatin in water for 15 mins ,put half amount of glycerin in water bath ,

dissolve other amount in zinc oxide.

soak gelatin in water for 15 mins ,put half amount of glycerin in water bath ,

dissolve other amount in zinc oxide.

Procedure

Venous UlcerVenous Ulcer

Rhei and co. mixture

Rx• Tr. Rhubarb…….….…………..40 ml

• Sod. Bicarbonate..………..…..20 gm

• Tr. gentian……………………..40ml

• Chloroform water to................300 ml

Dose: 10-20 ml 3 times dailyDose: 10-20 ml 3 times daily Mild Laxative&

bitter stomachic

Hyoscyamus and buchu mixture

Rx• Pot. Citrate………………...1 gm• Tr. Hyoscyamus…………..1ml• Tr. Buchu…………………..1ml• Chloroform water……. To 15 ml

Antiseptic AntispasmodicAntiseptic Antispasmodic

Hair fall preparation:

• / العال عبد حسن د / تركيبة العال عبد حسن د تركيبة Rx• Pilocarpine nitrate..........................1.5 gm• Tr. Jaborandi .............................. 15• Tr.cantharidis.................................7.5• Salicylic acid ................................ 3• Resorcinol..................................... 3• Olive oil ....................................... 50• Panthenol .................................. 50• Oil of lavender .............................Q.S• Alcohol 70%...........................To 300

•( ) / أطفال الخالق عبد كريمة د )تركيبة ) / أطفال الخالق عبد كريمة د تركيبة

Rx• Gentian violet ………………….5 ml.

• Glycerin borax………………….5 ml.

• Xylocaine vial …………………2.5 ml.

• Aqua ………………………..to 15 ml.

Thrush mouth preparation

( ) / وأذن أنف العزيز عبد حسين د )تركيبة ) / وأذن أنف العزيز عبد حسين د تركيبة

Rx• Adrenaline (epinephrine)…………...0.3

• Menthol……………………………….0.3

• Lanovaseline…………..………...….30 gm

Menthol nasal ointment

Cough mixtures:

• / شفيق محمود د / تركيبة شفيق محمود د تركيبة

Rx• Sod. Benzoate ………………….… 1 gm• K bromide ………………............... 1 gm• Ephedrine HCl ……….……………. 0.1• Tr. Lobelia ……………..…………... 1• Minophylline …………………….…. 0.2• Syrup tolu ……………………….…. 30• Aqua ………………………………to 150

•: / الحسن ابو محمد د :تركيبة / الحسن ابو محمد د تركيبة

Rx• Sod.benzoate ………............... 0.125• Tr. Squill ……………................ 0.125• Tr. Stramonium ....................... 0.125• Syrup codeine ......................... 1• Syrup tolu ................................ 1• Aqua anise ………………….…. 5• Fiat …………………………….. 20

Cough mixtures:

•: / التهامى فايز محمد د تركيبةRx• Tr. Ipeca …………................. 3 ml• Tr. Scilla …………..................3 ml• Tr. Lobellia ............................4 ml• Tr. Stramonium .................... 3 ml• Sod. Benzoate .......................2 gm• Syrup codeine .......................30 ml• Syrup allergyl ……………......30 ml• Aqua …………………….. to 100 ml

Cough mixtures:

Renal colic preparation:

• / فام عزيز د / تركيبة فام عزيز د تركيبة

Rx• Pot. citrate ……………… 15 gm• Sod. Bicarbonate ……….10 gm• Tr. Hyoscyamus ……..… 20 ml• Tr. Ammi visnaga ……… 40 ml• Glycerin ………………… Q.S• Infusion buchu ………..to 300 ml

Cough Cold preparation:

• / العال عبد على د / تركيبة العال عبد على د تركيبةRx• Elkosin … … … … … … … …2.5 tablet• Pot. Citrate… … … … … … . .1.75• Acetyl salicylic… … … … . . .1.75• Luminal… … … … … … … …0.020• Ephedrine… … … … … … . . 0.020• Syrup tolu… … … … …… … 20• Aqua… … … … … .… … . to 40• Fiat … … … .… … .… … … X

كبيرة اليوم 4ملعقة فى مرات

DMSO:DMSO:A clear, colourless, odourless, , hygroscopic

liquid: Soluble in water Insoluble in alcohol & In acetone having many pharmacological activity

including membrane penetration, anti-inflammatory effects, local analgesia, weak bacteriostasis, diuresis, vasodilatation, dissolution of collagen, and free-radical scavenging.

Rx • DEMSO………………………….20%• Cold Cream (Eva base)…..… 100gm

DMSO (Dimethyl Sulfoxide)

A vehicle for drugs ,

It aids penetration of the drug

into the skin

and so may enhance the drug's effect.

LiposomeLiposome

• Is a spherical vesicle composed of a bilayer membrane.

• Liposomes are used to deliver certain vaccines, enzymes, or drugs (e.g., insulin and some cancer drugs) to the body. When used in the delivery of certain cancer drugs, liposomes help to shield healthy cells from the drugs' toxicity and prevent their concentration in tissues (e.g., the kidneys, and liver), eliminating the common side effects of nausea, fatigue, and hair loss.

A- Unilamellar: Consisting of phospholipids bilayer

enclosing aqueous layer

B-Multilamellar vesicles (MLV) Consist of several lipid layers (up to 14) in

an onion-like arrangement separated from one another by a layer of aqueous solution

Liposome may beLiposome may be

• Liposomes are especially effective in treating diseases that affect the phagocytes of the immune system because they tend to accumulate in the phagocytes, which recognize them as foreign invaders. Liposomes are sometimes used in cosmetics because of their moisturizing qualities.

ApplicationApplication

Rx• Dinitra 5 mg……………………. 0.2 %

• Liposome base………………… 20 ml

• Lignocaine …………………….. 1 tube

Preparation for anal fissuresPreparation for anal fissures

Rx• Liposome…………..30 ml

• Dinitra 5%................5 tab

• Lignopanthen……...1 tube

• Phenytoin…………...20 tab

Piles preparation :Piles preparation :

Preparation for fungal infectionPreparation for fungal infection

))AA((

Clotrimazol.oint………………………15 ml Liposome base………………………10 ml

))BB((

Ciclopirox 1%(batrafin)………………3 bottles Diprosalic lotion................................1 bottle Liposome base……………………….15 ml

Preparation for fungal infectionPreparation for fungal infection

R x

5-fluro uracil……………………5%

liposome………………………..20 ml

Scars & keloid preparationScars & keloid preparation

Fluorouracil used for tissue

destruction