e. simko wcvm
DESCRIPTION
Repaire and regeneration. Prerequisites for healing: Debridement Tissue scaffold Germinal cells Blood supply. Healing: First intention Second intention. Reference reading: Repair of the skin pp318-322, in Applied Veterinary Histology, W. J. Banks, 1993. E. Simko WCVM. - PowerPoint PPT PresentationTRANSCRIPT
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E. Simko WCVM
Healing:• First intention
• Second intention
Prerequisites for healing:• Debridement
• Tissue scaffold
• Germinal cells
• Blood supply
Reference reading: Repair of the skin pp318-322, in Applied Veterinary Histology, W. J. Banks, 1993
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• Extreme temperatures (cold and burns)• Solar injury (direct effect and photosensitization)
• Chemical/toxic injuries (ergot, fescue, Se) • Self-inflicted injury
Acral lick dermatitis (lick granuloma)
Feline psychogenic alopecia
Pyotraumatic dermatitis (hot spots)
• Injection site reactions• Intertrigo (skin fold dermatitis)
E. Simko WCVM
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• Allergy (Hypersensitivity)severe reaction to harmless foreign antigen
E. Simko WCVM
• Autoimmune dzimmune reaction against self-antigens
Pathogenesis:tissue damage is mediated by four immune reactions: Type I, II, III, and IV
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Immunologic diseases
Allergen
IgE
Mast cell
E. Simko WCVM
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Immunologic diseases
E. Simko WCVM
IgG
Cytotoxic effect
Complement
T cell
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Immunologic diseases
E. Simko WCVM
ComplementImmune complex deposition
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Immunologic diseases
SensitizedT cell
Antigens
Cytokines Chemotaxis and activation of
macrophages
E. Simko WCVM
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Immunologic diseases
• Allergy (Hypersensitivity)severe reaction to harmless foreign
antigen
• Mediated by type I and/or type IV reactions
• Common in dogs and horses, less common in cats and uncommon in food animals
• Erythema, pruritus, self-induced trauma E. Simko WCVM
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Immunologic diseases - Allergic dz
• Inherited predisposition to type I reaction
• Average age of onset is from 1 to 3 years
• Respiratory route of allergen exposure (dogs)
• Lesions: erythema, urticaria,
self-inflicted trauma (licking, rubbing)
E. Simko WCVM
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Immunologic diseases - Allergic dz
• There is no single confirmatory test
• Skin biopsy
• Rule out other allergies
• Intradermal allergy testing
• ELISA for allergen specific IgE
Diagnosis
E. Simko WCVM
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Immunologic diseases - Allergic dz
• Most common allergic dermatitis in dogs and cats
• Type I and type IV reactions to flea saliva
• Seasonal pruritus with self-inflicted trauma(excoriation) and alopecia
E. Simko WCVM
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Immunologic diseases - Allergic dz
• Skin biopsy
• Demonstration of fleas
• Provocative exposure and response to therapy
Diagnosis
E. Simko WCVM
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Immunologic diseases - Allergic dz
• Type I and/or type IV reactions
• Non-seasonal erythema, urticaria, alopecia, pruritus
with self-inflicted trauma (licking, rubbing)
E. Simko WCVM
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Immunologic diseases - Allergic dz
• Skin biopsy
• Rule out other allergies
• Elimination diet trial (with absolute compliance)
Diagnosis
E. Simko WCVM
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Immunologic diseases - Allergic dz
• Type IV reaction to chemicals (dyes, plant, soaps, detergents,…)
• Erythema, pruritus with self-inflicted trauma (exudation, crusts, alopecia)
• Diagnosis
Skin biopsy
Elimination trial
E. Simko WCVM
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Immunologic diseases
• Vesiculo-pustular dz often presented as persistent erosions and crusting
• Autoimmune dzimmune reaction against self-antigens
• Mediated by type II or III reactions
• Variably pruritic, if not complicate by
pyodermaE. Simko WCVM
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Immunologic diseases - Autoimmune dz
• Group of vesicular/pustular diseases
• Pemphigus foliaceus (Ca, Fe, Eq, Cap) Acantholysis (anti-desmosomal antibodies)
• Bullous pemphigoid (Ca, Eq)(anti-hemidesmosomal antibodies)
E. Simko WCVM
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Immunologic diseases - Autoimmune dz
• Type III reaction
• Systemic lupus erythematosus
Multiorgan disease
• Discoid lupus erythematosus
Skin of the face
• Ab-Ag deposition
E. Simko WCVM
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Immunologic diseases - Autoimmune dz
• Autosomal dominant disease
• Puppies and young dogs
• Type III reaction - vasculitis
E. Simko WCVM
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Immunologic diseases - Autoimmune dz
• Clinical signs
• Histology
• Immunohistochemistry
E. Simko WCVM