Earl W. Sutherland, Jr Discovery of Cyclic AMP

Ferid MuradNitric Oxide Signaling

Alfred G. GilmanG-protein Signal Transduction

Heritage of the CWRU

Department of Pharmacology

Nobel Prize

Kris Palczewski, Chairman of

Pharmacology

First high resolution structure of a G-protein coupled receptor (GPCR)• most common target of

modern drug development

In the top five of most highly cited articles in Biology / Biochemistry

Thomas Reuters Survey

Continuing Tradition of Excellence in Pharmacology at CWRU

Membrane Structural Biology &

Pharmacology

Cellular / Molecular Biology

& Research Rotation

s

Molecular Pharmacolog

y & Cell

Regulation

Translational

Therapeutics

The MTTP provides students with outstanding training in the cellular, molecular, and physiological basis for therapeutics,

preparing them for independent careers in research and teaching in a variety of academic or industrial settings.

Molecular TherapeuticsTraining Program ( MTTP )

Cancer Therapeutics

Core and Advanced

Tracks

The NIH-funded Molecular Therapeutics Training Program (MTTP) involves faculty from six major research centers in Cleveland - CWRU, University Hospitals, Case Comprehensive Cancer Center, Cleveland Clinic Foundation, Cleveland VA Medical Center, and MetroHealth Medical Center.  Students enter the Pharmacology Graduate Program directly, or via the Biomedical Sciences Training Program (BSTP) or the Medical Sciences Training Program (MSTP).

Membrane Structural Biology &

Pharmacology

Cellular / Molecular Biology

& Research Rotation

s

Molecular Pharmacolog

y & Cell

Regulation

Translational

Therapeutics

The MTTP provides students with outstanding training in the cellular, molecular, and physiological basis for therapeutics,

preparing them for independent careers in research and teaching in a variety of academic or industrial settings.

Molecular TherapeuticsTraining Program ( MTTP )

Cancer Therapeutics

Core and Advanced

Tracks

The Molecular Pharmacology and Cellular RegulationTrack promotes common research interests in molecular mechanisms of drug actions and regulatory processes that are potential targets for drug development.

• Novel role of ATP as a chemoattractant that facilitates the immune component of the anti-tumor response associated with cancer chemotherapy …

Andrea Boyd-Tressler and George Dubyak

Molecular Pharmacology and Cellular Regulation Track

Luke Bury and Shasta Sabo • Modern electrophysiology and imaging used to

discover the mechanisms by which nerve synapses are formed in the developing brain - discovering the basis for autism …

Meghana Gupta and Danny Manor • Learning how phosphorylation of tyrosine residues affects

the biochemical and physiological activities of proteins that regulate G-protein signaling – discovering anti-cancer targets …

Membrane Structural Biology &

Pharmacology

Cellular / Molecular Biology

& Research Rotation

s

Molecular Pharmacolog

y & Cell

Regulation

Translational

Therapeutics

The MTTP provides students with outstanding training in the cellular, molecular, and physiological basis for therapeutics,

preparing them for independent careers in research and teaching in a variety of academic or industrial settings.

Molecular TherapeuticsTraining Program ( MTTP )

Cancer Therapeutics

Core and Advanced

Tracks

Benefiting from the Case Comprehensive Cancer Center, the Cancer Therapeutics Track fosters common interest in the concepts of cancer biology that form the basis for specific therapeutic strategies.

Cancer Therapeutics Track

• Studies of mechanisms of regulation of lymphocyte apoptosis via the TDAG8 G protein-coupled receptor in the context of leukemia.…

Chris Ryder Clark Distelhorst

• “The role of the microenvironment in mediating breast cancer progression.  Specifically I'm interested in the role of microRNAs on TGF-beta mediated-metastatic progression…”

MollyTaylor Billl Schiemann

Membrane Structural Biology &

Pharmacology

Cellular / Molecular Biology

& Research Rotation

s

Molecular Pharmacolog

y & Cell

Regulation

Translational

Therapeutics

The MTTP provides students with outstanding training in the cellular, molecular, and physiological basis for therapeutics,

preparing them for independent careers in research and teaching in a variety of academic or industrial settings.

Molecular TherapeuticsTraining Program ( MTTP )

Cancer Therapeutics

Core and Advanced

Tracks

The Translational Therapeutics Track interfaces basic science trainees with physician-scientists around a common interest in developing / improving the use of therapeutic agents in a rational and individualized manner.

• Antiplatelet therapeutics…”my project examines an agent that has ideal characteristics; it delays thrombosis but does not influence bleeding time…”

Michele Mumaw Marvin Nieman

Translational Therapeutics Track

• Structure function studies of Class A beta-lactamases. Understanding the factors that permit the successful evolution of beta-lactamases in the clinic…

Peter Levitt Robert Bonomo

• “I study the role of DNA repair in hematopoietic stem cells to understand the relationship between DNA repair, cell cycle status, and hematopoietic stem cell function.…”

Amar Desai Stan Gerson

Structural Biology & Pharmacology Track

…

Mike Mullins

Understanding the function of telomerase in

DNA replication pertaining to aging and cancer chemotherapy

Derek Taylor

Determining the structure of isolated discs from the rod cells of the eyes of

mouse models of human eye diseases

Neetu Gulati Phoebe StewartDirector, CCMSB

Chris Francy Jason Mears

Studying the molecular dynamics of Drp 1 in

mediating mitochondrial fission & fusion pertinent to

neurodegenerative diseases

Electron Microscopy NMR

X-ray generator Crystal robot

Mass spec, computational modeling, one of the 3 largest, best equipped facilities in the world!