Dynamic Simulation of Red Blood Cell Rheology in aU-shaped MicrotubeS.Y. Lin, Y.H. Chin, J.J. Hu, and A.J. Chung

Department of Aeronautics and AstronauticsNational Cheng Kung University

2012 2012 4 21-28

Introduction

Red Blood Cell Shape(Diameter) 6.0~9.5m (Thickness) 1.0m 2.0m (Average area) 120(Volume area) 87

Spring Network Model of Elastic RBC Membrane K.I. Tsubota, and S. Wada , International Journal of Mechanical Sciences, 2010.

Level 0 Level 1 Level 3 Level 4 W.X. Huang, C.B. Chang, and H.J. Sung, Journal of Computational Physics, 2011.Unstructured Triangular Mesh 3D level 0~3 sphere of the nodal positions in the Cartesian coordinates.

Spring Network Model of Elastic RBC MembraneLevel =21 Nodes =2402 Edges =7200 Areas =4800

Spring Network Model of Elastic RBC Membrane

Level =21; Nodes =2402; Edges =7200; Areas =4800 Various Shape Changes of Red Blood Cells

Various Shape Changes of a Swollen Red Bloodt=0.1t=0.3t=0.5t=0.7t=1.0t=0

PISO Scheme Step 1: Predictor Step 2: a) First corrector b) Second corrector

Staggered Grids

The Flow Induced Deformation of Red Blood Cells in the U TubeU Tube: PISO Scheme, Stagger GridMI=80, MJ=80, MK=120Radius = 5mInitial data: U=0, V=0, W=0, P=1, =1 Red Blood Cell:Level=9, Nodes=386, Edges=1152, Areas=768

The Flow Induced Deformation of Red Blood Cells in the U TubeU Tube: PISO Scheme, Stagger GridMI=80, MJ=80, MK=120Radius = 5mInitial data: U=0, V=0, W=0, P=1, =1 Red Blood Cell:Level=9, Nodes=386, Edges=1152, Areas=768

The Flow Induced Deformation of Red Blood Cells in the Y TubeY Tube: PISO Scheme, Stagger GridMI=160, MJ=80, MK=120

Initial data: U=0, V=0, W=0, P=1, =1 Red Blood Cell:Level=9, Nodes=386, Edges=1152, Areas=768

Thanks for your attention!