echocardiography of congenital heart disease...•lv •rv •ventricular septum •aortic valve...
TRANSCRIPT
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Pediatric EchocardiographySarah Clauss MDChildren’s National Medical CenterWashington DC
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What is your career?
A. Adult Echocardiographic SonographerB. Pediatric Echocardiography SonographerC. Adult and Pediatric D. RadiologyE. Other
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Objectives
• Implement current best practice standards in pediatric echocardiography
• Describe the basic pediatric echocardiogram. (views, imaging techniques, etc.)
• Improve the ability of the sonographer to understand and preform high risk pediatric echocardiograms.
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Congenital Heart Defects7-10/1,000 Live Births
DIAGNOSIS (Balt-Wash) PERCENTVentricular septal defect 26%Tetralogy of Fallot 9%Atrioventricular septal defect 9%Atrial septal defect 8%Pulmonary valve stenosis 7%Coarctation of the Aorta 7%Hypoplastic left heart syndrome 6%D-Transposition 5%
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CHD in Adults
30,000 babies born with CHD per year20,000 surgeries for CHD per year85% survive into adulthoodOver 1.2 million adults with CHDIncreasing at 5% per year8,500 per year reach adulthoodLess than 10% disabled
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Evolution of Cardiac SurgeryDiagnosis 1950’s 1960’s 1970’s 1980’s 1990’s 2000’s
ASD Rare Repair
Repair older child
Repair age 4
Repair age 2 Repair age 2-3
Device closure
VSD Rare Repair
Repair >10 kg or palliate
Repair < 1 year or palliate
Repair 6 months or prn
Repair premature infants
PDA Repair Repair Repair Repair Repair
TOF Palliate Late Repair in adults
Repair after palliation
Repair 2-8 months or prn
TGA No survivors
Rare Survivors
Atrial Repair
Transitional Decade
Arterial Repair
Single Ventricle
Comfort care
Palliate Rare Fontan
Fenestrated Fontan
Lateral Tunnel
Extra-cardiac Fontan
HLHS Comfort care
Comfort care
Surgery in Boston
Comfort vs. high risk surgery
Surgery & Fetal Diagnosis
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Embryology 101
19 Days: Two endocardial tubes have formed – these tubes will fuse to form a common, single primiative heart tube22 Days: Heart tube begins to beat23 Days: Folding commences30 Days: Primitive circulation 9 weeks (56 Days): All major structures identified
(In humans, several months of gestation remain for emergence of HLHS, PS, etc)
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The Cardiac Crescent and the Tube Heart
From Heart Development, 1999
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Looping and Septation
From Heart Development, 1999
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How do Congenital Heart Defects form?
Complex interaction between environmental and genetic etiology
• Multifactorial• 5-8% chance of recurrence
Environmental exposures may influence micro-uterine environment and either turn on or off needed protein development
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Echocardiography
1793 Italian priest studied bats1845 Austrian scientist Christian DopplerWWII Sonar detected submarines1954 Hertz & Edler
• (A&B mode echocardiogram)Reflection of US waves by targetDisplay based on
• Intensity of returned signal• Time of “flight” or depth
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Echo timeline
M-mode ultrasound early 1970’s2D echo late 1970’sDoppler Echo 1980’s
• Pulsed wave Doppler• Continuous wave Doppler• Color Doppler
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Pediatric Echo is Different
Anatomy and physiology over function Segmental approach for complex patients Improved resolution
• Heart is closer to chest wall• Higher frequency transducers• TEE rarely necessary for diagnosis
Inversion of apical and subcostal images
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Diagnostic accuracy depends on image quality
Improve signal/noise ratioImprove image resolutionAppropriate transducerFocus depth
OPTIMAL WINDOW SHOULD ALLOW US BEAM TO BE PERPENDICULAR TO AREA OF INTEREST FOR IMAGING AND PARALLAL TO FLOW JETS FOR DOPPLER AND COLOR
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5 Standard Views
SubcostalLeft ParasternalApicalSuprasternal NotchRight Parasternal
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Subcostal structures
• IVC• Hepatic veins• Abdominal aorta• Diaphragm• SVC• LA• RA• Atrial Septum• Ascending aorta• Branch PA
• Coronary sinus• Pulmonary veins• Mitral Valve• Tricuspid Valve• LV• RV• Ventricular Septum• Aortic Valve• Pulmonary Valve• Pericardium
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Left Parasternal
• IVC• SVC• LA• RA• Atrial septum• Coronary sinus• Pulmonary veins• MV• TV
• LV• RV• Ventricular septum• Aortic Valve• Pulmonary valve• Ascending aorta• Coronary arteries• MPA/BPA• Pericardium
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http://www.lai-echo.com/chapter4/video-4-6.asp
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Apical views
• IVC• LA• RA• Atrial Septum• Coronary sinus• Aortic valve• Pulmonary valve• Ascending Aorta
• Pulmonary veins• MV• TV• LV• RV• Ventricular Septum• MPA/BPA
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http://www.lai-echo.com/chapter4/video-4-4.asp
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Suprasternal notch
• SVC• LA• Pulmonary veins• Ascending aorta• Thoracic Aorta• MPA/BPA• Aortic Arch• Left Innominate vein
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http://www.lai-echo.com/chapter4/video-4-14.asp
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Right Parasternal
• IVC• SVC• RA• Atrial septum• Right pulmonary veins• Ascending Aorta• Right pulmonary artery
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Hemodynamic Measurements
Doppler insonation anglePressure gradients Bernoulli equation
• Modified Bernoulli Equation Δ P= 4 x v22
Flow• Qp=RVOT CSA x RVOT VTI• Qs= LVOT CSA x LVOT VTI• Qp/Qs= 1/1 normal , abnormal ≥ 1.5:1
PI velocity for PAEDP
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Echo in CHD
Doppler echo• Pulsed wave Doppler
• Quantitation of intracardiac hemodynamics– Valvar regurgitation– Intracardiac shunts– LVOT/RVOT obstruction
• Ventricular function– Systolic– Diastolic (mitral inflow, pulmonary venous inflow)
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Echo in CHD
Continuous wave Doppler• Non-invasive measurements of mean and peak
transvalvar gradients• Valvar stenosis
• Prediction of Ventricular Pressure (modified Bernoulli equation)
• VSD- LV: RV pressure gradient• TR/PR RV, PA pressure
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Echo in CHD
Color Doppler• Direction of cardiac flow
• TAPVR vs. LSVC• Velocity and Turbulence of cardiac flow
• Conduit obstruction• Identification of intracardiac shunts
– VSD, PDA, ASD• Assessment of Post-op CHD
– Shunt patency, residual intracardiac shunt
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Morphologic/Segmental approach
Define morphologic—not spatial—anatomy• Which atrium is the Right? Left?• Which ventricle is the Right? Left?• Which great artery is which?
Define segmental anatomy• Segments: Atrium, Ventricles, Great Arteries• What is the position of each segment relative to each other?
• Is the RA on the right? Is it connected to the RV? Is it connected to the PA?
• Is the LA on the left? Is it connected to the LV? Is it connected to the Aorta?
Predict the physiology• What is the physiology predicted by the segmental connections?
• Normal? Transposition? Obstructed flow?• What is the physiology predicted by flow in the ductus? Across
the foramen?
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The Cardiac Segments
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Abdominal and Atrial Situs
Cardiac position• Levocardia, Dextrocardia, Mesocardia, Dextroposition
Situs abnormalities• Inversus
• Not often associated with CHD• Ambiguous
• Heterotaxy syndromes– Asplenia/polysplenia– Abdominal malrotation– Cardiac defect
» AV canal defect» Conotruncal defects» Systemic and pulmonary venous anomalies
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The Endocardial Cushion
Define the connections• Concordant: RA to RV, LA to LV• Discordant: RA to LV, LA to RV• Common inlet: AV canal defect• Atretic inlet: mitral, tricuspid valve atresia• Double inlet
Assess AV valve anatomy and function• Morphology
• Ebstein’s tricuspid valve, parachute mitral valve• Hypoplastic
• Physiology• Stenosis• Atresia• Insufficiency
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LA
RV LV
RA
LVRV
RA LARA
LVRV
LANormal
Common AV inlet
Atretic AV inlet
LA
RV LV
RA
The Endocardial Cushion
UnbalancedBalanced
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The Ventricles
The Right Ventricle• Coarsely trabeculated• Moderator band• “Septophilic” tricuspid valve chordal insertions
The Left Ventricle• Finely trabeculated• 2 prominent MV papillary muscles• No septal attachments of valve
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The Great Arteries
Identify the great arteries:• Aorta
• Coronary artery origins• Origin of brachiocephalic vessels from arch• “Candy cane?”
• Pulmonary artery• Proximal bifurcation into branch PAs• No brachiocephalic vessel from the ductal arch• “Hockey stick?”
How many outlets?• One? = truncus arteriosus or semilunar valve atresia• Two? Are they normal? In position? In size?
Do the great arteries arise from the correct ventricles?• Aorta from LV, PA from RV = solitus (normal) GA • Aorta from RV, PA from LV = transposition of the GA• Both from RV = DORV
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Common Lesions
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Atrial Septal Defects
Secundum ASDPrimum ASDSinus Venosus defect
• Not truly a deficiency of the atrial septum, but the same physiology as an ASD
Common atrium
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Atrial Septal Development
http://www.med.unc.edu/embryo_images/unit-welcome/welcome_htms/contents.htm
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ASD: Clinical Correlation
Usually diagnosed in childhoodAsymptomaticF>MSystolic ejection murmur and widely split fixed S2EKG may show RBBB or RVH
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Atrial SeptumNormal Variants
Patent Foramen Ovale Atrial Septal Aneurysm
RA
LA
RA
LA
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Secundum ASD
RV
LV
LA
RV Dilation
RV
LV
Diastolic Septal Flattening
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Secundum ASD
Subcostal Coronal Subcostal Sagittal
LA
RA RA
LA
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Devices for ASD Closure
Cardio-SEAL Amplatzer
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Amplatzer Occlusion of Atrial Septal Defect
Clockwise from above: Transcatheter delivery of Amplatzer device, which is positioned across the atrial septal defect
Left: Amplatzer device in place
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ASD device
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Primum ASD
Part of spectrum of AV canal defects
Defect is contiguous with AV valves
Associated with cleft mitral valve
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Primum ASD
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Sinus Venosus Defects
Deficiency in the wall between the right pulmonary veins and the RA
PAPV-DRAINAGE• SVC type = RUPV• Inferior type = RLPV
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Sinus Venosus ASD
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Sinus Venosus ASD
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Partial Anomalous Pulmonary Venous Return (PAPVR)Right veins (more common):RASVC ( RUPV to the RA or base of the SVC-sinus venosus ASD)IVCLeft veins:Innominate veinCoronary sinus Rarely: SVC, IVC, right atrium, or left subclavian vein
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PAPVR to IVC
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PAPVR to SVC
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Total Anomalous Pulmonary Venous Return (TAPVR)I: Supracardiac: common pulmonary vein drains into the right superior vena cava from the left superior vena cava (vertical vein) and the left innominate vein (50%)II: Cardiac: coronary sinus, right atrium (20%)III: Infracardiac: subdiaphragmatic (portal vein, inferior vena cava, ductus venosus) (20%)IV: Mixed: any combination of types I, II, III, the least common
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TAPVR
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TAPVR to Vertical Vein
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TAPVR to IVC
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TAPVR to CS
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The Ventricular Septum
AV canal septum (1)Muscular septum including the trabecular portion (2) and the septal band (3)Conal septum (4)
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The Ventricular Septum
Left ventricular viewAV canal septum (1)Muscular septum including the trabecular portion (2) and the septal band (3)Conal septum (4)
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Muscular VSD
Within the muscular ventricular septumApical (black)Mid (pink)Anterior (green)Posterior/inlet (white)“Swiss cheese”Tend to get smaller with time
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Conoventricular VSD
In the area where the AV canal septum, conal septum and muscular septum meet“Membranous VSD”
• “Para-” or “Peri-” (red)Malalignment
• “TOF-type”, “VSD in the Y of septal band”(blue)
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AV Canal Type VSD
Deficiency of the AV cushion contribution to the ventricular septum (red)“Inlet VSD”Different from “Inlet muscular” VSD which is entirely surrounded by muscle (blue)
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VSD: Clinical Correlation
Size and pulmonary vascular resistance determines clinical presentation
• Fetal transitionSymptoms are determined by the size of the shunt
• Size of defect• Presence of other anomalies• Extracardiac abnormalities
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VSD: Clinical Correlation
Audible after several days (not immediately after birth), typically picked up at 1st visitLarge defects=congestive heart failure
• Tachypnea (RR>60)• Poor feeding/poor growth• Reflux/vomiting
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VSD: Clinical Correlation
Spontaneous resolutionOr not…Pulmonary disease
• Eisenmenger’s syndromeAortic regurgitation
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Muscular VSD
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Membranous VSD
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Membranous VSD w/ TV aneurysm tissue
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Membranous VSD w/Aortic Valve Prolapse
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Restrictive Membranous VSD
4.7 m/sec87 mm HgNormal RVP
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Unrestrictive Membranous VSD
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Atrioventricular Canal Defect- Complete
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Common AV Canal (CAVC)
Endocardial Cushion Defect (ECD)Atrioventricular Septal Defect (AVSD)
Failure of the AV canal to develop properly and form tricuspid, mitral valves and portions of atrial and ventricular septaeSpectrum of defects
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Definitions
Incomplete CAVC = lack the VSD component or ASD componentPartial CAVC = synonym for incomplete CAVC OR = primum ASD with cleft mitral valveTransitional CAVC = small VSD componentBalanced/Unbalanced
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Atrioventricular Canal Defect – Partial
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AV Septal Defect
Complete
Anterior Leaflet
Posterior Leaflet
VSD
ASD
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Best View of CAVC
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Transitional AVC
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Unbalanced
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Patent Ductus Arteriosus
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PDA: Clinical Correlation
Closed in 90% of infants by 48 hours of life• Prematuring, altitude
Anatomy• Derived from the left 6th embryonic arch
Closure• Muscular
constriction→endothelium→thrombosis→fibrous strandPhysiology↔ shunting
• Symptoms proportional to shuntingMurmurEKG
• Ventricular hypertrophy
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Patent Ductus Arteriosus
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Doppler of the PDA (L-R shunt)
CW Doppler tracing (right) seen above the baseline indicating flow toward the probe from the descending aorta through the PDA to the PA. The peak velocity is reached in late systole 4 m/s. L-R shunt
Color flow Doppler (left) showing a L-R shunt from the descending aorta through the PDA to the PA (red: towards the probe)
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Doppler of the PDA (bidirectional shunt)
CW Doppler from an infant with pulmonary artery hypertension and PDA. The negative deflection in systole below the baseline arises from the R-L shunt through the PDA from the PA to the Dao (away from the TDX).The positive deflection (late systole-into late diastole) arises from L-R shunt through the PDA from the Dao to the PA
Bidirectional blood flow through the PDAcan be a normal finding in newborn infants due to high pulmonary resistance
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Doppler of the PDA (R-L shunt)
The Doppler spectral tracing shows evidence of severe pulmonary hypertension and no evidence of a L-R shunt through the PDA. The shunt is R-L from the ductus arteriosus to the Dao (blue: away from the TDX)
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Patent Ductus Arteriosus –Ligation and Division
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Occlusion of Intracardiac and Vascular ShuntsCoil embolization of PDA
Left, top: Catheter crosses the PDA from the aortic side and delivers a coil.
Left, bottom: Withdrawal of catheter, leaving coil in PDA
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Amplatzer Ductal Occluders
Amplatzer ductal occluderIllustration courtesy AGA Medical Group
Aorta angiogram with device occlusion of PDA, lateral view
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Right Heart Obstructive Lesions
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Pulmonary Valve Stenosis
Valve anatomy• Doming, fused commissures• Thickened, immobile• Subvalvar obstruction• Supravalvar obstruction
Post stenotic dilationRVH
RV
PV
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PS: Clinical Correlation
AsymptomaticMurmur at birthEKG
• RAD, RVH proportional to obstructionManagement
• Balloon dilationExcellent outcome
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Pulmonary Artery Branch Stenosis
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Tetralogy of Fallot
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Tetralogy of Fallot
“Maladie Bleu” 1888Stensen 1671Sandifort 1777
Arthus Louis EtienneFALLOT
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Variations of Tetralogy
Tet, pulmonary atresia:MAPCAS“Mexican Tet”
• Hypoplastic or absent conal septumTetralogy with absent pulmonary valve
• Rudimentary pulmonary valve leaflets result in fetal pulmonary regurgitation, PA dilation
• Airway and lung development is compromised in severe cases
Tetralogy with CAVC
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TOF: Clinical Correlation
Most common cyanotic defectDefective neural crest migration resulting in abnormal conotruncal developmentClinical presentation depends on degree of subpulmonary narrowing
• This may change over timePresentation
• Fetal dx• Murmur
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TOF: Clinical Correlation
Cyanosis due to right to left shunting at ventricular levelDegree of cyanosis is proportional to amount of RVOTODynamic factors may worsen cyanosis
• Tet Spell→ no murmur→ deeply cyanoticEKG
• RVH, RAD, RAECXR
• Boot shaped heart
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Tetralogy of Fallot
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Transcatheter Pulmonary Valve
• Catheter delivered prosthetic pulmonary valve• Made from bovine jugular vein• Sewn within a platinum-iridium ballon expandable stent• For use in patients with a surgically placed conduit from the
RV to the PA• Used to treat significant conduit valve insufficiency and/or
stenosis that would otherwise require surgical conduit replacement
• FDA approved 2010
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DORV• Describes a relationship where the PA and Aorta both arise
from the anatomic RV• “DORV” is normal during heart development • Incidence 1 – 1.5% of patients with CHD• 1 per 10,000 live births• Possible association with trisomy 13 and trisomy 18• Van Praagh – both great arteries arise from the
morphologically RV• NO mitral - aortic fibrous continuity• Two functional ventricles in which a VSD provides the only
outlet for one ventricle• Anderson - 50% override rule – “if >50% of the aorta is over
the RV, its DORV”
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Left Heart Obstruction
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Aortic Stenosis
Valve, sub-valvar or supravalvarClinical manifestations
• Mild-moderate assymptomatic• Severe
• Depends on age of patient• Management
• Cath vs. surgery
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Coarctation of the Aorta
Aberrant ductal tissue within the wall of the aortaAll coarcts are “juxtaductal”Pseudocoarctation = kinking at the usual site of Coa, but WITHOUT obstruction
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Coarctation of the Aorta
NarrowedIsthmus
AAo
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Normal or CoA?
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Descending AO Doppler
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Coarctation
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Doppler “drag”
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Interrupted Aortic Arch
Type A = After the subclavian artery, probably an extreme form of coarctation with obliteration of the lumenType B = Between the LCC and LSCA, most common, defect of arch remodeling/neural crestType C = Between the Carotid arteries, most rare
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Complex Lesions
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D-Transposition of the Great Arteries
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D-TGA
First described by Baillie 1797Natural history: >90% mortality in infancyIncidence: ~5% of congenital heart diseaseRare association with syndromes or other anomaliesMale:Female = 2:1Possible association with infant of diabetic mother
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D-TGA
Ventriculo-arterial discordanceCirculation in parallelRA=>RV=>AoLA=>LV=>PAMust have mixing at atrial or ventricular level to survive
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D-TGA
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D-Transposition
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D-Transposition Balloon Septostomy
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Again…
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Arterial Switch Procedure
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Long Term Postoperative ConcernsArterial Switch OperationNeo-pulmonary stenosisCoronary abnormalities
• Obstruction and stenosis• Decreased flow reserve
Neo-aortic insufficiency• Almost always trivial/mild
LV function
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Mustard Repair
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Atrial Baffle RepairLong Term Sequelae
On going late mortality risk• 20% mortality at 20 years
ArrhythmiaSVC obstruction -- 14-17%IVC obstruction -- 1%Baffle Leak -- Significant 1-2%Systemic AV valve regurgitation -- 30%Systemic Ventricular Failure -- 15-20%
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Transposition of the Great Arteries –L Type
MV – mitral valveTV – tricuspid valve
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L-TGA
“Congenitally Corrected Transposition”Atrio-ventricular and ventriculo-arterial discordance (“double discordance”)RA ⇒ LV ⇒ PALA ⇒ RV ⇒ AoMay be an isolated, asymptomatic finding or may be associated with other heart malformations
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Truncus Arteriosus
A single vessel arising from the heart and giving rise to the coronary, pulmonary and systemic circulationsThe VSD is the same as TOF
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Truncus Arteriosus
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AP Window
Communication between aorta and PA
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Hypoplastic Left Heart Syndrome
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Hypoplastic Left Heart Syndrome
RV
LV
RA
LAMPA
1 mmAAo
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BT Shunt: History
1930: Vivien Thomas hired as Alfred Blalock’s lab assistant
1924: Failing to obtain a surgical residency at Hopkins, Alfred Blalock goes to Vanderbilt and begins research on traumatic shock
1938: Rabbit models with subclavian to PA anastomosis fail to produce pulmonary HTN
1941: Blalock and Thomas move to Hopkins
1941: Coarctation relief with subclavian to descending aorta shunt
1943: Helen Taussig, a Hopkins pediatrics residency graduate, approaches Blalock about help for “blue babies”
1944: “Anna,” a dog with a surgically created mixing lesion, successfully undergoes end-to-side subclavian-to-PA anastomosis, lives 15 years
November 29, 1944: Eileen Saxon, a 15-month-old 4.5 kg undergoes successful systemic-to-pulmonary shunt by Blalock with Thomas directly over his shoulder
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Norwood I: Anatomy
1. Atrial septectomy2. Ligation of main
pulmonary artery and construction of neo-aorta
3. Sano Modification/
Modified BT Shunt
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BT Shunt
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Norwood I: Sano
Sano modification• RV-to-PA conduit• Eliminates competitive flow to PAs in diastole• Enhances coronary perfusion
RV
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Sano Shunt
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Bidirectional Glenn: Anatomy
• End-to-side anastomosis of SVC to undivided right pulmonary artery
• Includes takedown of BT shunt
• Allows flow to both lungs from SVC via passive flow
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Glenn Shunt
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Glenn Doppler
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Original Fontan
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Fontan: Variations
Lateral tunnel runs within RA, using free wall plus conduit as baffle for IVC blood
• Fenestrations: R-to-L shunting through the fenestration hypoxemia
• Improve cardiac output, minimize systemic venous hypertension, decrease post-op thoracostomy drainage
• Can later be closed by cathExtracardiac is IVC to MPA
• Generally has lower rate of complications• Foreign material requires anticoagulation
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Fenestrated Fontan
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Hypoplastic Left Heart SyndromePalliative Reconstruction
Stage I -- Norwood Procedure• Birth
Stage II -- Bi-directional Cavopulmonary Shunt• 4-6 months
Stage III-- Fontan Procedure• 18-24 months for lateral tunnel procedure• > 15 kg for extracardiac procedure
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QUESTION 1A tachypneic 2 month old is not growing well and has a murmur. An echocardiogram is obtained:
E
SYSTOLE DIASTOLE
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QUESTION 1 (CONT)All of the following statements are likely to be true except:A. The patient is at increased risk to have Down SyndromeB. The patient’s pulmonary artery pressure is normalC. The patient has an endocardial cushion defectD. The patient has a normal oxygen saturationE. The patient may have a small mitral valve cleft after surgical repair
E
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QUESTION 2A cyanotic newborn has the following echocardiogram:
E
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QUESTION 2 (CONT)All of the following statements are likely to be true except:A. The aorta is malposed anterior and rightwardB. The right ventricle pumps blood to the bodyC. Oxygenated blood is pumped to the lungsD. The left ventricle pumps blood to the bodyE. The right ventricular pressure is greater than or equal to the left ventricular pressure
E
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QUESTION 3A 40 year old with atrial fibrillation has the following echo:
E
SYSTOLE DIASTOLE
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QUESTION 3 (CONT)Subsequent imaging is most likely to reveal the followingA. Tetralogy of FallotB. Large membranous ventricular septal defectC. Large patent ductus arteriosusD. Large secundum atrial septal defectE. No structural cardiac defect
E
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QUESTION 4A 3 month old with a loud murmur and intermittent perioral cyanosis has the following echo:
E
LV
RV
Ao
LA
RVOT
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QUESTION 4 (CONT)All of the following statements are likely to be true except:
A. The aorta is overriding the left and right ventricleB. There is a large ventricular septal defectC. There is pulmonary stenosisD. The right ventricular pressure is increasedE. The pulmonary artery pressure is increased
E
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QUESTION 5An asymptomatic 9 month old with a loud murmur and a BP of 79/48 and has the following parasternal long axis 2D and CW Doppler findings:
E
LA
LV
RV
LV
LA
RV
CW
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QUESTION 5 (CONT)The most likely diagnosis is:
A. Membranous VSD, normal RV pressureB. Membranous VSD, elevated RV pressureC. Muscular VSD, normal RV pressureD. Muscular VSD, elevated RV pressureE. Tricuspid regurgitation, elevated RV pressure
E
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Acknowledgements
Unattributed illustrations are from Nadas’ Pediatric CardiologyAmy L. JuraszekMargaret LasotaChildren’s National Medical Center
• 202-476-4880 Physician Line• 202-476-5579 Echo Lab