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  • EASIS Brief Introduction Page 1

    EASIS - Brief Introduction

    EASIS Background ...................................................................................................................................................... 1

    EASIS First Steps ......................................................................................................................................................... 2

    EASIS Search Functions .............................................................................................................................................. 2

    Simple Search ......................................................................................................................................................... 2

    Advanced Search .................................................................................................................................................... 5

    EASIS Study Questionnaires ....................................................................................................................................... 8

    Questionnaire actions .......................................................................................................................................... 10

    Questionnaire meta-data ..................................................................................................................................... 10

    Questionnaire data .............................................................................................................................................. 11

    EASIS Background EASIS, the Endocrine Active Substances Information System, is a web-based application open to the public for

    query and review of (eco)toxicological information about chemicals, with an emphasis on endocrine-related

    endpoints.

    The starting point of EASIS was the EAS Database1 created by the European Commission's Environment

    Directorate-General (DG ENV) in the 2000s. A new application, EASIS, was developed and the data from the DG

    ENV DB were migrated into EASIS. More data will be added over time.

    1 see https://eurl-ecvam.jrc.ec.europa.eu/laboratories-research/endocrine_disrupters/files_eds/database.zip

    https://eurl-ecvam.jrc.ec.europa.eu/laboratories-research/endocrine_disrupters/files_eds/database.zip

  • EASIS Brief Introduction Page 2

    EASIS First Steps The URL https://easis.jrc.ec.europa.eu leads to the EASIS main page:

    No login is necessary for browsing the data of EASIS.

    The Glossary and the Links buttons lead to pages with background information.

    The Search button leads to the main functionality, i.e. querying and reviewing studies in EASIS.

    EASIS Search Functions Clicking on the search tab in the main screen leads to two search options:

    Simple Search

    Advanced Search

    Simple Search The Simple Search is the default option selected:

    Any search term can be entered into the search field, and once the button is clicked, all DB fields will be

    examined whether the word appears there, and as a consequence, the Result Set is shown.

    Once the button is clicked, a turning wheel in the upper right hand corner of the screen (near the Login

    button) indicates that the search is currently being performed:

    https://easis.jrc.ec.europa.eu/

  • EASIS Brief Introduction Page 3

    Once the turning wheel disappears, the results are shown. Example: "ovaries" are entered as search term:

    This sample Result Set shows that 120 studies are in the database in which the term "ovaries" appears (in any

    field).

    The Result Set features the following fields:

    Result Set fields: Test Type and Target

    All studies in EASIS are of one of the following four types:

    In-vivo mammals

    In-vivo humans (epidemiology)

    In-vivo ecotox

    In-vitro

    Later we will see that EASIS study data are displayed in one of four possible "Questionnaires" which are forms

    that correspond to these four types.

    Result Set fields: Substance and CAS Number

    Indicates the substance that the study is about.

    Result Set field: General Effect Type

    Indicates what kind of effect was observed in the study. In most cases this field also contains the search term.

    Result Set field: Test Guideline

    Indicates what Test Guideline (OECD or other) was followed in the study, if any.

  • EASIS Brief Introduction Page 4

    Result Set field: Metric Endpoint

    Displays relevant numerical results of the study.

    Result Set field: View

    By clicking the arrow-down symbol in the "View" column

    columns to be displayed/not displayed in the Result Set can be selected:

    The "View" column features two clickable icons:

    - the "View matched fields" icon, which displays the field(s) in which the search term appeared (i.e. the

    reason why the study is displayed in the Result Set), and

    - the "View Study" icon, which leads to the display of the full study report, see chapter "EASIS Study

    Questionnaires".

    Filter Result Set

    The row of column headings features Filter fields. When selecting a filter term from one or more of the filter

    fields

  • EASIS Brief Introduction Page 5

    (e.g. "Ecotox" in the Target field), only the studies from within the Result Set that deal with "Ecotox" are

    shown:

    Filtering can be used to drill into the search result and get a less overwhelming Result Set.

    Advanced Search

    Clicking the tab activates the Advanced Search.

    Search criteria can be entered in one or more of the search fields, and once the button is clicked, the DB

    is searched for the occurrence of each of the search criteria, and the Result Set is shown:

  • EASIS Brief Introduction Page 6

    Search Example: CAS number = 63-25-2

    (Please note that depending on your screen resolution you might have to scroll down to see the results!)

    The Result Set shows 114 studies for this substance (Carbaryl).

    The columns of the Result Set correspond to the ones of the Simple Search (see above). Filtering and exporting

    are also the same as in the Simple Search.

    As is the case with the Simple Search, clicking the "View Study" icon in the View column leads to a detailed

    view of the selected study. For more details, see the chapter "EASIS Study Questionnaires".

  • EASIS Brief Introduction Page 7

    Search Example: Test Guideline = OECD Guideline 421:

    The Result Set shows 3 studies for this Guideline.

  • EASIS Brief Introduction Page 8

    Search Example: CAS number = 72-43-5 & Study Type = In vitro

    The Result Set shows 32 in-vitro studies for this substance (Methoxychlor).

    EASIS Study Questionnaires The Result Sets of both the Simple Search and the Advanced Search display one row per retrieved study. Next to

    each of these rows, the "View Study" icon leads to the display of the full study report.

  • EASIS Brief Introduction Page 9

    Clicking the View icon next to any study

    displays the main Study screen:

    Study Data in EASIS are displayed in an interconnected series of screens that are called Questionnaires.

    The questionnaires themselves are a long series of data display forms (top part of the screen, see chapter

    "Questionnaire data"); the bottom part of the screen shows assorted questionnaire meta-data (see next

    section).

  • EASIS Brief Introduction Page 10

    Questionnaire actions The section "actions" in the questionnaire shows icons for all manipulations that are possible with the current

    study (questionnaire). The two selectable actions are "Expand" (the section view) and "Close" (the study).

    Questionnaire meta-data The questionnaire meta-data give information about general overview data concerning the selected study:

    Questionnaire meta-data element Study information

    Several fields give information about relevant data concerning the questionnaire, like test type, target, creation

    date, etc.

    The study status is "published" for all publicly visible questionnaires, i.e. studies uploaded by the EASIS data

    management team.

    Questionnaire meta-data element Endpoints

    The EASIS data model supports the association between an EASIS questionnaire and the OECD Harmonised

    Template2 (OHT) format. Each questionnaire is linked to one distinct OHT, which makes subsequent re-use of

    the data in other environments and applications easier: OHTs are used in a number of regulatory programmes

    2 The OECD Harmonised Templates (OHTs) are standard data formats for reporting studies done on chemicals to determine their properties or effects on human health and the environment. For more details go to http://www.oecd.org/ehs/templates/

    http://www.oecd.org/ehs/templates/

  • EASIS Brief Introduction Page 11

    as the data reporting and exchange format, most prominently REACH3. Inserting data into EASIS makes them

    automatically compatible with these reporting standards for possible re-use in a regulatory context.

    Possible associations between Questionnaire types and OHTs are as follows:

    Questionnaire data Each questionnaire consists of several sections:

    3 REACH is a regulation of the European Union, adopted to improve the protection of human health and the environment from the risks that can be